메뉴 건너뛰기




Volumn 22, Issue 3, 2011, Pages 206-212

IGF system in cancer: From bench to clinic

Author keywords

cancer; insulin like growth factors; insulin like growth factors binding proteins

Indexed keywords

4 AMINO 5 (3 BENZYLOXYPHENYL) 7 [3 (1 PYRROLIDINYLMETHYL)CYCLOBUTYL] 7H PYRROLO[2,3 D]PYRIMIDINE; AMG 479; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; AVE 1642; AXL 1717; BIIB 022; BMS 536924; BMS 554417; BMS 754807; CELL SURFACE RECEPTOR; CIXUTUMUMAB; CYCLOLIGNAN PICROPODOPHYLLIN; DALOTUZUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; EXEL 228; FIGITUMUMAB; GANITUMAB; GEFITINIB; INSULIN RECEPTOR; MONOCLONAL ANTIBODY; NVP AEW 541; OSI 906; PODOPHYLLIN; PROTEIN TYROSINE KINASE INHIBITOR; ROBATUMUMAB; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 79951678633     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e32834258a1     Document Type: Review
Times cited : (37)

References (80)
  • 1
    • 0023473304 scopus 로고
    • Presence of somatomedin receptors on primary human breast and colon carcinomas
    • DOI 10.1016/0304-3835(87)90218-7
    • Pollak MN, Perdue JF, Margolese RG, Baer K, Richard M. Presence of somatomedin receptors on primary human breast and colon carcinomas. Cancer Lett 1987; 38:223-230. (Pubitemid 18005853)
    • (1987) Cancer Letters , vol.38 , Issue.1-2 , pp. 223-230
    • Pollak, M.N.1    Perdue, J.F.2    Margolese, R.G.3    Baer, K.4    Richard, M.5
  • 2
    • 0029973924 scopus 로고    scopus 로고
    • Growth, differentiation, and survival: Multiple physiological functions for insulin-like growth factors
    • Stewart CE, Rotwein P. Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol Rev 1996; 76:1005-1026. (Pubitemid 26346814)
    • (1996) Physiological Reviews , vol.76 , Issue.4 , pp. 1005-1026
    • Stewart, C.E.H.1    Rotwein, P.2
  • 3
    • 0022840625 scopus 로고
    • Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver
    • Roberts CTJr, Brown AL, Graham DE, Seelig S, Berry S, Gabbay KH, et al. Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver. J Biol Chem 1986; 261:10025-10028. (Pubitemid 17221930)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.22 , pp. 10025-10028
    • Roberts Jr., C.T.1    Brown, A.L.2    Graham, D.E.3
  • 4
    • 0025131648 scopus 로고
    • Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells
    • Soos MA, Whittaker J, Lammers R, Ullrich A, Siddle K. Receptors for insulin and insulin-like growth factor-I can form hybrid dimmers. Characterisation of hybrid receptors in transfected cells. Biochem J 1990; 270:383-390. (Pubitemid 20273478)
    • (1990) Biochemical Journal , vol.270 , Issue.2 , pp. 383-390
    • Soos, M.A.1    Whittaker, J.2    Lammers, R.3    Ullrich, A.4    Siddle, K.5
  • 5
    • 0034877139 scopus 로고    scopus 로고
    • Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors
    • DOI 10.1042/BST0290513
    • Siddle K, Ursø B, Niesler CA, Cope DL, Molina L, Surinya KH, et al. Specificity in ligand binding and intracellular signaling by insulin and insulin-like growth factor receptors. Biochem Soc Trans 2001; 29 (Pt 4):513-525. (Pubitemid 32783649)
    • (2001) Biochemical Society Transactions , vol.29 , Issue.4 , pp. 513-525
    • Siddle, K.1    Urso, B.2    Niesler, C.A.3    Cope, D.L.4    Molina, L.5    Surinya, K.H.6    Soos, M.A.7
  • 6
    • 0025362295 scopus 로고
    • Functionally distinct insulin receptors generated by tissue-specific alternative splicing
    • Mosthaf L, Grako K, Dull TJ, Coussens L, Ullrich A, McClain DA. Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J 1990; 9:2409-2413.
    • (1990) EMBO J , vol.9 , pp. 2409-2413
    • Mosthaf, L.1    Grako, K.2    Dull, T.J.3    Coussens, L.4    Ullrich, A.5    McClain, D.A.6
  • 7
    • 0027537050 scopus 로고
    • Ligand-binding properties of the two isoforms of the human insulin receptor
    • DOI 10.1210/en.132.3.1132
    • Yamaguchi Y, Flier JS, Benecke H, Ransil BJ, Moller DE. Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology 1993; 132:1132-1138. (Pubitemid 23068628)
    • (1993) Endocrinology , vol.132 , Issue.3 , pp. 1132-1138
    • Yamaguchi, Y.1    Flier, J.S.2    Ransil, H.B.B.J.3    Moller, D.E.4
  • 8
    • 0025941580 scopus 로고
    • Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells
    • Yamaguchi Y, Flier JS, Yokota A, Benecke H, Backer JM, Moller DE. Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells. Endocrinology 1991; 129:2058-2066.
    • (1991) Endocrinology , vol.129 , pp. 2058-2066
    • Yamaguchi, Y.1    Flier, J.S.2    Yokota, A.3    Benecke, H.4    Backer, J.M.5    Moller, D.E.6
  • 9
    • 0037508585 scopus 로고    scopus 로고
    • Signaling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate-1
    • DOI 10.1210/en.2002-0136
    • Sciacca L, Prisco M, Wu A, Belfiore A, Vigneri R, Baserga R. Signaling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate-1. Endocrinology 2003; 144:2650-2658. (Pubitemid 36629918)
    • (2003) Endocrinology , vol.144 , Issue.6 , pp. 2650-2658
    • Sciacca, L.1    Prisco, M.2    Wu, A.3    Belfiore, A.4    Vigneri, R.5    Baserga, R.6
  • 10
    • 14544269997 scopus 로고    scopus 로고
    • Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: Modulation by aging and differentiation in rat adipose tissue
    • DOI 10.1677/jme.1.01635
    • Serrano R, Villar M, Mart́inez C, Carrascosa JM, Gallardo N, Andrés A. Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat adipose tissue. J Mol Endocrinol 2005; 34: 153-161. (Pubitemid 40305557)
    • (2005) Journal of Molecular Endocrinology , vol.34 , Issue.1 , pp. 153-161
    • Serrano, R.1    Villar, M.2    Martinez, C.3    Carrascosa, J.M.4    Gallardo, N.5    Andres, A.6
  • 11
    • 0037131385 scopus 로고    scopus 로고
    • Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
    • DOI 10.1074/jbc.M202766200
    • Pandini G, Frasca F, Mineo R, Sciacca L,Vigneri R, Belfiore A. Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J Biol Chem 2002; 277:39684-39695. [Epub 22 July 2002]. (Pubitemid 35190951)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.42 , pp. 39684-39695
    • Pandini, G.1    Frasca, F.2    Mineo, R.3    Sciacca, L.4    Vigneri, R.5    Belfiore, A.6
  • 12
    • 70849120946 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    • [Epub 14 September 2009]
    • Belfiore A, Frasca F, Pandini G, Sciacca L,Vigneri R. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev 2009; 30:586-623. [Epub 14 September 2009].
    • (2009) Endocr Rev , vol.30 , pp. 586-623
    • Belfiore, A.1    Frasca, F.2    Pandini, G.3    Sciacca Lvigneri, R.4
  • 16
    • 0027423419 scopus 로고
    • Role of insulin-like growth factors in embryonic and postnatal growth
    • DOI 10.1016/0092-8674(93)90680-O
    • Baker J, Liu JP, Robertson EJ, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993; 75:73-82. (Pubitemid 23306022)
    • (1993) Cell , vol.75 , Issue.1 , pp. 73-82
    • Baker, J.1    Liu, J.-P.2    Robertson, E.J.3    Efstratiadis, A.4
  • 17
    • 0022800838 scopus 로고
    • Insulin-like growth factor i receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
    • Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, et al. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 1986; 5:2503-2512.
    • (1986) EMBO J , vol.5 , pp. 2503-2512
    • Ullrich, A.1    Gray, A.2    Tam, A.W.3    Yang-Feng, T.4    Tsubokawa, M.5    Collins, C.6
  • 18
    • 0023687661 scopus 로고
    • Expression and characterization of a functional human insulin-like growth factor i receptor
    • Steele-Perkins G, Turner J, Edman JC, Hari J, Pierce SB, Stover C, et al. Expression and characterization of a functional human insulin-like growth factor I receptor. J Biol Chem 1988; 263:11486-11492.
    • (1988) J Biol Chem , vol.263 , pp. 11486-11492
    • Steele-Perkins, G.1    Turner, J.2    Edman, J.C.3    Hari, J.4    Pierce, S.B.5    Stover, C.6
  • 19
    • 34047198390 scopus 로고    scopus 로고
    • Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2
    • Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV. Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. Cell Cycle 2007; 6:705-713. (Pubitemid 46535683)
    • (2007) Cell Cycle , vol.6 , Issue.6 , pp. 705-713
    • Dearth, R.K.1    Cui, X.2    Kim, H.-J.3    Hadsell, D.L.4    Lee, A.V.5
  • 20
    • 0028036724 scopus 로고
    • Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling
    • Yamauchi K, Pessin JE. Insulin receptorsubstrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling. J Biol Chem 1994; 269:31107-31114. (Pubitemid 24377605)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.49 , pp. 31107-31114
    • Yamauchi, K.1    Pessin, J.E.2
  • 22
    • 0034710915 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin
    • Playford MP, Bicknell D, Bodmer WF, Macaulay VM. Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. Proc Natl Acad Sci USA 2000; 97:12103-12108.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12103-12108
    • Playford, M.P.1    Bicknell, D.2    Bodmer, W.F.3    MacAulay, V.M.4
  • 23
    • 0742304062 scopus 로고    scopus 로고
    • Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression
    • DOI 10.1023/B:BREA.0000010709.31256.c6
    • Zhang X, Kamaraju S, Hakuno F, Kabuta T, Takahashi S, Sachdev D, et al. Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression. Breast Cancer Res Treat 2004; 83:161-170. (Pubitemid 38161263)
    • (2004) Breast Cancer Research and Treatment , vol.83 , Issue.2 , pp. 161-170
    • Zhang, X.1    Kamaraju, S.2    Hakuno, F.3    Kabuta, T.4    Takahashi, S.-I.5    Sachdev, D.6    Yee, D.7
  • 24
    • 25844465843 scopus 로고    scopus 로고
    • Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration
    • DOI 10.1007/s10549-005-4626-8
    • Zhang X, Lin M, Van Golen KL, Yoshioka K, Itoh K, Yee D. Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration. Breast Cancer Res Treat 2005; 93:159-168. (Pubitemid 41396777)
    • (2005) Breast Cancer Research and Treatment , vol.93 , Issue.2 , pp. 159-168
    • Zhang, X.1    Lin, M.2    Van Golen, K.L.3    Yoshioka, K.4    Itoh, K.5    Yee, D.6
  • 25
    • 33846807433 scopus 로고    scopus 로고
    • Disrupting insulin-like growth factor signaling as a potential cancer therapy
    • DOI 10.1158/1535-7163.MCT-06-0080
    • Sachdev D, Yee D. Disrupting insulin-like growth factor signaling as a potential cancer therapy. Mol Cancer Ther 2007; 6:1-12. (Pubitemid 46206663)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.1 , pp. 1-12
    • Sachdev, D.1    Yee, D.2
  • 26
    • 0031627219 scopus 로고    scopus 로고
    • Molecular regulation of insulin-like growth factor-I and its principal binding protein IGFBP-3
    • Phillips LS, Pao CI, Villafuerte BC. Molecular regulation of insulin-like growth factor-I and its principal binding protein, IGFBP-3. Prog Nucleic Acid Res Mol Biol 1998; 60:195-265.
    • (1998) Prog Nucleic Acid Res Mol Biol , vol.60 , pp. 195-265
    • Phillips, L.S.1    Pao, C.I.2    Villafuerte, B.C.3
  • 27
    • 0028910280 scopus 로고
    • Cloning and characterization of the promoter for the rat insulin-like growth factor-binding protein-3 gene
    • Albiston AL, Saffery R, Herington AC Cloning and characterization of the promoter for the rat insulin-like growth factor-binding protein-3 gene. Endocrinology 1995; 136:696-704.
    • (1995) Endocrinology , vol.136 , pp. 696-704
    • Albiston, A.L.1    Saffery, R.2    Herington, A.C.3
  • 28
    • 0024353902 scopus 로고
    • Inhibitory diffusible factor 45 bifunctional activity. As a cell growth inhibitor and as an insulin-like growth factor I-binding protein
    • Blat C, Delbe J,Villaudy J, Chatelain G, Golde A, Harel L. Inhibitory diffusible factor 45 bifunctional activity. As a cell growth inhibitor and as an insulin-like growth factor I-binding protein. J Biol Chem 1989; 264:12449-12454. (Pubitemid 19191135)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.21 , pp. 12449-12454
    • Blat, C.1    Delbe, J.2    Villaudy, J.3    Chatelain, G.4    Golde, A.5    Harel, L.6
  • 29
    • 0026794432 scopus 로고
    • Insulin-like growth factor binding protein-3 (IGFBP-3), an inhibitor of serum growth factors other than IGF-I and-II
    • Liu L, Delbé J, Blat C, Zapf J, Harel L. Insulin-like growth factor binding protein-3 (IGFBP-3), an inhibitor of serum growth factors other than IGF-I and-II. J Cell Physiol 1992; 153:15-21.
    • (1992) J Cell Physiol , vol.153 , pp. 15-21
    • Liu, L.1    Delbé, J.2    Blat, C.3    Zapf, J.4    Harel, L.5
  • 30
    • 0037474298 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-3 potentiates epidermal growth factor action in MCF-10A mammary epithelial cells. Involvement of p44/42 and p38 mitogen-activated protein kinases
    • DOI 10.1074/jbc.M210739200
    • Martin JL, Weenink SM, Baxter RC. Insulin-like growth factor-binding protein-3 potentiates epidermal growth factoraction in MCF-10A mammary epithelial cells. Involvement of p44/42 and p38 mitogenactivated protein kinases. J Biol Chem 2003; 278:2969-2976. (Pubitemid 36801203)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.5 , pp. 2969-2976
    • Martin, J.L.1    Weenink, S.M.2    Baxter, R.C.3
  • 31
    • 0027476724 scopus 로고
    • Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth
    • DOI 10.1210/me.7.3.380
    • Cohen P, Lamson G, Okajima T, Rosenfeld RG. Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth. Mol Endocrinol 1993; 7:380-386. (Pubitemid 23104526)
    • (1993) Molecular Endocrinology , vol.7 , Issue.3 , pp. 380-386
    • Cohen, P.1    Lamson, G.2    Okajima, T.3    Rosenfeld, R.G.4
  • 35
    • 0028127946 scopus 로고
    • Nutritional regulation of the insulin-like growth factors
    • DOI 10.1210/er.15.1.80
    • Thissen JP, Ketelslegers JM, Underwood LE. Nutritional regulation of the insulin-like growth factors. Endocr Rev 1994; 15:80-101. (Pubitemid 24058597)
    • (1994) Endocrine Reviews , vol.15 , Issue.1 , pp. 80-101
    • Thissen, J.-P.1    Ketelslegers, J.-M.2    Underwood, L.E.3
  • 37
    • 0030727705 scopus 로고    scopus 로고
    • Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53- deficient mice
    • Dunn SE, Kari FW, French J, Leininger JR, Travlos G, Wilson R, et al. Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res 1997; 57:4667-4672. (Pubitemid 27468963)
    • (1997) Cancer Research , vol.57 , Issue.21 , pp. 4667-4672
    • Dunn, S.E.1    Kari, F.W.2    French, J.3    Leininger, J.R.4    Travlos, G.5    Wilson, R.6    Barrett, J.C.7
  • 38
    • 0026714984 scopus 로고
    • Interference of the IGF system as a strategy to inhibit breast cancer growth
    • Arteaga CL. Interference of the IGF system as a strategy to inhibit breast cancer growth. Breast Cancer Res Treat 1992; 22:101-106.
    • (1992) Breast Cancer Res Treat , vol.22 , pp. 101-106
    • Arteaga, C.L.1
  • 41
    • 69449097339 scopus 로고    scopus 로고
    • Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
    • Gualberto A, Pollak M. Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene 2009; 28:3009-3021.
    • (2009) Oncogene , vol.28 , pp. 3009-3021
    • Gualberto, A.1    Pollak, M.2
  • 43
    • 0031965186 scopus 로고    scopus 로고
    • Structure and function of the insulin-like growth factor I receptor
    • DOI 10.1023/A:1005955017615
    • Sepp-Lorenzino L. Structure and function of the insulin-like growth factor I receptor. Breast Cancer Res Treat 1998; 47:235-253. (Pubitemid 28059820)
    • (1998) Breast Cancer Research and Treatment , vol.47 , Issue.3 , pp. 235-253
    • Sepp-Lorenzino, L.1
  • 46
    • 68849090494 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines
    • Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, et al. Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. Mol Cancer Ther 2009; 8:2122-2130.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2122-2130
    • Duan, Z.1    Choy, E.2    Harmon, D.3    Yang, C.4    Ryu, K.5    Schwab, J.6
  • 47
    • 47249143238 scopus 로고    scopus 로고
    • Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma
    • Economou MA, Andersson S, Vasilcanu D, All-Ericsson C, Menu E, Girnita A, et al. Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma. Invest Ophthalmol Vis Sci 2008; 49:2337-2342.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 2337-2342
    • Economou, M.A.1    Andersson, S.2    Vasilcanu, D.3    All-Ericsson, C.4    Menu, E.5    Girnita, A.6
  • 48
    • 1642494838 scopus 로고    scopus 로고
    • Cyclolignans as Inhibitors of the Insulin-Like Growth Factor-1 Receptor and Malignant Cell Growth
    • DOI 10.1158/0008-5472.CAN-03-2522
    • Girnita A, Girnita L, Del Prete F, Bartolazzi A, Larsson O, Axelson M. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res 2004; 64:236-242. (Pubitemid 38114104)
    • (2004) Cancer Research , vol.64 , Issue.1 , pp. 236-242
    • Girnita, A.1    Girnita, L.2    Del Prete, F.3    Bartolazzi, A.4    Larsson, O.5    Axelson, M.6
  • 49
    • 79952672340 scopus 로고    scopus 로고
    • Clinical phase i study with an insulin-like growth factor-1 receptor inhibitor: Experiences in patients with squamous non-small cell lung carcinoma
    • Early Online, 1-7
    • Ekman S, Frödin JE, Harmenberg J, Bergman A, Hedlund A, Dahg P, et al. Clinical phase I study with an insulin-like growth factor-1 receptor inhibitor: experiences in patients with squamous non-small cell lung carcinoma. Acta Oncol 2010 (Early Online, 1-7).
    • (2010) Acta Oncol
    • Ekman, S.1    Frödin, J.E.2    Harmenberg, J.3    Bergman, A.4    Hedlund, A.5    Dahg, P.6
  • 50
    • 0034719133 scopus 로고    scopus 로고
    • Substrate competitive inhibitors of IGF-1 receptor kinase
    • DOI 10.1021/bi001516y
    • Blum G, Gazit A, Levitzki A. Substrate competitive inhibitors of IGF-1 receptor kinase. Biochemistry 2000; 39:15705-15712. (Pubitemid 32038232)
    • (2000) Biochemistry , vol.39 , Issue.51 , pp. 15705-15712
    • Blum, G.1    Gazit, A.2    Levitzki, A.3
  • 51
    • 73449103570 scopus 로고    scopus 로고
    • Antisense oligonucleotide targeting of insulin-like growth factor-1 receptor (IGF-1R) in prostate cancer
    • Girnita A, Girnita L, Del Prete F, Bartolazzi A, Larsson O, Axelson M. Antisense oligonucleotide targeting of insulin-like growth factor-1 receptor (IGF-1R) in prostate cancer. Prostate 2010; 70:206-218.
    • (2010) Prostate , vol.70 , pp. 206-218
    • Girnita, A.1    Girnita, L.2    Del Prete, F.3    Bartolazzi, A.4    Larsson, O.5    Axelson, M.6
  • 52
    • 0347356289 scopus 로고    scopus 로고
    • Development of molecular agents for IGF receptortargeting
    • DOI 10.1055/s-2004-814158
    • Salisbury AJ, Macaulay VM. Development of molecular agents for IGF receptortargeting. Horm Metab Res 2003; 35:843-849. (Pubitemid 38058192)
    • (2003) Hormone and Metabolic Research , vol.35 , Issue.11-12 , pp. 843-849
    • Salisbury, A.J.1    Macaulay, V.M.2
  • 53
    • 0035871490 scopus 로고    scopus 로고
    • Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas
    • Andrews DW, Resnicoff M, Flanders AE, Kenyon L, Curtis M, Merli G, et al. Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas. J Clin Oncol 2001; 19:2189-2200. (Pubitemid 32366973)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.8 , pp. 2189-2200
    • Andrews, D.W.1    Resnicoff, M.2    Flanders, A.E.3    Kenyon, L.4    Curtis, M.5    Merli, G.6    Baserga, R.7    Iliakis, G.8    Aiken, R.D.9
  • 56
    • 0032401879 scopus 로고    scopus 로고
    • Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice
    • Liu X, Turbyville T, Fritz A, Whitesell L. Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice. Cancer Res 1998; 58:5432-5438. (Pubitemid 28551127)
    • (1998) Cancer Research , vol.58 , Issue.23 , pp. 5432-5438
    • Liu, X.1    Turbyville, T.2    Fritz, A.3    Whitesell, L.4
  • 58
    • 67349165458 scopus 로고    scopus 로고
    • Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells
    • Wang YH, Wang ZX, Qiu Y, Xiong J, Chen YX, Miao DS, et al. Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells. Mol Cell Biochem 2009; 327:257-266.
    • (2009) Mol Cell Biochem , vol.327 , pp. 257-266
    • Wang, Y.H.1    Wang, Z.X.2    Qiu, Y.3    Xiong, J.4    Chen, Y.X.5    Miao, D.S.6
  • 63
    • 57149124243 scopus 로고    scopus 로고
    • A phase i study of MK-0646, a humanized monoclonal antibody against the insulin-like growth factor receptor type 1 (IGF-IR) in advanced solid tumor patients in a q2 wk schedule
    • [Abstr 3520]
    • Hidalgo M, Tirado Gomez M, Lewis N, Vuky JL, Taylor G, Hayburn JL, et al. A phase I study of MK-0646, a humanized monoclonal antibody against the insulin-like growth factor receptor type 1 (IGF-IR) in advanced solid tumor patients in a q2 wk schedule. J Clin Oncol ASCO Annu Meet Proc 2008; 26: [Abstr 3520].
    • (2008) J Clin Oncol ASCO Annu Meet Proc , vol.26
    • Hidalgo, M.1    Tirado Gomez, M.2    Lewis, N.3    Vuky, J.L.4    Taylor, G.5    Hayburn, J.L.6
  • 64
    • 57149130704 scopus 로고    scopus 로고
    • A phase i study of AVE1642, a humanized monoclonal antibody IGF-1R (insulin like growth factor 1 receptor) antagonist, in patients (pts) with advanced solid tumors (ST)
    • [Abstr 3582]
    • Tolcher AW, Patnaik A, Till E, Takimoto CH, Papadopoulos KP, Massard C, et al. A phase I study of AVE1642, a humanized monoclonal antibody IGF-1R (insulin like growth factor 1 receptor) antagonist, in patients (pts) with advanced solid tumors (ST). J Clin Oncol ASCOAnnu Meet Proc 2008; 26: [Abstr 3582].
    • (2008) J Clin Oncol ASCOAnnu Meet Proc , vol.26
    • Tolcher, A.W.1    Patnaik, A.2    Till, E.3    Takimoto, C.H.4    Papadopoulos, K.P.5    Massard, C.6
  • 65
    • 72449138750 scopus 로고    scopus 로고
    • BIIB022, a human antibody targeting human insulin-like growth factor-1 receptor (IGF-1R), enhances the anti-tumor activities of Tarceva in non-small cell lung carcinoma (NSCLC) and rapamycin in sarcoma cell lines
    • [Abstr 4002]
    • Dong J, Tamraz S, Berquist L, Boccia A, Sereno A, Chu P, et al. BIIB022, a human antibody targeting human insulin-like growth factor-1 receptor (IGF-1R), enhances the anti-tumor activities of Tarceva in non-small cell lung carcinoma (NSCLC) and rapamycin in sarcoma cell lines. Proc Annu Meet Am Assoc Cancer Res. 2008, [Abstr 4002].
    • (2008) Proc Annu Meet Am Assoc Cancer Res.
    • Dong, J.1    Tamraz, S.2    Berquist, L.3    Boccia, A.4    Sereno, A.5    Chu, P.6
  • 66
    • 39549085059 scopus 로고    scopus 로고
    • Evaluating the safety and pharmacokinetics of afully human IGF-1 receptorantibody,SCH 717454, in healthy volunteers
    • San Francisco, USA 22-26 October
    • Seraj J, Tsai M, Sieberling M, Cutler D. Evaluating the safety and pharmacokinetics of afully human IGF-1 receptorantibody,SCH 717454, in healthy volunteers. Presented at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Meeting, San Francisco, USA, 22-26 October 2007, http://www.aacr.org/uploads/DocumentRepository/2007conf/moltar/mt07-postera.pdf.
    • (2007) Presented at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Meeting
    • Seraj, J.1    Tsai, M.2    Sieberling, M.3    Cutler, D.4
  • 67
    • 36148981957 scopus 로고    scopus 로고
    • A phase i study of q3W R1507, a human monoclonal antibody IGF-1R antagonist in patients with advanced cancer
    • [Abstr 3590]
    • Rodon J, Patnaik A, Stein M, Tolcher A, Ng C, Dias C, et al. A phase I study of q3W R1507, a human monoclonal antibody IGF-1R antagonist in patients with advanced cancer. J Clin Oncol ASCO Annu Meet Proc 2007; 25: [Abstr 3590].
    • (2007) J Clin Oncol ASCO Annu Meet Proc , vol.25
    • Rodon, J.1    Patnaik, A.2    Stein, M.3    Tolcher, A.4    Ng, C.5    Dias, C.6
  • 68
    • 10344247119 scopus 로고    scopus 로고
    • A recombinant humanized anti-insulin-like growth factor-receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts
    • DOI 10.1002/ijc.20543
    • Goetsch L, Gonzalez A, Leger O, Beck A, Pauwels PJ, Haeuw JF, et al. A recombinant humanized anti-insulin-like growth factor receptortype I antibody (h7C10) enhances the antitumor activity ofvinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts. Int J Cancer 2005; 113:316-328. (Pubitemid 39628325)
    • (2005) International Journal of Cancer , vol.113 , Issue.2 , pp. 316-328
    • Goetsch, L.1    Gonzalez, A.2    Leger, O.3    Beck, A.4    Pauwels, P.J.5    Haeuw, J.F.6    Corvaia, N.7
  • 70
    • 77952060250 scopus 로고    scopus 로고
    • Discovery of OSI-906: A selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor
    • Mulvihill M, Qun-Sheng J, Rosenfeld-Franklin M, Buck E, Cooke A, Eyzaguirre A, et al. Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor. Future Med Chem 2009;1:1153-1171.
    • (2009) Future Med Chem , vol.1 , pp. 1153-1171
    • Mulvihill, M.1    Qun-Sheng, J.2    Rosenfeld-Franklin, M.3    Buck, E.4    Cooke, A.5    Eyzaguirre, A.6
  • 71
  • 74
    • 23044493251 scopus 로고    scopus 로고
    • Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer
    • DOI 10.1016/S1359-6446(05)03512-9, PII S1359644605035129
    • Hofmann F, Garcia-Echeverria C. Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. Drug Discov Today 2005; 10:1041-1047. (Pubitemid 41074142)
    • (2005) Drug Discovery Today , vol.10 , Issue.15 , pp. 1041-1047
    • Hofmann, F.1    Garcia-Echeverria, C.2
  • 75
    • 34548010331 scopus 로고    scopus 로고
    • Simultaneous inhibition of IGF-1R and Src family kinases causes tumor growth inhibition and tumor regression in xenograft models
    • Aftab DT. Simultaneous inhibition of IGF-1R and Src family kinases causes tumor growth inhibition and tumor regression in xenograft models. Eur J Cancer Suppl 2006; 4:178.
    • (2006) Eur J Cancer Suppl , vol.4 , pp. 178
    • Aftab, D.T.1
  • 78
    • 65649137564 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor 1 (IGF-1) and outcome measures in advanced non-small cell lung cancer (NSCLC) patients treated with gefitinib
    • [Abstr 8036]
    • Fidler MJ, Basu S, Buckingham L, Kaiser K, McCormack SE, Coon JS, et al. Insulin-like growth factor receptor 1 (IGF-1) and outcome measures in advanced non-small cell lung cancer (NSCLC) patients treated with gefitinib. J Clin Oncol ASCO Annu Meet Proc 2008; 26: [Abstr 8036].
    • (2008) J Clin Oncol ASCO Annu Meet Proc , vol.26
    • Fidler, M.J.1    Basu, S.2    Buckingham, L.3    Kaiser, K.4    McCormack, S.E.5    Coon, J.S.6
  • 79
    • 77949579434 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small cell lung cancer (NSCLC) patients
    • Cappuzzo F,Tallini G, Finocchiaro G, Wilson RS, Ligorio C, Giordano L, et al. Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small cell lung cancer (NSCLC) patients. Ann Oncol 2010; 21:562-567.
    • (2010) Ann Oncol , vol.21 , pp. 562-567
    • Cappuzzo Ftallini, G.1    Finocchiaro, G.2    Wilson, R.S.3    Ligorio, C.4    Giordano, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.