Preclinical evaluation of a dual-acting microbicidal prodrug WHI-07 in combination with vanadocene dithiocarbamate in the female reproductive tract of rabbit, pig, and cat

Toxicologic Pathology

Volumn 35, Issue 7, 2007, Pages 910-927

  D'Cruz, Osmond J ^a,b   Uckun, Fatih M ^a  

^a Paradigm Pharmaceuticals   (United States)

^b Parker Hughes Clinics   (United States)

Author keywords

Gel microemulsion; HIV AIDS; Intravaginal; Local tolerance microbicide; Nucleoside prodrug; Spermicide; Vanadocene

Indexed keywords

[5 BROMO 6 METHOXY 5,6 DIHYDRO 3' AZIDOTHYMIDINE 5' (4 BROMOPHENYL)METHOXY ALANINYL PHOSPHATE]; ANTIRETROVIRUS AGENT; BENZALKONIUM CHLORIDE; CARBAMIC ACID DERIVATIVE; CD45 ANTIGEN; CYTOKINE; DNA NUCLEOTIDYLEXOTRANSFERASE; FLUORESCEIN ISOTHIOCYANATE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; MICROBICIDE; NONOXINOL 9; PRODRUG; SPERMICIDAL AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VANADIUM; VANADOCENE DITHIOCARBAMATE; WHI 07;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BODY FLUID; CAT; CHEMOLUMINESCENCE; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG SAFETY; FEMALE; GENITAL SYSTEM; HISTOPATHOLOGY; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATION; MICROEMULSION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RABBIT; SWINE; UTERINE CERVIX; UTERINE CERVIX CYTOLOGY; VAGINA MUCOSA; VAGINAL PRURITUS;

ANIMALS; ANTI-HIV AGENTS; APOPTOSIS; CATS; CYTOKINES; DIDEOXYNUCLEOTIDES; EMULSIONS; FEMALE; FLOW CYTOMETRY; GELS; GENITALIA, FEMALE; MUCOUS MEMBRANE; RABBITS; SPERMATOCIDAL AGENTS; SWINE; THYMIDINE MONOPHOSPHATE; VAGINA; VANADIUM COMPOUNDS; ZIDOVUDINE;

ANIMALIA; ORYCTOLAGUS CUNICULUS; SUIDAE; SUS;

EID: 37549068611     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1080/01926230701748115     Document Type: Article

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