Melatonin delivery in solid lipid nanoparticles: Prevention of cyclosporine A induced cardiac damage

Journal of Pineal Research

Volumn 46, Issue 3, 2009, Pages 255-261

  Rezzani, Rita ^a   Rodella, Luigi Fabrizio ^a   Fraschini, Franco ^b   Gasco, Maria Rosa ^c   Demartini, Germana ^b   Musicanti, Claudia ^c   Reiter, Russel J ^d  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c NANOVECTOR S R L   (Italy)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Apoptosis; Cardiotoxicity; Cyclosporine A; Melatonin; Solid lipid nanoparticles

Indexed keywords

CYCLOSPORIN A; INDUCIBLE NITRIC OXIDE SYNTHASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 15; MELATONIN; MEMBRANE RECEPTOR; PROTEIN BCL 2; SCAVENGER; SOLID LIPID NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; HEART; HEART INJURY; LIPID PEROXIDATION; MALE; MEMBRANE BINDING; MORPHOLOGY; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; CYCLOSPORINE; DRUG CARRIERS; HEART DISEASES; IMMUNOSUPPRESSIVE AGENTS; IN SITU NICK-END LABELING; LIPID PEROXIDATION; LIPIDS; MALE; MALONDIALDEHYDE; MELATONIN; MYOCARDIUM; NANOPARTICLES; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR;

EID: 62449126325     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2008.00651.x     Document Type: Article

References (48)

1. Vijayalaxmi, Thomas CR Jr., Reiter RJ, Herman TS. Melatonin: from basic research to cancer treatment clinics. J Clin Oncol 2002 20 : 2575 2601.
2. Reiter RJ, Tan DX, Korkmaz A et al. Light at night, chronodisruption, melatonin suppression, and cancer risk: a review. Crit Rev Oncogen 2007 13 : 303 328.
3. Wasdell MB, Jan JE, Bomben MM et al. A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. J Pineal Res 2008 44 : 57 64.
4. Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivates: a never-ending interaction of melatonin with reactive oxygen and reactive nitrogens species? J Pineal Res 2007 42 : 28 42.
5. Maldonado MD, Murillo-Cabezas F, Terron MP et al. The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma. J Pineal Res 2007 42 : 1 11.
6. Jou MJ, Peng TI, Yu PZ et al. Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis. J Pineal Res 2007 43 : 389 403.
7. Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ. Melatonin: a potent hydroxyl radical scavenger. Endocrine J 1993 1 : 57 60.
8. Allegra M, Reiter RJ, Tan DX, Gentile C, Tesoriere L, Livrea MA. The chemistry of melatonin's interaction with reactive species. J Pineal Res 2003 34 : 1 10.
9. Garcia JJ, Reiter RJ, Cabrera JD et al. Role of pinoline and melatonin in stabilizing hepatic microsomal membranes against oxidative stress. J Bioenerg Biomembr 1999 31 : 609 613.
10. Reiter RJ, Tan DX, Manchester LC, Qi W. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. Cell Biochem Biophys 2001 34 : 237 256.
11. Rodrigues C, Mayo JC, Sainz RM et al. Regulation of antioxidant enzymes: a significant role of melatonin. J Pineal Res 2004 36 : 1 9.
12. Rezzani R, Rodella LF, Bonomini F, Tengattini S, Bianchi R, Reiter RJ. Beneficial effects of melatonin in protecting against cyclosporine A-induced cardiotoxicity are receptor mediated. J Pineal Res 2006 41 : 288 295.
13. Tengattini S, Reiter RJ, Tan DX, Terron MP, Rodella LF, Rezzani R. Cardiovascular diseases: protective effects of melatonin. J Pineal Res 2008 44 : 16 25.
14. Tirkey N, Kaur G, Vij G, Chopra K. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC Pharmacol 2005 5 : 15.
15. Rezzani R. Exploring cyclosporine A-side effects and the protective role-played by antioxidants: the morphological and immunohistochemical studies. Histol Histopathol 2006 21 : 301 316.
16. Wongmekiat O, Thamprasert K. Investigating the protective effects of aged garlic extract on cyclosporin-induced nephrotoxicity in rats. Fundam Clin Pharmacol 2005 19 : 555 562.
17. Rezzani R, Buffoli B, Rodella L, Stacchiotti A, Bianchi R. Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver. Int Immunopharmacol 2005 5 : 1397 1405.
18. Florio S, Ciarcia R, Crispino L et al. Hydrocortisone has a protective effect on CyclosporinA-induced cardiotoxicity. J Cell Physiol 2003 195 : 21 26.
19. Rezzani R, Giugno L, Buffoli B, Bonomini F, Bianchi R. The protective effect of caffeic acid phenethyl ester against cyclosporine A-induced cardiotoxicity in rats. Toxicology 2005 212 : 155 164.
20. Hong F, Lee J, Song JW et al. Cyclosporin A blocks muscle differentiation by inducing oxidative stress and inhibiting the peptidyl-prolyl-cis-trans isomerase activity of cyclophilin A: cyclophilin A protects myoblasts from cyclosporin A-induced cytotoxicity. FASEB J 2002 16 : 1633 1635.
21. Servasi H, Ortiz A, Devuyst O, Denamur S, Tulkens PM, Mingeot-Leclercq MP. Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation. Apoptosis 2008 13 : 11 32.
22. Nathan M, Friehs I, Choi YH et al. Cyclosporin A but not FK-506 protects against dopamine-induced apoptosis in the stunned heart. Ann Thorac Surg 2005 79 : 1620 1626.
23. Pieper GM, Nilakantan V, Nguyen TK, Hilton G, Roza AM, Johnson CP. Reactive oxygen and reactive nitrogen as signaling molecules for caspase 3 activation in acute cardiac transplant rejection. Antioxid Redox Signal 2008 10 : 1031 1040.
24. Manda K, Ueno M, Anzai K. Melatonin mitigates oxidative damage and apoptosis in mouse cerebellum induced by high-LET 56Fe particle irradiation. J Pineal Res 2008 44 : 189 196.
25. Sainz RM, Mayo JC, Rodriguez C, Tan DX, Lopez-Burillo S, Reiter RJ. Melatonin and cell death: differential actions on apoptosis in normal and cancer cells. Cell Mol Life Sci 2003 60 : 1407 1426.
26. Lochner A, Genade S, Davids A, Ytrehus K, Moolman JA. Short- and long-term effects of melatonin on myocardial post-ischemic recovery. J Pineal Res 2006 40 : 56 63.
27. Gasco MR. Lipid nanoparticles: perspectives and challenges. Adv Drug Deliv Rev 2007 59 : 377 378.
28. Brioschi A, Zara GP, Calderoni S, Gasco MR, Mauro A. Cholesteryl butyrate solid lipid nanoparticles as a butyric acid prodrug. Molecules 2008 13 : 230 254.
29. Zara GP, Cavalli R, Bargoni A, Fundarò A, Vighetto D, Gasco MR. Intravenous administration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: pharmacokinetics and distribution of doxorubicin in brain and other tissues. J Drug Target 2002 10 : 327 335.
30. Mauro A, Miglietta A, Cavalli R et al. Enhanced cytotoxycity of Paclitaxel incorporated in Solid Lipid Nanoparticles against human glioma cells. Proceed Int'l Symp Control Rel Bioact Mater 2000 27 : 377 378.
31. Priano L, Esposti D, Esposti R et al. Solid lipid nanoparticles incorporating melatonin as new model for sustained oral and transdermal delivery systems. J Nanosci Nanotechnol 2007 7 : 3596 3601.
32. Dierling AM, Sloat BR, Cui Z. Gadolinium incorporated reconstituted chylomicron emulsion for potential application in tumor neutron capture therapy. Eur J Pharm Biopharm 2006 62 : 275 281.
33. Peira E, Marzola P, Podio V, Aime S, Sbarbati A, Gasco MR. In vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide. J Drug Target 2003 11 : 19 24.
34. Rezzani R, Rodella L, Dessy C, Daneau G, Bianchi R, Feron O. Changes in Hsp90 expression determine the effects of cyclosporine A on the NO pathway in rat myocardium. FEBS Lett 2003 552 : 125 129.
35. Selcoki Y, Uz E, Bayrak R et al. The protective effect of erdosteine against cyclosporine A-induced cardiotoxicity in rats. Toxicology 2007 239 : 53 59.
36. Ottaviano FG, Handy DE, Loscalzo J. Redox regulation in the extracellular environment. Circ J 2008 72 : 1 16.
37. Finsterer J. Is atherosclerosis a mitochondrial disorder? Vasa 2007 36 : 229 240.
38. Xie JR, Yu LN. Cardioprotective effects of cyclosporine A in an in vivo model of myocardial ischemia and reperfusion. Acta Anaesthesiol Scand 2007 51 : 909 913.
39. Merlini L, Angelin A, Tiepolo T et al. Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies. Proc Natl Acad Sci U S A 2008 105 : 5225 5229.
40. Oie E, Bjørnerheim R, Clausen OP, Attramadal H. Cyclosporin A inhibits cardiac hypertrophy and enhances cardiac dysfunction during postinfarction failure in rats. Am J Physiol Heart Circ Physiol 2000 278 : H2115 H2123.
41. Lee S, Kim W, Kim DH et al. Protective effect of COMP-angiopoietin-1 on cyclosporine-induced renal injury in mice. Nephrol Dial Transplant 2008 23 : 2784 2794.
42. Degli Esposti M. Mitochondria in apoptosis: past, present and future. Biochem Soc Trans 2004 32 : 493 495.
43. Javadov S, Karmazyn M. Mitochondrial permeability transition pore opening as an endpoin to initiate cell death and as a putative target for cardioprotection. Cell Physiol Biochem 2007 20 : 1 22.
44. Reiter RJ, Paredes SD, Korkmaz A, Jou M-J, Tan DX. Melatonin combats molecular terrorism at the mitochondrial levels. Interndis Toxicol 2008 1 : 137 149.
45. Nechushtan A, Smith CL, Lamensdorf I, Yoon SH, Youle RJ. Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. J Cell Biol 2001 153 : 1265 1276.
46. Yang G, Meguro T, Hong C et al. Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, wich could be due to apoptosis and fibrosis. J Mol Cell Cardiol 2001 33 : 1505 1514.
47. Bareford LM, Swaan PW. Endocytic mechanisms for targeted drug delivery. Adv Drug Deliv Rev 2007 59 : 748 758.
48. Radogna F, Paternoster L, Albertini MC et al. Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cells. J Pineal Res 2007 43 : 154 162.