Activin B mediated induction of Pdx1 in human embryonic stem cell derived embryoid bodies

Biochemical and Biophysical Research Communications

Volumn 362, Issue 3, 2007, Pages 568-574

  Frandsen, Ulrik ^a   Porneki, Ann Dorte ^a   Floridon, Charlotte ^b   Abdallah, Basem M ^a   Kassem, Moustapha ^a  

^a Medical Biotechnology Center   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Activin; Embryonic stem cells; Hedgehog; Pancreas development

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 3BETA; MYELOPID; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL SPECIFICITY; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; FETUS; HUMAN; HUMAN TISSUE; LIVER DEVELOPMENT; MARKER GENE; PRIMORDIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; UPREGULATION;

ACTIVINS; ANIMALS; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC STEM CELLS; ENDODERM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; MICE; PANCREAS; TERATOMA; TRANS-ACTIVATORS;

ERINACEIDAE;

EID: 34548437972     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.07.200     Document Type: Article

References (31)

1. Ahlgren U., Jonsson J., Jonsson L., Simu K., and Edlund H. β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev. 12 (1998) 1763-1768
2. Grapin-Botton A., and Melton D.A. Endoderm development: from patterning to organogenesis. Trends Genet. 16 (2000) 124-130
3. Gu G., Brown J.R., and Melton D.A. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech. Dev. 120 (2003) 35-43
4. Kim S.K., Hebrok M., and Melton D.A. Notochord to endoderm signaling is required for pancreas development. Development 124 (1997) 4243-4252
5. Lammert E., Cleaver O., and Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science 294 (2001) 564-567
6. Slack J.M. Developmental biology of the pancreas. Development 121 (1995) 1569-1580
7. Massague J., and Chen Y.G. Controlling TGF-β signaling. Genes Dev. 14 (2000) 627-644
8. Hebrok M., Kim S.K., and Melton D.A. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 12 (1998) 1705-1713
9. Kim S.K., Hebrok M., Li E., Oh S.P., Schrewe H., Harmon E.B., Lee J.S., and Melton D.A. Activin receptor patterning of foregut organogenesis. Genes Dev. 14 (2000) 1866-1871
10. Grapin-Botton A., Majithia A.R., and Melton D.A. Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev. 15 (2001) 444-454
11. Gamer L.W., and Wright C.V. Autonomous endodermal determination in Xenopus: regulation of expression of the pancreatic gene XlHbox 8. Dev. Biol. 171 (1995) 240-251
12. D'Amour K.A., Agulnick A.D., Eliazer S., Kelly O.G., Kroon E., and Baetge E.E. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat. Biotechnol. 23 (2005) 1534-1541
13. D'Amour K.A., Bang A.G., Eliazer S., Kelly O.G., Agulnick A.D., Smart N.G., Moorman M.A., Kroon E., Carpenter M.K., and Baetge E.E. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 24 (2006) 1392-1401
14. Gouon-Evans V., Boussemart L., Gadue P., Nierhoff D., Koehler C.I., Kubo A., Shafritz D.A., and Keller G. BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nat. Biotechnol. 24 (2006) 1402-1411
15. Kubo A., Shinozaki K., Shannon J.M., Kouskoff V., Kennedy M., Woo S., Fehling H.J., and Keller G. Development of definitive endoderm from embryonic stem cells in culture. Development 131 (2004) 1651-1662
16. Tada S., Era T., Furusawa C., Sakurai H., Nishikawa S., Kinoshita M., Nakao K., Chiba T., and Nishikawa S. Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development 132 (2005) 4363-4374
17. Yasunaga M., Tada S., Torikai-Nishikawa S., Nakano Y., Okada M., Jakt L.M., Nishikawa S., Chiba T., Era T., and Nishikawa S. Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells. Nat. Biotechnol. 23 (2005) 1542-1550
18. Cowan C.A., Klimanskaya I., McMahon J., Atienza J., Witmyer J., Zucker J.P., Wang S., Morton C.C., McMahon A.P., Powers D., and Melton D.A. Derivation of embryonic stem-cell lines from human blastocysts. N. Engl. J. Med. 350 (2004) 1353-1356
19. T)). Method Methods 25 (2001) 402-408
20. Vallier L., Reynolds D., and Pedersen R.A. Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway. Dev. Biol. 275 (2004) 403-421
21. Oster A., Jensen J., Edlund H., and Larsson L.I. Homeobox gene product Nkx 6.1 immunoreactivity in nuclei of endocrine cells of rat and mouse stomach. J. Histochem. Cytochem. 46 (1998) 717-721
22. Jonsson J., Carlsson L., Edlund T., and Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371 (1994) 606-609
23. Pedersen J.K., Nelson S.B., Jorgensen M.C., Henseleit K.D., Fujitani Y., Wright C.V., Sander M., and Serup P. Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev. Biol. 288 (2005) 487-501
24. Kumar M., Jordan N., Melton D., and Grapin-Botton A. Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev. Biol. 259 (2003) 109-122
25. van Eyll J.M., Pierreux C.E., Lemaigre F.P., and Rousseau G.G. Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin. A J. Cell Sci. 117 (2004) 2077-2086
26. Apelqvist A., Ahlgren U., and Edlund H. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr. Biol. 7 (1997) 801-804
27. Mfopou J.K., De G., Xu V.X., Heimberg H., and Bouwens L. Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development. Stem. Cells 25 (2007) 1156-1165
28. Beattie G.M., Lopez A.D., Bucay N., Hinton A., Firpo M.T., King C.C., and Hayek A. Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers. Stem Cells 23 (2005) 489-495
29. Vallier L., Alexander M., and Pedersen R.A. Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J. Cell Sci. 118 (2005) 4495-4509
30. James D., Levine A.J., Besser D., and Hemmati-Brivanlou A. TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 132 (2005) 1273-1282
31. McLean A.B., D'Amour K.A., Jones K.L., Krishnamoorthy M., Kulik M.J., Reynolds D.M., Sheppard A.M., Liu H., Xu Y., Baetge E.E., and Dalton S. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 25 (2007) 29-38