Age-related changes in plasma orexin-A concentrations

Experimental Gerontology

Volumn 37, Issue 8-9, 2002, Pages 1127-1130

  Matsumura, Takeshi ^a   Nakayama, Mika ^a   Nomura, Akihiro ^a   Naito, Asuka ^a   Kamahara, Kazuyuki ^a   Kadono, Kennosuke ^a   Inoue, Masaaki ^a   Homma, Toshiaki ^a   Sekizawa, Kiyohisa ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Age; Gender; Leptin; Orexins

Indexed keywords

OREXIN A;

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GROUPS BY AGE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION;

ADULT; AGED; AGING; CARRIER PROTEINS; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MALE; MIDDLE AGED; NEUROPEPTIDES;

EID: 0036696116     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(02)00092-X     Document Type: Article

References (18)

1. Al-Barazanji K.A., Wilson S., Baker J., Jessop D.S., Harbuz M.S. Central orexin-A activates hypothalamic-pituitary-adrenal axis and stimulates hypothalamic corticotrophin releasing factor and arginine vasopressin neurones in conscious rats. J. Neuroendocrinol. 13:2001;421-424.
2. Beck B., Richy S. Hypothalamic hypocretin/orexin and neuropeptide Y: divergent interaction with energy depletion and leptin. Biochem. Biophys. Res. Commun. 258:1999;119-122.
3. Bingham S., Davey P.T., Babbs A.J., Irving E.A., Sammons M.J., Wyles M., Jeffrey P., Cutler L., Riba I., Johns A., Porter R.A., Upton N., Hunter A.J., Parsons A.A. Orexin-A, a hypothalamic peptide with analgesic properties. Pain. 92:2001;81-90.
4. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 98:1999;437-451.
5. Clarkston W.K., Pantano M.M., Morley J.E., Horowits M., Littlefield J.M., Burton F.R. Evidence for the anorexia of aging: gastrointestinal transit and hunger in healthy elderly vs young adults. Am. J. Physiol. 272:1997;R243-R248.
6. Horvath T.L., Diano S., van den Pol A.N. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J. Neurosci. 19:1999;1072-1087.
7. Ida T., Nakahara K., Murakami T., Hanada R., Nakazato M., Murakami N. Possible involvement of orexin in the stress reaction in rats. Biochem. Biophys. Res. Commun. 270:2000;318-323.
8. Ishidori A.M., Strollo F., More M., Caprio M., Aversa A., Moretti C., Franjese G., Riondino G., Fabbri A. Leptin and aging: correlation with endocrine changes in men and women healthy adult populations of different body weights. J. Clin. Endocrinol. Metab. 85:2000;1954-1962.
9. Kirchgessner A.L. Orexins in the brain-gut axis. Endocr. Rev. 23:2002;1-15.
10. Komaki G., Matsumoto Y., Nishikata H., Kawai K., Nozaki T., Takii M., Sogawa H., Kugo C. Orexin-A and leptin change inversely in fasting non-obese subjects. Eur. J. Endocrinol. 144:2001;645-651.
11. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qiu X., de Jong P.J., Nishino S., Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 98:1999;365-376.
12. Mitsuma T., Hirooka Y., Kayama M., Mori Y., Yokoi Y., Rhue N., Ping J., Izumi M., Ikai R., Adachi K., Nogimori T. Radioimmunoassay for orexin-A. Life Sci. 66:2000;897-904.
13. Sakurai T., Amemia A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richarson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 92:1998;573-585.
14. Samson W.K., Gosnell B., Chang J.K., Resch Z.T., Murphy T.C. Cardiovascular regulatory actions of the hypocretins in brain. Brain Res. 831:1999;248-253.
15. Scarpace P.J., Matheny M., Moore R.L., Tumer N. Impaired leptin responsiveness in aged rats. Diabetes. 49:2000;431-435.
16. Sweet D.C., Levine A.S., Billington C.J., Kotz C.M. Feeding response to central orexins. Brain Res. 821:1999;535-538.
17. Yamada H., Okumura T., Motomura W., Kobayashi Y., Kohgo Y. Inhibition of food intake by central injection of anti-orexin antibody in fasted rats. Biochem. Biophys. Res. Commun. 267:2000;527-531.
18. Yamanaka A., Kunii K., Nambu T., Tsujino N., Sakai A., Matsuzaki I., Miwa Y., Goto K., Sakurai T. Orexin-induced food intake involves neuropeptide Y pathway. Brain Res. 859:2000;404-409.