Early microvascular reactions and blood-spinal cord barrier disruption are instrumental in pathophysiology of spinal cord injury and repair: Novel therapeutic strategies including nanowired drug delivery to enhance neuroprotection

Journal of Neural Transmission

Volumn 118, Issue 1, 2011, Pages 155-176

  Sharma, Hari Shanker ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Antibodies therapy; Blood spinal cord barrier; Edema formation; Electrophysiology; Endothelial cells; Glial cells; Microvascular reactions; Motoneurons; Nanowired drug delivery; Spinal cord injury; Spinal cord pathology; Treatment

Indexed keywords

5,7 DIHYDROXYTRYPTAMINE; ALPHA FLUOROMETHYLHISTIDINE; ANTIBODY; BIOLOGICAL FACTOR; DIAZEPAM; DYNORPHIN A; FENCLONINE; GROWTH FACTOR; HISTAMINE; IBUPROFEN; ICATIBANT; INDOMETACIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; METIROSINE; N(G) NITROARGININE METHYL ESTER; NALOXONE; NANOWIRE; NEURONAL NITRIC OXIDE SYNTHASE; NEUROPROTECTIVE AGENT; NEUROTRANSMITTER; NIMODIPINE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENOXYBENZAMINE; PROPRANOLOL; PROSTAGLANDIN; SEROTONIN; TITANIUM DIOXIDE; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNINDEXED DRUG;

ACTION POTENTIAL; ARTICLE; AUTOREGULATION; BLOOD BRAIN BARRIER; CELL DAMAGE; CELL FUNCTION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; EVOKED SPINAL CORD RESPONSE; HUMAN; INJURY SEVERITY; MEDIATOR; MICROVASCULARIZATION; MOTOR NERVE CONDUCTION; MOTOR PERFORMANCE; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RABBIT; RISK REDUCTION; SPINAL CORD; SPINAL CORD BLOOD FLOW; SPINAL CORD DECOMPRESSION; SPINAL CORD DISEASE; SPINAL CORD DORSAL HORN; SPINAL CORD EDEMA; SPINAL CORD HEMORRHAGE; SPINAL CORD INJURY; SPINAL CORD REGENERATION; TISSUE INJURY; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ANIMALS; DRUG DELIVERY SYSTEMS; EDEMA; ELECTROPHYSIOLOGICAL PHENOMENA; HUMANS; MATRIX METALLOPROTEINASES; MICROCIRCULATION; NANOWIRES; NEURONS; NEUROPROTECTIVE AGENTS; REGIONAL BLOOD FLOW; SPINAL CORD; SPINAL CORD INJURIES;

EID: 79951726508     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-010-0514-4     Document Type: Article

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111. HS Sharma T Winkler E Stålberg Y Olsson PK Dey 1991 Evaluation of traumatic spinal cord edema using evoked potentials recorded from the spinal epidural space. An experimental study in the rat J Neurol Sci 102 150 162 1:STN:280:DyaK3MzgtlWnuw%3D%3D 1830095 10.1016/0022-510X(91)90063-D
112. Sharma HS, Nyberg F, Olsson Y (1992) Dynorphin A content in the rat brain and spinal cord after a localized trauma to the spinal cord and its modification with p-chlorophenylalanine. An experimental study using radioimmunoassay technique. Neurosci Res 14(3):195-203 (Pubitemid 23000720)
113. HS Sharma Y Olsson J Cervós-Navarro 1993 Early perifocal cell changes and edema in traumatic injury of the spinal cord are reduced by indomethacin, an inhibitor of prostaglandin synthesis Acta Neuropathologica (Berlin) 85 145 153 1:STN:280:DyaK3s7ot1Gruw%3D%3D 10.1007/BF00227761 (Pubitemid 23068503)
114. HS Sharma Y Olsson F Nyberg PK Dey 1993 Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury. An experimental study in the rat Neuroscience 57 443 449 1:CAS:528:DyaK2cXivVClsg%3D%3D 8115048 10.1016/0306-4522(93)90076-R (Pubitemid 23345312)
115. HS Sharma Y Olsson J Cervós-Navarro 1993 p-Chlorophenylalanine, a serotonin synthesis inhibitor, reduces the response of glial fibrillary acidic protein induced by trauma to the spinal cord. An immunohistochemical investigation in the rat Acta Neuropathol 86 5 422 427 1:CAS:528: DyaK2cXitFCgsLc%3D 8310791 10.1007/BF00228575
116. Sharma HS, Nyberg F, Thörnwall M, Olsson Y (1993d) Met-enkephalin-Arg6-Phe7 in spinal cord and brain following traumatic injury to the spinal cord: influence of p-chlorophenylalanine. An experimental study in the rat using radioimmunoassay technique. Neuropharmacology 32(7):711-717
117. HS Sharma Y Olsson S Pearsson F Nyberg 1995 Trauma induced opening of the blood-spinal cord barrier is reduced by indomethacin, an inhibitor of prostaglandin synthesis. Experimental observations in the rat using 131I-sodium, Evans blue and lanthanum as tracers Restor Neurol Neurosci 7 207 215
118. Sharma HS, Olsson Y, Nyberg F (1995a) Influence of dynorphin-A antibodies on the formation of edema and cell changes in spinal cord trauma. In: Nyberg F, Sharma HS (eds) Progress in brain research, vol 104, Z Wissenfeld-Halin. Elsevier, Amsterdam, pp 401-416
119. HS Sharma J Westman Y Olsson P Alm 1996 Involvement of nitric oxide in acute spinal cord injury: an immunohistochemical study using light and electron microscopy in the rat Neurosci Res 24 373 384 1:CAS:528:DyaK28XjtV2ns7c%3D 8861107 10.1016/0168-0102(95)01015-7 (Pubitemid 26114183)
120. HS Sharma J Westman F Nyberg 1997 Topical application of 5-HT antibodies reduces edema and cell changes following trauma to the rat spinal cord Acta Neurochir (Wien) Suppl 70 155 158 1:STN:280:DyaK1c%2FnvValsQ%3D%3D (Pubitemid 127502080)
121. HS Sharma F Nyberg T Gordh P Alm J Westman 1997 Topical application of insulin like growth factor-1 reduces edema and upregulation of neuronal nitric oxide synthase following trauma to the rat spinal cord Acta Neurochir (Wien), Suppl 70 130 133 1:CAS:528:DyaK1cXltlaqs70%3D (Pubitemid 127502073)
122. Sharma HS, Nyberg F, Gordh T, Alm P, Westman J (1998a) Neurotrophic factors attenuate neuronal nitric oxide synthase upregulation, microvascular permeability disturbances, edema formation and cell injury in the spinal cord following trauma. In: Stålberg E, Sharma HS, Olsson Y (eds) Spinal cord monitoring. Basic principles. Regeneration, pathophysiology and clinical aspects. Springer, Wien, pp 181-210
123. HS Sharma F Nyberg J Westman P Alm T Gordh D Lindholm 1998 Brain derived neurotrophic factor and insulin like growth factor-1 attenuate upregulation of nitric oxide synthase and cell injury following trauma to the spinal cord. An immunohistochemical study in the rat Amino Acids 14 1-3 121 129 9871451 10.1007/BF01345252 (Pubitemid 28051161)
124. Sharma HS, Westman J, Nyberg F (1998c) Pathophysiology of brain edema and cell changes following hyperthermic brain injury. In: Sharma HS, Westman J (eds) Brain functions in hot environment, progress in brain research, vol 115. Elsevier, Amsterdam, pp 351-412 (Pubitemid 28264331)
125. Sharma HS, Alm P, Westman J (1998d) Nitric oxide and carbon monoxide in the pathophysiology of brain functions in heat stress. In: Sharma HS, Westman J (eds) Brain functions in hot environment. Prog Brain Res 115:297-333 (Pubitemid 28264329)
126. HS Sharma F Nyberg T Gordh P Alm J Westman 2000 Neurotrophic factors influence upregulation of constitutive isoform of heme oxygenase and cellular stress response in the spinal cord following trauma. An experimental study using immunohistochemistry in the rat Amino Acids 19 1 351 361 1:CAS:528: DC%2BD3cXnsVSnsL0%3D 11026506 10.1007/s007260070066
127. HS Sharma J Westman T Gordh P Alm 2000 Topical application of brain derived neurotrophic factor influences upregulation of constitutive isoform of heme oxygenase in the spinal cord following trauma an experimental study using immunohistochemistry in the rat Acta Neurochir Suppl 76 365 369 1:CAS:528:DC%2BD3MXlsV2qsbc%3D 11450046
128. Sharma HS, Sjöquist P-O, Westman J (2001) Pathophysiology of the blood-spinal cord barrier in spinal cord injury. Influence of a new antioxidant compound H-290/51. In: Kobiler D, Lustig S, Shapra S (eds) Blood-brain barrier. Drug delivery and brain pathology. Kluwer Academic/Plenum Publishers, New York, pp 401-416
129. HS Sharma T Winkler E Stålberg T Gordh P Alm J Westman 2003 Topical application of TNF-alpha antiserum attenuates spinal cord trauma induced edema formation, microvascular permeability disturbances and cell injury in the rat Acta Neurochir Suppl 86 407 413 1:CAS:528:DC%2BD2cXhvFart7o%3D 14753477
130. HS Sharma T Lundstedt M Flärdh J Westman C Post A Skottner 2003 Low molecular weight compounds with affinity to melanocortin receptors exert neuroprotection in spinal cord injury-an experimental study in the rat Acta Neurochir Suppl 86 399 405 1:CAS:528:DC%2BD2cXhvFart70%3D 14753476
131. HS Sharma RD Badgaiyan P Alm S Mohanty L Wiklund 2005 Neuroprotective effects of nitric oxide synthase inhibitors in spinal cord injury-induced pathophysiology and motor functions: an experimental study in the rat Ann N Y Acad Sci 1053 422 434 1:CAS:528:DC%2BD28XotlKqug%3D%3D 16179549 10.1196/annals.1344.037 (Pubitemid 43031123)
132. HS Sharma P Vannemreddy R Patnaik S Patnaik S Mohanty 2006 Histamine receptors influence blood-spinal cord barrier permeability, edema formation, and spinal cord blood flow following trauma to the rat spinal cord Acta Neurochir Suppl 96 316 321 1:STN:280:DC%2BD283kslKqsA%3D%3D 16671478 10.1007/3-211-30714- 1-67
133. HS Sharma F Nyberg T Gordh P Alm 2006 Topical application of dynorphin A (1-17) antibodies attenuates neuronal nitric oxide synthase up-regulation, edema formation, and cell injury following focal trauma to the rat spinal cord Acta Neurochir Suppl 96 309 315 1:STN:280:DC%2BD283kslKqsw%3D%3D 16671477 10.1007/3-211-30714-1-66
134. HS Sharma T Gordh L Wiklund S Mohanty PO Sjöquist 2006 Spinal cord injury induced heat shock protein expression is reduced by an antioxidant compound H-290/51. An experimental study using light and electron microscopy in the rat J Neural Transm 113 4 521 536 1:CAS:528:DC%2BD28XislWksLg%3D 16550329 10.1007/s00702-005-0405-2
135. HS Sharma A Skottner T Lundstedt M Flärdh L Wiklund 2006 Neuroprotective effects of melanocortins in experimental spinal cord injury. An experimental study in the rat using topical application of compounds with varying affinity to melanocortin receptors J Neural Transm 113 4 463 476 1:CAS:528:DC%2BD28XislWksLs%3D 16550325 10.1007/s00702-005-0404-3
136. HS Sharma T Lundstedt M Flärdh A Skottner L Wiklund 2007 Neuroprotective effects of melanocortins in CNS injury Curr Pharm Des 13 19 1929 1941 1:CAS:528:DC%2BD2sXot1Ogtbk%3D 17627526 10.2174/138161207781039797 (review) (Pubitemid 47040493)
137. HS Sharma SF Ali W Dong ZR Tian R Patnaik S Patnaik A Sharma A Boman P Lek E Seifert T Lundstedt 2007 Drug delivery to the spinal cord tagged with nanowire enhances neuroprotective efficacy and functional recovery following trauma to the rat spinal cord Ann N Y Acad Sci 1122 197 218 1:CAS:528: DC%2BD1cXhtVOksb4%3D 18077574 10.1196/annals.1403.014 (Pubitemid 350249549)
138. HS Sharma DF Muresanu A Sharma R Patnaik JV Lafuente 2009 Chapter 9 - Nanoparticles influence pathophysiology of spinal cord injury and repair Prog Brain Res 180 154 180 20302834 10.1016/S0079-6123(08)80009-X 1:CAS:528:DC%2BC3cXht1Wrtr8%3D (Epub 2009 Dec 8. Review)
139. HS Sharma SF Ali ZR Tian SM Hussain JJ Schlager PO Sjöquist A Sharma DF Muresanu 2009 Chronic treatment with nanoparticles exacerbate hyperthermia induced blood-brain barrier breakdown, cognitive dysfunction and brain pathology in the rat. Neuroprotective effects of nanowired-antioxidant compound H-290/51 J Nanosci Nanotechnol 9 8 5073 5090 1:CAS:528:DC%2BD1MXht1yrsbfO 19928186 10.1166/jnn.2009.GR10
140. HS Sharma S Ali ZR Tian R Patnaik S Patnaik P Lek A Sharma T Lundstedt 2009 Nano-drug delivery and neuroprotection in spinal cord injury J Nanosci Nanotechnol 9 8 5014 5037 1:CAS:528:DC%2BD1MXht1yrsbbE 19928182 10.1166/jnn.2009.GR04
141. HS Sharma R Patnaik A Sharma PO Sjöquist JV Lafuente 2009 Silicon dioxide nanoparticles (SiO2, 40-50 nm) exacerbate pathophysiology of traumatic spinal cord injury and deteriorate functional outcome in the rat. An experimental study using pharmacological and morphological approaches J Nanosci Nanotechnol 9 8 4970 4980 1:CAS:528:DC%2BD1MXht1yrsbbN 19928175 10.1166/jnn.2009.1717
142. HS Sharma S Zimmermann-Meinzingen CE Johanson 2010 Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change, brain pathology, and functional deficits following traumatic brain injury in the rat Ann N Y Acad Sci 1199 125 137 1:CAS:528:DC%2BC3cXhtV2it7jE 20633118 10.1111/j.1749-6632.2009. 05329.x
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