P38γ activation triggers dynamical changes in allosteric docking sites

Biochemistry

Volumn 50, Issue 8, 2011, Pages 1384-1395

  Rodriguez Limardo, Ramiro G ^a,b   Ferreiro, Dardo N ^a,b   Roitberg, Adrián E ^c   Marti, Marcelo A ^a,b   Turjanski, Adrian G ^a,b  

^a Instituto de Quimica Fisica de los Materiales Medio Ambiente y Energia   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c University of Florida   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LOOPS; ACTIVE SITE; ATP BINDING; BOUND STATE; CATALYTIC ACTIVITY; CONFORMATIONAL CHANGE; CORRELATED DYNAMICS; DOCKING SITES; DYNAMICAL FLUCTUATIONS; ISOFORMS; KEY FACTORS; MD SIMULATION; MITOGEN ACTIVATED PROTEIN KINASE; MOLECULAR DYNAMICS TECHNIQUES; MULTIPLE CELLULAR FUNCTIONS; PROTEIN DOMAINS; PROTEIN DYNAMICS; PROTEIN-PROTEIN INTERACTIONS; SIGNAL TRANSDUCTION PATHWAYS; SIGNALING NETWORKS; THREONINE KINASE; TWO DOMAINS;

AMINO ACIDS; BINDING ENERGY; DOCKING; DYNAMICS; ENZYMES; MOLECULAR DYNAMICS; PHOSPHORYLATION; PLASTICITY; SIGNAL TRANSDUCTION; SIGNALING;

CATALYST ACTIVITY;

ADENOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 GAMMA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; MOLECULAR DYNAMICS; MOTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIMULATION;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ENZYME ACTIVATION; MITOGEN-ACTIVATED PROTEIN KINASE 12; MOLECULAR DYNAMICS SIMULATION; MOVEMENT; PHOSPHORYLATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 79951920255     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1007518     Document Type: Article

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