Explore the mechanism of inhibitory effects of pseudolaric acid B on MCF-7 cells by high content analysis

Progress in Biochemistry and Biophysics

Volumn 37, Issue 12, 2010, Pages 1313-1322

  Duan, Shao Wei ^a   Xu, Bo ^a   Chen, Yun Li ^a   Li, Min ^a   Fu, Hong Zheng ^a   Cui, Jing Rong ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

Apoptosis; High content analysis; MCF 7 cells; Microtubule; Mitotic arrest; Pseudolaric acid B

Indexed keywords

PSEUDOLARIX; VITACEAE;

EID: 79951875535     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2010.00335     Document Type: Article

References (29)

1. Yang S P, Dong L, Wang Y, et al. Antifungal diterpenoids of Pseudolarix kaempferi, and their structure-activity relationship study. Bioorg Med Chem, 2003, 11(21): 4577-4584 (Pubitemid 37194262)
2. Pan D J, Li Z L, Hu C Q, et al. The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives1. Planta Med, 1990, 56(4): 383-385
3. Ma G, Chong L, Li X C, et al. Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B. J Cancer Res Clin Oncol, 2010, 136(9): 1333-1340
4. Wong V K W, Chiu P, Chung S S M, et al. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo. Clin Cancer Res, 2005, 11(16): 6002-6011 (Pubitemid 41170332)
5. Li K S, Gu X F, Li P, et al. Effect of pseudolaric acid B on gastric cancer cells: inhibition of proliferation and induction of apoptosis. World J Gastroenterol, 2005, 11(48): 7555-7559 (Pubitemid 43168415)
6. Wu W Y, Guo H Z, Qu G Q, et al. Mechanisms of pseudolaric acid B-induced apoptosis in Bel-7402 cell lines. Am J Chinese Med, 2006, 34(5): 887-899
7. Ko J K S, Leung W C, Ho W K, et al. Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene. Eur J Pharmacol, 2007, 559(1): 1-13 (Pubitemid 46274648)
8. Yu J H, Wang H J, Li X R, et al. Protein tyrosine kinase, JNK, and ERK involvement in pseudolaric acid B-induced apoptosis of human breast cancer MCF-7 cells. Acta Pharmacol Sin, 2008, 29(9): 1069-1076
9. Gong X F, Wang M W, Tashiro S I, et al. Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death. Exp Mol Med, 2006, 38(4): 428-434
10. Gong X F, Wang M W, Tashiro S, et al. Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells. Arch Pharm Res, 2005, 28(1): 68-72 (Pubitemid 44698768)
11. Tong Y G, Zhang X W, Geng M Y, et al. Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin. Mol Pharmacol, 2006, 69(4): 1226-1233
12. Li M H, Miao Z H, Tan W F, et al. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1α by promoting proteasome-mediated degradation. Clin Cancer Res, 2004, 10(24): 8266-8274
13. Giuliano K A, Debiasio R L, Dunlay R T, et al. High-content screening: A new approach to easing key bottlenecks in the drug discovery process. J Biomol Screen, 1997, 2(4): 249-259 (Pubitemid 127690015)
14. Abraham V C, Taylor D L, Haskins J R. High content screening applied to large-scale cell biology. Trends Biotechnol, 2004, 22(1): 15-22 (Pubitemid 38030316)
15. Skehan P, Storeng R, Scudiero D, et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst, 1990, 82(13): 1107-1112 (Pubitemid 20213250)
16. 50 values: identifying quinone subtypes effective against melanoma and leukemia cell classes. J Chem Inf Comput Sci, 2003, 43(5): 1652-1667
17. Gasparri F, Cappella P, Galvani A. Multiparametric cell cycle analysis by automated microscopy. J Biomol Screen, 2006, 11(6): 586-598 (Pubitemid 44315956)
18. Wong V K W, Chiu P, Chung S S M, et al. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo. Clin Cancer Res, 2005, 11(16): 6002-6011 (Pubitemid 41170332)
19. Shao R G, Cao C X, Shimizu T, et al. Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-O1) in human cancer cell lines, possibly influenced by p53 function. Cancer Res, 1997, 57 (18): 4029-4035 (Pubitemid 27427693)
20. Castedo M, Perfettini J L, Roumier T, et al. Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell Death Differ, 2002, 9(12): 1287-1293 (Pubitemid 36097698)
21. Clute P, Pines J. Temporal and spatial control of cyclin B1 destruction in metaphase. Nat Cell Biol, 1999, 1(2): 82-87 (Pubitemid 129501948)
22. Weaver B A A, Cleveland D W. Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell, 2005, 8(1): 7-12 (Pubitemid 40991810)
23. Diaz-Martinez L A, Clarke D J. Chromosome cohesion and the spindle checkpoint. Cell Cycle, 2009, 8(17): 2733-2740
24. Riffell J L, Zimmerman C, Khong A, et al. Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation. Cell Cycle, 2009, 8(18): 3025-3038
25. cdc2 inactivation and mitotic exit in mammalian cells. J Cell Biol, 1994, 127(3): 789-802
26. Bíagosklonny M V. Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive events. Cell Cycle, 2007, 6(1): 70-74
27. Camilleri-Broët S, Vanderwerff H, Caldwell E, et al. Distinct alterations in mitochondrial mass and function characterize different models of apoptosis. Exp Cell Res, 1998, 239(2): 277-292 (Pubitemid 28366627)
28. Mcgrogan B T, Gilmartin B, Camey D N, et al. Taxanes, microtubules and chemoresistant breast cancer. Biochim Biophys Acta, 2008, 1785(2): 96-132
29. Mansilla S, Bataller M, Portugal J. Mitotic catastrophe as a consequence of chemotherapy. Anticancer Agents Med Chem, 2006, 6(6): 589-602 (Pubitemid 44697117)