Neuroprotective effects of neurotrophins and melanocortins in spinal cord injury: An experimental study in the rat using pharmacological and morphological approaches

Annals of the New York Academy of Sciences

Volumn 1053, Issue , 2005, Pages 407-421

  Sharma, Hari Shanker ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Blood spinal cord barrier; Brain derived neurotrophic factor; Insulin like growth factor 1; Melanocortins; Neuroprotection; Spinal cord injury

Indexed keywords

ALBUMIN; BRAIN DERIVED NEUROTROPHIC FACTOR; EVANS BLUE; IODINE 131; LANTHANUM; M1 10501; ME 10092; ME 10354; ME 10393; ME 10431; ME 10501; MELANOCORTIN; MELANOCORTIN RECEPTOR; NEUROTROPHIN; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ASTROCYTE; CELL MEMBRANE PERMEABILITY; CONFERENCE PAPER; CONTROLLED STUDY; EDEMA; ENDOTHELIUM CELL; HISTOPATHOLOGY; MALE; MORPHOLOGY; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; RAT; SPINAL CORD INJURY; THORACIC SPINAL CORD; TISSUE INJURY; WATER CONTENT;

ANIMALIA;

EID: 29744464639     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1344.036     Document Type: Conference Paper

References (35)

1. SHARMA, H.S. 2005. Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr. Pharm. Des. 11: 1353-1389.
2. STÅLBERG, E., H.S. SHARMA & Y. OLSSON, Eds. 1998. Spinal Cord Monitoring: Basic Principles, Regeneration, Pathophysiology, and Clinical Aspects. Springer. Wien/New York.
3. SHARMA, H.S. 2004. Pathophysiology of the blood-spinal cord barrier in traumatic injury. In The Blood-Spinal Cord and Brain Barriers in Health and Disease, pp. 437-518. Elsevier Academic. San Diego.
4. SHARMA, H.S. 2004. Editorial. Int. J. Neuroprotec. Neuroregen. 1: 8.
5. SHARMA, H.S. & J. WESTMAN, Eds. 2004. The Blood-Spinal Cord and Brain Barriers in Health and Disease. Elsevier Academic. San Diego.
6. WINKLER, T., H.S. SHARMA, E. STÅLBERG & J. WESTMAN. 1998. Spinal cord bioelectrical activity, edema, and cell injury following a focal trauma to the spinal cord: an experimental study using pharmacological and morphological approach. In Spinal Cord Monitoring: Basic Principles, Regeneration, Pathophysiology and Clinical Aspects, pp. 281-348. Springer. Wien/New York.
7. SHARMA, H.S., F. NYBERG, T. GORDH et al. 1998. Neurotrophic factors attenuate neuronal nitric oxide synthase upregulation, microvascular permeability disturbances, edema formation, and cell injury in the spinal cord following trauma. In Spinal Cord Monitoring: Basic Principles, Regeneration, Pathophysiology and Clinical Aspects, pp. 118-148. Springer. Wien/New York.
8. SCHWAB, M.E. & D. BARTHOLDI. 1996. Degeneration and regeneration of axons in the lesioned spinal cord. Physiol. Rev. 76: 319-370.
9. BARDE, Y.A. 1994. Neurotrophins: a family of proteins supporting the survival of neurons. Prog. Clin. Biol. Res. 390: 45-56.
10. VAN DER KRAAN, M., J.B. TATRO, M.L. ENTWISTLE et al. 1999. Expression of melanocortin receptors and pro-opiomelanocortin in the rat spinal cord in relation to neurotrophic effects of melanocortins. Mol. Brain Res. 63: 276-286.
11. VAN DE MEENT, H., F.P. HAMERS, A.J. LANKHORST et al. 1997. Beneficial effects of the melanocortin alpha-melanocyte stimulating hormone on clinical and neurophysiological recovery after experimental spinal cord injury. Neurosurgery 40: 122-130.
12. MOUNTJOY, K.G., L.S. ROBBINS, M.T. MORTRUD & R.D. CONE. 1992. The cloning of a family of genes that encode the melanocortin receptors. Science 257: 543-546.
13. KAKULAS, B. 2004. Neuropathology: the foundation for new treatments in spinal cord injury. Spinal Cord 42: 549-563.
14. IANNOTTI, C., Y. PING ZHANG, C.B. SHIELDS et al. 2004. A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury. Exp. Neurol. 189: 317-332.
15. LU, P., H. YANG, L.L. JONES et al. 2004. Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J. Neurosci. 24: 6402-6409.
16. SHARMA, H.S. & Y. OLSSON. 1990. Edema formation and cellular alterations following spinal cord injury in rat and their modification with p-chlorophenylalanine. Acta Neuropathol. (Berlin) 79: 604-610.
17. SHARMA, H.S. 2003. Neurotrophic factors attenuate microvascular permeability disturbances and axonal injury following trauma to the rat spinal cord. Acta Neurochir. (Wien) Suppl. 86: 383-388.
18. SHARMA, H.S., T. WINKLER, E. STÅLBERG et al. 1991. Evaluation of traumatic spinal cord edema using evoked potentials recorded from the spinal epidural space: an experimental study in the rat. J. Neurol. Sci. 102: 150-162.
19. SHARMA, H.S., T. LUNDSTEDT, M. FLÄRDH et al. 2003. Low molecular weight compounds with affinity to melanocortin receptors exert neuroprotection in spinal cord injury: an experimental study in the rat. Acta Neurochir. (Wien) Suppl. 86: 399-405.
20. 131I-sodium, Evans blue, and lanthanum as tracers. Restor. Neurol. Neurosci. 7: 207-215.
21. SHARMA, H.S., Y. OLSSON & J. CERVÓS-NAVARRO. 1993. p-Chlorophenylalanine, a serotonin synthesis inhibitor, reduces the response of glial fibrillary acidic protein induced by trauma to the spinal cord. Acta Neuropathol. (Berlin) 86: 422-427.
22. SHARMA, H.S., Y. OLSSON & J. CERVOS-NAVARRO. 1993. Early perifocal cell changes and edema in traumatic injury of the spinal cord are reduced by indomethacin, an inhibitor of prostaglandin synthesis. Acta Neuropathol. (Berlin) 85: 145-153.
23. SHARMA, H.S., J. WESTMAN, Y. OLSSON & P. ALM. 1996. Involvement of nitric oxide in acute spinal cord injury: an immunohistochemical study using light and electron microscopy in the rat. Neurosci. Res. 24: 373-384.
24. SHARMA, H.S., R.D. BADGAIYAN, P. ALM et al. 2005. Neuroprotective effects of nitric oxide synthase inhibitors in spinal cord injury induced pathophysiology and motor functions: an experimental study in the rat. Ann. N.Y. Acad. Sci. This volume.
25. WU, W. 2000. Response of nitric oxide synthase to neuronal injury. In Functional Neuroanatomy of the Nitric Oxide System. Handb. Chem. Neuroanat. Vol. 17, pp. 315-353. Elsevier. Amsterdam/New York.
26. NOVIKOV, L., L. NOVIKOVA & J.O. KELLERTH. 1995. Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral nerve root avulsion. Neurosci. Lett. 200: 45-48.
27. SHARMA, H.S. & P. ALM. 2004. Role of nitric oxide on the blood-brain and the spinal cord barriers. In The Blood-Spinal Cord and Brain Barriers in Health and Disease, pp. 191-230. Elsevier Academic. San Diego.
28. DAWSON, V.L. & T.M. DAWSON. 1996. Nitric oxide neurotoxicity. J. Chem. Neuroanat. 10: 179-190.
29. SHARMA, H.S., F. NYBERG, J. WESTMAN et al. 1998. Brain derived neurotrophic factor and insulin like growth factor-1 attenuate upregulation of nitric oxide synthase and cell injury following trauma to the spinal cord. Amino Acids 14: 121-130.
30. SHARMA, H.S., F. NYBERG, T. GORDH et al. 1997. Topical application of insulin like growth factor-1 reduces edema and upregulation of neuronal nitric oxide synthase following trauma to the rat spinal cord. Acta Neurochir. (Suppl.) 70: 130-133.
31. WOOLTERINK, G., E. VAN ZANTEN, H. KAMSTEEG et al. 1990. Functional recovery after destruction of dopamine systems in the nucleus accumbens of rats. II. Facilitation by the ACTH (4-9) analog ORG 2766. Brain Res. 507: 101-108.
32. VRINTEN, D.H., C.J. KALKMAN, R.A.H. ADAN & W.H. GISPEN. 2001. Neuropathic pain: a possible role for the melanocortin system? Eur. J. Pharmacol. 429: 61-69.
33. SHARMA, H.S., J. WESTMAN & F. NYBERG. 1997. Topical application of 5-HT antibodies reduces edema and cell changes following trauma to the rat spinal cord. Acta Neurochir. (Suppl.) 70: 155-158.
34. PAN, W., A.J. KASTIN & C.G. PICK. 2004. The staircase test in mice after spinal cord injury. Int. J. Neuroprotec. Neuroregen. 1: 32-37.
35. WINKLER, T., H.S. SHARMA, E. STÅLBERG et al. 2003. An L-type calcium channel blocker, nimodipine, influences trauma induced cord conduction and axonal injury in the rat. Acta Neurochir. (Wien) Suppl. 86: 425-432.