메뉴 건너뛰기




Volumn 95, Issue 1, 1996, Pages 78-86

Clinical Studies of Iron Chelators in Malaria

Author keywords

Cellular immunity; Cerebral malaria; Deferiprone; Desferrioxamine B; Iron chelation; Iron chelators; Lipid peroxidation; Malaria; Plasmodium falciparum; Plasmodium vivax

Indexed keywords

ANTIMALARIAL AGENT; CHELATING AGENT; CHLOROQUINE; DEFERIPRONE; DEFEROXAMINE; FANSIDAR; QUININE;

EID: 0030043856     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000203953     Document Type: Article
Times cited : (41)

References (69)
  • 2
    • 85041167241 scopus 로고
    • Malaria Control in Countries Where Time-Limited Eradication Is Impracticable at Present
    • World Health Organization: Malaria Control in Countries Where Time-Limited Eradication Is Impracticable at Present. WHO Tech Report Ser 1974;537.
    • (1974) WHO Tech Report Ser , pp. 537
  • 3
    • 0025122572 scopus 로고
    • Mortality from Plasmodium falciparum in travellers from the United States, 1959 to 1987
    • Greenberg AE, Lobcl HO: Mortality from Plasmodium falciparum in travellers from the United States, 1959 to 1987. Ann Intern Med 1990;113:326-327.
    • (1990) Ann Intern Med , vol.113 , pp. 326-327
    • Greenberg, A.E.1    Lobcl, H.O.2
  • 4
    • 0023497553 scopus 로고
    • Recent trends in the epidemiology and control of malaria
    • Clyde DF: Recent trends in the epidemiology and control of malaria. Epidemiol Rev 1987;9: 219-243.
    • (1987) Epidemiol Rev , vol.9 , pp. 219-243
    • Clyde, D.F.1
  • 6
    • 0001403687 scopus 로고
    • Metabolism and organellar function during various stages of the life cycle: Proteins, lipids, nucleic acids and vitamins
    • Wemsdorfer W, McGregor I (eds), New York. Churchill Livingstone
    • Scheibel LW, Sherman IW: Metabolism and organellar function during various stages of the life cycle: Proteins, lipids, nucleic acids and vitamins; in Wemsdorfer W, McGregor I (eds): Malaria: Principles and Practice of Malariolo-gy. New York. Churchill Livingstone, 1988. pp 219-252.
    • (1988) Malaria: Principles and Practice of Malariolo-Gy. , pp. 219-252
    • Scheibel, L.W.1    Sherman, I.W.2
  • 7
    • 0002596913 scopus 로고
    • The biochemical features of iron
    • Jacobs A, Worwood M (eds), San Diego, Academic Press
    • Wrigglesworth JM, Baum H: The biochemical features of iron; in Jacobs A, Worwood M (eds): Iron in Biochemistry and Medicine II: San Diego, Academic Press, 1980, pp 29-86.
    • (1980) Iron in Biochemistry and Medicine II , pp. 29-86
    • Wrigglesworth, J.M.1    Baum, H.2
  • 8
    • 0002081173 scopus 로고
    • Plasmodial parasite biology: Carbohydrate metabolism and related organellar function during various stages of the life cycle
    • Wernsdorfer W, McGregor I (eds), New York, Churchill Livingstone
    • Scheibel LW: Plasmodial parasite biology: Carbohydrate metabolism and related organellar function during various stages of the life cycle; in Wernsdorfer W, McGregor I (eds): Malaria: Principles and Practice of Malariology. New York, Churchill Livingstone, 1988, pp 171— 217.
    • (1988) Malaria: Principles and Practice of Malariology
    • Scheibel, L.W.1
  • 9
    • 0024366384 scopus 로고
    • Antimalarial activity of selected aromatic chelators v. Localization of 59Fe in Plasmodium falciparum in the presence of oxines
    • 59Fe in Plasmodium falciparum in the presence of oxines. Prog Clin Biol Res 1989;313: 119-149.
    • (1989) Prog Clin Biol Res , vol.313 , pp. 119-149
    • Scheibel, L.W.1    Rodriguez, S.2
  • 10
    • 0019948542 scopus 로고
    • Plasmodium falciparum. Inhibition of in vitro growth by deferoxamine
    • Raventos-Suarez C, Pollack S, Nagel RL: Plasmodium falciparum. Inhibition of in vitro growth by deferoxamine. Am J Trop Med Hyg 1982;31:919-912.
    • (1982) Am J Trop Med Hyg , vol.31 , pp. 912-919
    • Raventos-Suarez, C.1    Pollack, S.2    Nagel, R.L.3
  • 11
    • 0023154279 scopus 로고
    • Plasmodium falciparum: Inhibition in vitro with Iactoferrin, desferrithiocin, and desferricrocin
    • Fritsch G, Sawatzki G, Treumer J, Jung A, Spria DT: Plasmodium falciparum: Inhibition in vitro with Iactoferrin, desferrithiocin, and desferricrocin. Exp Parasitol 1987;63:1-9.
    • (1987) Exp Parasitol , vol.63 , pp. 1-9
    • Fritsch, G.1    Sawatzki, G.2    Treumer, J.3    Jung, A.4    Spria, D.T.5
  • 12
    • 0024419571 scopus 로고
    • Antimalarial effect of HBED and other phenolic and catecholic iron chelators
    • Yinnon AM, Thcanacho EN, Grady RW, Spira DT, Hershko C: Antimalarial effect of HBED and other phenolic and catecholic iron chelators. Blood 1989;74:2166-2171.
    • (1989) Blood , vol.74 , pp. 2166-2171
    • Yinnon, A.M.1    Thcanacho, E.N.2    Grady, R.W.3    Spira, D.T.4    Hershko, C.5
  • 13
    • 0025088403 scopus 로고
    • Stage-depcdcnt effect of deferoxamine on growth of Plasmodium falciparum in vitro
    • Whitehead S, Peto TEA: Stage-depcdcnt effect of deferoxamine on growth of Plasmodium falciparum in vitro. Blood 1990;76:1250-1255.
    • (1990) Blood , vol.76 , pp. 1250-1255
    • Whitehead, S.1    Peto, T.2
  • 14
    • 0021984450 scopus 로고
    • Suppression of mouse infections with deferoxamine B
    • Fritsch G, Treumer J, Spira DT, Jung A: Suppression of mouse infections with deferoxamine B. Exp Parasitol 1985;60:171-174.
    • (1985) Exp Parasitol , vol.60 , pp. 171-174
    • Fritsch, G.1    Treumer, J.2    Spira, D.T.3    Jung, A.4
  • 15
    • 0023740339 scopus 로고
    • Deferoxamine inhibition of malaria is independent of host iron status
    • Hershko C, Peto TEA: Deferoxamine inhibition of malaria is independent of host iron status. J Exp Med 1988;168:375-387.
    • (1988) J Exp Med , vol.168 , pp. 375-387
    • Hershko, C.1    Peto, T.2
  • 20
    • 0022930795 scopus 로고
    • Jung A: UC-Desferrioxamine uptake into erythrocytes infected with Plasmodium falciparum
    • uC-Desferrioxamine uptake into erythrocytes infected with Plasmodium falciparum. Z Parasitenkd 1986,72:106.
    • (1986) Z Parasitenkd , vol.72 , pp. 106
    • Fritsch, G.1
  • 25
    • 0018777993 scopus 로고
    • Studies in desferrioxamine and fer-rioxamine in normal and iron-loaded subjects
    • Summers M, Jacobs A, Tudway D, Perera P, Ricketts C: Studies in desferrioxamine and fer-rioxamine in normal and iron-loaded subjects. Br J Haematol 1979;42:547-555.
    • (1979) Br J Haematol , vol.42 , pp. 547-555
    • Summers, M.1    Jacobs, A.2    Tudway, D.3    Perera, P.4    Ricketts, C.5
  • 28
    • 0037579289 scopus 로고
    • Treatment of rheumatoid arthritis with desferrioxamine: Relation between stores of iron before treatment and side effects
    • Poison RJ, Jawed A, Bomford A, Berry' H, Williams R: Treatment of rheumatoid arthritis with desferrioxamine: Relation between stores of iron before treatment and side effects. Br Med J 1985;291:448.
    • (1985) Br Med J , vol.291 , pp. 448
    • Poison, R.J.1    Jawed, A.2    Bomford, A.3    Berry', H.4    Williams, R.5
  • 31
    • 0024581210 scopus 로고
    • The effect of iron chelation therapy on malarial infection in Papua Guinean school children is independent of host iron status
    • Harvey PWJ, Heywood PF, Galmc K, Zegans M, Habicht JP, Bradin B, Forsyth K, Alpers MP: The effect of iron chelation therapy on malarial infection in Papua Guinean school children is independent of host iron status. Am J Trop Med Hyg 1989;40:12-18.
    • (1989) Am J Trop Med Hyg , vol.40 , pp. 12-18
    • Harvey, P.1    Heywood, P.F.2    Galmc, K.3    Zegans, M.4    Habicht, J.P.5    Bradin, B.6    Forsyth, K.7    Alpers, M.P.8
  • 33
    • 0025066690 scopus 로고
    • Evaluation of the oral iron chelator l,2-dimethyl-3-hydroxy-pyricin-4-one (LI) in iron loaded patients: A randomised cross-over comparison with deferoxamine. Effect on iron balance and dose response studies
    • Olivieri N, Koren G, Herman C, Bentur Y, Chung D, Klein J, St Louis P, Freeman MH, McClelland RA, Templeton DM: Evaluation of the oral iron chelator l,2-dimethyl-3-hydroxy-pyricin-4-one (LI) in iron loaded patients: A randomised cross-over comparison with deferoxamine. Effect on iron balance and dose response studies. Lancet 1990;336:1275-1279.
    • (1990) Lancet , vol.336 , pp. 1275-1279
    • Olivieri, N.1    Koren, G.2    Herman, C.3    Bentur, Y.4    Chung, D.5    Klein, J.6    St Louis, P.7    Freeman, M.H.8    McClelland, R.A.9    Templeton, D.M.10
  • 34
    • 0025974647 scopus 로고
    • The effect of N-alkyl modification on the antimalarial activity of 3-hydroxypyridin-4-one oral iron chelators
    • Hershko C, Theanacho EN, Spira DT, Peter HH, Dobbin P, Hider RC: The effect of N-alkyl modification on the antimalarial activity of 3-hydroxypyridin-4-one oral iron chelators. Blood 1991;77:637-643.
    • (1991) Blood , vol.77 , pp. 637-643
    • Hershko, C.1    Theanacho, E.N.2    Spira, D.T.3    Peter, H.H.4    Dobbin, P.5    Hider, R.C.6
  • 36
    • 0026680591 scopus 로고
    • Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chclator LI in thalassemia intermedia
    • Olivieri NF. Koren G. Matsui D, Liu PP. Blcn-dis L, Cameron R, McClelland RA, Templeton DM: Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chclator LI in thalassemia intermedia. Blood 1992;79:2741-2748.
    • (1992) Blood , vol.79 , pp. 2741-2748
    • Olivieri, N.F.1    Koren, G.2    Matsui, D.3    Liu, P.P.4    Blcn-Dis, L.5    Cameron, R.6    McClelland, R.A.7    Templeton, D.M.8
  • 37
    • 0026001164 scopus 로고
    • Relationship between the pharmacokinetics and iron excretion pharmacodynamics of the new oral iron chelator 1,2-dimc-thyl-3-hydroxypyridin-4-one in patients with thalassaemia
    • Matsui D. Klein J, Herman C, Gruneau V, McClelland R, Chung D, St Louis P, Olivieri N, Koren G: Relationship between the pharmacokinetics and iron excretion pharmacodynamics of the new oral iron chelator 1,2-dimc-thyl-3-hydroxypyridin-4-one in patients with thalassaemia. Clin Pharmacol Ther 1991:50: 294-298.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 294-298
    • Matsui, D.1    Klein, J.2    Herman, C.3    Gruneau, V.4    McClelland, R.5    Chung, D.6    St Louis, P.7    Olivieri, N.8    Koren, G.9
  • 40
    • 0024340659 scopus 로고
    • Clinical features and prognostic indicators in children w ith paediatric cerebral malaria: A study of 131 Malawian comatose children
    • Molyneux ME, Taylor TE, Wirima JJ, Borg-stein A: Clinical features and prognostic indicators in children w ith paediatric cerebral malaria: A study of 131 Malawian comatose children. Q J Med 1989:71:441 -459.
    • (1989) Q J Med , vol.71
    • Molyneux, M.E.1    Taylor, T.E.2    Wirima, J.J.3    Borg-Stein, A.4
  • 41
    • 0025221660 scopus 로고
    • Cerebral malaria in children
    • Phillips RE. Solomon T: Cerebral malaria in children. Lancet 1990;336:1355-1360.
    • (1990) Lancet , vol.336 , pp. 1355-1360
    • Phillips, R.E.1    Solomon, T.2
  • 42
    • 0025102616 scopus 로고
    • Parasite uptake of desferrioxamine: A prerequisite for antimalarial activity
    • Scott MD, Ranz A, Kuypers FA, Lubin BH, Meshnick SR: Parasite uptake of desferrioxamine: A prerequisite for antimalarial activity. BrJ Haematol 1990;75:598-602.
    • (1990) Brj Haematol , vol.75 , pp. 598-602
    • Scott, M.D.1    Ranz, A.2    Kuypers, F.A.3    Lubin, B.H.4    Meshnick, S.R.5
  • 43
    • 0027392073 scopus 로고
    • The antimalarial action of Dcsfcral involves a direct access route to erythrocytic (Plasmodium falciparum) parasites
    • Loyevsky M. Lytton SD, Mester B, Libman J, Shanzer A, Cabantchik ZI: The antimalarial action of Dcsfcral involves a direct access route to erythrocytic (Plasmodium falciparum) parasites. J Clin Invest 1993;91:218-224.
    • (1993) J Clin Invest , vol.91 , pp. 218-224
    • Loyevsky, M.1    Lytton, S.D.2    Mester, B.3    Libman, J.4    Shanzer, A.5    Cabantchik, Z.I.6
  • 45
    • 0020541188 scopus 로고
    • Ribonuclcotide reductase - A radical enzyme
    • Reichard P. Ehrenberg A: Ribonuclcotide reductase - A radical enzyme. Science 1983;221: 514-519.
    • (1983) Science , vol.221 , pp. 514-519
    • Reichard, P.1    Ehrenberg, A.2
  • 46
    • 0022357907 scopus 로고
    • Characterization of L1210 cell growth inhibition by the bacterial iron chelators parabactin and compound II
    • Cavanaugh PF, Porter CW, Tukalo D, Frankfurt DS. Pavelic ZP, Bergeron RJ: Characterization of L1210 cell growth inhibition by the bacterial iron chelators parabactin and compound II. Cancer Res 1985;45:4754-4759.
    • (1985) Cancer Res , vol.45 , pp. 4754-4759
    • Cavanaugh, P.F.1    Porter, C.W.2    Tukalo, D.3    Frankfurt, D.S.4    Pavelic, Z.P.5    Bergeron, R.J.6
  • 47
    • 0022586690 scopus 로고
    • Iron: A controlling nutrient in proliferative processes
    • Bergeron RJ: Iron: A controlling nutrient in proliferative processes. Trends Biochem Sci 1986;11:133-136.
    • (1986) Trends Biochem Sci , vol.11 , pp. 133-136
    • Bergeron, R.J.1
  • 48
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL: TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 49
    • 0026616876 scopus 로고
    • Induction of TH1 and TH2 responses: A key role for the ‘natural’ immune response?
    • Romagagni S: Induction of TH1 and TH2 responses: A key role for the ‘natural’ immune response? Immunol Today 1992;13:379-381.
    • (1992) Immunol Today , vol.13 , pp. 379-381
    • Romagagni, S.1
  • 51
    • 0026631115 scopus 로고
    • Therapy of Plasmodium falciparum parasitemia with desferrioxamine
    • Weiss G, Fuchs D, Werner-Fclmayer G, Wächter H: Therapy of Plasmodium falciparum parasitemia with desferrioxamine. Blood 1992;80:843-844.
    • (1992) Blood , vol.80 , pp. 843-844
    • Weiss, G.1    Fuchs, D.2    Werner-Fclmayer, G.3    Wächter, H.4
  • 52
    • 0025761982 scopus 로고
    • IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepato-cytes by and L-arginine pathway
    • Mellouk S. Green SJ, Nacy CA, Hoffman SI: IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepato-cytes by and L-arginine pathway. J Immunol 1991:146:3971-3976.
    • (1991) J Immunol , vol.146 , pp. 3971-3976
    • Mellouk, S.1    Green, S.J.2    Nacy, C.A.3    Hoffman, S.I.4
  • 53
    • 0026065305 scopus 로고
    • Arginine dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation
    • Nussler A, Drapier JC, Renia L, Pied S, Milt-gen F, Gentilin M, Mazier D: /.-arginine dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation. Eur J Immunol 1991;21:227-230.
    • (1991) Eur J Immunol , vol.21 , pp. 227-230
    • Nussler, A.1    Drapier, J.C.2    Renia, L.3    Pied, S.4    Milt-Gen, F.5    Gentilin, M.6    Mazier, D.7
  • 58
    • 0021884874 scopus 로고
    • Human cerebral malaria: A quantitative ultrastructural analysis of parasitised erythrocyte sequestration
    • MacPherson GG, Warrell MJ. Looareesuwan S, Warrell DA: Human cerebral malaria: A quantitative ultrastructural analysis of parasitised erythrocyte sequestration. Am J Pathol 1985;119:385-401.
    • (1985) Am J Pathol , vol.119 , pp. 385-401
    • Macpherson, G.G.1    Warrell, M.J.2    Looareesuwan, S.3    Warrell, D.A.4
  • 59
    • 0023724337 scopus 로고
    • Human cerebral malaria
    • Aikawa M: Human cerebral malaria. Am J TropMed Hyg 1988:39:3-10.
    • (1988) Am J Tropmed Hyg , vol.39 , pp. 3-10
    • Aikawa, M.1
  • 60
    • 0021984681 scopus 로고
    • Oxygen-derived free radicals in postischemic tissue injury
    • McCord JM: Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985; 312:159-163.
    • (1985) N Engl J Med , vol.312 , pp. 159-163
    • McCord, J.M.1
  • 61
    • 0023140258 scopus 로고
    • Tissue injury in inflammation: Oxidants, proteinases, and cationic proteins
    • Henson PM. Johnson RB: Tissue injury in inflammation: Oxidants, proteinases, and cationic proteins. J Clin Invest 1987;79:669-674.
    • (1987) J Clin Invest , vol.79 , pp. 669-674
    • Henson, P.M.1    Johnson, R.B.2
  • 64
    • 0024431912 scopus 로고
    • Induction of hypoferrcmia and modulation of macrophage iron metabolism by tumor necrosis factor
    • Alvarez-Hernandez X, Liceaga J, McKay IC, Brock JH: Induction of hypoferrcmia and modulation of macrophage iron metabolism by tumor necrosis factor. Lab Invest 1989:61:319— 322.
    • (1989) Lab Invest , vol.61
    • Alvarez-Hernandez, X.1    Liceaga, J.2    McKay, I.C.3    Brock, J.H.4
  • 67
    • 0021049624 scopus 로고
    • Evidence for role of hydroxyl radical in complement and neutrophil-dependent injur)'
    • Ward PA, Till GO, Kunkel R, Beauchamp C: Evidence for role of hydroxyl radical in complement and neutrophil-dependent injur. J Clin Invest 1983;72:369-371.
    • (1983) J Clin Invest , vol.72 , pp. 369-371
    • Ward, P.A.1    Till, G.O.2    Kunkel, R.3    Beauchamp, C.4
  • 69
    • 0023626933 scopus 로고
    • Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: The role of iron in the pathogenesis of reperfusion injur)'
    • Ambrosio G, Zweier JL, Jacobus WE, Weis-feldt ML, Flaherty JT: Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: The role of iron in the pathogenesis of reperfusion injur. Circulation 1987; 76:906-915.
    • (1987) Circulation , vol.76 , pp. 906-915
    • Ambrosio, G.1    Zweier, J.L.2    Jacobus, W.E.3    Weis-Feldt, M.L.4    Flaherty, J.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.