Activin in Glucose Metabolism

Vitamins and Hormones

Volumn 85, Issue , 2011, Pages 217-234

  Hashimoto, Osamu ^a   Funaba, Masayuki ^b  

^a KITASATO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Adipose inflammation; Energy metabolism; Insulin sensitivity; Metabolic syndrome; TGF family

Indexed keywords

ACTIVIN; GLUCOSE; INSULIN;

ANIMAL; BOOK; ENERGY METABOLISM; HUMAN; METABOLISM;

ACTIVINS; ANIMALS; ENERGY METABOLISM; GLUCOSE; HUMANS; INSULIN;

EID: 79951908000     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385961-7.00011-1     Document Type: Book

References (100)

1. Ahmed N., Thornalley P.J. Advanced glycation endproducts: What is their relevance to diabetic complications?. Diabetes Obes. Metab. 2007, 9:233-245.
2. Akpan I., Goncalves M.D., Dhir R., Yin X., Pistilli E.E., Bogdanovich S., Khurana T.S., Ucran J., Lachey J., Ahima R.S. The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity. Int. J. Obes. 2009, 33:1265-1273.
3. Alessi M.C., Bastelica D., Morange P., Berthet B., Leduc I., Verdier M., Geel O., Juhan-Vague I. Plasminogen activator inhibitor 1, transforming growth factor-β1, and BMI are closely associated in human adipose tissue during morbid obesity. Diabetes 2000, 49:1374-1380.
4. Bertolino P., Holmberg R., Reissmann E., Andersson O., Berggren P.O., Ibáñez C.F. Activin B receptor ALK7 is a negative regulator of pancreatic β-cell function. Proc. Natl. Acad. Sci. USA 2008, 105:7246-7251.
5. Cai D., Yuan M., Frantz D.F., Melendez P.A., Hansen L., Lee J., Shoelson S.E. Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nat. Med. 2005, 11:183-190.
6. Cannon B., Nedergaard J. Brown adipose tissue: Function and physiological significance. Physiol. Rev. 2004, 84:277-359.
7. Carlsson L.M., Jacobson P., Walley A., Froguel P., Sjöström L., Svensson P.A., Sjöholm K. ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. Biochem. Biophys. Res. Commun. 2009, 382:309-314.
8. Cederberg A., Grønning L.M., Ahrén B., Taskén K., Carlsson P., Enerbäck S. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 2001, 106:563-573.
9. Choy L., Derynck R. Transforming growth factor-β inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J. Biol. Chem. 2003, 278:9609-9619.
10. Conery A.R., Cao Y., Thompson E.A., Townsend C.M., Ko T.C., Luo K. Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β induced apoptosis. Nat. Cell Biol. 2004, 6:366-372.
11. Cuschieri J., Bulger E., Grinsell R., Garcia I., Maier R.V. Insulin regulates macrophage activation through activin A. Shock 2008, 29:285-290.
12. De Bleser P.J., Niki T., Xu G., Rogiers V., Geerts A. Localization and cellular sources of activins in normal and fibrotic rat liver. Hepatology 1997, 26:905-912.
13. Deli A., Kreidl E., Santifaller S., Trotter B., Seir K., Berger W., Schulte-Hermann R., Rodgarkia-Dara C., Grusch M. Activins and activin antagonists in hepatocellular carcinoma. World J. Gastroenterol. 2008, 14:1699-1709.
14. Demeterco C., Beattie G.M., Dib S.A., Lopez A.D., Hayek A. A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth. J. Clin. Endocrinol. Metab. 2000, 85:3892-3897.
15. Dennler S., Itoh S., Vivien D., ten Dijke P., Huet S., Gauthier J.M. Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 1998, 17:3091-3100.
16. Dichmann D.S., Miller C.P., Jensen J., Scott Heller R., Serup P. Expression and misexpression of members of the FGF and TGFβ families of growth factors in the developing mouse pancreas. Dev. Dyn. 2003, 226:663-674.
17. Flier J.S. Obesity wars: Molecular progress confronts an expanding epidemic. Cell 2004, 116:337-350.
18. Florio P., Luisi S., Marchetti P., Lupi R., Cobellis L., Falaschi C., Sugino H., Navalesi R., Genazzani A.R., Petraglia F. Activin A stimulates insulin secretion in cultured human pancreatic islets. J. Endocrinol. Invest. 2000, 23:231-234.
19. Frandsen U., Porneki A.D., Floridon C., Abdallah B.M., Kassem M. Activin B mediated induction of Pdx1 in human embryonic stem cell derived embryoid bodies. Biochem. Biophys. Res. Commun. 2007, 362:568-574.
20. Fujita H., Kang M., Eren M., Gleaves L.A., Vaughan D.E., Kume T. Foxc2 is a common mediator of insulin and transforming growth factor β signaling to regulate plasminogen activator inhibitor type I gene expression. Circ. Res. 2006, 98:626-634.
21. Furth M.E., Atala A. Stem cell sources to treat diabetes. J. Cell. Biochem. 2009, 106:507-511.
22. Furutani Y., Umemoto T., Murakami M., Matsui T., Funaba M. Role of endogenous TGF-β family in myogenic differentiation of C2C12 cells. J. Cell. Biochem. 2011, In press.
23. Gilson H., Schakman O., Kalista S., Lause P., Tsuchida K., Thissen J.P. Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin. Am. J. Physiol. Endocrinol. Metab. 2009, 297:E157-E164.
24. Gold E.J., Zhang X., Wheatley A.M., Mellor S.L., Cranfield M., Risbridger G.P., Groome N.P., Fleming J.S. βA- and βC-activin, follistatin, activin receptor mRNA and βC-activin peptide expression during rat liver regeneration. J. Mol. Endocrinol. 2005, 34:505-515.
25. Goto Y., Nomura M., Tanaka K., Kondo A., Morinaga H., Okabe T., Yanase T., Nawata H., Takayanagi R., Li E. Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets. Dev. Dyn. 2007, 236:2865-2874.
26. Guo T., Jou W., Chanturiya T., Portas J., Gavrilova O., McPherron A.C. Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLoS ONE 2009, 4:e4937.
27. Hashimoto O., Ushiro Y., Sekiyama K., Yamaguchi O., Yoshioka K., Mutoh K., Hasegawa Y. Impaired growth of pancreatic exocrine cells in transgenic mice expressing human activin βE subunit. Biochem. Biophys. Res. Commun. 2006, 341:416-424.
28. Hashimoto O., Sekiyama K., Matsuo T., Hasegawa Y. The role of activin E in glucose metabolism: Transcriptional regulation of the inhibin/activin βE subunit gene in the liver. Life Sci. 2009, 85:534-540.
29. He L., Vichev K., Huang R., Christ B., Patel K., Amthor H. Activin A inhibits formation of skeletal muscle during chick development. Anat. Embryol. 2005, 209:401-407.
30. Hebrok M., Kim S.K., Melton D.A. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 1998, 12:1705-1713.
31. Hevener A.L., Olefsky J.M., Reichart D., Nguyen M.T., Bandyopadyhay G., Leung H.Y., Watt M.J., Benner C., Febbraio M.A., Nguyen A.K., Folian B., Subramaniam S., et al. Macrophage PPAR-γ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J. Clin. Invest. 2007, 117:1658-1669.
32. Hildén K., Tuuri T., Erämaa M., Ritvos O. Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor. Blood 1994, 83:2163-2170.
33. Hirai S., Yamanaka M., Kawachi H., Matsui T., Yano H. Activin A inhibits differentiation of 3T3-L1 preadipocyte. Mol. Cell. Endocrinol. 2005, 232:21-26.
34. Hirai S., Matsumoto H., Moriya N.H., Kawachi H., Yano H. Follistatin rescues the inhibitory effect of activin A on the differentiation of bovine preadipocyte. Domest. Anim. Endocrinol. 2007, 33:269-280.
35. Ho J., de Guise C., Kim C., Lemay S., Wang X.F., Lebrun J.J. Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1. Cell. Signal. 2004, 16:693-701.
36. Hoggard N., Cruickshank M., Moar K.M., Barrett P., Bashir S., Miller J.D. Inhibin βB expression in murine adipose tissue and its regulation by leptin, insulin and dexamethasone. J. Mol. Endocrinol. 2009, 43:171-177.
37. Hotamisligil G.S., Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat. Rev. Immunol. 2008, 8:923-934.
38. Jiang J., Au M., Lu K., Eshpeter A., Korbutt G., Fisk G., Majumdar A.S. Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 2007, 25:1940-1953.
39. Jiang W., Shi Y., Zhao D., Chen S., Yong J., Zhang J., Qing T., Sun X., Zhang P., Ding M., Li D., Deng H. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res. 2007, 17:333-344.
40. Jones K.L., Mansell A., Patella S., Scott B.J., Hedger M.P., de Kretser D.M., Phillips D.J. Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia. Proc. Natl. Acad. Sci. USA 2007, 104:16239-16244.
41. Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest. 2006, 116:1784-1792.
42. Kawabata N., Kamiya N., Suzuki N., Matsumoto M., Takagi M. Changes in extracellular activin A: Follistatin ratio during differentiation of a mesenchymal progenitor cell line, ROB-C26 into osteoblasts and adipocytes. Life Sci. 2007, 81:8-18.
43. Kim S.K., Hebrok M., Li E., Oh S.P., Schrewe H., Harmon E.B., Lee J.S., Melton D.A. Activin receptor patterning of foregut organogenesis. Genes Dev. 2000, 14:1866-1871.
44. Kogure K., Zhang Y.Q., Shibata H., Kojima I. Immediate onset of DNA synthesis in remnant rat liver after 90% hepatectomy by an administration of follistatin. J. Hepatol. 1998, 29:977-984.
45. Kojima I., Nobusawa R., Zhang Y.Q., Sekine N., Mine T., Shibata H. Attenuation of glycogenolytic action of activin A in intact rat liver. Am. J. Physiol. 1995, 269:E846-E851.
46. Lau A.L., Kumar T.R., Nishimori K., Bonadio J., Matzuk M.M. Activin βC and βE genes are not essential for mouse liver growth, differentiation, and regeneration. Mol. Cell. Biol. 2000, 20:6127-6137.
47. Le Roith D., Zick Y. Recent advances in our understanding of insulin action and insulin resistance. Diabetes Care 2001, 24:588-597.
48. Li M., Miyagawa J., Moriwaki M., Yuan M., Yang Q., Kozawa J., Yamamoto K., Imagawa A., Iwahashi H., Tochino Y., Yamagata K., Matsuzawa Y. Analysis of expression profiles of islet-associated transcription and growth factors during β-cell neogenesis from duct cells in partially duct-ligated mice. Pancreas 2003, 27:345-355.
49. Li L., Yi Z., Seno M., Kojima I. Activin A and betacellulin: Effect on regeneration of pancreatic β-cells in neonatal streptozotocin-treated rats. Diabetes 2004, 53:608-615.
50. Li L., Shen J.J., Bournat J.C., Huang L., Chattopadhyay A., Li Z., Shaw C., Graham B.H., Brown C.W. Activin signaling: Effects on body composition and mitochondrial energy metabolism. Endocrinology 2009, 150:3521-3529.
51. Link B.A., Nishi R. Opposing effects of activin A and follistatin on developing skeletal muscle cells. Exp. Cell Res. 1997, 233:350-362.
52. Maehama T., Taylor G.S., Dixon J.E. PTEN and myotubularin: Novel phosphoinositide phosphatases. Annu. Rev. Biochem. 2001, 70:247-279.
53. Mamin A., Philippe J. Activin A decreases glucagon and arx gene expression in α-cell lines. Mol. Endocrinol. 2007, 21:259-273.
54. Mantovani A., Sica A., Sozzani S., Allavena P., Vecchi A., Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004, 25:677-686.
55. Mashima H., Shibata H., Mine T., Kojima I. Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor. Endocrinology 1996, 137:3969-3976.
56. McPherron A.C., Lawler A.M., Lee S.J. Regulation of skeletal muscle mass in mice by a new TGF-β family member. Nature 1997, 387:83-90.
57. Mine T., Kojima I., Ogata E. Stimulation of glucose production by activin-A in isolated rat hepatocytes. Endocrinology 1989, 125:586-591.
58. Mukherjee A., Sidis Y., Mahan A., Raher M.J., Xia Y., Rosen E.D., Bloch K.D., Thomas M.K., Schneyer A.L. FSTL3 deletion reveals roles for TGF-β family ligands in glucose and fat homeostasis in adults. Proc. Natl. Acad. Sci. USA 2007, 104:1348-1353.
59. O'Bryan M.K., Sebire K.L., Gerdprasert O., Hedger M.P., Hearn M.T., de Kretser D.M. Cloning and regulation of the rat activin βE subunit. J. Mol. Endocrinol. 2000, 24:409-418.
60. Ogawa K., Abe K., Kurosawa N., Kurohmaru M., Sugino H., Takahashi M., Hayashi Y. Expression of a βA and βB subunits of inhibin or activin and follistatin in rat pancreatic islets. FEBS Lett. 1993, 319:217-220.
61. Ogawa K., Funaba M., Mathews L.S., Mizutani T. Activin A stimulates type IV collagenase (matrix metalloproteinase-2) production in mouse peritoneal macrophages. J. Immunol. 2000, 165:2997-3003.
62. Ogawa K., Funaba M., Chen Y., Tsujimoto M. Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages. J. Immunol. 2006, 177:6787-6794.
63. Rebbapragada A., Benchabane H., Wrana J.L., Celeste A.J., Attisano L. Myostatin signals through a transforming growth factor β-like signaling pathway to block adipogenesis. Mol. Cell. Biol. 2003, 23:7230-7242.
64. Rodgarkia-Dara C., Vejda S., Erlach N., Losert A., Brusch W., Berger W., Schulte-Hermann R., Grusch M. The activin axis in liver biology and disease. Mutat. Res. 2006, 613:123-137.
65. Schenk S., Saberi M., Olefsky J.M. Insulin sensitivity: Modulation by nutrients and inflammation. J. Clin. Invest. 2008, 118:2992-3002.
66. Seale P., Bjork B., Yang W., Kajimura S., Chin S., Kuang S., Scimè A., Devarakonda S., Conroe H.M., Erdjument-Bromage H., Tempst P., Rudnicki M.A., et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008, 454:961-967.
67. Seoane J., Le H.V., Shen L., Anderson S.A., Massagué J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 2004, 117:211-223.
68. Shibasaki M., Takahashi K., Itou T., Miyazawa S., Ito M., Kobayashi J., Bujo H., Saito Y. Alterations of insulin sensitivity by the implantation of 3T3-L1 cells in nude mice. A role for TNF-α?. Diabetologia 2002, 45:518-526.
69. Shim J.H., Kim S.E., Woo D.H., Kim S.K., Oh C.H., McKay R., Kim J.H. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 2007, 50:1228-1238.
70. Shiozaki S., Tajima T., Zhang Y.Q., Furukawa M., Nakazato Y., Kojima I. Impaired differentiation of endocrine and exocrine cells of the pancreas in transgenic mouse expressing the truncated type II activin receptor. Biochim. Biophys. Acta 1999, 1450:1-11.
71. Sjöholm K., Palming J., Lystig T.C., Jennische E., Woodruff T.K., Carlsson B., Carlsson L.M. The expression of inhibin βB is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease. Biochem. Biophys. Res. Commun. 2006, 344:1308-1314.
72. Souza T.A., Chen X., Guo Y., Sava P., Zhang J., Hill J.J., Yaworsky P.J., Qiu Y. Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators. Mol. Endocrinol. 2008, 22:2689-2702.
73. Sugino H., Sugino K., Hashimoto O., Shoji H., Nakamura T. Follistatin and its role as an activin-binding protein. J. Med. Invest. 1997, 44:1-14.
74. Sulzbacher S., Schroeder I.S., Truong T.T., Wobus A.M. Activin A-induced differentiation of embryonic stem cells into endoderm and pancreatic progenitors-the influence of differentiation factors and culture conditions. Stem Cell Rev. 2009, 5:159-173.
75. Suryawan A., Frank J.W., Nguyen H.V., Davis T.A. Expression of the TGF-β family of ligands is developmentally regulated in skeletal muscle of neonatal rats. Pediatr. Res. 2006, 59:175-179.
76. Tateishi K., He J., Taranova O., Liang G., D'Alessio A.C., Zhang Y. Generation of insulin-secreting islet-like clusters from human skin fibroblasts. J. Biol. Chem. 2008, 283:31601-31607.
77. Teruel T., Valverde A.M., Benito M., Lorenzo M. Transforming growth factor β1 induces differentiation-specific gene expression in fetal rat brown adipocytes. FEBS Lett. 1995, 364:193-197.
78. Teruel T., Valverde A.M., Benito M., Lorenzo M. Transforming growth factor β1 induces mitogenesis in fetal rat brown adipocytes. J. Cell. Physiol. 1996, 166:577-584.
79. Totsuka Y., Tabuchi M., Kojima I., Shibai H., Ogata E. A novel action of activin A: Stimulation of insulin secretion in rat pancreatic islets. Biochem. Biophys. Res. Commun. 1988, 156:335-339.
80. Tsuchida K., Nakatani M., Yamakawa N., Hashimoto O., Hasegawa Y., Sugino H. Activin isoforms signal through type I receptor serine/threonine kinase ALK7. Mol. Cell. Endocrinol. 2004, 220:59-65.
81. Tsuchida K., Nakatani M., Hitachi K., Uezumi A., Sunada Y., Ageta H., Inokuchi K. Activin signaling as an emerging target for therapeutic interventions. Cell Commun. Signal. 2009, 7:15.
82. Tuuri T., Erämaa M., Hildén K., Ritvos O. The tissue distribution of activin βA- and βB-subunit and follistatin messenger ribonucleic acids suggests multiple sites of action for the activin-follistatin system during human development. J. Clin. Endocrinol. Metab. 1994, 78:1521-1524.
83. Verspohl E.J., Ammon H.P., Wahl M.A. Activin A: Its effects on rat pancreatic islets and the mechanism of action involved. Life Sci. 1993, 53:1069-1078.
84. Wang S.Y., Tai G.X., Zhang P.Y., Mu D.P., Zhang X.J., Liu Z.H. Inhibitory effect of activin A on activation of lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. Cytokine 2008, 42:85-91.
85. Wasserman D.H. Regulation of glucose fluxes during exercise in the postabsorptive state. Annu. Rev. Physiol. 1995, 57:191-218.
86. Watanabe R., Shen Z.P., Tsuda K., Yamada Y. Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic β-cells. Biochem. Biophys. Res. Commun. 2008, 377:867-872.
87. Weigert J., Neumeier M., Wanninger J., Schober F., Sporrer D., Weber M., Schramm A., Wurm S., Stögbauer F., Filarsky M., Schäffler A., Aslanidis C., et al. Adiponectin upregulates monocytic activin A but systemic levels are not altered in obesity or type 2 diabetes. Cytokine 2009, 45:86-91.
88. Wiater E., Vale W. Activins and inhibins. The TGF-β Family 2008, 79-120. Cold Spring Harbor Laboratory Press, New York. R. Derynck, K. Miyazono (Eds.).
89. Wu L., Derynck R. Essential role of TGF-β signaling in glucose-induced cell hypertrophy. Dev. Cell 2009, 17:35-48.
90. Yamaoka T., Idehara C., Yano M., Matsushita T., Yamada T., Ii S., Moritani M., Hata J., Sugino H., Noji S., Itakura M. Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants. J. Clin. Invest. 1998, 102:294-301.
91. Yang Y., Zhou F., Fang Z., Wang L., Li Z., Sun L., Wang C., Yao W., Cai X., Jin J., Zha X. Post-transcriptional and post-translational regulation of PTEN by transforming growth factor-β1. J. Cell. Biochem. 2009, 106:1102-1112.
92. Yasuda H., Inoue K., Shibata H., Takeuchi T., Eto Y., Hasegawa Y., Sekine N., Totsuka Y., Mine T., Ogata E. Existence of activin-A in A- and D-cells of rat pancreatic islet. Endocrinology 1993, 133:624-630.
93. Yasuda H., Mine T., Shibata H., Eto Y., Hasegawa Y., Takeuchi T., Asano S., Kojima I. Activin A: An autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J. Clin. Invest. 1993, 92:1491-1496.
94. Yuan M., Konstantopoulos N., Lee J., Hansen L., Li Z.W., Karin M., Shoelson S.E. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science 2001, 293:1673-1677.
95. WAF1/Cip1, CDK4 and Rb in activin A mediated signaling leading to hepatoma cell growth inhibition. Oncogene 1997, 15:1705-1711.
96. Zhang Y.E. Non-Smad TGF-β signaling pathways. The TGF-β Family 2008, 419-437. Cold Spring Harbor Laboratory Press, New York. R. Derynck, K. Miyazono (Eds.).
97. Zhang Y.Q., Zhang H., Maeshima A., Kurihara H., Miyagawa J., Takeuchi T., Kojima I. Up-regulation of the expression of activins in the pancreatic duct by reduction of the β-cell mass. Endocrinology 2002, 143:3540-3547.
98. Zhang Y.-Q., Cleary M.M., Si Y., Liu G., Eto Y., Kritzik M., Dabernat S., Kayali A.G., Sarvetnick N. Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic β-cells. Diabetes 2004, 53:2024-2033.
99. Zhang N., Kumar M., Xu G., Ju W., Yoon T., Xu E., Huang X., Gaisano H., Peng C., Wang Q. Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines. Diabetologia 2006, 49:506-518.
100. Zhou J., Tai G., Liu H., Ge J., Feng Y., Chen F., Yu F., Liu Z. Activin A down-regulates the phagocytosis of lipopolysaccharide-activated mouse peritoneal macrophages in vitro and in vivo. Cell. Immunol. 2009, 255:69-75.