Insulin regulates macrophage activation through activin A1

Shock

Volumn 29, Issue 2, 2008, Pages 285-290

  Cuschieri, Joseph ^a,b   Bulger, Eileen ^a   Grinsell, Rebecca ^a   Garcia, Iris ^a   Maier, Ronald V ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

AKT; Endotoxin; Lipid raft; SHIP; TGF

Indexed keywords

ACTIVIN; ACTIVIN A RECEPTOR; ACTIVIN RECEPTOR; ENDOTOXIN; GLUCOSE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MYOINOSITOL 1 PHOSPHATE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SH2; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; INSULIN METABOLISM; LIPID RAFT; MACROPHAGE ACTIVATION; MULTIPLE ORGAN FAILURE; NONHUMAN; PROTEIN ANALYSIS;

ACTIVINS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; CYTOKINES; ENDOTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; I-KAPPA B PROTEINS; INSULIN; INTERLEUKIN-8; MACROPHAGE ACTIVATION; MEMBRANE MICRODOMAINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; PHOSPHORIC MONOESTER HYDROLASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 38349105018     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/shk.0b013e318123e4d0     Document Type: Article

References (26)

1. Zuev SM, Kingsmore SF, Gessler DD: Sepsis progression and outcome: a dynamical model. Theor Biol Med Model 3:8, 2006.
2. Moore FA, Moore EE, Read RA: Postinjury multiple organ failure: role of extrathoracic injury and sepsis in adult respiratory distress syndrome. New Horiz 1:538-549, 1993.
3. Moore FA, Moore EE: Evolving concepts in the pathogenesis of postinjury multiple organ failure. Surg Clin North Am 75:257-277, 1995.
4. Maier RV: Pathogenesis of multiple organ dysfunction syndrome - endotoxin, inflammatory cells, and their mediators: cytokines and reactive oxygen species. Surg Infect (Larchmt) 1:197-204, 2000; discussion 204-205.
5. Triantafilou M, Miyake K, Golenbock DT, Triantafilou K: Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J Cell Sci 115:2603-2611, 2002.
6. Cuschieri J, Bulmus V, Gourlay D, Garcia I, Hoffman A, Stayton P, Maier RV: Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation. Shock 21:182-188, 2004.
7. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, et al.: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med 30:536-555, 2004.
8. O'Brien JM Jr., Abraham E: New approaches to the treatment of sepsis. Clin Chest Med 24:521-548, 2003, v.
9. Soop M, Duxbury H, Agwunobi AO, Gibson JM, Hopkins SJ, Childs C, Cooper RG, Maycock P, Little RA, Carlson GL: Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans. Am J Physiol Endocrinol Metab 282:E1276-E1285, 2002.
10. Ratajczak J, Majka M, Kijowski J, Baj M, Pan ZK, Marquez LA, Janowska-Wieczorek A, Ratajczak MZ: Biological significance of MAPK, AKT and JAK-STAT protein activation by various erythropoietic factors in normal human early erythroid cells. Br J Haematol 115:195-204, 2001.
11. Okamura H, Yoshida K, Sasaki E, Qiu L, Amorim BR, Morimoto H, Haneji T: Expression of PTEN and Akt phosphorylation in lipopolysaccharide-treated NIH3T3 cells. Cell Biol Int 31:119-125, 2007.
12. Iida KT, Suzuki H, Sone H, Shimano H, Toyoshima H, Yatoh S, Asano T, Okuda Y, Yamada N: Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway. Arterioscler Thromb Vasc Biol 22:380-386, 2002.
13. Beutler B: SHIP, TGF-beta, and endotoxin tolerance. Immunity 21:134-135, 2004.
14. Cuschieri J, Bulger E, Biligren J, Garcia I, Maier RV: Vitamin E inhibits endotoxin-mediated transport of phosphatases to lipid rafts. Shock 27:19-24, 2007.
15. Sly LM, Rauh MJ, Kalesnikoff J, Song CH, Krystal G: LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity 21:227-239, 2004.
16. Fang H, Pengal RA, Cao X, Ganesan LP, Wewers MD, Marsh CB, Tridandapani S: Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP. J Immunol 173:360-366, 2004.
17. Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA: Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 24:99-146, 2006.
18. Martin M, Schifferle RE, Cuesta N, Vogel SN, Katz J, Michalek SM: Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J Immunol 171:717-725, 2003.
19. Valderrama-Carvajal H, Cocolakis E, Lacerte A, Lee EH, Krystal G, Ali S, Lebrun JJ: Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP. Nat Cell Biol 4:963-969, 2002.
20. Van den Berghe GH: Role of intravenous insulin therapy in critically ill patients. Endocr Pract 10(Suppl 2):17-20, 2004.
21. Ellger B, Debaveye Y, Vanhorebeek I, Langouche L, Giulietti A, Van Etten E, Herijgers P, Mathieu C, Van den Berghe G: Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin. Diabetes 55:1096-1105, 2006.
22. Das UN: Is insulin an antiinflammatory molecule? Nutrition 17:409-413, 2001.
23. Neumann B, Zantl N, Veihelmann A, Emmanuilidis K, Pfeffer K, Heidecke CD, Holzmann B: Mechanisms of acute inflammatory lung injury induced by abdominal sepsis. Int Immunol 11:217-227, 1999.
24. Suzuki E, Umezawa K: Inhibition of macrophage activation and phagocytosis by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin. Biomed Pharmacother 60:578-586, 2006.
25. Brix-Christensen V, Gjedsted J, Andersen SK, Vestergaard C, Nielsen J, Rix T, Nyboe R, Andersen NT, Larsson A, Schmitz O, et al.: Inflammatory response during hyperglycemia and hyperinsulinemia in a porcine endotoxemic model: the contribution of essential organs. Acta Anaesthesiol Scand 49:991-998, 2005.
26. Zhang XJ, Li Y, Tai GX, Xu GY, Zhang PY, Yang Y, Lao FX, Liu ZH: Effects of activin A on the activities of the mouse peritoneal macrophages. Cell Mol Immunol 2:63-67, 2005.