In vivo evaluation of the release of zidovudine and polystyrene sulfonate from a dual intravaginal bioadhesive polymeric device in the pig model

Journal of Pharmaceutical Sciences

Volumn 100, Issue 4, 2011, Pages 1416-1435

  Ndesendo, Valence M K ^a   Pillay, Viness ^a   Choonara, Yahya E ^a   Du Toit, Lisa C ^a   Meyer, Leith C R ^a   Buchmann, Eckhart ^b   Kumar, Pradeep ^a   Khan, Riaz A ^c  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c MANAV RACHNA INTERNATIONAL INSTITUTE OF RESEARCH AND STUDIES   (India)

Author keywords

Formulation; HIV AIDS; Intravaginal drug delivery; Molecular dynamics; Permeability; large white pig model; Pharmacokinetics; Polymeric drug delivery systems; STIs; Zidovudine; polystyrene sulfonate

Indexed keywords

MUCIN; POLYMER; POLYSTYRENESULFONIC ACID; SUBTILISIN; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BIOMATERIAL; CHELATING AGENT; POLYSTYRENE DERIVATIVE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BRAIN FORNIX; CONTROLLED STUDY; DEVICE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG ISOLATION; DRUG RELEASE; DRUG TISSUE LEVEL; ENERGY; EPITHELIUM HYPERPLASIA; FEMALE; FOREIGN BODY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; INTRAVAGINAL BIOADHESIVE POLYMERIC DEVICE; JUGULAR VEIN; MOLECULAR MECHANICS; NONHUMAN; SEXUALLY TRANSMITTED DISEASE; SIMULATION; VAGINA; ADHESION; ANIMAL; BLOOD; CHEMISTRY; DEVICES; INTRAVAGINAL DRUG ADMINISTRATION; METABOLISM; SWINE;

ADHESIVENESS; ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTI-HIV AGENTS; BIOCOMPATIBLE MATERIALS; CHELATING AGENTS; DRUG DELIVERY SYSTEMS; FEMALE; POLYMERS; POLYSTYRENES; SWINE; VAGINA; ZIDOVUDINE;

EID: 79951889468     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22365     Document Type: Article

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