-
1
-
-
0022558297
-
Replacing the complementarity-determining regions in a human antibody with those from a mouse
-
Jones, P.T., P.H. Dear, J. Foote, M.S. Neuberger, and G. Winter. 1986. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature. 321:522-525.
-
(1986)
Nature
, vol.321
, pp. 522-525
-
-
Jones, P.T.1
Dear, P.H.2
Foote, J.3
Neuberger, M.S.4
Winter, G.5
-
2
-
-
0021716682
-
Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains
-
Morrison, S.L., M.J. Johnson, L.A. Herzenberg, and V.T. Oi. 1984. Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc. Natl. Acad. Sci. USA. 81:6851-6855.
-
(1984)
Proc. Natl. Acad. Sci. USA
, vol.81
, pp. 6851-6855
-
-
Morrison, S.L.1
Johnson, M.J.2
Herzenberg, L.A.3
Oi, V.T.4
-
3
-
-
0021713342
-
Production of functional chimaeric mouse/human antibody
-
Boulianne, G.L., N. Hozumi, and M.J. Shulman. 1984. Production of functional chimaeric mouse/human antibody. Nature. 312:643-646.
-
(1984)
Nature
, vol.312
, pp. 643-646
-
-
Boulianne, G.L.1
Hozumi, N.2
Shulman, M.J.3
-
4
-
-
0021826932
-
A hapten-specific chimaeric IgE antibody with human physiological effector function
-
Neuberger, M.S., G.T. Williams, E.B Mitchell, S.S. Jouhal, J.G. Flanagan, and T.H. Rabbitts. 1985. A hapten-specific chimaeric IgE antibody with human physiological effector function. Nature. 314:268-270.
-
(1985)
Nature
, vol.314
, pp. 268-270
-
-
Neuberger, M.S.1
Williams, G.T.2
Mitchell, E.B.3
Jouhal, S.S.4
Flanagan, J.G.5
Rabbitts, T.H.6
-
5
-
-
0027231544
-
The immunoglobulin kappa locus: Polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals
-
Schaible, G., G.A. Rappold, W. Pargent, and H.G. Zachau. 1993. The immunoglobulin kappa locus: polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals. Hum. Genet. 91:261-267.
-
(1993)
Hum. Genet.
, vol.91
, pp. 261-267
-
-
Schaible, G.1
Rappold, G.A.2
Pargent, W.3
Zachau, H.G.4
-
6
-
-
0027475327
-
Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus
-
Matsuda, F., E.K. Shin, H. Nagaoka, R. Matsumura, M. Haino, Y. Fukita, S. Taka-Ishi, T. Imai, J.H. Riley, R. Anand, E. Soeda, and T. Honjo. 1993. Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat. Genet. 3:88-94.
-
(1993)
Nat. Genet.
, vol.3
, pp. 88-94
-
-
Matsuda, F.1
Shin, E.K.2
Nagaoka, H.3
Matsumura, R.4
Haino, M.5
Fukita, Y.6
Taka-Ishi, S.7
Imai, T.8
Riley, J.H.9
Anand, R.10
Soeda, E.11
Honjo, T.12
-
7
-
-
0028235295
-
A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q
-
Cook, G.P., I.M. Tomlinson, G. Walter, H. Riethman, N.P. Carter, L. Buluwela, G. Winter, and T.H. Rabbitts. 1994. A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q. Nat. Genet. 7:162-168.
-
(1994)
Nat. Genet.
, vol.7
, pp. 162-168
-
-
Cook, G.P.1
Tomlinson, I.M.2
Walter, G.3
Riethman, H.4
Carter, N.P.5
Buluwela, L.6
Winter, G.7
Rabbitts, T.H.8
-
8
-
-
0029157017
-
Ethnic differences in polymorphism of an immunoglobulin VH3 gene
-
Sasso, E.H., J.H. Buckner, and L.A. Suzuki. 1995. Ethnic differences in polymorphism of an immunoglobulin VH3 gene. J. Clin. Invest. 96:1591-1600.
-
(1995)
J. Clin. Invest.
, vol.96
, pp. 1591-1600
-
-
Sasso, E.H.1
Buckner, J.H.2
Suzuki, L.A.3
-
9
-
-
0344802120
-
Organization of the human VH locus and rearrangement patterns of the VH3 gene family
-
M. Zouali, editor. Springer, New York
-
Milner, E.C.B. 1996. Organization of the human VH locus and rearrangement patterns of the VH3 gene family. In Human B Cell Superantigens. M. Zouali, editor. Springer, New York. 1-10.
-
(1996)
Human B Cell Superantigens
, pp. 1-10
-
-
Milner, E.C.B.1
-
10
-
-
0024204319
-
Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H
-
Hale, G., M.J.S. Dyer, M.R. Clark, J.M. Phillips, R. Marcus, L. Riechmann, G. Winter, and H. Waldmann. 1988. Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H. Lancet. 2:1394-1399.
-
(1988)
Lancet
, vol.2
, pp. 1394-1399
-
-
Hale, G.1
Dyer, M.J.S.2
Clark, M.R.3
Phillips, J.M.4
Marcus, R.5
Riechmann, L.6
Winter, G.7
Waldmann, H.8
-
11
-
-
0014828908
-
An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity
-
Wu, T.T., and E.A. Kabat. 1970. An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. J. Exp. Med. 132:211-250.
-
(1970)
J. Exp. Med.
, vol.132
, pp. 211-250
-
-
Wu, T.T.1
Kabat, E.A.2
-
12
-
-
0015247402
-
Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains
-
Kabat, E.A., and T.T. Wu. 1971. Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains. Ann. NY Acad. Sci. 190:382-393.
-
(1971)
Ann. NY Acad. Sci.
, vol.190
, pp. 382-393
-
-
Kabat, E.A.1
Wu, T.T.2
-
14
-
-
0031091762
-
Structural consequences of humanizing an antibody
-
Holmes, M.A., and J. Foote. 1997. Structural consequences of humanizing an antibody. J. Immunol. 158:2192-2201.
-
(1997)
J. Immunol.
, vol.158
, pp. 2192-2201
-
-
Holmes, M.A.1
Foote, J.2
-
15
-
-
0004032583
-
-
US Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda
-
Kabat, E.A., T.T. Wu, H.M. Perry, K.S. Gottesman, and K. Coeller. 1991. Sequences of Proteins of Immunological Interest. 5th ed. US Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda.
-
(1991)
Sequences of Proteins of Immunological Interest. 5th Ed.
-
-
Kabat, E.A.1
Wu, T.T.2
Perry, H.M.3
Gottesman, K.S.4
Coeller, K.5
-
16
-
-
0025151612
-
Small rearrangements in structures of Fv and Fab fragments of antibody D1.3 on antigen binding
-
Bhat, T.N., G.A. Bentley, T.O. Fischmann, G. Boulot, and R.J. Poljak. 1990. Small rearrangements in structures of Fv and Fab fragments of antibody D1.3 on antigen binding. Nature. 347:483-485.
-
(1990)
Nature
, vol.347
, pp. 483-485
-
-
Bhat, T.N.1
Bentley, G.A.2
Fischmann, T.O.3
Boulot, G.4
Poljak, R.J.5
-
17
-
-
0022519337
-
Three-dimensional structure of an antigen-antibody complex at 2.8 Å resolution
-
Amit, A.G., R.A. Mariuzza, S.E.V. Phillips, and R.J. Poljak. 1986. Three-dimensional structure of an antigen-antibody complex at 2.8 Å resolution. Science. 233:747-753.
-
(1986)
Science
, vol.233
, pp. 747-753
-
-
Amit, A.G.1
Mariuzza, R.A.2
Phillips, S.E.V.3
Poljak, R.J.4
-
18
-
-
0015733869
-
Three-dimensional structure of the Fab′ fragment of a human immunoglobulin at 2.8 Å resolution
-
Poljak, R.J., L.M. Amzel, H.P. Avey, B.L. Chen, R.P. Phizackerly, and F. Saul. 1973. Three-dimensional structure of the Fab′ fragment of a human immunoglobulin at 2.8 Å resolution. Proc. Natl. Acad. Sci. USA. 70:3305-3310.
-
(1973)
Proc. Natl. Acad. Sci. USA
, vol.70
, pp. 3305-3310
-
-
Poljak, R.J.1
Amzel, L.M.2
Avey, H.P.3
Chen, B.L.4
Phizackerly, R.P.5
Saul, F.6
-
19
-
-
0026706824
-
Crystal structure of human immunoglobulin fragment Fab New refined at 2.0 Å resolution
-
Saul, F.A., and R.J. Poljak. 1992. Crystal structure of human immunoglobulin fragment Fab New refined at 2.0 Å resolution. Proteins. 14:363-371.
-
(1992)
Proteins
, vol.14
, pp. 363-371
-
-
Saul, F.A.1
Poljak, R.J.2
-
20
-
-
0016804680
-
The molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0 Å resolution
-
Epp, O., E.E. Lattman, M. Schiffer, R. Huber, and W. Palm. 1975. The molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0 Å resolution. Biochemistry. 14:4943-4952.
-
(1975)
Biochemistry
, vol.14
, pp. 4943-4952
-
-
Epp, O.1
Lattman, E.E.2
Schiffer, M.3
Huber, R.4
Palm, W.5
-
21
-
-
0026559783
-
Antibody residues affecting conformation of the hypervariable loops
-
Foote, J., and G. Winter. 1992. Antibody residues affecting conformation of the hypervariable loops. J. Mol. Biol. 224: 487-499.
-
(1992)
J. Mol. Biol.
, vol.224
, pp. 487-499
-
-
Foote, J.1
Winter, G.2
-
22
-
-
0026502047
-
High level Escherichia coli expression and production of a bivalent humanized antibody fragment
-
Carter, P., R.F. Kelley, M.L. Rodrigues, B. Snedecor, M. Covarrubias, M.D. Velligan, W.L.T. Wong, A.M. Rowland, C.E. Kotts, M.E. Carver, et al. 1992. High level Escherichia coli expression and production of a bivalent humanized antibody fragment. Bio/Technology 10:163-167.
-
(1992)
Bio/Technology
, vol.10
, pp. 163-167
-
-
Carter, P.1
Kelley, R.F.2
Rodrigues, M.L.3
Snedecor, B.4
Covarrubias, M.5
Velligan, M.D.6
Wong, W.L.T.7
Rowland, A.M.8
Kotts, C.E.9
Carver, M.E.10
-
24
-
-
0024292736
-
Assembly of a functional immunoglobulin Fv fragment in Escherichia coli
-
Skerra, A., and A. Plückthun. 1988. Assembly of a functional immunoglobulin Fv fragment in Escherichia coli. Science. 240: 1038-1041.
-
(1988)
Science
, vol.240
, pp. 1038-1041
-
-
Skerra, A.1
Plückthun, A.2
-
25
-
-
0031059866
-
Processing of x-ray diffraction data collected in oscillation mode
-
Otwinowski, Z., and W. Minor. 1997. Processing of x-ray diffraction data collected in oscillation mode. Methods Enzymol. 276:307-326.
-
(1997)
Methods Enzymol.
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
28
-
-
0026597444
-
Free R value: A novel statistical quantity for assessing the accuracy of crystal structures
-
Brünger, A.T. 1992. Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. Nature. 355: 472-475.
-
(1992)
Nature
, vol.355
, pp. 472-475
-
-
Brünger, A.T.1
-
29
-
-
0029644940
-
When freedom is given, liberties are taken
-
Kleywegt, G.J., and T.A Jones. 1995. When freedom is given, liberties are taken. Structure. 3:535-540.
-
(1995)
Structure
, vol.3
, pp. 535-540
-
-
Kleywegt, G.J.1
Jones, T.A.2
-
31
-
-
0000243829
-
PROCHECK: A program to check the stereochemistry of protein structures
-
Laskowski, R.A., M.W. MacArthur, D.S. Moss, and J.M. Thornton. 1993. PROCHECK: a program to check the stereochemistry of protein structures. J. Appl. Crystallogr. 26: 283-291.
-
(1993)
J. Appl. Crystallogr.
, vol.26
, pp. 283-291
-
-
Laskowski, R.A.1
MacArthur, M.W.2
Moss, D.S.3
Thornton, J.M.4
-
32
-
-
0024279567
-
One type of gamma-turn, rather than the other gives rise to chain-reversal in proteins
-
Milner-White, E.J., B.M. Ross, R. Ismail, K. Belhadj-Mostefa, and R. Poet. 1988. One type of gamma-turn, rather than the other gives rise to chain-reversal in proteins. J. Mol. Biol. 204:777-782.
-
(1988)
J. Mol. Biol.
, vol.204
, pp. 777-782
-
-
Milner-White, E.J.1
Ross, B.M.2
Ismail, R.3
Belhadj-Mostefa, K.4
Poet, R.5
-
33
-
-
0002705842
-
A visual protein crystallographic software system for X11/Xview
-
McRee, D.E. 1992. A visual protein crystallographic software system for X11/Xview. J. Mol. Graphics. 10:44-46.
-
(1992)
J. Mol. Graphics.
, vol.10
, pp. 44-46
-
-
McRee, D.E.1
-
34
-
-
0028289241
-
Anatomy of the antibody molecule
-
Padlan, E.A. 1994. Anatomy of the antibody molecule. Mol. Immunol. 31:169-217.
-
(1994)
Mol. Immunol.
, vol.31
, pp. 169-217
-
-
Padlan, E.A.1
-
35
-
-
0028014642
-
Bound water molecules and conformational stabilization help mediate an antigen-antibody association
-
Bhat, T.N., G.A. Bentley, G. Boulot, M.I. Green, D. Tello, W. Dall'Acqua, H. Souchon, F.P. Schwarz, R.A. Mariuzza, and R.J. Poljak. 1994. Bound water molecules and conformational stabilization help mediate an antigen-antibody association. Proc. Natl. Acad. Sci. USA. 91:1089-1093.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 1089-1093
-
-
Bhat, T.N.1
Bentley, G.A.2
Boulot, G.3
Green, M.I.4
Tello, D.5
Dall'Acqua, W.6
Souchon, H.7
Schwarz, F.P.8
Mariuzza, R.A.9
Poljak, R.J.10
-
36
-
-
0023920595
-
Reshaping human antibodies: Grafting an antilysozyme activity
-
Verhoeyen, M.E., C. Milstein, and G. Winter. 1988. Reshaping human antibodies: grafting an antilysozyme activity. Science. 239:1534-1536.
-
(1988)
Science
, vol.239
, pp. 1534-1536
-
-
Verhoeyen, M.E.1
Milstein, C.2
Winter, G.3
-
37
-
-
0025939121
-
An autoantibody to single-stranded DNA: Comparison of the three-dimensional structures of the unliganded Fab and a deoxynucleotide-Fab complex
-
Herron, J.N., X.M. He, D.W. Ballard, P.R. Blier, P.E. Pace, A.L.M. Bothwell, E.W. Voss, Jr., and A.B. Edmundson. 1991. An autoantibody to single-stranded DNA: comparison of the three-dimensional structures of the unliganded Fab and a deoxynucleotide-Fab complex. Proteins. 11:159-175.
-
(1991)
Proteins
, vol.11
, pp. 159-175
-
-
Herron, J.N.1
He, X.M.2
Ballard, D.W.3
Blier, P.R.4
Pace, P.E.5
Bothwell, A.L.M.6
Voss Jr., E.W.7
Edmundson, A.B.8
-
38
-
-
0026587998
-
Structural evidence for induced fit as a mechanism for antibody-antigen recognition
-
Rini, J.M., U. Schulze-Gahmen, and I.A. Wilson. 1992. Structural evidence for induced fit as a mechanism for antibody-antigen recognition. Science. 255:959-963.
-
(1992)
Science
, vol.255
, pp. 959-963
-
-
Rini, J.M.1
Schulze-Gahmen, U.2
Wilson, I.A.3
-
39
-
-
0001039702
-
Kinetic evidence for hapten-induced conformational transition in immunoglobulin MOPC 460
-
Lancet, D., and I. Pecht. 1976. Kinetic evidence for hapten-induced conformational transition in immunoglobulin MOPC 460. Proc Natl. Acad. Sci. USA. 73:3548-3553.
-
(1976)
Proc Natl. Acad. Sci. USA
, vol.73
, pp. 3548-3553
-
-
Lancet, D.1
Pecht, I.2
-
40
-
-
0013446025
-
Dual conformations of an immunoglobulin light-chain dimer: Heterogeneity of antigen specificity and idiotope profile may result from multiple variable-domain interaction mechanisms
-
Stevens, F.J., C.-H. Chang, and M. Schiffer. 1988. Dual conformations of an immunoglobulin light-chain dimer: heterogeneity of antigen specificity and idiotope profile may result from multiple variable-domain interaction mechanisms. Proc. Natl. Acad. Sci. USA. 85:6895-6899.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 6895-6899
-
-
Stevens, F.J.1
Chang, C.-H.2
Schiffer, M.3
-
41
-
-
0027943261
-
Conformational isomensm and the diversity of antibodies
-
Foote, J., and C. Milstein. 1994. Conformational isomensm and the diversity of antibodies. Proc. Natl. Acad. Sci. USA. 91: 10370-10374.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 10370-10374
-
-
Foote, J.1
Milstein, C.2
-
42
-
-
0023278330
-
Canonical structures for the hypervariable regions of immunoglobulins
-
Chothia, C., and A.M. Lesk. 1987. Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 96:901-917.
-
(1987)
J. Mol. Biol.
, vol.96
, pp. 901-917
-
-
Chothia, C.1
Lesk, A.M.2
-
43
-
-
0025063143
-
Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins
-
Tramontano, A., C. Chothia, and A.M. Lesk. 1990. Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins. J. Mol. Biol. 215:175-182.
-
(1990)
J. Mol. Biol.
, vol.215
, pp. 175-182
-
-
Tramontano, A.1
Chothia, C.2
Lesk, A.M.3
-
44
-
-
0029364787
-
Conservation of water molecules in an antibody-antigen interaction
-
Braden, B.C., B.A. Fields, and R.J. Poljak. 1995. Conservation of water molecules in an antibody-antigen interaction. J. Mol. Recognit. 8:317-325.
-
(1995)
J. Mol. Recognit.
, vol.8
, pp. 317-325
-
-
Braden, B.C.1
Fields, B.A.2
Poljak, R.J.3
-
45
-
-
0029706920
-
The effect of water activity on the association constant and the enthalpy of reaction between lysozyme and the specific antibodies D1.3 and D44.1
-
Goldbaum, F.A., F.P. Schwarz, E. Eisenstein, A. Cauerhff, R.A. Mariuzza, and R.J. Poljak. 1996. The effect of water activity on the association constant and the enthalpy of reaction between lysozyme and the specific antibodies D1.3 and D44.1. J. Mol. Recognit. 9:6-12.
-
(1996)
J. Mol. Recognit.
, vol.9
, pp. 6-12
-
-
Goldbaum, F.A.1
Schwarz, F.P.2
Eisenstein, E.3
Cauerhff, A.4
Mariuzza, R.A.5
Poljak, R.J.6
-
46
-
-
0026244229
-
MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
-
Kraulis, P.J. 1991. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24:946-950.
-
(1991)
J. Appl. Crystallogr.
, vol.24
, pp. 946-950
-
-
Kraulis, P.J.1
|