The effect of doxorubicin on rats that received toxic and carcinogenic benzo(a)pyrene

Folia Histochemica et Cytobiologica

Volumn 46, Issue 3, 2008, Pages 367-372

  Cosan, Didem ^a,b   Basaran, Ayse ^a   Gunes, Hasan Veysi ^a   Degirmenci, Irfan ^a   Aral, Erinc ^a  

^a ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Benzo(a)pyrene; Catalase; Doxorubicin; Kidney; Liver; Malondialdehyde; Rat; Serum; Superoxide dismutase

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BENZO[A]PYRENE; CATALASE; CORN OIL; CREATINE; CREATININE; DOXORUBICIN; MALONALDEHYDE; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; UREA DERIVATIVE; URIC ACID; ANTINEOPLASTIC ANTIBIOTIC; CARCINOGEN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD CHEMISTRY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; CREATININE URINE LEVEL; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; KIDNEY DISEASE; KIDNEY FUNCTION; LIVER DISEASE; LIVER FUNCTION; MALE; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; UREA NITROGEN BLOOD LEVEL; URIC ACID URINE LEVEL; URINALYSIS; ANIMAL; DRUG EFFECT; KIDNEY; LIVER; METABOLISM; PATHOLOGY;

RATTUS; ZEA MAYS;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BENZO(A)PYRENE; CARCINOGENS; DOXORUBICIN; KIDNEY; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 58949085093     PISSN: 02398508     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10042-008-0048-x     Document Type: Article

References (29)

1. Cavalieri EL, Roman EG, Devanesan PD, Cremonesi P, Cerny RL, Groos ML, Bodell WJ. Binding of benzo(a)pyrene to DNA by cytochrome P-450 catalyzed one-electron oxidation in rat liver microsomes and nuclei. Biochemistry. 1990; 29:4820-4827.
2. Fujita I, Sindhu RK, Kikkawa Y. Hepatic cytochrome P450 enzyme imprinting in adult rat by neonetal benzo(a)pyrene administration. Pediatr Res. 1995;37:646-651.
3. Garner RC, Stanton CA, Martin CN, Harris CC, Grafstrom RC. Rat and human explant metabolism, binding studies, and DNA adduct analysis of benzo(a)pyrene and its 6-nitro derivative. Cancer Res. 1985;45:6225-6231.
4. Obi FO, Billett MA. Preferential binding of the carcinogen benzo(a)pyrene to proteins of the nuclear matrix. Carcinogenesis. 1991;12:481-486.
5. Phillips DH. Fifty years of benzo(a)pyrene. Nature. 1983; 303:468-472.
6. Willems MI, Roggeband R, Baan RA, Wilmer JW, De Raat WK, Lohman PH. Monitoring the exposure of rats to benzo(a)pyrene by the determination of mutagenic activity in excreta, chorosome aberrations and sister chromatid exchanges in peripheral blood cells, and DNA adducts in peripheral blood lymphocytes and liver. Mutagenesis. 1991; 6:151-158.
7. Tudek B, Bird RP, Bruce WR. Foci of abberant crypts in the colons of mice and rats exposed to carcinogens associated with foods. Cancer Res. 1989;49:1236-1240.
8. Rudo KM, Dauterman WC, Langenbach R. Human and rat kidney cell metabolism of 2- acetylaminofluorene and benzo(a)pyrene. Cancer Res. 1989;49:1187-1192.
9. Tan B, Chu FL. Effects of palm carotenoids in rat hepatic cytochrome P450 - mediated benzo(a)pyrene metabolism. Am J Clin Nutr. 1991;53:1071S-1075S.
10. Bevan DR, Manger WE. Effect of particulates on metabolism and mutagenicity of benzo(a) pyrene. Mutagenesis. 1985;56: 13-28.
11. Nanno M, Morotomi M, Takayama H, Kuroshima T, Tanaka R, Mutai M. Mutagenic activation of biliary metabolites of benzo(a)pyrene by - glucuronidase - positive bacteria in human faeces. J Med Microbiol. 1986;22:351-355.
12. Utesch D, Glatt H, Oesch F. Rat hepatocyte-mediated bacterial mutagenicity in relation to the carcinogenic potency of benzo(a)anthracene, and twenty-five methylated derivatives. Cancer Res. 1987;47:1509-1515.
13. Raiczyk BG, Pinto J. Inhibition of flavin metabolism by adriamycin in skeletal muscle. Biochem Pharmacol. 1988;37:1741-1744.
14. Okasora T, Takikawa T, Utsunomiya Y, Senoh I, Hayashibara H, Shiraki K, Kasagi T, Shimizu F. Suppressive effect of superoxide dismutase on adriamycin nephropathy. Nephron. 1992;60:199-203.
15. Rosselli F, Zaccaro L, Venturi M, Rossi AM. Persistence of drug -induced chromosome aberrations in peripheral blood lymphocytes of the rat. Mutat Res. 1990;232:107-114.
16. Mycek MJ, Harvey RA, Champe PC, Fisher BD, Cooper M, Berkman K. Lippincott's Illustrated Reviews Pharmacology. 1997; 2nd edition, Lippincott-Raven, Philadelphia.
17. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988;34:497-500.
18. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351-358.
19. Goth L. A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta. 1991;196:143-151.
20. Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper's Biochemistry. 1990; 22nd Ed., Appleton & Lange, San Mateo, CA.
21. Chen R-M, Chou MC Queen T-H. Induction of cytochrome P450 1A in hamster liver and lung by 6-Nitrochrysene. Arch Toxicol. 1998;72:395-401.
22. Valentovic MA, Alejandro N, Betts Carpenter A, Brown PI, Ramos K. Streptozotocin (STZ) diabetes enhances benzo(alpha)pyrene induced renal injury in Sprague Dawley rats. Toxicol Lett. 2006;164:214-220.
23. Nagano N, Miyata S, Obana S, Ozai M, Kobayashi N, Fukushima N, Burke SK, Wada M. Sevelamer hydrochloride (Renagel), a non-calcaemic phosphate binder, arrest parathyroid gland gland hyperplasia in rats with progressive chronic renal insufficiency. Nephrol Dial Transplant. 2001;16:1870-1878.
24. Oz E, Ilhan M. Effects of melatonin in reducing the toxic effects of doxorubicin. Mol Cell Biochem. 2006;286:11-15.
25. Lakshmi B, Ajith TA, Jose N, Janardhanan KK. Antimutagenic activity of methanolic extract of ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene. J Ethnopharmacol. 2006;107:297-303.
26. Kunitomo M, Yamaguchi Y, Matsushima K, Futagawa Y, Bando Y. Hyperlipidemic effects of adriamycin in rats. Jpn J Pharmacol. 1985;39:323-329.
27. Kim HS, Kwack SJ, Lee BM. Lipid peroxidation, antioxidant enzymes, and benzo[a]pyrene-quinones in the blood of rats treated with benzo[a]pyrene. Chem Biol Interact. 2000;127: 139-150.
28. Kim KB, Lee BM. Oxidative stress to DNA, protein, and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo(a)pyrene. Cancer Lett. 1997;113:205-212.
29. Kaya E, Keskin K, Aydogdu I, Kuku I, Bayraktar N, Erkut MA. Oxidant/ antioxidant parameters and their relationship with chemotherapy in Hodgkin's lymphoma. J Int Med Res. 2005;33:687-692.