Spinal cord injury induced heat shock protein expression is reduced by an antioxidant compound H-290/51. An experimental study using light and electron microscopy in the rat

Journal of Neural Transmission

Volumn 113, Issue 4, 2006, Pages 521-536

  Sharma, H S ^a,d   Gordh, T ^a   Wiklund, L ^a   Mohanty, S ^b   Sjoquist P O ^c  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b BANARAS HINDU UNIVERSITY   (India)

^c ASTRAZENECA R AND D   (Sweden)

^d NONE   (Sweden)

Author keywords

Antioxidants; Edema formation; H 290 51; Heat shock protein 72 expression; Lipid peroxidation; Motor function; Neuronal injury; Spinal cord injury

Indexed keywords

ANTIOXIDANT; EQUITHESIN; H 290 51; HEAT SHOCK PROTEIN 72; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; MALE; MOTOR PERFORMANCE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SPINAL CORD DORSAL HORN; SPINAL CORD INJURY; UPREGULATION;

ANIMALS; ANTIOXIDANTS; CAPILLARY PERMEABILITY; HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; INDOLES; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MOTOR ACTIVITY; NEUROPIL; OXIDATIVE STRESS; RATS; RATS, WISTAR; SPINAL CORD INJURIES;

EID: 33645103142     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-005-0405-2     Document Type: Article

References (46)

1. TG Buchman PA Abello EH Smith GB Bulkley 1993 Induction of heat shock response leads to apoptosis in endothelial cells previously exposed to endotoxin. Am J Physiol 265 1 Pt 2 H165 H170
2. JP Cobb RS Hotchkiss IE Karl TG Buchman 1996 Mechanisms of cell injury and death. Br J Anaesth 77 1 3 10
3. SL DeMeester TG Buchman Y Qiu AK Jacob K Dunnigan RS Hotchkiss I Karl JP Cobb 1997 Heat shock induces IkappaB-alpha and prevents stress-induced endothelial cell apoptosis. Arch Surg 132 12 1283 1287 ; discussion 1287-1288
4. SL DeMeester TG Buchman JP Cobb 2001 The heat shock paradox: does NF-kappaB determine cell fate? FASEB J 15 1 270 274
5. IA Drummond RA Steinhardt 1987 The role of oxidative stress in the induction of Drosophila heat-shock proteins. Exp Cell Res 173 2 439 449
6. C Ferran DM Stroka AZ Badrichani JT Cooper CJ Wrighton M Soares ST Grey FH Bach 1998 A20 inhibits NF-kappaB activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis. Blood 91 7 2249 2258
7. CA Gullo G Teoh 2004 Heat shock proteins: to present or not, that is the question. Immunol Lett 94 1-2 1 10
8. S Hedlund HS Sharma PO Sjöquist J Westman 1999 A new antioxidant compound H-290/51 attenuates heat shock protein (HSP 72∈kD) response, breakdown of the blood-brain barrier permeability, edema and cell injury following acute heat exposure. An experimental study using light and electron microscopy in the rat. J Therm Biol 24 409 414
9. T Iwaki A Iwaki J Tateishi Y Sakaki JE Goldman 1993 Alpha B-crystallin and 27-kd heat shock protein are regulated by stress conditions in the central nervous system and accumulate in Rosenthal fibers. Am J Pathol 143 2 487 495
10. M Iwata M Mukai Y Nakai R Iseki 1992 Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes. J Immunol 149 10 3302 3308
11. H Kamencic RW Griebel AW Lyon PG Paterson BH Juurlink 2001 Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function. FASEB J 15 1 243 250
12. S Kato A Hirano M Kato F Herz E Ohama 1993 Comparative study on the expression of stress-response protein (srp) 72, srp 27, alpha B-crystallin and ubiquitin in brain tumours. An immunohistochemical investigation. Neuropathol Appl Neurobiol 19 5 436 442
13. S Lindquist 1986 The heat-shock response. Annu Rev Biochem 55 1151 1191
14. A Matsuzawa H Ichijo 2005 Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid Redox Signal 7 3-4 472 481
15. G Minowada WJ Welch 1995 Clinical implications of the stress response. J Clin Invest 95 1 3 12
16. A Mustafa HS Sharma Y Olsson T Gordh P Thoren PO Sjoquist P Roos A Adem F Nyberg 1995 Vascular permeability to growth hormone in the rat central nervous system after focal spinal cord injury. Influence of a new anti-oxidant H-290/51 and age. Neurosci Res 23 2 185 194
17. RN Nishimura BE Dwyer R Cole J de Vellis K Picard 1989 Induction of the major inducible 68-kDa heat-shock protein after rapid changes of extracellular pH in cultured rat astrocytes. Exp Cell Res 180 1 276 280
18. RR Ratan TH Murphy JM Baraban 1994 Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione. J Neurosci 14 7 4385 4392
19. PA Sandstrom MD Mannie TM Buttke 1994 Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis. J Leukoc Biol 55 2 221 226
20. HS Sharma Y Olsson 1990 Edema formation and cellular alterations following spinal cord injury in the rat and their modification with p-chlorophenylalanine. Acta Neuropathol (Berl) 79 6 604 610
21. Sharma HS, Olsson Y, Dey PK (1990a) Changes in blood-brain barrier and cerebral blood flow following elevation of circulating serotonin level in anesthetized rats. Brain Res 28; 517(1-2): 215-223
22. HS Sharma Y Olsson PK Dey 1990 Early accumulation of serotonin in rat spinal cord subjected to traumatic injury. Relation to edema and blood flow changes. Neuroscience 36 3 725 730
23. HS Sharma Y Olsson J Westman 1995 A serotonin synthesis inhibitor, p-chlorophenylalanine reduces the heat shock protein response following trauma to the spinal cord: an immunohistochemical and ultrastructural study in the rat. Neurosci Res 21 3 241 249
24. 131I-sodium, Evans blue and lanthanum as tracers. Restor Neurol Neurosci 7 207 215
25. HS Sharma J Westman 1997 Prostaglandins modulate constitutive isoform of heat shock protein (72∈kD) response following trauma to the rat spinal cord. Acta Neurochir [Suppl] 70 134 137
26. HS Sharma J Westman P Alm PO Sjoquist J Cervos-Navarro F Nyberg 1997 Involvement of nitric oxide in the pathophysiology of acute heat stress in the rat. Influence of a new antioxidant compound H-290/51. Ann NY Acad Sci 813 581 590
27. Sharma HS, Sjöquist PO, Westman J (2001) Pathophysiology of the blood-spinal cord barrier in spinal cord injury. Influence of a new antioxidant compound H-290/51. In: Kobiler D, Lustig S, Shapra S (eds) Blood-brain barrier. Drug delivery and brain pathology. Kluwer Academic/Plenum Publishers, New York, pp 401-416
28. HS Sharma PO Sjoquist 2002 A new antioxidant compound H-290/51 modulates glutamate and GABA immunoreactivity in the rat spinal cord following trauma. Amino Acids 23 1-3 261 272
29. HS Sharma P Alm PO Sjoquist J Westman 2000 A new antioxidant compound H-290/51 attenuates upregulation of constitutive isoform of hemeoxygenase (HO-2) following trauma to the rat spinal cord. Acta Neurochir [Suppl] 76 153 157
30. HS Sharma J Westman 2003 Depletion of endogenous serotonin synthesis with p-CPA attenuates upregulation of constitutive isoform of heme oxygenase-2 expression, edema formation and cell injury following a focal trauma to the rat spinal cord. Acta Neurochir [Suppl] 86 389 394
31. Sharma HS, Westman J (2004) The heat shock proteins and hemeoxygenase response in central nervous system injuries. In: Sharma HS, Westman J (eds) The blood-spinal cord and brain barriers in health and disease. Elsevier Academic Press, San Diego, pp 329-360
32. HS Sharma 1987 Effect of captopril (a converting enzyme inhibitor) on blood-brain barrier permeability and cerebral blood flow in normotensive rats. Neuropharmacology 26 1 85 92
33. HS Sharma 1999 Pathophysiology of blood-brain barrier, brain edema and cell injury following hyperthermia: new role of heat shock protein, nitric oxide and carbon monoxide. An experimental study in the rat using light and electron microscopy. Acta Universitatis Upsaliensis 830 1 94
34. HS Sharma 2004a Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Current Pharmaceutical Design 10 236 268
35. Sharma HS (2004b) Pathophysiology of the blood-spinal cord barrier in traumatic injury. In: Sharma HS, Westman J (eds) The blood-spinal cord and brain barriers in health and disease. Elsevier Academic Press, San Diego, pp 437-518
36. Sharma HS, Westman J (2004) The heat shock proteins and hemeoxygenase response in central nervous system injuries. In: Sharma HS, Westman J (eds) The blood-spinal cord and brain barriers in health and disease. Elsevier Academic Press, San Diego, pp 329-360
37. L Svensson I Borjesson B Kull PO Sjoquist 1993 Automated procedure for measuring TBARS for in vitro comparison of the effect of antioxidants on tissues. Scand J Clin Lab Invest 53 1 83 85
38. M Tariq C Morais PN Kishore N Biary S Al Deeb K Al Moutaery 1998 Neurological recovery in diabetic rats following spinal cord injury. J Neurotrauma 15 4 239 251
39. M Thornwall HS Sharma T Gordh PO Sjoquist F Nyberg 1997 Substance P endopeptidase activity in the rat spinal cord following injury: influence of the new anti-oxidant compound H-290/51. Acta Neurochir [Suppl] 70 212 215
40. CM Troy ML Shelanski 1994 Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells. Proc Natl Acad Sci USA 91 14 6384 6387
41. S Wang Q Yang CJ Moller FR Sharp KG Haglid 1996 Eliprodil prevents expression of the 70∈kDa heat shock protein in MK801-injured neurones. Pharmacol Toxicol 79 3 166 168
42. JH Wang HP Redmond RW Watson D Bouchier-Hayes 1997 Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses. Am J Physiol 272 5 Pt 1 C1543 C1551
43. M Waza H Adachi M Katsuno M Minamiyama C Sang F Tanaka A Inukai M Doyu G Sobue 2005 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Nature Med 11 10 1088 1095
44. WJ Welch 1992 Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease. Physiol Rev 72 4 1063 1081
45. FA Welsh DJ Moyer VA Harris 1992 Regional expression of heat shock protein-70 mRNA and c-fos mRNA following focal ischemia in rat brain. J Cereb Blood Flow Metab 12 2 204 212
46. YH Zhang K Takahashi GZ Jiang M Kawai M Fukada T Yokochi 1993 In vivo induction of apoptosis (programmed cell death) in mouse thymus by administration of lipopolysaccharide. Infect Immun 61 12 5044 5048