Adverse effects of cyclosporine A on HSP25, alpha B-crystallin and myofibrillar cytoskeleton in rat heart

Toxicology

Volumn 262, Issue 3, 2009, Pages 192-198

  Stacchiotti, Alessandra ^a   Bonomini, Francesca ^a   Lavazza, Antonio ^b   Rodella, Luigi Fabrizio ^a   Rezzani, Rita ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLA LOMBARDIA E DELL EMILIA ROMAGNA   (Italy)

Author keywords

Cyclosporine A; Cytoskeleton; Heat shock proteins; Immunohistochemistry; Transmission electron microscopy

Indexed keywords

ACTIN; ALPHA ACTININ; ALPHA CRYSTALLIN; CYCLOSPORIN A; DESMIN; HEAT SHOCK PROTEIN 25;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; CYTOSKELETON; DESMOSOME; HEART MUSCLE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HISTOPATHOLOGY; MALE; MUSCLE FIBRIL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN TRANSPORT; RAT; SARCOLEMMA; SARCOMERE; TRANSMISSION ELECTRON MICROSCOPY;

ACTININ; ACTINS; ALPHA-CRYSTALLIN B CHAIN; ANIMALS; CYCLOSPORINE; CYTOSKELETON; DESMIN; FIBROSIS; HSP27 HEAT-SHOCK PROTEINS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MYOCYTES, CARDIAC; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; SARCOMERES; TIME FACTORS;

RATTUS;

EID: 67651011396     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.06.007     Document Type: Article

References (53)

1. Arrigo A.P. The cellular "networking" of mammalian Hsp27 and its functions in the control of protein folding, redox state and apoptosis. Adv. Exp. Med. Biol. 594 (2007) 14-26
2. Bes S., Vandroux D., Tissier C., Devillard L., Brochot A., Tatou E., Duvillard L., Rochette L., and Athias P. Direct, pleiotropic protective effect of cyclosporin A against simulated ischemia-induced injury in isolated cardiomyocytes. Eur. J. Pharmacol. 511 (2005) 109-120
3. Bianchi R., Rodella L., and Rezzani R. Cyclosporine A up-regulates expression of matrix metalloproteinase 2 and vascular endothelial growth factor in rat heart. Int. Immunopharmacol. 3 (2003) 427-433
4. Borrmann C., Grund C., Kuhn C., Hofmann I., Pieperhoff S., and Franke W. The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. Colocalizations of desmosomal and fascia adhaerens molecules in the intercalated disk. Eur J. Cell. Biol. 85 (2006) 469-485
5. Costa M.L., Escaleira R., Cataldo A., Oliveira F., and Mermelstein C.S. Desmin: molecular interactions and putative functions of the muscle intermediate filament protein. Braz. J. Med. Biol. Res. 37 (2004) 1819-1830
6. Delogu G., Signore M., Mechelli A., and Famularo G. Heat shock proteins and their role in heart injury. Curr. Opin. Crit. Care 8 (2002) 411-416
7. Eigenthaler M., Engelhardt S., Schinke B., Kobsar A., Schmitteckert E., Gambaryan S., Engelhardt C., Krenn V., Eliava M., Jarchau T., Lohse M., Walter U., and Hein L. Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy. Am. J. Physiol. Heart Circ. Physiol. 285 (2003) H2471-H2481
8. Golenhofen N., der Perng M., Quinlan R.A., and Drenckhlan D. Comparison of the small heat shock proteins αB-crystallin, MKBP, HSP25, HSP20, and cvHSP in heart and skeletal muscle. Histochem. Cell. Biol. 122 (2004) 415-425
9. Golenhofen N., Redel A., Wawrousek E.F., and Drenckhahn D. Ischemia-induced increase of stiffness of alphaB-crystallin/HSPB2-deficient myocardium. Pflugers Arch. 451 (2006) 518-525
10. Hein S., Kostin S., Heling A., Maeno Y., and Schaper J. The role of the cytoskeleton in heart failure. Cardiovasc. Res. 45 (2000) 273-278
11. Heling A., Zimmermann R., Kostin S., Maeno Y., Hein S., Devaux B., Bauer E., Klovekorn W., Schlepper M., Schaper W., and Schaper J. Increased expression of cytoskeletal linkage, and extracellular proteins in failing human myocardium. Circ. Res. 86 (2000) 846-853
12. Janssen P.M., Zeitz O., Keweloh B., Siegel U., Maier l.S., Barckhausen P., Pieske B., Prestle J., Lehnart S.E., and Hasenfuss G. Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium. Cardiovasc. Res. 47 (2000) 4-5
13. Jurado F., Bellon J., Pareja J., Golitsin A., Millan L., Pascual G., and Bujan J. Effects of ischemia-reperfusion and cyclosporin-A on cardiac muscle ultrastructure. Histol. Histopathol. 13 (1998) 761-774
14. Kolcz J., Drukala J., Jurkiewicz A., Pfitzner R., Garlicki M., Czyz J., and Korohoda W. Effects of cyclosporin A on contractile activity and cytoskeleton in chick embryo cardiomyocytes. Biochem. Cell Biol. 77 (1999) 133-140
15. Kostin S., and Schaper J. Tissue-specific patterns of Gap junctions in adult rat atrial and ventricular cardiomyocytes in vivo and in vitro. Circ Res. 88 (2001) 933-999
16. Kostin S., Hein S., Arnon E., Scholz D., and Schaper J. The cytoskeleton and related proteins in the human failing heart. Heart Fail. Rev. 5 (2000) 271-280
17. Kumarapeli A.R., and Wang X. Genetic modification of the heart: chaperones and the cytoskeleton. J. Mol. Cell Cardiol. 37 (2004) 1097-1109
18. Latchmann D.S. Heat shock proteins and cardiac protection. Cardiovasc. Res. 51 (2001) 637-646
19. Leach I., Tsang M., Church R., and Lowe J. Alpha-B crystallin in the normal human myocardium and cardiac conducting system. J. Pathol. 173 (1994) 255-260
20. Lee Y., Cho H., Jeoung D., Soh J., Cho C., Bae S., Chung H., Lee S., and Lee Y. Hsp25 overexpression attenuates oxidative stress-induced apoptosis: roles of ERK1/2 signaling and manganese superoxide dismutase. Free Rad. Biol. Med. 36 (2004) 429-444
21. Lutsch G., Vetter R., Offhauss U., Wieske M., Grone H.J., Klemenz R., Schimke I., Stahl J., and Benndorf R. Abundance and location of the small heat shock proteins HSP25 and alpha B-crystallin in rat and human heart. Circulation 96 (1997) 3466-3476
22. Macario A., and Conway de Macario E. Molecular chaperones: multiple functions, pathologies, and potential applications. Front. Biosci. 12 (2007) 2588-2600
23. Mao Y., Liu J., Xiang H., and Li D. Human alphaA- and alphaB crystallins bind to Bax and Bcl-Xs to sequester their translocation during staurosporine-induced apoptosis. Cell Death Diff. 11 (2004) 512-526
24. Miller L.W. Cardiovascular toxicities of immunosuppressive agents. Am. J. Transplant. 2 (2002) 807-818
25. Morimoto R.I., and Santoro M.G. Stress-inducible responses and heat shock proteins: new pharmacological targets for cytoprotection. Nat. Biotechnol. 16 (1998) 833-888
26. Nakamoto H., and Vigh L. The small heat shock proteins and their clients. Cell. Mol. Life Sci. 64 (2007) 294-306
27. Niemann C.U., Saeed M., Akbari H., Jacobsen W., Benet L.Z., Christians U., and Serkova N. Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. J. Pharmacol. Exp. Ther. 302 (2002) 1123-1128
28. Panasenko O.O., Kim M.V., Marston S.B., and Gusev N.B. Interaction of the small heat shock protein with molecular mass 25 kDa (hsp25) with actin. Eur. J. Biochem. 270 (2003) 892-901
29. Papp E., Nardai G., Soti C., and Csermely P. Molecular chaperones, stress proteins and redox homeostasis. Biofactors 17 (2003) 249-257
30. Paslaru L., Davidson S., Popescu I., and Morange M. The effect of cyclosporine A on cardiomyocytes differentiation. J. Cell. Mol. Med. 11 (2007) 369-371
31. Paulin D., and Li Z. Desmin: a major intermediate filament protein essential for the structural integrity and function of muscle. Exp. Cell Res. 301 (2004) 1-7
32. Perng M., Wen S., van den Ijssel P., Prescott A., and Quinlan R. Desmin aggregate formation by R120G alpha B-crystallin is caused by altered filament interactions and is dependent upon network status in cells. Mol. Biol. Cell. 15 (2004) 2335-2346
33. Prignano F., Domenici-Lombardo L., Gerlini G., Pimpinelli N., and Romagnoli P. Cyclosporin-A affects the organization of cytoskeleton of normal human keratinocytes in culture. Histol. Histopathol. 11 (1996) 889-894
34. Pyle W.G., and Solaro R.J. At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function. Circ. Res. 94 (2004) 296-305
35. Rezzani R., Rodella L., and Bianchi R. Cyclosporine affects the organization of cytoskeletal fibrillar proteins in rat thymus. Acta Histochem. 102 (2000) 57-67
36. Rezzani R., Rodella L., Dessy C., Daneau G., Bianchi R., and Feron O. Changes in Hsp90 expression determine the effects of cyclosporine A on the NO pathway in rat myocardium. FEBS Lett. 552 (2003) 125-129
37. Rezzani R. Cyclosporine A and adverse effects on organs: histochemical studies. Prog. Histoc. Cytoc. 39 (2004) 85-128
38. Rezzani R., Buffoli B., Rodella L., Stacchiotti A., and Bianchi R. Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver. Int. Immunopharmacol. 5 (2005) 1397-1405
39. Rezzani R., Rodella L., Buffoli B., Giugno L., Stacchiotti A., and Bianchi R. Cyclosporine A induces vascular fibrosis and heat shock protein expression in rat. Int. Immunopharmacol. 5 (2005) 169-176
40. Rezzani R., Rodella L., Bonomini F., Tengattini S., Bianchi R., and Reiter R.J. Beneficial effects of melatonin in protecting against cyclosporineA-induced cardiotoxicity are receptor mediated. J. Pin. Res. 41 (2006) 288-295
41. Rezzani R., Pompili E., Agostini C., Buffoli B., Bonomini F., Nori S., Fumagalli L., and Bianchi R. Expression of non-muscle myosin heavy chain in rat heart after immunosuppressive treatment. Int. Immunopharmacol. 6 (2006) 962-967
42. Rezzani R., Rodella L., Fraschini F., Gasco M., Demartini G., Musicanti C., and Reiter R. Melatonin delivery in solid lipid nanoparticles: prevention of cyclosporine A induced cardiac damage. J. Pin. Res. 46 (2009) 255-261
43. Sanger J., Ayoob J., Chowrashi P., Zurawski D., and Sanger J.M. Assembly of myofibrils in cardiac muscle cells. Adv. Exp. Med. Biol. 481 (2000) 89-102
44. Singh B., Rao K., Ramakrishna T., Rangaraj N., and Rao C. Association of alphaB-crystallin, a small heat shock protein, with actin: role in modulating actin filament dynamics in vivo. J. Mol. Biol. 366 (2007) 756-767
45. Stacchiotti A., Rezzani R., Angoscini P., Rodella L., and Bianchi R. Small heat shock proteins expression in rat kidneys treated with cyclosporine A alone and combined with melatonin. Histochem. J. 34 (2002) 305-312
46. Sun Y., and Mac Rae T. The small heat shock proteins and their role in human disease. FEBS J. 272 (2005) 2613-2627
47. Vasioukhin V., Bauer C., Yin M., and Fuchs E. Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell 100 (2000) 209-219
48. Verschuure P., Croes Y., van den Ijssel P., Quinlan R., de Jong W., and Boelens W. Translocation of small heat shock proteins to the actin cytoskeleton upon proteasomal inhibition. J. Mol. Cell Cardiol. 34 (2002) 117-128
49. Wang X., Osinka H., Dorn G., Nieman M., Lorenz J., Gerdes M., Witt S., Kimball T., Gulick J., and Robbins J. Mouse model of desmin-related cardiomyopathy. Circulation 103 (2001) 2402-2407
50. White M., Ghambly B., Jeremy R., and Cordwell S. Ischemia-specific phosphorylation and myofilament translocation of heat shock protein 27 precedes alpha B-crystallin and occurs independently of reactive oxygen species in rabbit myocardium. J. Mol. Cell. Cardiol. 40 (2006) 761-774
51. Williamson C.L., Dabkowski E., and Hollander J.M. Contractile dysfunction in the diabetic heart is associated with enhanced apoptosis and decreased Hsp25 phosphorylation. FASEB J. 21 (2007) 943.8
52. Zakliczynski M., Nozynski J., Swierad M., Koecka-Mrowka D., and Zembala M. Pathologic assessment of cardiomyocytes in heart transplant recipients treated with rapamycin or cyclosporine. Transplant. Proc. 35 (2003) 2329-2330
53. Zhang W. Old and new tools to dissect calcineurin's role in pressure-overload cardiac hypertrophy. Cardiovasc. Res. 53 (2002) 294-303