Adult rat bone marrow stromal cells express genes associated with dopamine neurons

Biochemical and Biophysical Research Communications

Volumn 343, Issue 4, 2006, Pages 1045-1052

  Kramer, Brian C ^a   Woodbury, Dale ^a   Black, Ira B ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

GDNF; Nurr 1; Parkinson's disease; Regenerative medicine; Stem cell

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; GLYCOSYLPHOSPHATIDYLINOSITOL; NUCLEAR RECEPTOR RELATED FACTOR 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR OTX;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; DNA SYNTHESIS; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; GENETIC TRANSCRIPTION; MESENCEPHALON; MULTIGENE FAMILY; NERVE CELL DIFFERENTIATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION; STROMA CELL;

ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; DNA-BINDING PROTEINS; DOPAMINE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; NEURONS; OTX TRANSCRIPTION FACTORS; RATS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STROMAL CELLS; TRANSCRIPTION FACTORS;

ANIMALIA; ERINACEIDAE;

EID: 33646043770     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.02.191     Document Type: Article

References (30)

1. Barker R.A. Prospects for the treatment of Parkinson's disease using neural grafts. Expert Opin. Pharmacother. 1 (2000) 889-902
2. Brazelton T.R., Rossi F.M., Keshet G.I., and Blau H.M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290 (2000) 1775-1779
3. Gash D.M., Zhang Z., and Gerhardt G. Neuroprotective and neurorestorative properties of GDNF. Ann. Neurol. 44 (1998) S121-S125
4. Hou J.G., Cohen G., and Mytilineou C. Basic fibroblast growth factor stimulation of glial cells protects dopamine neurons from 6-hydroxydopamine toxicity: involvement of the glutathione system. J. Neurochem. 69 (1997) 76-83
5. Hou J.G., and Mytilineou C. Secretion of GDNF by glial cells does not account for the neurotrophic effect of bFGF on dopamine neurons in vitro. Brain Res. 724 (1996) 145-148
6. Hynes M., Porter J.A., Chiang C., Chang D., Tessier-Lavigne M., Beachy P.A., and Rosenthal A. Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron 15 (1995) 35-44
7. Kearns C.M., and Gash D.M. GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo. Brain Res. 672 (1995) 104-111
8. Kim K.S., Kim C.H., Hwang D.Y., Seo H., Chung S., Hong S.J., Lim J.K., Anderson T., and Isacson O. Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner. J. Neurochem. 85 (2003) 622-634
9. Kordower J.H., Freeman T.B., Chen E.Y., Mufson E.J., Sanberg P.R., Hauser R.A., Snow B., and Olanow C.W. Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease. Mov. Disord. 13 (1998) 383-393
10. Kramer B.C., Goldman A.D., and Mytilineou C. Glial cell line derived neurotrophic factor promotes the recovery of dopamine neurons damaged by 6-hydroxydopamine in vitro. Brain Res. 851 (1999) 221-227
11. Lin L.F., Doherty D.H., Lile J.D., Bektesh S., and Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260 (1993) 1130-1132
12. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
13. Maira M., Martens C., Philips A., and Drouin J. Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Mol. Cell. Biol. 19 (1999) 7549-7557
14. Mezey E., Chandross K.J., Harta G., Maki R.A., and McKercher S.R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290 (2000) 1779-1782
15. Munoz-Elias G., Marcus A.J., Coyne T.M., Woodbury D., and Black I.B. Adult bone marrow stromal cells in the embryonic brain: engraftment, migration, differentiation, and long-term survival. J. Neurosci. 24 (2004) 4585-4595
16. Nagatsu T., Levitt M., and Undenfriend S. Tyrosine hydroxylase: the initial step in norepinephrine biosynthesis. J. Biol. Chem. 239 (1964) 2910-2917
17. Olanow C.W., Freeman T., and Kordower J. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 345 (2001) 146 discussion 147
18. Paratcha G., Ledda F., Baars L., Coulpier M., Besset V., Anders J., Scott R., and Ibanez C.F. Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts. Neuron 29 (2001) 171-184
19. Park T.H., and Mytilineou C. Protection from 1-methyl-4-phenylpyridinium (MPP+) toxicity and stimulation of regrowth of MPP(+)-damaged dopaminergic fibers by treatment of mesencephalic cultures with EGF and basic FGF. Brain Res. 599 (1992) 83-97
20. Saucedo-Cardenas O., Quintana-Hau J.D., Le W.D., Smidt M.P., Cox J.J., De Mayo F., Burbach J.P., and Conneely O.M. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA 95 (1998) 4013-4018
21. Shults C.W., Ray J., Tsuboi K., and Gage F.H. Fibroblast growth factor-2-producing fibroblasts protect the nigrostriatal dopaminergic system from 6-hydroxydopamine. Brain Res. 883 (2000) 192-204
22. Tomac A., Lindqvist E., Lin L.F., Ogren S.O., Young D., Hoffer B.J., and Olson L. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373 (1995) 335-339
23. Trupp M., Arenas E., Fainzilber M., Nilsson A.S., Sieber B.A., Grigoriou M., Kilkenny C., Salazar-Grueso E., Pachnis V., and Arumae U. Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature 381 (1996) 785-788
24. Wallen A.A., Castro D.S., Zetterstrom R.H., Karlen M., Olson L., Ericson J., and Perlmann T. Orphan nuclear receptor nurr1 is essential for ret expression in midbrain dopamine neurons and in the brain stem. Mol. Cell. Neurosci. 18 (2001) 649-663
25. Wang M.Z., Jin P., Bumcrot D.A., Marigo V., McMahon A.P., Wang E.A., Woolf T., and Pang K. Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein. Nat. Med. 1 (1995) 1184-1188
26. Woodbury D., Reynolds K., and Black I.B. Adult bone marrow stromal stem cells express germline, ectodermal, endodermal and mesodermal genes prior to neurogenesis. J. Neurosci. Res. 96 (2002) 908-917
27. Woodbury D., Schwarz E.J., Prockop D.J., and Black I.B. Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 61 (2000) 364-370
28. Zetterstrom R.H., Solomin L., Jansson L., Hoffer B.J., Olson L., and Perlmann T. Dopamine neuron agenesis in Nurr1-deficient mice. Science 276 (1997) 248-250
29. Zetterstrom R.H., Williams R., Perlmann T., and Olson L. Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. Brain Res. Mol. Brain Res. 41 (1996) 111-120
30. Zuch C.L., Nordstroem V.K., Briedrick L.A., Hoernig G.R., Granholm A.C., and Bickford P.C. Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion. J. Comp. Neurol. 427 (2000) 440-454