Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver

Pediatric Surgery International

Volumn 22, Issue 5, 2006, Pages 428-434

  Karaman, Abdurrahman ^a   Fadillioglu, Ersin ^a   Turkmen, Emine ^a   Tas, Erkan ^a   Yilmaz, Zumrut ^a  

^a INONU UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Antioxidants; Ischemia reperfusion; Leflunomide; Liver; Myeloperoxidase; Oxidant

Indexed keywords

CARBONYL DERIVATIVE; CATALASE; IMMUNOMODULATING AGENT; LEFLUNOMIDE; MALONALDEHYDE; MYELOPEROXIDASE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TERIFLUNOMIDE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HEMORRHAGIC SHOCK; HISTOLOGY; INFLAMMATION; LEUKOCYTE ACTIVATION; LIVER CELL DAMAGE; LIVER FAILURE; LIVER INJURY; LIVER ISCHEMIA; LIVER PROTECTION; LIVER RESECTION; LIVER TRANSPLANTATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; FEMALE; HEPATOCYTES; ISOXAZOLES; LIVER; MALONDIALDEHYDE; NEUTROPHIL ACTIVATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; SUPEROXIDE DISMUTASE;

EID: 33646453495     PISSN: 01790358     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00383-006-1668-x     Document Type: Article

References (55)

1. Allan T, Takashi K, Atsunori N, Lifang S et al (2005) Ethyl pyruvate ameliorates liver ischemia-reperfusion injury by decreasing hepatic necrosis and apoptosis. Transplantation 79:196-204
2. De Tata V, Brizi S, Saviozzi M, Lazzarotti A et al (2005) Protective role of dehydroascorbate in rat liver ischemia-reperfusion injury. J Surg Res 123:215-221
3. Liu DL, Jeppsson B, Hakansson CH et al (1996) Multiplesystem organ damage resulting from prolonged hepatic inflow interruption. Arch Surg 131:442
4. Lemasters JJ, Thurman RG (1997) Reperfusion injury after liver preservation for transplantation. Annu Rev Pharmacol Toxicol 37:327-338
5. Olthoff KM (2001) Can reperfusion injury of the liver be prevented? Trying to improve on a good thing. Pediatr Transplant 5:390-393
6. Man K, Ng KT, Lee TK, Lo Cm et al (2005) FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers. Am J Transplant 5:40-49
7. Jaeschke H (2000) Reactive oxygen and mechanisms of inflammatory liver injury. J Gastroenterol Hepatol 15:718-724
8. Fondevila C, Shen X, Tsuchiyashi S, Yamashita K et al (2004) Biliverdin therapy protects rat livers from ischemia and reperfusion injury. Hepatology 40:1333-1341
9. McCord JM (1985) Oxygen-derived free radicals in postischemic tissue injury. N Engl Med 312:159-163
10. Farber JL, Kyle ME, Coleman JB (1990) Mechanisms of cell injury by activated oxygen species. Lab Invest 62:670-679
11. Hensley K, Robinson KA, Gabbita SP, Salsman S, Floyd RA (2000) Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 28:1456-1462
12. Kurokawa T, Nonami T, Harada A, Nakao A, Takagi H (1996) Mechanism and prevention of ischemia-reperfusion injury of the liver. Semin Surg Oncol 12:179-182
13. Sanders S, Harisdangkul V. (2002) Leflunomide for the treatment of rheumatoid arthritis and autoimmunity. Am J Med Sci 323:190-193
14. Osiri M, Shea B, Robinson V, Suarez-Almazor M et al (2003) Leflunomide for the treatment of rheumatoid arthritis: a systematic review and metaanalysis. J Rheumatol 30:1182-1190
15. Williams JW, Mital D, Chong A, Kottayil A et al (2002) Experiences with leflunomide in solid organ transplantation. Transplantation 73:358-366
16. Kessel A, Toubi E (2002) Leflunomide in systemic lupus erythematosus. Harefuah 141:355-357
17. Prajapati DN, Knox JF, Emmons J, Saeian K et al (2003) Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy. J Clin Gastroenterol 37:125-128
18. Breedveld FC, Dayer JM (2000) Leflunomide: mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis 59:841-849
19. Herrmann ML, Schleyerbach R, Kirschbaum BJ (2000) Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Immunopharmacology 47:273-289
20. Li WD, Ran GX, Teng HL, Lin ZB (2002) Dynamic effects of leflunomide on IL-1, IL-6, and TNF-an activity produced from peritoneal macrophages in adjuvant arthritis rats. Acta Pharmacol Sin 23:752-756
21. Bartlett RR, Anagnostopulos H, Zielinski T, Mattar T, Schleyerbach R (1993) Effects of lefunomide on immune responses and models of inflammation. Springer Semin Immunopathol 14:381-394
22. Irmak MK, Koltuksuz U, Kutlu NO et al (2001) The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with alpha-tocopherol in rat kidneys. Urol Res 29:190-193
23. Lowry O, Rosenbraugh N, Farr L, Rondall R (1951) Protein measurement with the folin-phenol reagent. J Biol Chem 183:265-275
24. Aebi H (1974) Catalase. In: Bergmeyer HU (eds) Methods of enzymatic analysis. Academic, New York, pp 673-677
25. Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497-500
26. Prajda N, Weber G (1975) Malign transformation-linked imbalance: decreased XO activity in hepatomas. FEBS Lett 59:245-249
27. Cortas NK, Wakid NW (1990) Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 36:1440-1443
28. Esterbauer H, Cheeseman KH (1990) Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal. In: Packer L, Glazer AN (eds) Methods in enzymology, vol 186. Oxygen radicals in biological systems. Academic, New York, pp 407-421
29. Levine RL, Garland D, Oliver CN, Amici A et al (1990) Determination of carbonyl content in oxidatively modified proteins. In: Packer L, Glazer AN (eds) Methods in enzymology, vol 186. Oxygen radicals in biological systems. Academic, New York, pp 464-478
30. Wei H, Frenkel K (1993) Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis 14:1195-1201
31. Suzuki S, Toledo-Pereyra LH, Rodriguez FJ, Cejalvo D (1993) Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. Transplantation 55:1265-1272
32. Aydemir EO, Var A, Uyanik BS, Ilkgul Ö et al (2003) The protective mechanisms of defibrotide on liver ischaemia-reperfusion injury. Cell Biochem Funct 21:307-310
33. Galley HF, Richardson N, Howdle PD, Walker BE, Webster NR (1995) Total antioxidant capacity and lipid peroxidation during liver transplantation. Clin Sci 89:329-332
34. Goode HF, Webster NR, Howdle PD, Leek JP, Lodge JP (1994) Reperfusion injury, antioxidants and hemodynamics during orthotopic liver transplantation. Hepatology 19:354-359
35. Arii S, Teramoto K, Kawamura T (2003) Current progress in the understanding of and therapeutic strategies for ischemia and reperfusion injury of the liver. J Hepatobiliary Pancreat Surg 10:189-194
36. McCord JM (1985) Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312:159-163
37. Adkins D, Hollwarth ME, Benoit JN, Parks DA et al (1986) Role of free radicals in ischemia-reperfusion injury to the liver. Acta Physiol Scand Suppl 548:101-107
38. Tomizawa N, Ohwada S, Ohya T, Kawashima Y et al (1999) The effect of neutrophil elastase inhibitor in hepatectomy with ischemia in dogs. J Surg Res 81:230-237
39. Shen YC, Chen CF, Sung YJ (1999) Tetrandrine ameliorates ischaemiareperfusion injury of rat myocardium through inhibition of neutrophil priming and activation. Br J Pharmacol 128:1593-1601
40. Hansen PR (1995) Role of neutrophils in myocardial ischemia and reperfusion. Circulation 91:1872-1885
41. Manna SK, Aggarwal BB (1999) Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kB activation and gene expression. J Immunol 162:2095-2102
42. Manna SK, Mukhopadhyay A, Aggarwal BB (2000) Leflunomide suppresses TNF-induced cellular responses: effects on NF-kB, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J Immunol 165:5962-5969
43. Krawisz JE, Sharon P, Stenson WF (1984) Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology 87:1334-1350
44. Liu Z, Xu Z, Shen W, Li Y et al (2004) Effect of pharmacologic preconditioning with tetrandrine on subsequent ischemia/reperfusion injury in rat liver. World J Surg 28:620-624
45. Slater TF (1984) Free-radical mechanisms in tissue injury. Biochem J 222:1
46. Taha MO, Carvalho CA, Souza HS, Fagundes DJ (2004) Cytoprotective effects of alpha-tocopherol on ischemia/reperfusion injury in rat liver: biochemical and histological evaluation. Transplant Proc 36:276-282
47. Busse R, Mulsch A (1990) Calcium-dependent nitric oxide synthesis in endothelial cells is mediated by nitric oxide: a cytotoxic activated macrophage effector molecule. FEBS Lett 265:133-136
48. Gaboury J, Woodman R, Granger D, Reinhardt P, Kubes P (1993) Nitric oxide prevents leukocyte adherence: a role of superoxide. Am J Physiol 265:862-867
49. Zweir JL, Wang P, Samouilov A, Kuppusamy P (1995) Enzyme-independent formation of nitric-oxide in biological tissues. Nat Med 1:804-809
50. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624
51. Demir S, Inal-Erden M (1998) Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury. Clin Chim Acta 275:127-135
52. Elkayam O, Yaron I, Shirazi I et al (2003) Active leflunomide metabolite inhibits interleukin 1b, tumour necrosis factor a, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures. Ann Rheum Dis 62:440-443
53. Reddy SVB, Wanchu A, Khullar M et al (2005) Leflunomide reduces nitric oxide production in patients with active rheumatoid arthritis. Int Immunopharmacol 5:1085-1090
54. Yao HW, Li J, Jin Y et al (2003) Effect of leflunomide on immunological liver injury in mice. World J Gastroenterol 9:320-923
55. Yao HW, Li J, Chen JO, Xu SU (2004) Inhibitory effect of leflunomide on hepatic fibrosis induced by CCl4 in rats. Acta Pharmacol Sin 25:915-920