Iron, mycobacteria and tuberculosis

Tuberculosis

Volumn 84, Issue 1-2, 2004, Pages 110-130

  Ratledge, Colin ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

Author keywords

Bacterioferritin; Carboxymycobactin; Disease management; Exochelin; Inhibitors; Mycobactin; PAS; Salicylic acid; Siderophores; Tuberculosis

Indexed keywords

4 AMINOBENZOIC ACID; AMINOSALICYLIC ACID; APOPROTEIN; BACTERIOFERRITIN; CARBOXYMYCOBACTIN; EXOCHELIN; FERRIC ION; FERRITIN; FERROUS ION; IRON DERIVATIVE; LACTOFERRIN; MYCOBACTIN; OXIDOREDUCTASE; PORPHYRIN; SALICYLIC ACID; SIDEROPHORE; TRANSFERRIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

BACTERIAL CELL; BACTERIAL GENETICS; BACTERIAL GROWTH; BACTERIAL MEMBRANE; BACTERIAL METABOLISM; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BINDING AFFINITY; BIOSYNTHESIS; CELL MEMBRANE; CONFERENCE PAPER; CYTOPLASM; DIETARY INTAKE; DRUG ACTIVITY; EXTRACELLULAR SPACE; HOST; IRON METABOLISM; IRON STORAGE; IRON TRANSPORT; MOLECULE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SOLUBILITY; TUBERCULOSIS;

EID: 0347722524     PISSN: 14729792     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tube.2003.08.012     Document Type: Conference Paper

References (109)

1. Bullen JJ, Griffiths E. editors. Iron and infection: molecular, physiological and clinical aspects, 2nd ed. Chichester, UK: Wiley; 1999.
2. Hantke K. Iron and metal regulation in bacteria. Curr Opin Microbiol 2001;4:172-7.
3. Ratledge C, Dover LG. Iron metabolism in pathogenic bacteria. Annu Rev Microbiol 2000;54:881-941.
4. Winkelmann G, Winge DR. Metal ions in fungi. New York: Marcel Dekker; 1994.
5. Woodridge KG, Williams PH. Iron uptake mechanisms in pathogenic bacteria. FEMS Microbiol Rev 1993;12:325-48.
6. De Voss JJ, Rutter K, Schroeder BG, Barry III CE. Iron acquisition and metabolism by mycobacteria. J Bacteriol 1999;181:4443-51.
7. Ratledge C. Iron metabolism. In: Ratledge C, Dale J, editors. Mycobacteria: molecular biology and virulence. Oxford, UK: Blackwell Science; 1999. p. 206-86.
8. Sritharan M. Iron as a candidate in virulence and pathogenesis in mycobacteria and other organisms. World J Microbiol Biotechnol 2000;16:769-80.
9. Gomez M, Smith I. Determinants of mycobacterial gene expression. In: Hatfull GF, Jacobs WR, editors. Molecular genetics of mycobacteria. Washington, DC: American Society for Microbiology Press; 2000. p. 111-29.
10. Liu J, Barry III CE, Nikaido H. Cell wall: physical structure and permeability. In: Ratledge C, Dale JW, editors. Mycobacteria molecular biology and virulence. Oxford, UK: Blackwell Sciences; 1999. p. 220-39.
11. Chipperfield JR, Ratledge C. Salicylate is not a bacterial siderophore: a theoretical study. Biometals 2000;13:165-8.
12. 2+ levels. Infect Immun 2000;68:4518-22.
13. Aisen P. Transferrin, the transferrin receptor, and the uptake of iron by cells. In: Sigel A, Sigel H, editors. Metal ions in biological systems, Iron transport and storage in microorganisms, plants, and animals, vol. 35. New York: Marcel Dekker; 1998. p. 585-631.
14. Chasteen ND. Ferritin, uptake, storage, and release of iron. In: Sigel A, Sigel H, editors. Metal ions in biological systems, iron transport and storage in microorganisms, plants, and animals, vol. 35. New York: Marcel Dekker; 1998. p. 479-541.
15. Harrison PM, Hempstead PC, Artymiuk PJ, Andrews SC. Structure-function relationships in the ferritins. In: Sigel A, Sigel H, editors. Metal ions in biological systems, Iron transport and storage in microorganisms, plants, and animals, vol. 35. New York: Marcel Dekker; 1998. p. 435-77.
16. Weinberg ED. Iron loading and disease surveillance. Emerging Infect Dis 1999;5:346-52.
17. Weinberg ED. Therapeutic potential of human transferring and lactoferrin. ASM News 2002;68:65-9.
18. Kochan I. Role of iron in bacterial infections with special consideration to host-tubercle bacillus interaction. Curr Top Microbiol Immun 1973;60:1-30.
19. Barclay R, Ratledge C. Participation of iron in the growth inhibition of pathogenic strains of Mycobacterium avium and Mycobacterium paratuberculosis in serum. Z Bakt Mikrobiol Hyg 1986;A262:189-94.
20. Gobin J, Horwitz MA. Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the Mycobacterium tuberculosis cell wall. J Exp Med 1996;183:1527-32.
21. Douvas GS, May MH, Crowle AJ. Transferrin, iron, and serum lipids enhance or inhibit Mycobacterium avium replication in human macrophages. J Infect Dis 1993;167: 857-64.
22. Lounis N, Truffot-Pernot C, Grosset J, Gordeuk VR, Boelaert JR. Iron and Mycobacterium tuberculosis infection. J Clin Virol 2001;20:123-6.
23. Winkelmann G, Drechsel H. Microbial siderophores. Weinheim, Germany: Verlag Chemie; 1997.
24. Sigel A, Sigel H In: Metal ions in biological systems, iron transport and storage in microorganisms, plants, and animals, vol. 35. New York: Marcel Dekker; 1999.
25. Griffiths E, Williams PH. The iron-uptake systems of pathogenic bacteria, fungi and protozoa. In: Bullen JJ, Griffiths E, editors. Iron and infection, molecular, physiological and clinical aspects. 2nd ed., Chichester UK: Wiley; 1999. p. 87-212.
26. Winkelmann G. CRC handbook of microbial iron chelates. Boca Raton, FL: CRC Press; 1991.
27. Snow GA. Mycobactins: iron-chelating growth factors from mycobacteria. Bacteriol Rev 1970;34:99-125.
28. Barclay R, Ratledge C. Iron-binding compounds of Mycobacterium, Mycobacterium scrofulaceum and mycobactin-dependent Mycobacterium paratuberculosis and Mycobacterium avium. J Bacteriol 1983;153:1138-46.
29. Barclay R, Furst V, Smith I. A simple and rapid method for the detection and identification of mycobacteria using mycobactin. J Med Microbiol 1992;37:286-90.
30. Bosne S, Levy-Frebault W. Mycobactin analysis as an aid for the identification of Mycobacterium fortuitum and Mycobacterium chelonae subspecies. J Clin Microbiol 1992;30: 1225-31.
31. Hall RM. Mycobactins: how to obtain them and how to employ them as chemotaxonomic characters for the mycobacteria and related organisms. Actinomycetes 1986;19:92-106.
32. Hall RM, Ratledge C. Mycobactins as chemotaxonomic characters for some rapidly growing mycobacteria. J Gen Microbiol 1984;130:1883-92.
33. Leite CQF, Barreto AMW, Leite SRA. TLC of mycobactins and mycolic acid for the identification of clinical mycobacteria. Rev Microbiol (Sao Paulo) 1995;26:192-9.
34. Sritharan M, Ratledge C. Iron-regulated envelope proteins of mycobacteria grown in vitro and their occurrence in Mycobacterium avium and Mycobacterium leprae grown in vivo. Biol Met 1990;2:203-8.
35. Lambrecht RS, Collins MT. Inability to detect mycobactin in mycobacteria infected tissues suggests an alternative iron acquisition mechanism by mycobacteria in vivo. Microb Pathog 1993;14:229-38.
36. De Voss JJ, Rutter K, Schroeder BG, Su H, Zhu YQ, Barry III CE. The salicylate-derived mycobacteria siderophores of Mycobacterium tuberculosis are essential for growth in microphages. Proc Natl Acad Sci USA 2000;97:1252-7.
37. Hobson RJ, McBride AJA, Kempsell KE, Dale JW. Use of an assayed promotor-probe library for the identification of macrophage-regulated genes in Mycobacterium tuberculosis. Microbiology 2002;148:1571-9.
38. Ratledge C, Winder FG. The accumulation of salicylic acid by mycobacteria during growth on iron-deficient medium. Biochem J 1962;84:501-6.
39. Sokol PA, Lewis CJ, Dennis JJ. Isolation of a novel siderophore from Pseudomonas cepacia. J Med Microbiol 1992;36:184-9.
40. Visca P, Ciervo A, Sanfilippo V, Orsi N. Iron-regulated salicylate synthesis by Pseudomonas spp. J Gen Microbiol 1993;139:1995-2001.
41. Ratledge C, Macham LP, Brown KA, Marshall BJ. Iron transport in Mycobacterium smegmatis: a restricted role for salicylic acid in the extracellular environment. Biochim Biophys Acta 1974;372:39-51.
42. Macham LP, Ratledge C. A new group of water-soluble iron-binding compounds from mycobacteria: the exochelins. J Gen Microbiol 1975;89:379-82.
43. Macham LP, Ratledge C, Nocton JC. Extracellular iron acquisition by mycobacteria: role of the exochelins and evidence against the participation of mycobactin. Infect Immun 1975;12:1242-51.
44. Sharman GJ, Williams DH, Ewing DF, Ratledge C. Isolation purification and structure of exochelin MS, the extracellular siderophore from Mycobacterium smegmatis. Biochem J 1995;305:187-96.
45. Sharman GJ, Williams DH, Ewing DF, Ratledge C. Determination of the structure of exochelin MN, the extracellular Mycobacterium neoaurum. Chem Biol 1995;2:553-61.
46. Gobin J, Moore CH, Reeve Jr JR, Wong DK, Gibson BW, Horwitz MA. Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins. Proc Natl Acad Sci USA 1995;92: 5189-93.
47. Lane SJ, Marshall PS, Upton RJ, Ratledge C, Ewing M. Novel extracellular mycobactins, the carboxymycobactins from Mycobacterium avium. Tetrahedron Lett 1995;36: 4129-32.
48. Adilakshmi T, Ayling PD, Ratledge C. Mutational analysis of a role for salicylic acid in iron metabolism of Mycobocterium smegmatis. J Bacteriol 2000;182:264-71.
49. Gobin J, Wong DK, Gibson BW, Horwitz MA. Characterization of exochelins of the Mycobacterium bovis type strain and BCG substrains. Infect Immun 1999;67:2035-9.
50. Zhu W, Arceneaux JEL, Beggs ML, Eisenbach KD, Ludrigan MD. Exochelin genes in Mycobacterium smegmatis: identification of an ABC transporter and two nonribosomal peptide synthetase genes. Mol Microbiol 1998;29:629-39.
51. Lane SJ, Marshall PS, Upton RJ, Ratledge C. Isolation and characterisation of carboxymycobactin as the second extracellular siderophore in Mycobacterium smegmatis. Biometals 1998;11:13-20.
52. Ratledge C, Ewing M. The occurrence of carboxymycobactin, the siderophore of pathogenic mycobacteria, as a second extracellular siderophore in Mycobacterium smegmatis. Microbiology 1996;142:2207-12.
53. Stephenson MC, Ratledge C. Iron transport in Mycobacterium smegmatis: uptake of iron from ferriexochelin. J Gen Microbiol 1979;110:193-202.
54. Fiss EH, Yu S, Jacobs WR. Identification of genes involved in the sequestration of iron in mycobacteria: the ferric exochelin biosynthetic and uptake pathways. Mol Microbiol 1994;14:557-69.
55. Yu S, Fiss E, Jacobs WR. Analysis of the exochelin locus in Mycobacterium smegmatis: biosynthesis genes have homology with genes of the peptide synthetase family. J Bacteriol 1998;180:4676-85.
56. Hall RM, Sritharan M, Messenger AJM, Ratledge C. Iron transport in Mycobacterium smegmotis: occurrence of iron-regulated envelope proteins as potential receptors for iron uptake. J Gen Microbiol 1987;133:2107-14.
57. Dover LG, Ratledge C. Identification of a 29kDa protein in the envelope of Mycobacterium smegmatis as a putative ferri-exochelin receptor. Microbiology 1996;142:1521-30.
58. Pavelka Jr. MS. Genetics of mycobacterial metabolism. In: Hatfull GF, Jacobs Jr WR, editors. Molecular genetics of mycobacteria. Washington, DC: American Society for Microbiology; 2000. p. 221-34.
59. Stephenson MC, Ratledge C. Specificity of exochelins for iron transport in three species of mycobacteria. J Gen Microbiol 1980;116:521-3.
60. Trias J, Benz R. Permeability of the cell wall of Mycobacterium smegmatis. Mol Microbiol 1994;14:283-90.
61. Trias J, Jarlier V, Benz R. Porins in the cell wall of mycobacteria. Science 1992;258:1479-81.
62. Hough E, Rogers D. The crystal structure of ferrimycobactin P, a growth factor for the mycobacteria. Biochem Biophys Res Commun 1974;57:73-7.
63. Calder KM, Horwitz MA. Identification of iron-regulated proteins of Mycobacterium tuberculosis and cloning of tandem genes encoding a low-iron-induced protein and a metal transporting ATPase with similarities to two-component metal transport systems. Microb Pathog 1998;24: 133-43.
64. Brown KA, Ratledge C. Iron transport in Mycobacterium smegmatis: ferrimycobactin reductase (NAD(P)H: ferrimycobactin oxidoreductase), the enzyme releasing iron from its carrier. FEBS Lett 1975;53:262-6.
65. McCready KA, Ratledge C. Ferrimycobactin reductase activity from Mycobacterium smegmatis. J Gen Microbiol 1979;113:67-72.
66. Ratledge C. Transport of iron by mycobactin in Mycobacterium smegmatis. Biochem Biophys Res Commun 1971;45:856-61.
67. Dailey TA, Dailey HA. Identification of [2Fe-2S] clusters in microbial ferrochelatase. J Bacteriol 2002;184:2460-4.
68. McCready KA, Ratledge C. Amounts of iron, haem and related compounds in Mycobacterium smegmatis grown in various concentrations of iron. Biochem Soc Trans 1978;6:421-3.
69. Ratledge C, Patel PV, Mundy J. Iron transport in Mycobacterium smegmatis: the location of mycobactin by electron microscopy. J Gen Microbiol 1982;128:1559-65.
70. Pessolani MCV, Smith DR, Rivoire B, McCormick J, Hefta SA, Cole ST, Brennan PJ. Purification, characterization, gene sequence and significance of a bacterioferritin from Mycobacterium leprae. J Exp Med 1994;180: 319-27.
71. Quadri LEN, Sello J, Keating TA, Weinreb PH, Walsh CT. Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for the assembly of the virulence-conferring siderophore mycobactin. Chem Biol 1998;5:631-45.
72. Gehring AM, DeMoll E, Fetherstone JD, Mori I, Mayhew GF, Blattner FR, Walsh CT, Perry RD. Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis. Chem Biol 1998;5:573-86.
73. Gehring AM, Mori I, Perry RD, Walsh CT. The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron chelating virulence factor of Yersinia pestis. Biochemistry 1998;37: 11637-50.
74. Marshall BJ, Ratledge C. Salicylic acid biosynthesis and its control in Mycobacterium smegmatis. Biochim Biophys Acta 1972;264:106-16.
75. Ratledge C. Nutrition, growth and metabolism. In: Ratledge C, Stanford J, editors. The biology of the mycobacteria, vol. 1. London: Academic Press; 1982. p. 85-271.
76. Wong DK, Lee BY, Horwitz MA, Gibson BW. Identification of Fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry. Infect Immun 1999;67:327-36.
77. Deretic V, Song J, Pagan-Ramos E. Loss of oxyR in Mycobacterium tuberculosis. Trends Microbiol 1997;5: 367-72.
78. Timm J, Gomez M, Smith I. Gene expression and regulation. In: Ratledge C, Dale J, editors. Mycobacteria: molecular biology and virulence. Oxford, UK: Blackwell Science; 1999. p. 59-92.
79. Gold B, Rodriguez GM, Marras SAE, Pentecost M, Smith I. The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of glues involved in iron acquisition, iron storage and survival in macrophages. Mol Microbiol 2001;42:851-65.
80. Manabe YC, Saviola BJ, Sun L, Murphy JR, Bishai WR. Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor. Proc Natl Acad Sci USA 1999;96:12844-8.
81. Trousseau A. True, false chlorosis. In: Lectures on clinical medicine, vol. 5. London: The New Sydenham Society; 1872. p. 95-117 [also published by Lindsay & Blakiston, Philadelphia].
82. Weinberg ED. The development of awareness of iron-withholding defense. Perspect Biol Med 1993;36:215-21.
83. Griffiths E. Iron in biological systems. In: Bullen JJ, Griffiths E, editors. Iron and infection, molecular, physiological and clinical aspects. 2nd ed., Chichester UK: Wiley; 1999. p. 1-26.
84. Dhople AM, Ibanez MA, Poirer TC. Role of mammalian serum on in vitro growth of Mycobacterium avium. Biomed Lett 1996;53:155-61.
85. Dhople AM, Ibanez MA, Poirer TC. Role of Iron in the pathogenesis of Mycobacterium avium infection in mice. Microbios 1996;87:77-87.
86. Gomez MS, Boelaert JR, Appelberg R. Role of iron in experimental Mycobacterium avium infection. J Clin Virol 2001;20:117-22.
87. Sato K, Matsumoto H, Ogasa T, Takahashi M, Takeda A, Fujita Y, Yamazaki Y, Tobise K. Three cases of Mycobacterium avium lung disease in an iron foundry. J Jpn Respir Soc 2000;38:697-701.
88. Lehmann J. Poro-aminosalicylic acid in the treatment of tuberculosis. Lancet 1946;1:15-6.
89. Brown KA, Ratledge C. The effect of p-aminosalicylic acid on iron transport and assimilation in mycobacteria. Biochim Biophys Acta 1975;385:207-20.
90. Ratledge C, Brown KA. Inhibition of mycobactin formation in Mycobacterium smegmatis by p-aminosalicylic acid. A new proposal for the mode of action of PAS. Am Rev Respir Dis 1972;106:774-6.
91. Ratledge C, Hall MJ. Isolation and properties of auxotrophic mutants of Mycobacterium smegmatis requiring salicylic acid or mycobactin. J Gen Microbiol 1972;72: 143-50.
92. Goodacre CL, Mitchell BW, Seymour DE. Pura-aminosalicylic acid. Part II. The in vitro tuberculostatic behaviour of para-aminosalicylic acid and related compounds. Q J Pharm 1948;21:301-5.
93. Winder F. The antibacterial action of streptomycin, isoniazid and PAS. In: Barry V, editor. Chemotherapy of tuberculosis. London: Butterworths; 1964. p. 111-49.
94. Tateson JE. Early steps in the biosynthesis of mycobactins P and S. Biochem J 1970;118:747-53.
95. Douvas GS, May MH, Kolnagou A, Koutoghiorghes GJ. Effects on Mycobacterium avium replication in normal human macrophages by deferiprone (L1) and other iron chelators. Arzneim-Forsch Drug Res 2002;52:45-52.
96. Bosne-David S, Bricard L, Ramiandrasoa F, DeRoussent A, Kunesch A, Andrewmont A. Evaluation of growth promotion and inhibition from mycobactin and non-mycobacterial siderophores (desferrioxasmine and FR160) in Mycobacterium aurum. Antimicrob Agents Chemother 1997;41: 1837-9.
97. Matzanke BF, Möllmann U, Reissbrodt R, Schünemann V, Trautwein AX. Siderophore transport in mycobacteria analysed by Mössbauer spectroscopy possible routes to novel antibiotics against these organisms? Hyperfine Interactions 1998;112:123-8.
98. Rajir J, Dam T, Kumar S, Bose M, Aggarwal KK, Babu CR. Inhibition of the in-vitro growth of Mycobacterium tuberculosis by a phytosiderophore. J Med Microbiol 2001;50:916-8.
99. Schumann G, Mollmann U. Screening system for xenosiderophores as potential drugs/delivery agents in mycobacteria. Antimicrob Agents Chemother 2001;45: 1317-22.
100. Hu J, Miller MJ. Total synthesis of a mycobactin S, a siderophore and growth promoter of Mycobacterium smegmatis, and determination of its growth inhibitory activity against Mycobacterium tuberculosis. J Am Chem Soc 1997;119:3462-8.
101. Xu Y, Miller JJ. Total synthesis of mycobactin analogues as potent antimycobacterial agents using a minimal protecting group strategy. J Org Chem 1998;63:431-522.
102. Barclay R, Ratledge C. Metal analogues of mycobacterin and exochelin fail to act as effective antimycobacterial agents. Z Bakt Mikrobiol Hyg 1986;A264:203-7.
103. Stojiljkovic I, Kumar V, Srinivasan N. Non-iron metalloporphyrins: potent antibacterial compounds that exploit haem/Hb uptake systems of pathogenic bacteria. Mol Microbiol 1999;31:429-42.
104. Miller MJ, Darwish I, Ghosh A, Ghosh M, Hansel G, Hu J, Niu C, Ritter A, Scheidt K, Suling C, Sun S, Zhang D, Budde A, De Clercq E, Leong S, Malouin F, Moellmann U. Design, synthesis and studies of new antibacterial, antifungal and antiviral agents. In: Bentley PH, O'Hanlon PJ, editors. Anti-infectives. Recent advances in chemistry and structure-activity relationships. Cambridge, UK: Royal Society of Chemistry; 1997. p. 116-38.
105. Basker MJ, Edmondson RA, Knott SJ, Ponford RJ, Slocombe B, White SJ. In vitro antibacterial properties of BRL 36650, a novel 6α-substituted penicillin. Antimicrob Agents Chemother 1984;26:734-40.
106. Basker MJ, Frydrych CH, Harrington FP, Milner PH. Antibacterial activity of catecholic piperacillin analogues. J Antibiot 1989;42:1328-30.
107. Critchley IA, Basker MJ, Edmondson RA, Knott SJ. Uptake of a catecholic cephalosporin by the iron transport system of Escherichia coli. J Antimicrob Chemother 1991;28:377-88.
108. Barry III CE, Slayden RA, Sampson AE, Lee RE. Use of genomics and combinational chemistry in the development of new antimycobacterial drugs. Biochem Pharmacol 2000;59:221-31.
109. Webb V, Davies J. Antibiotics and antibiotic resistance in mycobacteria. In: Ratledge C, Dale JW, editors. Mycobacteria virulence and molecular biology. Oxford, UK: Blackwell Science; 1999. p. 287-306.