Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells

Molecular and Cellular Biochemistry

Volumn 327, Issue 1-2, 2009, Pages 257-266

  Wang, Yin He ^a,b   Wang, Zhao Xia ^a   Qiu, Yong ^b   Xiong, Jin ^b   Chen, Yi Xin ^b   Miao, Deng Shun ^a   De, Wei ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

Author keywords

Growth; Insulin like growth factor 1 receptor; Invasion; Osteosarcoma; Radiosensitivity; RNA interference

Indexed keywords

BONE NEOPLASMS; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; DOWN-REGULATION; GENE SILENCING; HUMANS; LENTIVIRUS; OSTEOSARCOMA; RADIATION TOLERANCE; RECEPTOR, IGF TYPE 1; RNA INTERFERENCE; RNA, MESSENGER; TIME FACTORS; TRANSFECTION;

LENTIVIRUS;

EID: 67349165458     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0064-y     Document Type: Article

References (30)

1. Bertoni F, Bacchini P (1998) Classification of bone tumors. Eur J Radiol 27:S74-S76. doi: 10.1016/S0720-048X(98)00046-1
2. Weber K, Damron TA, Frassica FJ et al (2008) Malignant bone tumors. Instr Course Lect 57:673-688
3. Bielack S, Carrle D, Jost L et al (2008) Osteosarcoma: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 19:iI94-ii96. doi: 10.1093/annonc/mdn102
4. Ilić I, Manojlović S, Cepulić M et al (2004) Osteosarcoma and Ewing's sarcoma in children and adolescents: retrospective clinicopathological study. Croat Med J 45:740-745
5. Adams TE, Epa VC, Garrett TP et al (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 57:1050-1093. doi: 10.1007/PL00000744
6. Nguyen TT, Sheppard AM, Kaye PL et al (2007) IGF-I and insulin activate mitogen-activated protein kinase via the type 1 IGF receptor in mouse embryonic stem cells. Reproduction 134:41-49. doi: 10.1530/REP-06-0087
7. Pass HI, Mew DJ, Carbone M et al (1996) Inhibition of hamster mesothelioma tumorigenesis by an antisense expression plasmid to the insulin-like growth factor-1 receptor. Cancer Res 56:4044-4048
8. Dziadziuszko R, Camidge DR, Hirsch FR (2008) The insulin-like growth factor pathway in lung cancer. J Thorac Oncol 3:815-818
9. Lee CY, Jeon JH, Kim HJ et al (2008) Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: Immunohistochemical analysis. Korean J Intern Med 23:116-120. doi: 10.3904/kjim.2008.23.3.116
10. Belinsky MG, Rink L, Cai KQ et al (2008) The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors. Cell Cycle 7:2949-2955
11. Steller MA, Delgado CH, Bartels CJ et al (1996) Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells. Cancer Res 56:1761-1765
12. All-Ericsson C, Girnita L, Seregard S et al (2002) Insulin-like growth factor-1 receptor in uveal melanoma: A predictor for metastatic disease and a potential therapeutic target. Investig Ophthalmol Vis Sci 43:1-8
13. Al Sarakbi W, Chong YM, Williams SL et al (2006) The mRNA expression of IGF-1 and IGF-1R in human breast cancer: Association with clinico-pathological parameters. J Carcinog 5:16. doi: 10.1186/ 1477-3163-5-16
14. Saikali Z, Setya H, Singh G et al (2008) Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells. Cancer Cell Int 8:10. doi: 10.1186/1475-2867-8-10
15. Karagiannis TC, El-Osta A (2004) siRNAs: Mechanism of RNA interference, in vivo and potential clinical applications. Cancer Biol Ther 3:1069-1074
16. Tiscornia G, Singer O, Ikawa M et al (2003) A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci USA 100:1844-1848. doi: 10.1073/ pnas.0437912100
17. Malashicheva AB, Kanzler B, Tolkunova EN et al (2008) The application of lentiviral vectors for tissue-specific gene manipulations. Tsitologiia 50:370-375
18. Sinn PL, Arias AC, Brogden KA et al (2008) Lentivirus vector can be readministered to nasal epithelia without blocking immune responses. J Virol 82:10684-10692. doi: 10.1128/JVI.00227-08
19. Chou AJ, Geller DS, Gorlick R (2008) Therapy for osteosarcoma: Where do we go from here? Paediatr Drugs 10:315-327. doi: 10.2165/ 00148581-200810050-00005
20. Lamoureux F, Trichet V, Chipoy C et al (2007) Recent advances in the management of osteosarcoma and forthcoming therapeutic strategies. Expert Rev Anticancer Ther 7:169-181. doi: 10.1586/14737140.7.2.169
21. Kohn DB, Anderson WF, Blaese RM (1989) Gene therapy for genetic diseases. Cancer Investig 7:179-192. doi: 10.3109/07357908909038283
22. Dass CR, Choong PF (2008) Gene therapy for osteosarcoma: Steps towards clinical studies. J Pharm Pharmacol 60:405-413. doi: 10.1211/ jpp.60.4.0001
23. Lundstrom K (2003) Latest development in viral vectors for gene therapy. Trends Biotechnol 21:117-122. doi: 10.1016/S0167-7799(02)00042-2
24. Sinn PL, Sauter SL, McCray PB Jr (2005) Gene therapy progress and prospects: Development of improved lentiviral and retroviral vectors - design, biosafety, and production. Gene Ther 12:1089-1098. doi: 10.1038/ sj.gt.3302570
25. Dropulic B (2005) Genetic modification of hematopoietic cells using retroviral and lentiviral vectors: Safety considerations for vector design and delivery into target cells. Curr Hematol Rep 4:300-304
26. White PJ, Fogarty RD, Werther GA et al (2000) Antisense inhibition of IGF receptor expression in HaCaT keratinocytes: A model for antisense strategies in keratinocytes. Antisense Nucleic Acid Drug Dev 10:195-203
27. Yeh J, Litz J, Hauck P, Ludwig DL et al (2008) Selective inhibition of SCLC growth by the A12 anti-IGF-1R monoclonal antibody correlates with inhibition of Akt. Lung Cancer 60:166-174. doi: 10.1016/ j.lungcan.2007.09.023
28. Brodt P, Samani A, Navab R (2000) Inhibition of the type I insulin-like growth factor receptor expression and signaling: Novel strategies for antimetastatic therapy. Biochem Pharmacol 60:1101-1107. doi: 10.1016/ S0006-2952(00)00422-6
29. Kucab JE, Dunn SE (2003) Role of IGF-1R in mediating breast cancer invasion and metastasis. Breast Dis 17:41-47
30. Ma Z, Dong A, Kong M et al (2007) Silencing of the type 1 insulin-like growth factor receptor increases the sensitivity to apoptosis and inhibits invasion in human lung adenocarcinoma A549 cells. Cell Mol Biol Lett 12:556-572. doi: 10.2478/s11658-007-0022-1