Cyclosporin A inhibits apoptosis of human endothelial cells by preventing release of cytochrome C from mitochondria

Circulation

Volumn 98, Issue 12, 1998, Pages 1153-1157

  Walter, Dirk H ^b   Haendeler, Judith ^b   Galle, Jan ^b   Zeiher, Andreas M ^a   Dimmeler, Stefanie ^b  

^a GOETHE UNIVERSITY   (Germany)

^b NONE

Author keywords

Apoptosis; Atherosclerosis; Cells; Cyclosporin A; Endothelium; Lipoproteins

Indexed keywords

ANGIOTENSIN; CYCLOSPORIN A; CYTOCHROME C; LOW DENSITY LIPOPROTEIN; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MEMBRANE PERMEABILITY; MITOCHONDRION; PRIORITY JOURNAL;

EID: 0032558412     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.98.12.1153     Document Type: Article

References (23)

1. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320:915-924.
2. Ballantyne CM, Radovancevic B, Farmer JA, Frazier OH, Chandler L, Payton-Ross C, Cocanougher B, Jones PH, Young JB, Gotto AM. Hyperlipidemia after heart transplantation: report of a 6-year experience with treatment recommendations. J Am Coll Cardiol. 1992;19: 1315-1321.
3. Juckett MB, Balla J, Balla G, Jessurun J, Jacob HS, Vercellotti GM. Ferritin protects endothelial cells from oxidized low density lipoprotein in vitro. J Pathol. 1995;147:782-789.
4. Dimmeler S, Haendeler J, Galle J, Zeiher AM. Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases: a mechanistic clue to the response to injury hypothesis. Circulation. 1997;95:1760-1763.
5. Reed JC. Cytochrome c: can't live with it - can't live without it. Cell. 1997;91:559-562.
6. Kroemer G, Zamzami N, Susin SA. Mitochondrial control of apoptosis. Immunol Today. 1997;18:44-51.
7. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91: 479-489.
8. Drew AF, Tipping PG. Cyclosporine treatment reduces early atherosclerosis in cholesterol-fed rabbit. Atherosclerosis. 1995;116:181-189.
9. Andersen HO, Madsen G, Nordestgaard BG, Kjeldsen K, Stender S. Cyclosporin suppresses experimental transplant atherosclerosis. Transplant Proc. 1994;26:1738.
10. Valentine H, Hunt S, Gamberg P, Miller J, Luikart H. Impact of cyclosporine dose on long-term outcome after heart transplantation. Transplant Proc. 1994;26:2710-2712.
11. Zamzami N, Marchetti P, Castedo M, Hirsch T, Susin SA, Masse B, Kroemer G. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis. FEBS Lett. 1996;384:53-57.
12. Dimmeler S, Rippmann V, Weiland U, Haendeler J, Zeiher AM. Angiotensin II induces apoptosis of human endothelial cells: protective effect of nitric oxide. Circ Res. 1997;81:970-976.
13. Dimmeler S, Haendeler J, Nehls M, Zeiher AM. Suppression of apoptosis by nitric oxide via inhibition of ICE-like and CPP32-like proteases. J Exp Med. 1997;185:601-608.
14. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 1997;275:1132-1136.
15. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 1997;90:405-413.
16. Handa N, Hatanaka M, Baumgartner WA, Reitz BA, Sandford G, Esa AH, Herskowitz A. Late cyclosporine treatment ameliorates established coronary graft disease in rat allograft. Transplantation. 1993; 56:535-540.
17. Sarris GE, Moore KA, Schroeder JS, Hunt SA, Fowler MB, Valentine HA, Vagelos RH, Billingham ME, Oyer PH, Stinson EB, Reitz BA, Shumway NE. Cardiac transplantation: the Stanford experience in the cyclosporine era. J Thorac Cardiovasc Surg. 1994;108:240-252.
18. Valantine HA, Schroeder JS. HMG-CoA reductase inhibitors reduce transplant coronary artery disease and mortality: evidence for antigen-independent mechanisms? Circulation. 1997;96:1370-1373.
19. Wenke K, Meiser B, Thiery J, Nagel D, von Scheidt W, Steinbeck G, Seidel D, Reichart B. Simvastatin reduces graft vessel disease and mortality after heart transplantation: a four-year randomized trial. Circulation. 1997;96:1398-1402.
20. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med. 1997;3:614-620.
21. Zhivotovsky B, Orrenius S, Brustugun OD, Doskeland SO. Injected cytochrome c induces apoptosis. Nature. 1998;391:449-450.
22. Bellon JM, Bujan MJ, Jurado F, Hernando A, Ga-Honduvilla N, Dominguez B, Contreras L. Atherogenic effects of cyclosporine in an experimental model of arterial autograft. Transplantation. 1995;60: 407-414.
23. Roselaar SE, Schonfeld G, Daugherty A. Enhanced development of atherosclerosis in cholesterol-fed rabbits by suppression of cell-mediated immunity. J Clin Invest. 1995;96:1389-1394.