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2
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33847388023
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Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development
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McDermott S.P., Ranheim E.A., Leatherberry V.S., Khwaja S.S., Klos K.S., and Alexander C.M. Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development. Oncogene 26 (2007) 1407-1416
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McDermott, S.P.1
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Khwaja, S.S.4
Klos, K.S.5
Alexander, C.M.6
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The role of syndecans in the regulation of body weight and synaptic plasticity
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Reizes O., Benoit S.C., and Clegg D.J. The role of syndecans in the regulation of body weight and synaptic plasticity. Int J Biochem Cell Biol 40 (2008) 28-45
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Reizes, O.1
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Clegg, D.J.3
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62649131671
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A role for Syndecan-4 in neural induction involving ERK- and PKC-dependent pathways
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This study demonstrates that the PKCalpha/Rho pathway implicated in syndecan-4 mediated cell migration is also important in neuronal cell specification.
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Kuriyama S., and Mayor R. A role for Syndecan-4 in neural induction involving ERK- and PKC-dependent pathways. Development 136 (2009) 575-584. This study demonstrates that the PKCalpha/Rho pathway implicated in syndecan-4 mediated cell migration is also important in neuronal cell specification.
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Development
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Kuriyama, S.1
Mayor, R.2
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Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA
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Matthews H.K., Marchant L., Carmona-Fontaine C., Kuriyama S., Larrain J., Holt M.R., Parsons M., and Mayor R. Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA. Development 135 (2008) 1771-1780
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Matthews, H.K.1
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Larrain, J.5
Holt, M.R.6
Parsons, M.7
Mayor, R.8
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7
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33744997855
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Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos
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This paper shows that syndecan-4 ligation of fibronectin results in the translocation of Disheveled to the plasma membrane and that syndecan-4 cooperates with Frizzled 7 to activate noncanonical Wnt signaling in Xenopus.
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Munoz R., Moreno M., Oliva C., Orbenes C., and Larrain J. Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos. Nat Cell Biol 8 (2006) 492-500. This paper shows that syndecan-4 ligation of fibronectin results in the translocation of Disheveled to the plasma membrane and that syndecan-4 cooperates with Frizzled 7 to activate noncanonical Wnt signaling in Xenopus.
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Nat Cell Biol
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Munoz, R.1
Moreno, M.2
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8
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67349158348
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Syndecan-1 regulates BMP signaling and dorso-ventral patterning of the ectoderm during early Xenopus development
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Olivares G.H., Carrasco H., Aroca F., Carvallo L., Segovia F., and Larrain J. Syndecan-1 regulates BMP signaling and dorso-ventral patterning of the ectoderm during early Xenopus development. Dev Biol 329 (2009) 338-349
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Olivares, G.H.1
Carrasco, H.2
Aroca, F.3
Carvallo, L.4
Segovia, F.5
Larrain, J.6
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9
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34047257842
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Cellular adhesion responses to the heparin-binding (HepII) domain of fibronectin require heparan sulfate with specific properties
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Mahalingam Y., Gallagher J.T., and Couchman J.R. Cellular adhesion responses to the heparin-binding (HepII) domain of fibronectin require heparan sulfate with specific properties. J Biol Chem 282 (2007) 3221-3230
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Mahalingam, Y.1
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Couchman, J.R.3
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10
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Heparan sulphate proteoglycans fine-tune mammalian physiology
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Bishop J.R., Schuksz M., and Esko J.D. Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature 446 (2007) 1030-1037
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Interactions between heparan sulfate and proteins: the concept of specificity
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Kreuger J., Spillmann D., Li J.P., and Lindahl U. Interactions between heparan sulfate and proteins: the concept of specificity. J Cell Biol 174 (2006) 323-327
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Kreuger, J.1
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Lindahl, U.4
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12
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34047121229
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The heparanome - the enigma of encoding and decoding heparan sulfate sulfation
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Lamanna W.C., Kalus I., Padva M., Baldwin R.J., Merry C.L., and Dierks T. The heparanome - the enigma of encoding and decoding heparan sulfate sulfation. J Biotechnol 129 (2007) 290-307
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Lamanna, W.C.1
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Padva, M.3
Baldwin, R.J.4
Merry, C.L.5
Dierks, T.6
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13
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A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain
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Whiteford J.R., and Couchman J.R. A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain. J Biol Chem 281 (2006) 32156-32163
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Whiteford, J.R.1
Couchman, J.R.2
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14
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63449129028
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Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor
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This research demonstrates that the extracellular domain of syndecan-1 directly interacts with and activates the alpha(v)beta(3) and alpha(v)beta(5) integrins to promote angiogenesis.
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Beauvais D.M., Ell B.J., McWhorter A.R., and Rapraeger A.C. Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. J Exp Med 206 (2009) 691-705. This research demonstrates that the extracellular domain of syndecan-1 directly interacts with and activates the alpha(v)beta(3) and alpha(v)beta(5) integrins to promote angiogenesis.
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J Exp Med
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Beauvais, D.M.1
Ell, B.J.2
McWhorter, A.R.3
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15
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0345169052
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Syndecans: proteoglycan regulators of cell-surface microdomains?
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Couchman J.R. Syndecans: proteoglycan regulators of cell-surface microdomains?. Nat Rev Mol Cell Biol 4 (2003) 926-937
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Couchman, J.R.1
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16
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Synergistic control of cell adhesion by integrins and syndecans
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Morgan M.R., Humphries M.J., and Bass M.D. Synergistic control of cell adhesion by integrins and syndecans. Nat Rev Mol Cell Biol 8 (2007) 957-969
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Morgan, M.R.1
Humphries, M.J.2
Bass, M.D.3
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Syndecans: new kids on the signaling block
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Tkachenko E., Rhodes J.M., and Simons M. Syndecans: new kids on the signaling block. Circ Res 96 (2005) 488-500
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Tkachenko, E.1
Rhodes, J.M.2
Simons, M.3
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18
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30044440012
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Transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4
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Choi S., Lee E., Kwon S., Park H., Yi J.Y., Kim S., Han I.O., Yun Y., and Oh E.S. Transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4. J Biol Chem 280 (2005) 42573-42579
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Choi, S.1
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Han, I.O.7
Yun, Y.8
Oh, E.S.9
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19
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38049174634
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Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions
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Dews I.C., and Mackenzie K.R. Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions. Proc Natl Acad Sci U S A 104 (2007) 20782-20787
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Proc Natl Acad Sci U S A
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Dews, I.C.1
Mackenzie, K.R.2
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20
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Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region
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Asundi V.K., and Carey D.J. Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region. J Biol Chem 270 (1995) 26404-26410
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Asundi, V.K.1
Carey, D.J.2
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21
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34249867935
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Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway
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This study reveals a novel signaling pathway in which syndecan-2 by directly interacting with neurofibromin activates PKA that consequently phosphorylates Ena/VASP, promoting filopodia formation
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Lin Y.L., Lei Y.T., Hong C.J., and Hsueh Y.P. Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway. J Cell Biol 177 (2007) 829-841. This study reveals a novel signaling pathway in which syndecan-2 by directly interacting with neurofibromin activates PKA that consequently phosphorylates Ena/VASP, promoting filopodia formation
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(2007)
J Cell Biol
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Lin, Y.L.1
Lei, Y.T.2
Hong, C.J.3
Hsueh, Y.P.4
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22
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0035959932
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EphB/syndecan-2 signaling in dendritic spine morphogenesis
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Ethell I.M., Irie F., Kalo M.S., Couchman J.R., Pasquale E.B., and Yamaguchi Y. EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron 31 (2001) 1001-1013
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Kalo, M.S.3
Couchman, J.R.4
Pasquale, E.B.5
Yamaguchi, Y.6
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23
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Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons
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Ethell I.M., and Yamaguchi Y. Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons. J Cell Biol 144 (1999) 575-586
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Ethell, I.M.1
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Syndecan-4 and focal adhesion function
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Woods A., and Couchman J.R. Syndecan-4 and focal adhesion function. Curr Opin Cell Biol 13 (2001) 578-583
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Woods, A.1
Couchman, J.R.2
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25
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Syndecan-4: dispensable or indispensable?
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Wilcox-Adelman S.A., Denhez F., Iwabuchi T., Saoncella S., Calautti E., and Goetinck P.F. Syndecan-4: dispensable or indispensable?. Glycoconj J 19 (2002) 305-313
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Goetinck, P.F.6
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26
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24144482654
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Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6
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The first study identifying the mechanism of syndecan endocytic recycling and showing it is supported by its interaction with the PDZ protein syntenin.
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Zimmermann P., Zhang Z., Degeest G., Mortier E., Leenaerts I., Coomans C., Schulz J., N'Kuli F., Courtoy P.J., and David G. Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6. Dev Cell 9 (2005) 377-388. The first study identifying the mechanism of syndecan endocytic recycling and showing it is supported by its interaction with the PDZ protein syntenin.
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Zimmermann, P.1
Zhang, Z.2
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Schulz, J.7
N'Kuli, F.8
Courtoy, P.J.9
David, G.10
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27
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34248159909
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Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix
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Demonstration of the role of syndecan-4 in mediating directionally persistent migration by localizing active Rac1, in response to the ECM.
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Bass M.D., Roach K.A., Morgan M.R., Mostafavi-Pour Z., Schoen T., Muramatsu T., Mayer U., Ballestrem C., Spatz J.P., and Humphries M.J. Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J Cell Biol 177 (2007) 527-538. Demonstration of the role of syndecan-4 in mediating directionally persistent migration by localizing active Rac1, in response to the ECM.
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J Cell Biol
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Bass, M.D.1
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Muramatsu, T.6
Mayer, U.7
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Humphries, M.J.10
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28
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Syndecan-4 clustering induces cell migration in a PDZ-dependent manner
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Tkachenko E., Elfenbein A., Tirziu D., and Simons M. Syndecan-4 clustering induces cell migration in a PDZ-dependent manner. Circ Res 98 (2006) 1398-1404
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Tkachenko, E.1
Elfenbein, A.2
Tirziu, D.3
Simons, M.4
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29
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1642545636
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Syndecan-4 regulates localization, activity and stability of protein kinase C-alpha
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Keum E., Kim Y., Kim J., Kwon S., Lim Y., Han I., and Oh E.S. Syndecan-4 regulates localization, activity and stability of protein kinase C-alpha. Biochem J 378 (2004) 1007-1014
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Keum, E.1
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Oh, E.S.7
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30
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PKCalpha-dependent activation of RhoA by syndecan-4 during focal adhesion formation
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Dovas A., Yoneda A., and Couchman J.R. PKCalpha-dependent activation of RhoA by syndecan-4 during focal adhesion formation. J Cell Sci 119 (2006) 2837-2846
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Dovas, A.1
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Couchman, J.R.3
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31
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p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4
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This study demonstrates the role of syndcan-4 in regulating Rho activation at the leading edge by inducing the redistribution of p190RhoGAP between the membrane and the cytosol.
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Bass M.D., Morgan M.R., Roach K.A., Settleman J., Goryachev A.B., and Humphries M.J. p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4. J Cell Biol 181 (2008) 1013-1026. This study demonstrates the role of syndcan-4 in regulating Rho activation at the leading edge by inducing the redistribution of p190RhoGAP between the membrane and the cytosol.
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J Cell Biol
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, pp. 1013-1026
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Bass, M.D.1
Morgan, M.R.2
Roach, K.A.3
Settleman, J.4
Goryachev, A.B.5
Humphries, M.J.6
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32
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60349109301
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Fibroblast growth factor-2 modulates melanoma adhesion and migration through a syndecan-4-dependent mechanism
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Chalkiadaki G., Nikitovic D., Berdiaki A., Sifaki M., Krasagakis K., Katonis P., Karamanos N.K., and Tzanakakis G.N. Fibroblast growth factor-2 modulates melanoma adhesion and migration through a syndecan-4-dependent mechanism. Int J Biochem Cell Biol 41 (2009) 1323-1331
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Int J Biochem Cell Biol
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Chalkiadaki, G.1
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Berdiaki, A.3
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Katonis, P.6
Karamanos, N.K.7
Tzanakakis, G.N.8
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33
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44949220276
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The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling
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Luyten A., Mortier E., Van Campenhout C., Taelman V., Degeest G., Wuytens G., Lambaerts K., David G., Bellefroid E.J., and Zimmermann P. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. Mol Biol Cell 19 (2008) 1594-1604
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Mol Biol Cell
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Luyten, A.1
Mortier, E.2
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Taelman, V.4
Degeest, G.5
Wuytens, G.6
Lambaerts, K.7
David, G.8
Bellefroid, E.J.9
Zimmermann, P.10
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34
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33748121374
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Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin
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This study shows that the modification of the syndecan HS-chains by heparanase works as an 'off-on' switch for the interaction between lacritin and syndecan-1.
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Ma P., Beck S.L., Raab R.W., McKown R.L., Coffman G.L., Utani A., Chirico W.J., Rapraeger A.C., and Laurie G.W. Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. J Cell Biol 174 (2006) 1097-1106. This study shows that the modification of the syndecan HS-chains by heparanase works as an 'off-on' switch for the interaction between lacritin and syndecan-1.
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J Cell Biol
, vol.174
, pp. 1097-1106
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Ma, P.1
Beck, S.L.2
Raab, R.W.3
McKown, R.L.4
Coffman, G.L.5
Utani, A.6
Chirico, W.J.7
Rapraeger, A.C.8
Laurie, G.W.9
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35
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Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma
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Mahtouk K., Hose D., Raynaud P., Hundemer M., Jourdan M., Jourdan E., Pantesco V., Baudard M., De Vos J., Larroque M., et al. Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma. Blood 109 (2007) 4914-4923
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Blood
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Mahtouk, K.1
Hose, D.2
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Hundemer, M.4
Jourdan, M.5
Jourdan, E.6
Pantesco, V.7
Baudard, M.8
De Vos, J.9
Larroque, M.10
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36
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58149091543
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Syndecan-1 ectodomain shedding is regulated by the small GTPase Rab5
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This study shows that the association of Rab5 with syndecan-1 cytoplasmic domain controls shedding and that the dissociation of the complex is agonist induced.
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Hayashida K., Stahl P.D., and Park P.W. Syndecan-1 ectodomain shedding is regulated by the small GTPase Rab5. J Biol Chem 283 (2008) 35435-35444. This study shows that the association of Rab5 with syndecan-1 cytoplasmic domain controls shedding and that the dissociation of the complex is agonist induced.
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J Biol Chem
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Hayashida, K.1
Stahl, P.D.2
Park, P.W.3
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37
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62349114465
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Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression
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Nikolova V., Koo C.Y., Ibrahim S.A., Wang Z., Spillmann D., Dreier R., Kelsch R., Fischgrabe J., Smollich M., Rossi L.H., et al. Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression. Carcinogenesis 30 (2009) 397-407
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Carcinogenesis
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Nikolova, V.1
Koo, C.Y.2
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Wang, Z.4
Spillmann, D.5
Dreier, R.6
Kelsch, R.7
Fischgrabe, J.8
Smollich, M.9
Rossi, L.H.10
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38
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34447500705
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Shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via FGF2 activation
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Su G., Blaine S.A., Qiao D., and Friedl A. Shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via FGF2 activation. J Biol Chem 282 (2007) 14906-14915
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J Biol Chem
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Su, G.1
Blaine, S.A.2
Qiao, D.3
Friedl, A.4
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39
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The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo
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This paper shows that, in Xenopus embryos, binding of FGF to syndecan-4 stimulates the secreted serine protease xHtrA1 mediated shedding of syndecan-4 and that these soluble FGF-syndecan-4 complexes act as a long-range signaling complex.
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Hou S., Maccarana M., Min T.H., Strate I., and Pera E.M. The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo. Dev Cell 13 (2007) 226-241. This paper shows that, in Xenopus embryos, binding of FGF to syndecan-4 stimulates the secreted serine protease xHtrA1 mediated shedding of syndecan-4 and that these soluble FGF-syndecan-4 complexes act as a long-range signaling complex.
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(2007)
Dev Cell
, vol.13
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Hou, S.1
Maccarana, M.2
Min, T.H.3
Strate, I.4
Pera, E.M.5
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40
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1542677095
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Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling
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Schulz J.G., Annaert W., Vandekerckhove J., Zimmermann P., De Strooper B., and David G. Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling. J Biol Chem 278 (2003) 48651-48657
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