Quinolinate induces selective loss of melanin-concentrating hormone neurons, rather than orexin neurons, in the hypothalamus of mice and young rats

Neuroscience

Volumn 170, Issue 1, 2010, Pages 298-307

  Obukuro, K ^a   Takigawa, M ^a   Hisatsune, A ^a   Isohama, Y ^a   Katsuki, H ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Excitotoxicity; Hypocretin; Narcolepsy; Quinolinic acid

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; DIZOCILPINE; MELANIN CONCENTRATING HORMONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OREXIN B; PICROTOXIN; QUINOLINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL LOSS; CIRCADIAN RHYTHM; CONTROLLED STUDY; CYTOTOXICITY; EXCITOTOXICITY; IN VIVO STUDY; MALE; MOUSE; NARCOLEPSY; NONHUMAN; PRIORITY JOURNAL; RAT;

AGE FACTORS; ANIMALS; CELL COUNT; CIRCADIAN RHYTHM; HYPOTHALAMIC HORMONES; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MELANINS; MELANOPHORES; MICE; MICE, INBRED C57BL; NEURONS; NEUROPEPTIDES; PITUITARY HORMONES; QUINOLINIC ACID; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 77955920655     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.06.081     Document Type: Article

References (39)

1. Abercrombie M. Estimation of nuclear population from microtome sections. Anat Rec 1946, 94:239-247.
2. Alon T., Friedman J.M. Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons. J Neurosci 2006, 26:389-397.
3. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999, 98:437-451.
4. Cvetkovic-Lopes V., Bayer L., Dorsaz S., Maret S., Pradervand S., Dauvilliers Y., Lecendreux M., Lammers G.J., Donjacour C.E., Du Pasquier R.A., Pfister C., Petit B., Hor H., Mühlethaler M., Tafti M. Elevated tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest 2010, 120:713-719.
5. DeGiorgio L.A., Konstantinov K.N., Lee S.C., Hardin J.A., Volpe B.T., Diamond B. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med 2001, 7:1189-1193.
6. Doble A. The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol Ther 1999, 81:163-221.
7. Eggermann E., Bayer L., Serafin M., Saint-Mleux B., Bernheim L., Machard D., Jones B.E., Muhlethaler M. The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization. J Neurosci 2003, 23:1557-1562.
8. Erdo S., Michler A., Wolff J.R. GABA accelerates excitotoxic cell death in cortical cultures: protection by blockers of GABA-gated chloride channels. Brain Res 1991, 542:254-258.
9. Gerashchenko D., Shiromani P.J. Effects of inflammation produced by chronic lipopolysaccharide administration on the survival of hypocretin neurons and sleep. Brain Res 2004, 1019:162-169.
10. Griffond B., Risold P.Y. MCH and feeding behavior-interaction with peptidic network. Peptides 2009, 30:2045-2051.
11. Hallmayer J., Faraco J., Lin L., Hesselson S., Winkelmann J., Kawashima M., Mayer G., Plazzi G., Nevsimalova S., Bourgin P., Hong S.C., Honda Y., Honda M., Högl B., Longstreth W.T., Montplaisir J., Kemlink D., Einen M., Chen J., Musone S.L., Akana M., Miyagawa T., Duan J., Desautels A., Erhardt C., Hesla P.E., Poli F., Frauscher B., Jeong J.H., Lee S.P., Ton T.G., Kvale M., Kolesar L., Dobrovolná M., Nepom G.T., Salomon D., Wichmann H.E., Rouleau G.A., Gieger C., Levinson D.F., Gejman P.V., Meitinger T., Young T., Peppard P., Tokunaga K., Kwok P.Y., Risch N., Mignot E. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet 2009, 41:708-711.
12. Harris G.C., Aston-Jones G. Arousal and reward: a dichotomy in orexin function. Trends Neurosci 2006, 29:571-577.
13. Hassani O.K., Lee M.G., Jones B.E. Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle. Proc Natl Acad Sci U S A 2009, 106:2418-2422.
14. Herrera A.J., Castaño A., Venero J.L., Cano J., Machado A. The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system. Neurobiol Dis 2000, 7:429-447.
15. Huang H., van den Pol A.N. Rapid direct excitation and long-lasting enhancement of NMDA response by group I metabotropic glutamate receptor activation of hypothalamic melanin-concentrating hormone neurons. J Neurosci 2007, 27:11560-11572.
16. Katsuki H., Akaike A. Excitotoxic degeneration of hypothalamic orexin neurons in slice culture. Neurobiol Dis 2004, 15:61-69.
17. Katsuki H., Akaike A. Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation. Neuroreport 2005, 16:1157-1161.
18. Lee M.G., Hassani O.K., Jones B.E. Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J Neurosci 2005, 25:6716-6720.
19. Mileykovskiy B.Y., Kiyashchenko L.I., Siegel J.M. Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 2005, 46:787-798.
20. Murphy J.A., Deurveilher S., Semba K. Stimulant doses of caffeine induce c-FOS activation in orexin/hypocretin-containing neurons in rat. Neuroscience 2003, 121:269-275.
21. Nishino S., Ripley B., Overeem S., Lammers G.J., Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000, 355:39-40.
22. Nishino S., Ripley B., Overeem S., Nevsimalova S., Lammers G.J., Vankova J., Okun M., Rogers W., Brooks S., Mignot E. Low cerebrospinal fluid hypocretin (orexin) and energy homeostasis in human narcolepsy. Ann Neurol 2001, 50:381-388.
23. Overeem S., Black J.L., Lammers G.J. Narcolepsy: immunological aspects. Sleep Med Rev 2008, 12:95-107.
24. Panchuk-Voloshina N., Haugland R.P., Bishop-Stewart J., Bhalgat M.K., Millard P.J., Mao F., Leung W.Y., Haugland R.P. Alexa dyes, a series of new fluorescent dyes that yield exceptionally bright, photostable conjugates. J Histochem Cytochem 1999, 47:1179-1188.
25. Peyron C., Faraco J., Rogers W., Ripley B., Overeem S., Charnay Y., Nevsimalova S., Aldrich M., Reynolds D., Albin R., Li R., Hungs M., Pedrazzoli M., Padigaru M., Kucherlapati M., Fan J., Maki R., Lammers G.J., Bouras C., Kucherlapati R., Nishino S., Mignot E. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000, 6:991-997.
26. Peyron C., Sapin E., Leger L., Luppi P.H., Fort P. Role of the melanin-concentrating hormone neuropeptide in sleep regulation. Peptides 2009, 30:2052-2059.
27. Sakurai T. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci 2007, 8:171-181.
28. Sakurai T., Nagata R., Yamanaka A., Kawamura H., Tsujino N., Muraki Y., Kageyama H., Kunita S., Takahashi S., Goto K., Koyama Y., Shioda S., Yanagisawa M. Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron 2005, 46:297-308.
29. Scammell T.E. The neurobiology, diagnosis, and treatment of narcolepsy. Ann Neurol 2003, 53:154-166.
30. Shimada M., Tritos N.A., Lowell B.B., Flier J.S., Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 1998, 396:670-674.
31. Shimogori T., Lee D.A., Miranda-Angulo A., Yang Y., Wang H., Jiang L., Yoshida A.C., Kataoka A., Mashiko H., Avetisyan M., Qi L., Qian J., Blackshaw S. A genomic atlas of mouse hypothalamic development. Nat Neurosci 2010, 13:767-775.
32. Smith T., Groom A., Zhu B., Turski L. Autoimmune encephalomyelitis ameliorated by AMPA antagonists. Nat Med 2000, 6:62-66.
33. Stone T.W. Kynurenines in the CNS: from endogenous obscurity to therapeutic importance. Prog Neurobiol 2001, 64:185-218.
34. Thannickal T.C., Moore R.Y., Nienhuis R., Ramanathan L., Gulyani S., Aldrich M., Cornford M., Siegel J.M. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000, 27:469-474.
35. Tsujino N., Sakurai T. Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system. Pharmacol Rev 2009, 61:162-176.
36. Vezzani A., Moneta D., Conti M., Richichi C., Ravizza T., De Luigi A., De Simoni M.G., Sperk G., Andell-Jonsson S., Lundkvist J., Iverfeldt K., Bartfai T. Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc Natl Acad Sci U S A 2000, 97:11534-11539.
37. Willie J.T., Sinton C.M., Maratos-Flier E., Yanagisawa M. Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression. Neuroscience 2008, 156:819-829.
38. Yamazaki S., Mochizuki Y., Terai T., Sugimoto M., Uchida I., Matsuoka N., Mutoh S. Intracerebroventricular injection of the antibiotic cefoselis produces convulsion in mice via inhibition of GABA receptors. Pharmacol Biochem Behav 2002, 74:53-59.
39. A receptor activation. Acta Neuropathol 1998, 95:592-596.