Mesenchymal stromal cells: Past, present, and future

Veterinary Surgery

Volumn 40, Issue 2, 2011, Pages 129-139

  Spencer, Nakia D ^a   Gimble, Jeffrey M ^b   Lopez, Mandi J ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ADULT STEM CELL; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; HUMAN; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NOMENCLATURE; ORTHOPEDIC SURGERY; PHYSIOLOGY; REGENERATIVE MEDICINE; REVIEW; STEM CELL RESEARCH; STROMA CELL; TISSUE ENGINEERING;

ADULT; ADULT STEM CELLS; ANIMALS; CELL DIFFERENTIATION; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; ORTHOPEDIC PROCEDURES; REGENERATIVE MEDICINE; STEM CELL RESEARCH; STROMAL CELLS; TERMINOLOGY AS TOPIC; TISSUE ENGINEERING;

EID: 79951808622     PISSN: 01613499     EISSN: 1532950X     Source Type: Journal    
DOI: 10.1111/j.1532-950X.2010.00776.x     Document Type: Review

References (165)

1. Weissman IL: Translating stem and progenitor cell biology to the clinic: barriers and opportunities. Science 2000;287:1442-1446
2. Caplan AI: Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng 2005;11:1198-1211
3. Caplan AI: Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 2007;213:341-347
4. Chen Y, Shao JZ, Xiang LX, et al: Mesenchymal stem cells: a promising candidate in regenerative medicine. Int J Biochem Cell Biol 2008;40:815-820
5. Horwitz EM, Le Blanc K, Dominici M, et al: Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 2005;7:393-395
6. Alison MR, Poulsom R, Forbes S, et al: An introduction to stem cells. J Pathol 2002;197:419-423
7. Takahashi K, Tanabe K, Ohnuki M, et al: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-872
8. Cutler C, Antin JH: Peripheral blood stem cells for allogeneic transplantation: a review. Stem Cells 2001;19:108-117
9. da Silva Meirelles L, Chagastelles PC, Nardi NB: Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 2006;119:2204-2213
10. Eyden BP, Ponting J, Davies H, et al: Defining the myofibroblast: normal tissues, with special reference to the stromal cells of Wharton's jelly in human umbilical cord. J Submicrosc Cytol Pathol 1994;26:347-355
11. Hu Y, Liao L, Wang Q, et al: Isolation and identification of mesenchymal stem cells from human fetal pancreas. J Lab Clin Med 2003;141:342-349
12. Jiang Y, Vaessen B, Lenvik T, et al: Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol 2002;30:896-904
13. Lee OK, Kuo TK, Chen WM, et al: Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 2004;103:1669-1675
14. Mihu CM, Mihu D, Costin N, et al: Isolation and characterization of stem cells from the placenta and the umbilical cord. Rom J Morphol Embryol 2008;49:441-446
15. Pittenger MF, Mackay AM, Beck SC, et al: Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147
16. Wakitani S, Saito T, Caplan AI: Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 1995;18:1417-1426
17. Sago K, Tamahara S, Tomihari M, et al: In vitro differentiation of canine celiac adipose tissue-derived stromal cells into neuronal cells. J Vet Med Sci 2008;70:353-357
18. Scholer H: The potential of stem cells. An inventory. Aldershot, Ashgate Publishing Ltd, 2007
19. Hanna J, Wernig M, Markoulaki S, et al: Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 2007;318:1920-1923
20. Carr AJ, Vugler AA, Hikita ST, et al: Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat. PLoS One 2009;4:e8152
21. Dominici M, Le Blanc K, Mueller I, et al: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-317
22. Prockop DJ: Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276:71-74
23. Friedenstein AJ, Petrakova KV, Kurolesova AI, et al.: Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 1968;6:230-247
24. Friedenstein AJ, Chailakhjan RK, Lalykina KS: The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 1970;3:393-403
25. Friedenstein AJ: Precursor cells of mechanocytes. Int Rev Cytol 1976;47:327-359
26. Owen ME: Lineage of osteogenic cells and their relationship to the stromal system, in Peck WJ (ed): Bone and mineral (ed 3), Vol. 3. Amsterdam, Elsevier, 1985, pp 1-25
27. Owen M, Friedenstein AJ: Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp 1988;136:42-60
28. Lalykina KS, Friedenshtein A: Induction of thymus cells to form bone. Biull Eksp Biol Med 1972;73:88-90
29. Urist MR: Bone: formation by autoinduction. Science 1965;150:893-899
30. Urist MR, DeLange RJ, Finerman GA: Bone cell differentiation and growth factors. Science 1983;220:680-686
31. Reddi AH, Huggins C: Biochemical sequences in the transformation of normal fibroblasts in adolescent rats. Proc Natl Acad Sci U S A 1972;69:1601-1605
32. Caplan AI: Effects of the nicotinamide-sensitive teratogen3-acetylpyridine on chick limb cells in culture. Exp Cell Res 1970;62:341-355
33. Caplan AI: The molecular control of muscle and cartilage development, Proceedings, 39th Annual Symposium of the Society for Developmental Biology, New York, 1981
34. Caplan AI, Koutroupas S: The control of muscle and cartilage development in the chick limb: the role of differential vascularization. J Embryol Exp Morphol 1973;29:571-583
35. Caplan AI, Marshall R, Urist MD: Bioactive factors in bone: Kerrville, Texas. Connect Tissue Res 1989;23:103-106
36. Caplan AI: Cartilage begets bone versus endochondral myelopoiesis. Clin Orthop Relat Res 1990;261: 257-267
37. Lucas PA, Syftestad GT, Caplan AI: Partial isolation and characterization of a chemotactic factor from adult bovine bone for mesenchymal cells. Bone 1986;7:365-371
38. Lucas PA, Syftestad GT, Caplan AI: A water-soluble fraction from adult bone stimulates the differentiation of cartilage in explants of embryonic muscle. Differentiation 1988;37:47-52
39. Syftestad GT, Caplan AI: A fraction from extracts of demineralized adult bone stimulates the conversion of mesenchymal cells into chondrocytes. Dev Biol 1984;104:348-356
40. Syftestad GT, Lucas PA, Caplan AI: The in vitro chondrogenic response of limb-bud mesenchyme to a water-soluble fraction prepared from demineralized bone matrix. Differentiation 1985;29:230-237
41. Syftestad GT, Triffitt JT, Urist MR, et al: An osteo-inductive bone matrix extract stimulates the in vitro conversion of mesenchyme into chondrocytes. Calcif Tissue Int 1984;36:625-627
42. Connolly JF, Guse R, Tiedeman J, et al: Autologous marrow injection as a substitute for operative grafting of tibial nonunions. Clin Orthop Relat Res 1991;266: 259-270
43. Gimble JM: The function of adipocytes in the bone marrow stroma. New Biol 1990;2:304-312
44. Caplan AI: Mesenchymal stem cells. J Orthop Res 1991;9:641-650
45. Pereira RF, Halford KW, O'Hara MD, et al: Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc Natl Acad Sci U S A 1995;92:4857-4861
46. Pereira RF, O'Hara MD, Laptev AV, et al.: Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci U S A 1998;95:1142-1147
47. Horwitz EM, Gordon PL, Koo WK, et al: Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci U S A 2002;99:8932-8937
48. Horwitz EM, Prockop DJ, Fitzpatrick LA, et al: Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999;5:309-313
49. Keating A, Berkahn L, Filshie R: A phase I study of the transplantation of genetically marked autologous bone marrow stromal cells. Hum Gene Ther 1998;9:591-600
50. Horwitz EM, Keating A: Nonhematopoietic mesenchymal stem cells: what are they? Cytotherapy 2000;2:387-388
51. Gronthos S, Zannettino AC, Hay SJ, et al: Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci 2003;116:1827-1835
52. Lazarus HM, Haynesworth SE, Gerson SL, et al: Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplant 1995;16:557-564
53. D'Ippolito G, Diabira S, Howard GA, et al: Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. J Cell Sci 2004;117:2971-2981
54. Gimble JM, Guilak F: Differentiation potential of adipose derived adult stem (ADAS) cells. Curr Top Dev Biol 2003;58:137-160
55. Conget PA, Minguell JJ: Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells. J Cell Physiol 1999;181:67-73
56. Gimble JM, Katz AJ, Bunnell BA: Adipose-derived stem cells for regenerative medicine. Circ Res 2007;100:1249-1260
57. Jaiswal N, Haynesworth SE, Caplan AI, et al: Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 1997;64:295-312
58. Tapp H, Hanley EN Jr, Patt JC, et al: Adipose-derived stem cells: characterization and current application in orthopaedic tissue repair. Exp Biol Med (Maywood) 2009;234:1-9
59. Castro-Malaspina H, Gay RE, Resnick G, et al: Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood 1980;56:289-301
60. Wang QR, Yan ZJ, Wolf NS: Dissecting the hematopoietic microenvironment VI. The effects of several growth factors on the in vitro growth of murine bone marrow CFU-F. Exp Hematol 1990;18:341-347
61. Kuo CK, Tuan RS: Mechanoactive tenogenic differentiation of human mesenchymal stem cells. Tissue Eng Part A 2008;14:1615-1627
62. The Cluster of Differentiation (CD). Antigens (ed 7). New York, McGraw-Hill, 2005
63. Dicker A, Le Blanc K, Astrom G, et al: Functional studies of mesenchymal stem cells derived from adult human adipose tissue. Exp Cell Res 2005;308:283-290
64. Festy F, Hoareau L, Bes-Houtmann S, et al: Surface protein expression between human adipose tissue-derived stromal cells and mature adipocytes. Histochem Cell Biol 2005;124:113-121
65. Gronthos S, Franklin DM, Leddy HA, et al: Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol 2001;189:54-63
66. Haniffa MA, Wang XN, Holtick U, et al: Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells. J Immunol 2007;179:1595-1604
67. Kolf CM, Cho E, Tuan RS: Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res Ther 2007;9:204-213
68. Mitchell JB, McIntosh K, Zvonic S, et al: Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells 2006;24:376-385
69. Oedayrajsingh-Varma MJ, van Ham SM, Knippenberg M, et al: Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure. Cytotherapy 2006;8:166-177
70. Varma MJ, Breuls RG, Schouten TE, et al: Phenotypical and functional characterization of freshly isolated adipose tissue-derived stem cells. Stem Cells Dev 2007;16:91-104
71. Wagner W, Wein F, Seckinger A, et al: Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 2005;33:1402-1416
72. Yanez R, Lamana ML, Garcia-Castro J, et al: Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease. Stem Cells 2006;24:2582-2591
73. Huss R: Perspectives on the morphology and biology of CD34-negative stem cells. J Hematother Stem Cell Res 2000;9:783-793
74. Majumdar MK, Thiede MA, Haynesworth SE, et al: Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res 2000;9:841-848
75. Zuk PA, Zhu M, Ashjian P, et al: Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-4295
76. Crisan M, Yap S, Casteilla L, et al: A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008;3:301-313
77. Sacchetti B, Funari A, Michienzi S, et al: Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 2007;131:324-336
78. Zannettino AC, Paton S, Arthur A, et al: Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo. J Cell Physiol 2008;214:413-421
79. Niku M, Ilmonen L, Pessa-Morikawa T, et al: Limited contribution of circulating cells to the development and maintenance of nonhematopoietic bovine tissues. Stem Cells 2004;22:12-20
80. Kadiyala S, Young RG, Thiede MA, et al: Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro. Cell Transplant 1997;6:125-134
81. Neupane M, Chang CC, Kiupel M, et al: Isolation and characterization of canine adipose-derived mesenchymal stem cells. Tissue Eng Part A 2008;14:1007-1015
82. Fortier LA, Nixon AJ, Williams J, et al: Isolation and chondrocytic differentiation of equine bone marrow-derived mesenchymal stem cells. Am J Vet Res 1998;59:1182-1187
83. Martin DR, Cox NR, Hathcock TL, et al: Isolation and characterization of multipotential mesenchymal stem cells from feline bone marrow. Exp Hematol 2002;30:879-886
84. Izadpanah R, Trygg C, Patel B, et al: Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem 2006;99:1285-1297
85. Meirelles Lda S, Nardi NB: Murine marrow-derived mesenchymal stem cell: isolation, in vitro expansion, and characterization. Br J Haematol 2003;123:702-711
86. Harting M, Jimenez F, Pati S, et al: Immunophenotype characterization of rat mesenchymal stromal cells. Cytotherapy 2008;10:243-253
87. Vidal MA, Kilroy GE, Johnson JR, et al: Cell growth characteristics and differentiation frequency of adherent equine bone marrow-derived mesenchymal stromal cells: adipogenic and osteogenic capacity. Vet Surg 2006;35:601-610
88. Vidal MA, Kilroy GE, Lopez MJ, et al: Characterization of equine adipose tissue-derived stromal cells: adipogenic and osteogenic capacity and comparison with bone marrow-derived mesenchymal stromal cells. Vet Surg 2007;36:613-622
89. Cui L, Yin S, Liu W, et al: Expanded adipose-derived stem cells suppress mixed lymphocyte reaction by secretion of prostaglandin E2. Tissue Eng 2007;13:1185-1195
90. Hoogduijn MJ, Crop MJ, Peeters AM, et al: Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacities. Stem Cells Dev 2007;16:597-604
91. McIntosh K, Zvonic S, Garrett S, et al: The immunogenicity of human adipose-derived cells: temporal changes in vitro. Stem Cells 2006;24:1246-1253
92. Niemeyer P, Kornacker M, Mehlhorn A, et al: Comparison of immunological properties of bone marrow stromal cells and adipose tissue-derived stem cells before and after osteogenic differentiation in vitro. Tissue Eng 2007;13:111-121
93. Puissant B, Barreau C, Bourin P, et al: Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells. Br J Haematol 2005;129:118-129
94. Le Blanc K, Tammik C, Rosendahl K, et al: HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 2003;31:890-896
95. Le Blanc K, Tammik L, Sundberg B, et al: Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 2003;57:11-20
96. Lopez MJ, McIntosh KR, Spencer ND, et al: Acceleration of spinal fusion using syngeneic and allogeneic adult adipose derived stem cells in a rat model. J Orthop Res 2009;27:366-373
97. McIntosh KR, Lopez MJ, Borneman JN, et al: Immunogenicity of allogeneic adipose-derived stem cells in a rat spinal fusion model. Tissue Eng Part A 2009;15:2677-2686
98. Kincade PW, Lee G, Pietrangeli CE, et al: Cells and molecules that regulate B lymphopoiesis in bone marrow. Annu Rev Immunol 1989;7:111-143
99. Weiss L, Sakai H: The hematopoietic stroma. Am J Anat 1984;170:447-463
100. Whitlock CA, Tidmarsh GF, Muller-Sieburg C, et al: Bone marrow stromal cell lines with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule. Cell 1987;48:1009-1021
101. Zhang J, Li L: Stem cell niche: microenvironment and beyond. J Biol Chem 2008;283:9499-9503
102. Bajada S, Mazakova I, Richardson JB, et al: Updates on stem cells and their applications in regenerative medicine. J Tissue Eng Regen Med 2008;2:169-183
103. Kallis YN, Alison MR, Forbes SJ: Bone marrow stem cells and liver disease. Gut 2007;56:716-724
104. Nardi NB, Alfonso ZZ: The hematopoietic stroma. Braz J Med Biol Res 1999;32:601-609
105. Hubin F, Humblet C, Belaid Z, et al: Murine bone marrow stromal cells sustain in vivo the survival of hematopoietic stem cells and the granulopoietic differentiation of more mature progenitors. Stem Cells 2005;23:1626-1633
106. Cai J, Weiss ML, Rao MS: In search of "stemness". Exp Hematol 2004;32:585-598
107. Baddoo M, Hill K, Wilkinson R, et al: Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection. J Cell Biochem 2003;89:1235-1249
108. Meirelles Lda S, Fontes AM, Covas DT, et al: Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 2009;20:419-427
109. Rehman J, Traktuev D, Li J, et al: Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004;109:1292-1298
110. Hung SC, Pochampally RR, Chen SC, et al: Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis. Stem Cells 2007;25:2363-2370
111. Halvorsen YD, Franklin D, Bond AL, et al: Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng 2001;7:729-741
112. Jäger M, Fischer J, Dohrn W, et al: Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro. J Orthop Res 2008;26:1440-1448
113. Vallee M, Cote JF, Fradette J: Adipose-tissue engineering: taking advantage of the properties of human adipose-derived stem/stromal cells. Pathol Biol (Paris) 2009;57:309-317
114. Murdoch AD, Grady LM, Ablett MP, et al: Chondrogenic differentiation of human bone marrow stem cells in transwell cultures: generation of scaffold-free cartilage. Stem Cells 2007;25:2786-2796
115. Deng J, Petersen BE, Steindler DA, et al: Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation. Stem Cells 2006;24:1054-1064
116. Deng W, Obrocka M, Fischer I, et al: In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP. Biochem Biophys Res Commun 2001;282:148-152
117. Kamishina H, Deng J, Oji T, et al: Expression of neural markers on bone marrow-derived canine mesenchymal stem cells. Am J Vet Res 2006;67:1921-1928
118. Sanchez-Ramos J, Song S, Cardozo-Pelaez F, et al: Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000;164:247-256
119. Woodbury D, Schwarz EJ, Prockop DJ, et al: Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 2000;61:364-370
120. Neuhuber B, Gallo G, Howard L, et al: Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype. J Neurosci Res 2004;77:192-204
121. Safford KM, Rice HE: Stem cell therapy for neurologic disorders: therapeutic potential of adipose-derived stem cells. Curr Drug Targets 2005;6:57-62
122. Guo L, Yin F, Meng HQ, et al: Differentiation of mesenchymal stem cells into dopaminergic neuron-like cells in vitro. Biomed Environ Sci 2005;18:36-42
123. Kramer BC, Woodbury D, Black IB: Adult rat bone marrow stromal cells express genes associated with dopamine neurons. Biochem Biophys Res Commun 2006;343:1045-1052
124. Li Y, Chen J, Wang L, et al: Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson's disease. Neurosci Lett 2001;316:67-70
125. Chong AK, Ang AD, Goh JC, et al: Bone marrow-derived mesenchymal stem cells influence early tendon-healing in a rabbit achilles tendon model. J Bone Joint Surg Am 2007;89:74-81
126. Goel A, Sangwan SS, Siwach RC, et al: Percutaneous bone marrow grafting for the treatment of tibial non-union. Injury 2005;36:203-206
127. Park HC, Shim YS, Ha Y, et al: Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor. Tissue Eng 2005;11:913-922
128. Hiyama A, Mochida J, Iwashina T, et al: Transplantation of mesenchymal stem cells in a canine disc degeneration model. J Orthop Res 2008;26:589-600
129. Atala A, Bauer SB, Soker S, et al: Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet 2006;367:1241-1246
130. Janssens S, Dubois C, Bogaert J, et al: Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 2006;367:113-121
131. Murphy JM, Fink DJ, Hunziker EB, et al: Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 2003;48:3464-3474
132. Richardson LE, Dudhia J, Clegg PD, et al: Stem cells in veterinary medicine-attempts at regenerating equine tendon after injury. Trends Biotechnol 2007;25:409-416
133. Black LL, Gaynor J, Gahring D, et al: Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. Vet Ther 2007;8:272-284
134. Young RG, Butler DL, Weber W, et al: Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair. J Orthop Res 1998;16:406-413
135. Singer E: How injured racehorses might save your knees. Available at, 2009
136. Dahlgren L: Use of adipose derived stem cells in tendeon and ligament injuries. Proceedings, American College of Veterinary Surgery Symposium Equine Small Animal Proceedings, 2006
137. Harman R, Cowles B, Orava C: A retrospective review of 62 cases of suspensory ligament injury in sport horses treated with adipose-derived stem and regenerative cell therapy, Proceedings, of the Veterniary Orthopedic Society, 2006
138. Kim KM, Evans GR: Tissue engineering: The future of stem cells, in Ashammakhi N, Reis RL (eds): Topics in tissue engineering, Vol 2 2005, pp 1-21
139. Green WT Jr: Articular cartilage repair. Behavior of rabbit chondrocytes during tissue culture and subsequent allografting. Clin Orthop Relat Res 1977; 124: 237-250
140. Chick WL, Like AA, Lauris V: Beta cell culture on synthetic capillaries: an artificial endocrine pancreas. Science 1975;187:847-849
141. Viola J, Lal B, Grad O: The emergence of tissue engineering as a research field. Arlington, National Science Foundation, 2004
142. Hicok KC, Du Laney TV, Zhou YS, et al: Human adipose-derived adult stem cells produce osteoid in vivo. Tissue Eng 2004;10:371-380
143. Justesen J, Pedersen SB, Stenderup K, et al: Subcutaneous adipocytes can differentiate into bone-forming cells in vitro and in vivo. Tissue Eng 2004;10:381-391
144. Jafarian M, Eslaminejad MB, Khojasteh A, et al: Marrow-derived mesenchymal stem cells-directed bone regeneration in the dog mandible: a comparison between biphasic calcium phosphate and natural bone mineral. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:e14-24
145. Jang BJ, Byeon YE, Lim JH, et al: Implantation of canine umbilical cord blood-derived mesenchymal stem cells mixed with beta-tricalcium phosphate enhances osteogenesis in bone defect model dogs. J Vet Sci 2008;9:387-393
146. Teixeira S, Ferraz MP, Monteiro FJ: Biocompatibility of highly macroporous ceramic scaffolds: cell adhesion and morphology studies. J Mater Sci Mater Med 2008;19:855-859
147. Wahl DA, Czernuszka JT: Collagen-hydroxyapatite composites for hard tissue repair. Eur Cell Mater 2006;11:43-56
148. Wahl DA, Sachlos E, Liu C, et al: Controlling the processing of collagen-hydroxyapatite scaffolds for bone tissue engineering. J Mater Sci Mater Med 2007;18:201-209
149. Cui L, Liu B, Liu G, et al: Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model. Biomaterials 2007;28:5477-5486
150. Drury JL, Mooney DJ: Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials 2003;24:4337-4351
151. Glowacki J, Mizuno S: Collagen scaffolds for tissue engineering. Biopolymers 2008;89:338-344
152. Kim BS, Mooney DJ: Scaffolds for engineering smooth muscle under cyclic mechanical strain conditions. J Biomech Eng 2000;122:210-215
153. Pattison MA, Wurster S, Webster TJ, et al: Three-dimensional, nano-structured PLGA scaffolds for bladder tissue replacement applications. Biomaterials 2005;26:2491-2500
154. Macchiarini P, Jungebluth P, Go T, et al: Clinical transplantation of a tissue-engineered airway. Lancet 2008;372:2023-2030
155. Patrick CW Jr: Adipose tissue engineering: the future of breast and soft tissue reconstruction following tumor resection. Semin Surg Oncol 2000;19:302-311
156. Wakitani S, Goto T, Pineda SJ, et al: Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg Am 1994;76:579-592
157. Wakitani S, Imoto K, Yamamoto T, et al: Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage 2002;10:199-206
158. Wakitani S, Mitsuoka T, Nakamura N, et al: Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports. Cell Transplant 2004;13:595-600
159. Daar AS, Greenwood HL: A proposed definition of regenerative medicine. J Tissue Eng Regen Med 2007;1:179-184
160. Branski LK, Gauglitz GG, Herndon DN, et al: A review of gene and stem cell therapy in cutaneous wound healing. Burns 2009;35:171-180
161. Orlic D, Kajstura J, Chimenti S, et al: Bone marrow cells regenerate infarcted myocardium. Nature 2001;410:701-705
162. Mangi AA, Noiseux N, Kong D, et al: Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003;9:1195-1201
163. Gnecchi M, He H, Noiseux N, et al: Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 2006;20:661-669
164. Bi B, Schmitt R, Israilova M, et al: Stromal cells protect against acute tubular injury via an endocrine effect. J Am Soc Nephrol 2007;18:2486-2496
165. Higashiyama R, Inagaki Y, Hong YY, et al: Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Hepatology 2007;45:213-222