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Volumn 3, Issue 6, 2010, Pages 428-433

Doxorubicin toxicity can be ameliorated during antioxidant L-carnitine supplementation

Author keywords

Antioxidant agent; Doxorubicin; Gene expression; Hepatotoxicity; L carnitine

Indexed keywords

ALKALINITY; AMINO ACIDS; GENE EXPRESSION; PEPTIDES; PHOSPHATASES; POLYMERASE CHAIN REACTION;

EID: 79951534492     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.4161/oxim.3.6.14416     Document Type: Article
Times cited : (62)

References (57)
  • 1
    • 77953806921 scopus 로고    scopus 로고
    • Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model
    • Sayed-Ahmed MM, Al-Shabanah OA, Hafez MM, Aleisa AM, Al-Rejaie SS. Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model. Eur J Pharmacol 2010; 640:143-9.
    • (2010) Eur J Pharmacol , vol.640 , pp. 143-149
    • Sayed-Ahmed, M.M.1    Al-Shabanah, O.A.2    Hafez, M.M.3    Aleisa, A.M.4    Al-Rejaie, S.S.5
  • 3
    • 77957223613 scopus 로고    scopus 로고
    • Protection from doxorubicin-induced cardiomyopathy using the modified anthracycline N-benzyladriamycin-14-valerate (AD 198)
    • Cai C, Lothstein L, Morrison RR, Hofmann PA. Protection from doxorubicin-induced cardiomyopathy using the modified anthracycline N-benzyladriamycin-14-valerate (AD 198). J Pharmacol Exp Ther 2010; 335:223-30.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 223-230
    • Cai, C.1    Lothstein, L.2    Morrison, R.R.3    Hofmann, P.A.4
  • 4
    • 77956233231 scopus 로고    scopus 로고
    • Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect
    • Koka S, Das A, Zhu SG, Durrant D, Xi L, Kukreja RC. Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect. J Pharmacol Exp Ther 2010; 334:1023-30.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 1023-1030
    • Koka, S.1    Das, A.2    Zhu, S.G.3    Durrant, D.4    Xi, L.5    Kukreja, R.C.6
  • 5
    • 37349123107 scopus 로고    scopus 로고
    • Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway
    • DOI 10.1124/jpet.107.125773
    • Kim KH, Oudit GY, Backx PH. Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway. J Pharmacol Exp Ther 2008; 324:160-9. (Pubitemid 350294149)
    • (2008) Journal of Pharmacology and Experimental Therapeutics , vol.324 , Issue.1 , pp. 160-169
    • Kim, K.-H.1    Oudit, G.Y.2    Backx, P.H.3
  • 6
    • 34347394526 scopus 로고    scopus 로고
    • Collateral damage in cancer chemotherapy: Oxidative stress in nontargeted tissues
    • DOI 10.1124/mi.7.3.6
    • Chen Y, Jungsuwadee P, Vore M, Butterfield DA, St. Clair DK. Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues. Mol Interv 2007; 7:147-56. (Pubitemid 47026725)
    • (2007) Molecular Interventions , vol.7 , Issue.3 , pp. 147-156
    • Chen, Y.1    Jungsuwadee, P.2    Vore, M.3    Butterfield, D.A.4    St, C.D.K.5
  • 7
    • 77956455088 scopus 로고    scopus 로고
    • Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer
    • Essick EE, Sam F. Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer. Oxid Med Cell Longev 2010; 3:168-77.
    • (2010) Oxid Med Cell Longev , vol.3 , pp. 168-177
    • Essick, E.E.1    Sam, F.2
  • 8
    • 33646453495 scopus 로고    scopus 로고
    • Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver
    • Karaman A, Fadillioglu E, Turkmen E, Tas E, Yilmaz Z. Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver. Pediatr Surg Int 2006; 22:428-34.
    • (2006) Pediatr Surg Int , vol.22 , pp. 428-434
    • Karaman, A.1    Fadillioglu, E.2    Turkmen, E.3    Tas, E.4    Yilmaz, Z.5
  • 10
    • 77957658505 scopus 로고    scopus 로고
    • Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide
    • Kasapovic J, Pejic S, Stojiljkovic V, Todorovic A, Radosevic-Jelic L, Saicic ZS, et al. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. Clin Biochem 2010; 43:1287-93.
    • (2010) Clin Biochem , vol.43 , pp. 1287-1293
    • Kasapovic, J.1    Pejic, S.2    Stojiljkovic, V.3    Todorovic, A.4    Radosevic-Jelic, L.5    Saicic, Z.S.6
  • 11
    • 77957363916 scopus 로고    scopus 로고
    • Exogenous antioxidants - Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses
    • Bouayed J, Bohn T. Exogenous antioxidants - Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid Med Cell Longev 2010; 3:228-37.
    • (2010) Oxid Med Cell Longev , vol.3 , pp. 228-237
    • Bouayed, J.1    Bohn, T.2
  • 14
    • 70350463946 scopus 로고    scopus 로고
    • Carnitine in the treatment of valproic acid-induced toxicity
    • Phila
    • Lheureux PE, Hantson P. Carnitine in the treatment of valproic acid-induced toxicity. Clin Toxicol (Phila) 2009; 47:101-11.
    • (2009) Clin Toxicol , vol.47 , pp. 101-111
    • Lheureux, P.E.1    Hantson, P.2
  • 15
    • 77957353044 scopus 로고    scopus 로고
    • Carnitine deficiency and oxidative stress provoke cardiotoxicity in an ifosfamide-induced Fanconi syndrome rat model
    • Sayed-Ahmed MM, Darweesh AQ, Fatani AJ. Carnitine deficiency and oxidative stress provoke cardiotoxicity in an ifosfamide-induced Fanconi syndrome rat model. Oxid Med Cell Longev 2010; 3:266-74.
    • (2010) Oxid Med Cell Longev , vol.3 , pp. 266-274
    • Sayed-Ahmed, M.M.1    Darweesh, A.Q.2    Fatani, A.J.3
  • 16
    • 78751577615 scopus 로고    scopus 로고
    • The influence of L-carnitine suplementation on the antioxidative abilities of serum and the central nervous system of ethanol-induced rats
    • Augustyniak A, Skrzydlewska E. The influence of L-carnitine suplementation on the antioxidative abilities of serum and the central nervous system of ethanol-induced rats. Metab Brain Dis 2010.
    • (2010) Metab Brain Dis
    • Augustyniak, A.1    Skrzydlewska, E.2
  • 17
    • 84904846845 scopus 로고    scopus 로고
    • L-carnitine decreases oxidative stress induced by experimental hypobaric hypoxia
    • Bodea F, Bocea A, Decea N. [L-carnitine decreases oxidative stress induced by experimental hypobaric hypoxia]. Pediatr Endocrinol Diabetes Metab 2010; 16:78-81.
    • (2010) Pediatr Endocrinol Diabetes Metab , vol.16 , pp. 78-81
    • Bodea, F.1    Bocea, A.2    Decea, N.3
  • 18
    • 36949012725 scopus 로고    scopus 로고
    • The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: An overview
    • DOI 10.1007/s11064-007-9403-0
    • Liu J. The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. Neurochem Res 2008; 33:194-203. (Pubitemid 350242787)
    • (2008) Neurochemical Research , vol.33 , Issue.1 , pp. 194-203
    • Liu, J.1
  • 19
    • 79951521852 scopus 로고    scopus 로고
    • Protective effect of L-carnitine on experimental lead toxicity in rats: A clinical, histopathological and immunohistochemical study
    • Ozsoy S, Ozsoy B, Ozyildiz Z, Aytekin I. Protective effect of L-carnitine on experimental lead toxicity in rats: a clinical, histopathological and immunohistochemical study. Biotech Histochem 2010.
    • (2010) Biotech Histochem
    • Ozsoy, S.1    Ozsoy, B.2    Ozyildiz, Z.3    Aytekin, I.4
  • 20
    • 70349490367 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha plays a crucial role in L-carnitine anti-apoptosis effect in renal tubular cells
    • Chen HH, Sue YM, Chen CH, Hsu YH, Hou CC, Cheng CY, et al. Peroxisome proliferator-activated receptor alpha plays a crucial role in L-carnitine anti-apoptosis effect in renal tubular cells. Nephrol Dial Transplant 2009; 24:3042-9.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 3042-3049
    • Chen, H.H.1    Sue, Y.M.2    Chen, C.H.3    Hsu, Y.H.4    Hou, C.C.5    Cheng, C.Y.6
  • 21
    • 34249656771 scopus 로고    scopus 로고
    • The use of carnitine in pediatric nutrition
    • Crill CM, Helms RA. The use of carnitine in pediatric nutrition. Nutr Clin Pract 2007; 22:204-13.
    • (2007) Nutr Clin Pract , vol.22 , pp. 204-213
    • Crill, C.M.1    Helms, R.A.2
  • 22
    • 53749084068 scopus 로고    scopus 로고
    • Carnitine in metabolic disease: Potential for pharmacological intervention
    • Arduini A, Bonomini M, Savica V, Amato A, Zammit V. Carnitine in metabolic disease: potential for pharmacological intervention. Pharmacol Ther 2008; 120:149-56.
    • (2008) Pharmacol Ther , vol.120 , pp. 149-156
    • Arduini, A.1    Bonomini, M.2    Savica, V.3    Amato, A.4    Zammit, V.5
  • 23
    • 71149086727 scopus 로고    scopus 로고
    • Carnitine in parenteral nutrition
    • Borum PR. Carnitine in parenteral nutrition. Gastroenterology 2009; 137:129-34.
    • (2009) Gastroenterology , vol.137 , pp. 129-134
    • Borum, P.R.1
  • 24
    • 77954259596 scopus 로고    scopus 로고
    • Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity
    • Karanth J, Jeevaratnam K. Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity. Indian J Exp Biol 2010; 48:503-10.
    • (2010) Indian J Exp Biol , vol.48 , pp. 503-510
    • Karanth, J.1    Jeevaratnam, K.2
  • 25
    • 77954818479 scopus 로고    scopus 로고
    • The therapeutic prospects of using L-carnitine to manage hypertension-related organ damage
    • Mate A, Miguel-Carrasco JL, Vazquez CM. The therapeutic prospects of using L-carnitine to manage hypertension-related organ damage. Drug Discov Today 2010; 15:484-92.
    • (2010) Drug Discov Today , vol.15 , pp. 484-492
    • Mate, A.1    Miguel-Carrasco, J.L.2    Vazquez, C.M.3
  • 28
    • 78751698486 scopus 로고    scopus 로고
    • Treatment with carnitine, acetyl carnitine, l-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia
    • Morgante G, Scolaro V, Tosti C, Di Sabatino A, Piomboni P, De Leo V. [Treatment with carnitine, acetyl carnitine, l-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia]. Minerva Urol Nefrol 2010; 62:213-8.
    • (2010) Minerva Urol Nefrol , vol.62 , pp. 213-218
    • Morgante, G.1    Scolaro, V.2    Tosti, C.3    Di Sabatino, A.4    Piomboni, P.5    De Leo, V.6
  • 29
    • 43049183443 scopus 로고    scopus 로고
    • Platelet additive solutions: A future perspective
    • van der Meer PF. Platelet additive solutions: a future perspective. Transfus Clin Biol 2007; 14:522-5.
    • (2007) Transfus Clin Biol , vol.14 , pp. 522-525
    • Van Der Meer, P.F.1
  • 30
  • 31
    • 77954961184 scopus 로고    scopus 로고
    • Protective effect of tetrandrine on doxorubicin-induced cardiotoxicity in rats
    • Xu M, Sheng L, Zhu X, Zeng S, Chi D, Zhang GJ. Protective effect of tetrandrine on doxorubicin-induced cardiotoxicity in rats. Tumori 2010; 96:460-4.
    • (2010) Tumori , vol.96 , pp. 460-464
    • Xu, M.1    Sheng, L.2    Zhu, X.3    Zeng, S.4    Chi, D.5    Zhang, G.J.6
  • 32
    • 67349234999 scopus 로고    scopus 로고
    • Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
    • Danz ED, Skramsted J, Henry N, Bennett JA, Keller RS. Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway. Free Radic Biol Med 2009; 46:1589-97.
    • (2009) Free Radic Biol Med , vol.46 , pp. 1589-1597
    • Danz, E.D.1    Skramsted, J.2    Henry, N.3    Bennett, J.A.4    Keller, R.S.5
  • 35
    • 67349137097 scopus 로고    scopus 로고
    • Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver?
    • Firat O, Kirdok O, Makay O, Caliskan C, Yilmaz F, Ilgezdi S, et al. Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver? J Hepatobiliary Pancreat Surg 2009; 16:346-52.
    • (2009) J Hepatobiliary Pancreat Surg , vol.16 , pp. 346-352
    • Firat, O.1    Kirdok, O.2    Makay, O.3    Caliskan, C.4    Yilmaz, F.5    Ilgezdi, S.6
  • 36
    • 58949085093 scopus 로고    scopus 로고
    • The effect of doxorubicin on rats that received toxic and carcinogenic benzo(a)pyrene
    • Cosan D, Basaran A, Gunes HV, Degirmenci I, Aral E. The effect of doxorubicin on rats that received toxic and carcinogenic benzo(a)pyrene. Folia Histochem Cytobiol 2008; 46:367-72.
    • (2008) Folia Histochem Cytobiol , vol.46 , pp. 367-372
    • Cosan, D.1    Basaran, A.2    Gunes, H.V.3    Degirmenci, I.4    Aral, E.5
  • 37
    • 0022891180 scopus 로고
    • Serum carnitine during valproic acid therapy
    • Laub MC, Paetzke-Brunner I, Jaeger G. Serum carnitine during valproic acid therapy. Epilepsia 1986; 27:559-62. (Pubitemid 16026053)
    • (1986) Epilepsia , vol.27 , Issue.5 , pp. 559-562
    • Laub, M.C.1    Paetzke-Brunner, I.2    Jaeger, G.3
  • 39
    • 35449005177 scopus 로고    scopus 로고
    • Deficiency of the carnitine transporter (OCTN2) with partial N-acetylglutamate synthase (NAGS) deficiency
    • Hwu WL, Chien YH, Tang NL, Law LK, Lin CY, Lee NC. Deficiency of the carnitine transporter (OCTN2) with partial N-acetylglutamate synthase (NAGS) deficiency. J Inherit Metab Dis 2007; 30:816.
    • (2007) J Inherit Metab Dis , vol.30 , pp. 816
    • Hwu, W.L.1    Chien, Y.H.2    Tang, N.L.3    Law, L.K.4    Lin, C.Y.5    Lee, N.C.6
  • 40
    • 11944275346 scopus 로고    scopus 로고
    • L-carnitine inhibits hepatocarcinogenesis via protection of mitochondria
    • DOI 10.1002/ijc.20636
    • Chang B, Nishikawa M, Nishiguchi S, Inoue M. L-carnitine inhibits hepatocarcinogenesis via protection of mitochondria. Int J Cancer 2005; 113:719-29. (Pubitemid 40101252)
    • (2005) International Journal of Cancer , vol.113 , Issue.5 , pp. 719-729
    • Chang, B.1    Nishikawa, M.2    Nishiguchi, S.3    Inoue, M.4
  • 41
    • 26444451680 scopus 로고    scopus 로고
    • Protective agent, erdosteine, against cisplatin-induced hepatic oxidant injury in rats
    • DOI 10.1007/s11010-005-6630-z
    • Koc A, Duru M, Ciralik H, Akcan R, Sogut S. Protective agent, erdosteine, against cisplatin-induced hepatic oxidant injury in rats. Mol Cell Biochem 2005; 278:79-84. (Pubitemid 41418922)
    • (2005) Molecular and Cellular Biochemistry , vol.278 , Issue.1-2 , pp. 79-84
    • Koc, A.1    Duru, M.2    Ciralik, H.3    Akcan, R.4    Sogut, S.5
  • 43
    • 73449094974 scopus 로고    scopus 로고
    • Oxidative stress and antioxidant defense mechanisms linked to exercise during cardiopulmonary and metabolic disorders
    • Fisher-Wellman K, Bell HK, Bloomer RJ. Oxidative stress and antioxidant defense mechanisms linked to exercise during cardiopulmonary and metabolic disorders. Oxid Med Cell Longev 2009; 2:43-51.
    • (2009) Oxid Med Cell Longev , vol.2 , pp. 43-51
    • Fisher-Wellman, K.1    Bell, H.K.2    Bloomer, R.J.3
  • 44
    • 57849125020 scopus 로고    scopus 로고
    • Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer
    • Injac R, Perse M, Cerne M, Potocnik N, Radic N, Govedarica B, et al. Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer. Biomaterials 2009; 30:1184-96.
    • (2009) Biomaterials , vol.30 , pp. 1184-1196
    • Injac, R.1    Perse, M.2    Cerne, M.3    Potocnik, N.4    Radic, N.5    Govedarica, B.6
  • 45
    • 13944283745 scopus 로고    scopus 로고
    • Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin
    • Kalender Y, Yel M, Kalender S. Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin. Toxicology 2005; 209:39-45.
    • (2005) Toxicology , vol.209 , pp. 39-45
    • Kalender, Y.1    Yel, M.2    Kalender, S.3
  • 50
    • 77249101159 scopus 로고    scopus 로고
    • Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: Preliminary study
    • Zekri AR, Hafez MM, Bahnassy AA, Hassan ZK, Mansour T, Kamal MM, et al. Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: preliminary study. BMC Res Notes 2008; 1:106.
    • (2008) BMC Res Notes , vol.1 , pp. 106
    • Zekri, A.R.1    Hafez, M.M.2    Bahnassy, A.A.3    Hassan, Z.K.4    Mansour, T.5    Kamal, M.M.6
  • 51
    • 0030787406 scopus 로고    scopus 로고
    • Study of the effects of theophylline-related changes in total, free, short-chain acyl and long-chain acyl carnitine concentrations in rat heart
    • DOI 10.1016/S0300-483X(97)00067-X, PII S0300483X9700067X
    • Alhomida AS. Study of the effects of theophylline-related changes in total, free, short-chain acyl and long-chain acyl carnitine concentrations in rat heart. Toxicology 1997; 121:205-13. (Pubitemid 27296747)
    • (1997) Toxicology , vol.121 , Issue.3 , pp. 205-213
    • Alhomida, A.S.1
  • 52
    • 59649125048 scopus 로고    scopus 로고
    • Comparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine after single oral administration of L-carnitine in healthy volunteers
    • Cao Y, Wang YX, Liu CJ, Wang LX, Han ZW, Wang CB. Comparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine after single oral administration of L-carnitine in healthy volunteers. Clin Invest Med 2009; 32:13-9.
    • (2009) Clin Invest Med , vol.32 , pp. 13-19
    • Cao, Y.1    Wang, Y.X.2    Liu, C.J.3    Wang, L.X.4    Han, Z.W.5    Wang, C.B.6
  • 53
    • 0017067418 scopus 로고
    • Glutathione peroxidase activity in selenium-deficient rat liver
    • Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 1976; 71:952-8.
    • (1976) Biochem Biophys Res Commun , vol.71 , pp. 952-958
    • Lawrence, R.A.1    Burk, R.F.2
  • 55
    • 0016275313 scopus 로고
    • Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
    • Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249:7130-9.
    • (1974) J Biol Chem , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 56
    • 0023952554 scopus 로고
    • A simple method for clinical assay of superoxide dismutase
    • Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988; 34:497-500.
    • (1988) Clin Chem , vol.34 , pp. 497-500
    • Sun, Y.1    Oberley, L.W.2    Li, Y.3
  • 57
    • 0027518384 scopus 로고
    • A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction [1]
    • DOI 10.1016/0009-8981(93)90307-P
    • Durak I, Yurtarslanl Z, Canbolat O, Akyol O. A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clin Chim Acta 1993; 214:103-4. (Pubitemid 23055374)
    • (1993) Clinica Chimica Acta , vol.214 , Issue.1 , pp. 103-104
    • Durak, I.1    Yurtarslanl, Z.2    Canbolat, O.3    Akyol, O.4


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