Breakdown of the blood-brain barrier in stress alters cognitive dysfunction and induces brain pathology: New perspectives for neuroprotective strategies

Brain Protection in Schizophrenia, Mood and Cognitive Disorders

Volumn , Issue , 2010, Pages 243-303

  Sharma, Hari Shanker ^a   Sharma, Aruna ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Blood brain barrier; Brain edema; Brain pathology; Cognitive dysfunction; Cytokines; Neuropsychiatry diseases; Prostaglandin; Sensory motor abnormalities; Serotonin; Stress

Indexed keywords

EID: 79951679168     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-90-481-8553-5_9     Document Type: Chapter

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156. Sharma HS, Patnaik R, Sharma A, Sjöquist P-O, Lafuente, LV. Silicon Dioxide Nanoparticles (SiO2, 40-50 nm) Exacerbate pathophysiology of traumatic spinal cord injury and deteriorate functional outcome in the rat. An experimental study using pharmacological and morphological approaches. J Nanosci Nanotechnol 2009;9:4970-4980
157. Brown DM, Stone V, Findlay P, MacNee W, Donaldson K. Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components. Occup Environ Med 2000;57:685-691. [PubMed]
158. Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol Appl Pharmacol 2001;175:191-199
159. Derfus AM, Chan WCW, Bhatia SN. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 2004;4(1):11-18
160. Joo SH, Feitz AJ, Waite TD. Oxidative degradation of the carbothioate herbicide, molinate, using nanoscale zerovalent iron. Environ Sci Technol 2004;38:2242-2247
161. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, et al. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 2003;111:455-460
162. Oberdörster E. Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in brain of juvenile largemouth bass. Environ Health Perspect 2004;112:1058-1062
163. Sayes C, Fortner J, Guo W, Lyon D, Boyd AM, Ausman KD, et al. The differential cytotoxicity of water-soluble fullerenes. Nano Lett 2004;4:1881-1887
164. Shvedova AA, Kisin ER, Murray A, Kommineni C, Vallyathan V, Castranova V. Pro/antioxidant status in murine skin following topical exposure to cumene hydroperoxide throughout the ontogeny of skin cancer. Biochemistry (Mosc) 2004 Jan; 69(1):23-31
165. Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich AI, Tyurina YY, Gorelik O, Arepalli S, Schwegler-Berry D, Hubbs AF, Antonini J, Evans DE, Ku BK, Ramsey D, Maynard A, Kagan VE, Castranova V, Baron P. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 2005 Nov; 289(5):L698-L708
166. Sharma HS, Sjöquist PO, Ali SF. Drugs of abuse-induced hyperthermia, blood-brain barrier dysfunction and neurotoxicity: neuroprotective effects of a new antioxidant compound H-290/51. Curr Pharm Des 2007;13(18):1903-1923. Review
167. Sharma HS, Sjoquist PO, Alm P. A new antioxidant compound H-290151attenuates spinal cord injury induced expression of constitutive and inducible isoforms of nitric oxide synthase and edema formation in the rat. Acta Neurochir Suppl 2003;86:415-420
168. Sharma HS, Gordh T, Wiklund L, Mohanty S, Sjoquist PO. Spinal cord injury induced heat shock protein expression is reduced by an antioxidant compound H-290/51. An experimental study using light and electron microscopy in the rat. J Neural Transm 2006 Apr; 113(4):521-536
169. Jordan A, Scholz R, Maier-Hauff K, Van Landeghem FK, Waldoefner N, Teichgraeber U, Pinkernelle J, Bruhn H, Neumann F, Thiesen B, Von Deimling A, Felix R. The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma. J Neurooncol 2006 May; 78(1):7-14
170. Plotkin M, Gneveckow U, Meier-Hauff K, Amthauer H, Feussner A, Denecke T, Gutberlet M, Jordan A, Felix R, Wust P. 18F-FET PET for planning of thermotherapy using magnetic nanoparticles in recurrent glioblastoma. Int J Hyperthermia 2006 Jun; 22(4):319-325
171. Inoue K, Takano H, Yanagisawa R, Hirano S, Sakurai M, Shimada A, Yoshikawa T. Effects of airway exposure to nanoparticles on lung inflammation induced by bacterial endotoxin in mice. Environ Health Perspect 2006 Sep; 114(9):1325-1330
172. Sharma H S, Sjöquist P-O, Westman J. Pathophysiology of the blood-spinal cord barrier in spinal cord injury. Influence of a new antioxidant compound H-290/51. In: Kobiler D, Lustig S, Shapra S (eds) Blood-Brain Barrier. Drug Delivery and Brain Pathology, Kluwer Academic/Plenum Publishers, New York, 2001; pp. 401-416
173. MacNee W, Donaldson K. How can ultrafine particles be responsible for increased mortality? Monaldi Arch Chest Dis 2000 Apr; 55(2):135-139. Review
174. Sharma HS, Olsson Y, Nyberg F. Influence of dynorphin A antibodies on the formation of edema and cell changes in spinal cord trauma. Prog Brain Res 1995;104:401-416. Review
175. Sharma HS, Westman J, Olsson Y, Alm P. Involvement of nitric oxide in acute spinal cord injury: an immunocytochemical study using light and electron microscopy in the rat. Neurosci Res 1996 Mar; 24(4):373-384
176. Faden AI. Opioid and nonopioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury. Ann Neurol 1990 Jan; 27(1):67-74
177. Sharma HS, Westman J, Nyberg F. Topical application of 5-HT antibodies reduces edema and cell changes following trauma of the rat spinal cord. Acta Neurochir Suppl 1997;70:155-158
178. Sharma HS, Patnaik R, Patnaik S, Mohanty S, Sharma A, Vannemreddy P. Antibodies to serotonin attenuate closed head injury induced blood brain barrier disruption and brain pathology. Ann NY Acad Sci 2007 Dec; 1122:295-312
179. Sharma HS, Winkler T, Stålberg E, Gordh T, Alm P, Westman J. Topical application of TNF-alpha antiserum attenuates spinal cord trauma induced edema formation, microvascular permeability disturbances and cell injury in the rat. Acta Neurochir Suppl 2003;86:407-413
180. Wahl M, Unterberg A, Baethmann A, Schilling L. Mediators of blood-brain barrier dysfunction and formation of vasogenic brain edema. J Cereb Blood Flow Metab 1988 Oct; 8(5):621-634. Review
181. Olsson Y, Sharma HS, Pettersson CA. Effects of p-chlorophenylalanine on microvascular permeability changes in spinal cord trauma. An experimental study in the rat using 131I-sodium and lanthanum tracers. Acta Neuropathol 1990;79(6):595-603
182. Sharma HS, Westman J, Olsson Y, Johansson O, Dey PK. Increased 5-hydroxytryptamine immunoreactivity in traumatized spinal cord. An experimental study in the rat. Acta Neuropathol 1990;80(1):12-17
183. Sharma HS, Olsson Y. Edema formation and cellular alterations following spinal cord injury in the rat and their modification with p-chlorophenylalanine. Acta Neuropathol 1990;79(6):604-610
184. Sharma HS, Olsson Y, Cervós-Navarro J. p-Chlorophenylalanine, a serotonin synthesis inhibitor, reduces the response of glial fibrillary acidic protein induced by trauma to the spinal cord. An immunohistochemical investigation in the rat. Acta Neuropathol 1993;86(5):422-427
185. Sharma HS Pathophysiology of the blood-spinal cord barrier in traumatic injury. In: Sharma HS, Westman J (eds) The Blood-Spinal Cord and Brain Barriers in Health and Disease, Elsevier Academic Press, San Diego, 2004; pp. 437-518
186. Sharma HS, Alm P, Westman J. Nitric oxide and carbon monoxide in the brain pathology of heat stress. Prog Brain Res 1998;115:297-333. Review
187. Sharma HS, Nyberg F, Thörnwall M, Olsson Y. Met-enkephalin-Arg6-Phe7 in spinal cord and brain following traumatic injury to the spinal cord: influence of p-chlorophenylalanine. An experimental study in the rat using radioimmunoassay technique. Neuropharmacology 1993 Jul; 32(7):711-717
188. Sharma HS, Olsson Y, Westman J. A serotonin synthesis inhibitor, p-chlorophenylalanine reduces the heat shock protein response following trauma to the spinal cord: an immunohistochemical and ultrastructural study in the rat. Neurosci Res 1995 Jan; 21(3):241-249
189. Sharma HS, Olsson Y, Nyberg F, Dey PK. Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury: an experimental study in the rat. Neuroscience 1993 Nov; 57(2):443-449
190. Winkler T, Sharma HS, Stålberg E, Olsson Y. Indomethacin, an inhibitor of prostaglandin synthesis attenuates alteration in spinal cord evoked potentials and edema formation after trauma to the spinal cord: an experimental study in the rat. Neuroscience 1993 Feb; 52(4):1057-1067
191. Sharma HS, Olsson Y, Cervós-Navarro J. Early perifocal cell changes and edema in traumatic injury of the spinal cord are reduced by indomethacin, an inhibitor of prostaglandin synthesis. Experimental study in the rat. Acta Neuropathol 1993;85(2):145-153
192. Sharma HS, Westman J. Prostaglandins modulate constitutive isoform of heat shock protein (72 kD) response following trauma to the rat spinal cord. Acta Neurochir Suppl 1997;70:134-137
193. Ray SK, Banik NL. Calpain and its involvement in the pathophysiology of CNS injuries and diseases: therapeutic potential of calpain inhibitors for prevention of neurodegeneration. Curr Drug Targets CNS Neurol Disord 2003 Jun; 2(3):173-189. Review
194. Sharma HS, Drieu K, Alm P, Westman J. Role of nitric oxide in blood-brain barrier permeability, brain edema and cell damage following hyperthermic brain injury. An experimental study using EGB-761 and Gingkolide B pretreatment in the rat. Acta Neurochir Suppl 2000;76:81-86
195. Sharma HS, Drieu K, Westman J. Antioxidant compounds EGB-761 and BN-52021attenuate brain edema formation and hemeoxygenase expression following hyperthermic brain injury in the rat. Acta Neurochir Suppl 2003;86:313-319
196. Olesen SP. An electrophysiological study of microvascular permeability and its modulation by chemical mediators. Acta Physiol Scand Suppl 1989;579:1-28
197. Kiyatkin EA, Sharma HS. Permeability of the blood-brain barrier depends on brain temperature. Neuroscience 2009 Jul. 7;161(3):926-939. Epub 2009 Apr. 9
198. Sharma HS, Kiyatkin EA. Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: an experimental study using light and electron microscopy. J Chem Neuroanat 2009 Jan; 37(1):18-32. Epub 2008 Aug. 19
199. Kiyatkin EA, Brown PL, Sharma HS. Brain edema and breakdown of the blood-brain barrier during methamphetamine intoxication: critical role of brain hyperthermia. Eur J Neurosci 2007 Sep; 26(5):1242-1253
200. Sharma HS, Ali SF. Alterations in blood-brain barrier function by morphine and methamphetamine. Ann NY Acad Sci 2006 Aug; 1074:198-224