The toxic responses induced by okadaic acid involve processing of multiple caspase isoforms

Toxicon

Volumn 39, Issue 6, 2001, Pages 763-770

  Rossini, G P ^a   Sgarbi, N ^a   Malaguti, C ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Apoptosis; Cytotoxicity; Okadaic acid; Phycotoxin; Protein phoshatase

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 2; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; ENZYME PRECURSOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OKADAIC ACID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL LYSATE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME DEGRADATION; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROCESSING;

BLOTTING, WESTERN; CASPASES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; ISOENZYMES; OKADAIC ACID; PROTEIN PROCESSING, POST-TRANSLATIONAL; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0035178875     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(00)00202-6     Document Type: Article

References (41)

1. Death receptors: Signaling and modulation
2. Caspase activation in MCF7 cells responding to etoposide treatment
3. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases
4. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells
5. Caspases: The executioners of apoptosis
6. Protein phosphatases come of age
7. RAIDD is a new "death" adaptor molecule
8. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis
9. Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes
10. Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors
11. Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds
12. Protein phosphorylation in apoptosis
13. Apoptosis: Molecular regulation of cell death
14. Caspase 1-related protease inhibition retards the execution of okadaic acid- and camptothecin-induced apoptosis and PAI-2 cleavage, but not commitment to cell death in HL 60 cells
15. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
16. Caspase-3 is required for α-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis
17. Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis
18. Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A
19. Expression of transcriptional repressor protein mSin3A but not mSin3B is induced during neuronal apoptosis
20. A simple, rapid, and sensitive DNA assay procedure
21. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
22. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak
23. The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis
24. Protein serine/threonine phosphatases as binding proteins for okadaic acid
25. Caspases: Killer proteases
26. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
27. Neoplastic activity of DSP toxins
28. Inhibitors of phosphoprotein phosphatases 1 and 2A cause activation of a 53-kDa protein kinase accompanying the apoptotic response of breast cancer cells
29. Different sensitivities of p42 mitogen-activated protein kinase to phorbol ester and okadaic acid tumor promoters among cell types
30. Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells
31. Measurement of protein using bicinchoninic acid
32. L functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells
33. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product
34. Caspases: Enemies within
35. A combinatorial approach defines specificities of members of the caspase family and granzyme B
36. Apoptosis induction by inhibitors of ser/thr phosphatases 1 and 2A is associated with transglutaminase activation in two different human epithelial tumor lines
37. Serine/threonine protein phosphatases
38. Diarrhetic shellfish toxins
39. cdc2), cyclins A/B, and the tumor suppressor gene Rb in transformed cells by okadaic acid
40. Proteases in apoptosis