Diminished feeding responsiveness to orexin A (hypocretin 1) in aged rats is accompanied by decreased neuronal activation

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 289, Issue 2 58-2, 2005, Pages

  Kotz, Catherine M ^a,b,c   Mullett, Mary A ^d   Wang, ChuanFeng ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b University of Minnesota   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Aging; c Fos immunoreactivity; Feeding behavior; Lateral hypothalamus; Sleep

Indexed keywords

OREXIN A;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR HYPOTHALAMUS; APPETITE; ARTICLE; CONTROLLED STUDY; FEEDING BEHAVIOR; FOOD INTAKE; IMMUNOREACTIVITY; LATERAL HYPOTHALAMUS; MALE; NERVE CELL NETWORK; NERVE CONDUCTION; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SLEEP; STIMULUS RESPONSE;

AGING; ANIMALS; BRAIN; EATING; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEDIODORSAL THALAMIC NUCLEUS; NEURONS; NEUROPEPTIDES; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, INBRED F344; TIME FACTORS;

EID: 23044469009     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00717.2004     Document Type: Article

References (46)

1. Backberg M, Hervieu G, Wilson S, and Meister B. Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake. Eur J Neurosci 15: 315-328, 2002.
2. Bernardis LL and Bellinger LL. The lateral hypothalamic area revisited: ingestive behavior. Neurosci Biobehav Rev 20: 189-287, 1996.
3. Blanton CA, Horwitz BA, Blevins JE, Hamilton JS, Hernandez EJ, and McDonald RB. Reduced feeding response to neuropeptide Y in senescent Fischer 344 rats. Am J Physiol Regul Integr Comp Physiol 280: R1052-R1060, 2001.
4. Blanton CA, Horwitz BA, Murtagh-Mark C, Gietzen DW, Griffey SM, and McDonald RB. Meal patterns associated with the age-related decline in food intake in the Fischer 344 rat. Am J Physiol Regul Integr Comp Physiol 275: R1494-R1502, 1998.
5. Cai XJ, Widdowson PS, Harrold J, Wilson S, Buckingham RE, Arch JR, Tadayyon M, Clapham JC, Wilding J, and Williams G. Hypothalamic orexin expression: modulation by blood glucose and feeding. Diabetes 48: 2132-2137, 1999.
6. Clarkston WK, Pantano MM, Morley JE, Horowitz M, Littlefield JM, and Burton FR. Evidence for the anorexia of aging: gastrointestinal transit and hunger in healthy elderly vs. young adults. Am J Physiol Regul Integr Comp Physiol 272: R243-R248, 1997.
7. Cluderay JE, Harrison DC, and Hervieu GJ. Protein distribution of the orexin-2 receptor in the rat central nervous system. Regul Pept 104: 131-144, 2002.
8. Cole RL and Sawchenko PE. Neurotransmitter regulation of cellular activation and neuropeptide gene expression in the paraventricular nucleus of the hypothalamus. J Neurosci 22: 959-969, 2002.
9. Coppola JD, Horwitz BA, Hamilton J, and McDonald RB. Expression of NPY Y1 and Y5 receptors in the hypothalamic paraventricular nucleus of aged Fischer 344 rats. Am J Physiol Regul Integr Comp Physiol 287: R69-R75, 2004.
10. de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FSn, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, and Sutcliffe JG. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95: 322-327, 1998.
11. Dube MG, Kalra SP, and Kalra PS. Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res 842: 473-477, 1999.
12. Gosnell BA, Levine AS, and Morley JE. The effects of aging on opioid modulation of feeding in rats. Life Sci 32: 2793-2799, 1983.
13. Gruenewald DA and Matsumoto AM. Age-related decrease in proopiomelanocortin gene expression in the arcuate nucleus of the male rat brain. Neurobiol Aging 12: 113-121, 1991.
14. Kaczmarek L. c-Fos in learning: beyond the mapping of neuronal activity. In: Handbook of Chemical Neuroanatomy: Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction, edited by Kaczmarek, L and Robertson, HJ. New York: Elsevier, 2002, pp. 189-215.
15. Kanbayashi T, Yano T, Ishiguro H, Kawanishi K, Chiba S, Aizawa R, Sawaishi Y, Hirota K, Nishino S, and Shimizu T. Hypocretin-1 (orexin-A) levels in human lumbar CSF in different age groups: infants to elderly persons. Sleep 25: 337-339, 2002.
16. Kirchgessner AL, Sclafani A, and Nilaver G. Histochemical identification of a PVN-hindbrain feeding pathway. Physiol Behav 42: 529-543, 1988.
17. Kotz CM, Grace MK, Briggs J, Levine AS, and Billington CJ. Effects of opioid antagonists naloxone and naltrexone on neuropeptide Y-induced feeding and brown fat thermogenesis in the rat. Neural site of action. J Clin Invest 96: 163-170, 1995.
18. Kotz CM, Weldon D, Billington CJ, and Levine AS. Age-related changes in brain proDynorphin gene expression in the rat. Neurobiol Aging 25: 1343-1347, 2004.
19. Levine AS and Billington CJ. Opioids as agents of reward-related feeding: a consideration of the evidence. Physiol Behav 82: 57-61, 2004.
20. MacIntosh CG, Sheehan J, Davani N, Morley JE, Horowitz M, and Chapman IM. Effects of aging on the opioid modulation of feeding in humans. J Am Geriatr Soc 49: 1518-1524, 2001.
21. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, and Elmquist JK. Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435: 6-25, 2001.
22. Miller IJJ and Reedy FEJ. Variation in human taste bud density as a function of age. Physiol Behav 47: 1213-1219, 1990.
23. Mistretta CM. Anatomy and neurophysiology of the taste system in aged animals. Ann NY Acad Sci 561: 277-290, 1989.
24. Morley JE. Anorexia in older persons: epidemiology and optimal treatment. Drugs Aging 8: 134-155, 1996.
25. Morley JE. Anorexia of aging: physiologic and pathologic mechanisms. Am J Clin Nutr 66: 760-773, 1997.
26. Mullett MA, Billington CJ, Levine AS, and Kotz CM. Hypocretin I in the lateral hypothalamus activates key feeding-regulatory brain sites. Neuroreport 11: 103-108, 2000.
27. Nambu T, Sakurai T, Mizukami K, Hosoya Y, Yanasigawa M, and Goto K. Distribution of orexin neurons in the adult rat brain. Brain Res 827: 243-260, 1999.
28. Nicholson C. Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity. Brain Res 333: 325-329, 1985.
29. Park TH and Carr KD. Neuroanatomical patterns of fos-like immunoreactivity induced by a palatable meal and meal-paired environment in saline- and naltrexone-treated rats. Brain Res 805: 169-180, 1998.
30. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates. San Diego, CA: Academic, 1990.
31. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, and Kilduff TS. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18: 9996-10015, 1998.
32. Rinaman L, Baker EA, Hoffman GE, Stricker EM, and Verbalis JG. Medullary c-Fos activation in rats after ingestion of a satiating meal. Am J Physiol Regul Integr Comp Physiol 275: R262-R268, 1998.
33. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, and Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-585, 1998.
34. Sweet DC, Levine AS, Billington CJ, and Kotz CM. Feeding response to central orexins. Brain Res 821: 535-538, 1999.
35. Tajuddin NF and Druse MJ. Effects of chronic ethanol consumption and aging on proenkephalin and neurotensin. Alcohol Clin Exp Res 22: 1152-1160, 1998.
36. Takano S, Kanai S, Hosoya H, Ohta M, Uematsu H, and Miyasaka K. Orexin-A does not stimulate food intake in old rats. Am J Physiol Gastrointest Liver Physiol 287: G1182-G1187, 2004.
37. Terao A, Apte-Deshpande A, Morairty S, Freund YR, and Kilduff TS. Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain. Neurosci Lett 332: 190-194, 2002.
38. Thorpe AJ, Mullett MA, Wang C, and Kotz CM. Peptides that regulate food intake: regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation. Am J Physiol Regul Integr Comp Physiol 284: R1409-R1417, 2003.
39. Timofeeva E, Picard F, Duclos M, Deshaies Y, and Richard D. Neuronal activation and corticotropin-releasing hormone expression in the brain of obese (fa/fa) and lean (fa/?) Zucker rats in response to refeeding. Eur J Neurosci 15: 1013-1029, 2002.
40. Trivedi P, Yu H, MacNeil DJ, Van der Ploeg LHT, and Guan XM. Distribution of orexin receptor mRNA in the rat brain. FEBS Lett 438: 71-75, 1998.
41. Willie JT, Chemelli RM, Sinton CM, and Yanagisawa M. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci 24: 429-458, 2001.
42. Wolden-Hanson T, Marck BT, and Matsumoto AM. Blunted hypothalamic neuropeptide gene expression in response to fasting, but preservation of feeding responses to AgRP in aging male Brown Norway rats. Am J Physiol Regul Integr Comp Physiol 287: R138-R146, 2004.
43. Wolden-Hanson T, Marck BT, and Matsumoto AM. Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression. Exp Gerontol 37: 679-691, 2002.
44. Yamanaka A, Kunii K, Nambu T, Tsujino N, Sakai A, Matsuzaki I, Miwa Y, Goto K, and Sakurai T. Orexin-induced food intake involves neuropeptide Y pathway. Brain Res 859: 404-409, 2000.
45. Zhang JH, Sampogna S, Morales FR, and Chase MH. Age-related changes in hypocretin (orexin) immunoreactivity in the cat brainstem. Brain Res 930: 206-211, 2002.
46. Zheng H, Corkern MM, Crousillac SM, Patterson LM, Phifer CB, and Berthoud HR. Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP. Am J Physiol Regul Integr Comp Physiol 282: R1773-R1781, 2002.