The influence of L-carnitine suplementation on the antioxidative abilities of serum and the central nervous system of ethanol-induced rats

Metabolic Brain Disease

Volumn 25, Issue 4, 2010, Pages 381-389

  Augustyniak, Agnieszka ^a   Skrzydlewska, Elzbieta ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Antioxidants; Brain; Ethanol; L carnitine; Lipid peroxidation; Protein oxidation; Rats; Serum

Indexed keywords

4 HYDROXYNONENAL; ALCOHOL; ALPHA TOCOPHEROL; ASCORBIC ACID; CARNITINE; COPPER; DRINKING WATER; GLUTATHIONE; GLUTATHIONE DISULFIDE; LIPID HYDROPEROXIDE; MALONALDEHYDE; RETINOL; SUPEROXIDE DISMUTASE; TRYPTOPHAN; ZINC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SERUM;

ALDEHYDES; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BIOLOGICAL MARKERS; BRAIN CHEMISTRY; CARNITINE; CATALASE; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LIPID PEROXIDATION; LIPID PEROXIDES; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; VITAMIN A; VITAMIN E;

RATTUS;

EID: 78751577615     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-010-9217-7     Document Type: Article

References (57)

1. YU Adachi K Watanabe H Higuchi T Satoh ES Vizi 2001 Oxygen inhalation enhances striatal dopamine metabolism and monoamineoxidase enzyme inhibition prevents it: a microdialysis study Eur. J. Pharmacol. 422 61 68 1:CAS:528:DC%2BD3MXks1Olu78%3D 10.1016/S0014-2999(01)01074-3 11430914 (Pubitemid 32595575)
2. H Aebi 1984 Catalase in Vitro Methods Enzymol. 105 121 127 1:CAS:528:DyaL2cXltVKis7s%3D 10.1016/S0076-6879(84)05016-3 6727660
3. A Agarwal TM Said 2004 Carnitines and male infertility Reprod. Biomed. Online. 8 376 384 1:CAS:528:DC%2BD2cXjslygu7w%3D 10.1016/S1472-6483(10)60920-0 15149558
4. R Berger DS Sachan 1991 Effects of supplementary levels of L-carnitine on blood and urinary carnitines and on the portal- systemic blood ethanol concentration in the rat J. Nutr. Biochem. 2 282 286 10.1016/0955-2863(91)90097- O
5. TM Berger MC Polidori J Morrow PJ Evans B Halliwell JD Morrow LJ Roberts B Frei 1997 Antioxidant activity of vitamin C in iron-overloaded human plasma J. Biol. Chem. 272 15656 15660 1:CAS:528:DyaK2sXktFCgtL0%3D 10.1074/jbc.272.25. 15656 9188455 (Pubitemid 27265535)
6. F Bosch-Morell L Flohe N Marin FJ Romero 1999 4-Hydroxynonenal inhibits glutathione peroxidase: protection by glutathione Free Radic. Biol. Med. 26 1383 1387 1:STN:280:DyaK1MzivFyntg%3D%3D 10.1016/S0891-5849(98)00335-9 10401601 (Pubitemid 29302270)
7. I Bykov H Järveläinen K Lindros 2003 L-Carnitine alleviates alcohol-induced liver damage in rats: role of tumour necrosis factor-alpha Alcohol Alcohol. 38 400 406 1:CAS:528:DC%2BD3sXmsVGgs78%3D 12915513
8. GD Castro MH Costantini JA Castro 2009 Rat ventral prostate xanthine oxidase-mediated metabolism of acetaldehyde to acetyl radical Hum. Exp. Toxicol. 28 203 208 1:CAS:528:DC%2BD1MXht1yltrjI 10.1177/0960327109105406 19734271
9. YS Cha DS Sachan 1995 Acetylcarnitine-mediated inhibition of ethanol oxidation in hepatocytes Alcohol 12 289 294 1:CAS:528:DyaK2MXmsVGqurc%3D 10.1016/0741-8329(95)00007-E 7639964
10. A De Leenher V De Bevere MG De Rutyer AC Claeys 1979 Simultaneous determination of retinol and α-tocopherol in human serum by HPLC J. Chromatogr. A 162 408 413
11. N Derin VN Izgut-Uysal A Agac Y Aliciguzel N Demir 2004 L-carnitine protects gastric mucosa by decreasing ischemia -reperfusion induced lipid peroxidation J. Physiol. Pharmacol. 55 595 606 1:CAS:528:DC%2BD2cXptlKhtrw%3D 15381830
12. SA Devi MV Subramanyam R Vani K Jeevaratnam 2005 Adaptations of the antioxidant system in erythrocytes of trained adult rats: impact of intermittent hypobaric-hypoxia at two altitudes Comp. Biochem. Physiol. C Toxicol. Pharmacol. 140 59 67 10.1016/j.cca.2005.01.003 (Pubitemid 40409880)
13. I Gulcin 2006 Antioxidant and antiradical activities of L-carnitine Life Sci. 78 803 811 10.1016/j.lfs.2005.05.103 16253281 (Pubitemid 43082302)
14. JW Heinecke 2002 Tyrosyl radical production by myeloperoxidase: a phagocyte pathway for lipid peroxidation and dityrosine cross-linking of proteins Toxicology 177 11 22 1:CAS:528:DC%2BD38Xlt1OksLs%3D 10.1016/S0300-483X(02)00192-0 12126792 (Pubitemid 34786241)
15. D Ivanovic A Popovic D Radulovic M Medenica 1999 Reversed phase ion-pair HPLC determination of some water-soluble vitamins in pharmaceuticals J. Pharm. Biomed. Anal. 18 999 1004 1:CAS:528:DyaK1MXnvF2mtQ%3D%3D 10.1016/S0731-7085(98) 00109-5 9925335 (Pubitemid 29012421)
16. JA Joseph B Shukitt-Hale G Casadesus D Fisher 2005 Oxidative stress and inflammation in brain aging: nutritional considerations Neurochem. Res. 30 927 935 1:CAS:528:DC%2BD2MXhtVektLbM 10.1007/s11064-005-6967-4 16187227 (Pubitemid 41413949)
17. ME Jung JW Simpkins AM Wilson HF Downey RT Mallet 2008 Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn rats J. Appl. Physiol. 105 510 517 10.1152/japplphysiol.90317. 2008 18499779
18. M Kerman B Cirak FM Ozguner A Dagtekin R Sutcu I Altuntas N Delibas 2005 Does melatonin protect or treat brain damage from traumatic oxidative stress? Exp Brain Res. 163 406 410 1:CAS:528:DC%2BD2MXkvVClurc%3D 10.1007/s00221-005- 2338-2 (Pubitemid 41175264)
19. M Kinter R Roberts 1996 Glutathione consumption and glutathione peroxidase inactivation in fibroblast cell lines by 4HNE Free Radic. Biol. Med. 21 457 462 1:CAS:528:DyaK28XlvVWrtLY%3D 10.1016/0891-5849(96)00128-1 8886795 (Pubitemid 26313941)
20. P Klivenyi OA Andreassen RJ Ferrante A Dedeoglu G Mueller E Lancelot M Bogdanov JK Andersen D Jiang MF Beal 2000 Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1, 2, 5, 6-Tetrahydropyridine J. Neurosci. 20 1 7 1:CAS:528:DC%2BD3cXhtF2itb4%3D 10627575
21. D Liu F Bao J Wen J Liu 2007 Mutation of superoxide dismutase elevates reactive species: comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis Neuroscience 146 255 264 10.1016/j.neuroscience.2007.01.028 17368952 (Pubitemid 46654601)
22. D Londero PL Greco 1996 Automated HPLC separation with spectrofluorometric detection of malondialdehyde-thiobarbituric acid adduct in plasma J. Chromatogr. A 729 207 210 1:CAS:528:DyaK28XjtFeht7c%3D 10.1016/0021-9673(95)00959-0 9004941 (Pubitemid 26135017)
23. MA Lovell WD Ehmann SM Butler WR Markesbery 1995 Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease Neurology 45 1594 1601 1:CAS:528:DyaK2MXns1SisL8%3D 7644059
24. I Matalliotakis Y Koumantaki A Evageliou G Matalliotakis A Goumenou S Koumantaki 2000 L-carnitine levels in the seminal plasma of fertile and infertile men: correlation with sperm quality Int. J. Fertil. Womens Med. 45 236 240 1:CAS:528:DC%2BD3cXlvVOltrY%3D 10929687
25. TJ Mauch TM Donohue RK Zetterman MF Sorrel DJ Tuma 1986 Covalent binding of acetaldehyde selectivity inhibits the catalytic activity of lysine-dependent enzymes Hepatology 6 263 269 1:CAS:528:DyaL28XhvVWmtLY%3D 10.1002/hep.1840060218 2937708
26. C Michiels M Raes O Toussaint J Remacle 1994 Importance of Se-glutathione peroxidase, catalase and Cu/Zn SOD for cell survival against oxidative stress Free Radic. Biol. Med. 17 235 248 1:CAS:528:DyaK2cXmslOitLg%3D 10.1016/0891-5849(94)90079-5 7982629
27. HP Misra I Fridovich 1972 The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase J. Biol. Chem. 247 3170 3175 1:CAS:528:DyaE38XhsFSntLk%3D 4623845
28. CE Mize RG Langdon 1962 Hepatic glutathione reductase. Purification and general kinetic properties J. Biol. Chem. 237 1589 1595 1:CAS:528:DyaF3sXktFyq 14474846
29. AD Muthuswamy K Vedagiri M Ganesan P Chinnakannu 2006 Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of L-carnitine and DL-alpha-lipoic acid Clin. Chim. Acta 368 84 92 1:CAS:528:DC%2BD28Xlt1Clsrg%3D 10.1016/j.cca.2005.12.010 16480704 (Pubitemid 43776025)
30. P Navasumrit TH Ward NJF Dodd PJ O'Connor 2000 Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants: effects of acute and chronic ethanol exposure Carcinogenesis 21 93 99 1:CAS:528:DC%2BD3cXhtValtbg%3D 10.1093/carcin/21.1.93 10607739
31. DE Paglia WN Valentine 1967 Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase J. Lab. Clin. Med. 70 58 169
32. BC Ponnappa E Rubin 2000 Modeling Alcohol's effects on organs in animal models Alcohol Res. Health 24 93 104 1:STN:280:DC%2BD3M7isFSjtQ%3D%3D 11199283
33. P Pronko L Bardina V Satanovskaya A Kuzmich S Zimatkin 2002 Effect of chronic alcohol consumption on the ethanol- and acetaldehyde-metabolizing systems in the rat gastrointestinal tract Alcohol Alcohol. 37 229 235 1:CAS:528:DC%2BD38Xks1Ogt7k%3D 12003909
34. PJ Rani C Panneerselvam 2001 Carnitine as a free radical scavenger and aging Exp. Gerontol. 36 1713 1726 10.1016/S0531-5565(01)00116-4 (Pubitemid 32982875)
35. AZ Resnik VE Kagan R Ramsey 1992 Antiradical effects of L-propionyl carnitine protection of the heart against ischemia reperfusion injury: the possible role of iron chelation Arch. Biochem. Biophys. 296 394 401 10.1016/0003-9861(92)90589-O
36. Rice-Evans CA, Diplock AT, Symons MCR (1991) Techniques in free radical research. Laboratory Techniques in Biochemistry and Molecular Biology, Elsevier, Amsterdam, In
37. CA Rottkamp A Nunomura AK Raina LM Sayre G Perry MA Smith 2000 Oxidative stress, antioxidant, and Alzheimer disease Alzheimer Dis. Assoc. Disord. 14 62 66 10.1097/00002093-200000001-00010 (Pubitemid 30406774)
38. DS Sachan R Berger 1987 Attenuation of ethanol metabolism by supplementary carnitine in rats Alcohol 4 31 35 1:CAS:528:DyaL2sXhvFGisLg%3D 10.1016/0741-8329(87)90057-7 3828061 (Pubitemid 17033520)
39. DS Sachan YS Cha 1994 Acetylcarnitine inhibits alcohol dehydrogenase Biochem. Biophys. Res. Commun. 103 1496 1501 10.1006/bbrc.1994.2354 (Pubitemid 24321532)
40. SMH Sadrzadeh Y Saffari 2004 Iron and Brain Disorders Am. J. Clin. Pathol. 121 S64 S70 10.1309/XLNDTE289WAQYK0Y 15298151
41. NE Savaskan AU Bräuer M Kühbacher IY Eyüpoglu A Kyriakopoulos O Ninnemann D Behne R Nitsch 2002 Selenium deficiency increases susceptibility to glutamate-induced excitotoxicity FASEB J. online 1 1 17
42. S Shila V Kokilavani M Subathra C Panneerselvam 2005 Brain regional responses in antioxidant system to alpha-lipoic acid in arsenic intoxicated rat Toxicology 210 25 36 1:CAS:528:DC%2BD2MXivVejsrs%3D 10.1016/j.tox.2005.01.003 15804455 (Pubitemid 40459639)
43. WG Siems H Zoller T Grune H Esterbauer 1997 Metabolic fate of 4HNE in hepatocytes: 1, 4-dihydroxynonene is not the main product J. Lipid Res. 38 612 622 1:CAS:528:DyaK2sXis12qsbg%3D 9101442
44. N Signorini-Allibe B Gonthier F Lamarche H Eysseric L Barret 2005 Chronic consumption of ethanol leads to substantial cell damage in cultured rat astrocytes in conditions promoting acetaldehyde accumulation Alcohol Alcohol. 40 163 171 1:CAS:528:DC%2BD2MXjtlegu78%3D 15767272
45. LL Smith BH Johnson 1989 Biological activities of oxysterols Free Radic. Biol. Med. 7 285 332 1:CAS:528:DyaK3MXksVChu7Y%3D 10.1016/0891-5849(89)90136-6 2673947 (Pubitemid 19234179)
46. M Somville A Houben M Raes A Houbion V Henin J Remacle 1985 Alteration of enzymes in ageing human fibroblasts in culture. III. Modification of superoxide dismutase as an environmental and reversible process Mech. Ageing Dev. 29 35 51 1:CAS:528:DyaL2MXhsVKltb0%3D 10.1016/0047-6374(85)90045-4 3982081 (Pubitemid 15128549)
47. ER Stadtman RL Levine 2003 Free radical-mediated oxidation of free amino acids and amino acid residues in proteins Amino Acids 25 207 218 1:CAS:528:DC%2BD3sXpsFOntL8%3D 10.1007/s00726-003-0011-2 14661084 (Pubitemid 38043943)
48. AY Sun GY Sun 2001 Ethanol and oxidative mechanisms in the brain J. Biomed. Sci. 8 37 43 1:CAS:528:DC%2BD3MXhtVeitbo%3D 10.1007/BF02255969 11173974
49. A Sykes FX McCormac Jr TJ O'Brien 1978 Preliminary study of the superoxide dismutase content of some human tumors Cancer Res. 38 2759 2762 1:CAS:528:DyaE1cXlsVCksLg%3D 679181
50. S Tokumaru I Tsukamoto H Iguchi S Kojo 1995 Specific and sensitive determination of lipid hydroperoxides with chemical derivatization into 1-naphthyldiphenylphosphine oxide and HPLC Anal. Chim. Acta. 307 97 102 1:CAS:528:DyaK2MXlvFKjt7k%3D 10.1016/0003-2670(95)00045-2
51. H Tsukaguchi T Tokui B Mackenzie UV Berger XZ Chen Y Wang RF Brubaker MA Hediger 1999 A family of mammalian Na∈+∈-dependent L-ascorbic acid transporters Nature 399 70 75 1:CAS:528:DyaK1MXjt1Olsbs%3D 10.1038/19986 10331392 (Pubitemid 29226048)
52. SC Upadhya V Ravindranath 2002 Detection and localization of protein-acetaldehyde adducts in rat brain after chronic ethanol treatment Alcohol Clin. Exp. Res. 26 856 863 1:CAS:528:DC%2BD38XlslCls74%3D 12068255
53. P Venkataraman K Selvakumar G Krishnamoorthy S Muthusami R Rameshkumar S Prakash J Arunakaran 2010 Effect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats Neurosci. Res. 66 189 197 1:CAS:528:DC%2BC3cXhtVKht7s%3D 10.1016/j.neures.2009.10.015 19914309
54. P Walter AO Schaffhauser 2000 L-Carnitine, a 'vitamin-like substance' for functional food Ann. Nutr. Metab. 44 75 96 1:CAS:528:DC%2BD3cXnt12gtLg%3D 10.1159/000012825 10970996
55. DS Warner H Sheng I Batinic-Haberle 2004 Oxidants, antioxidants and the ischemic brain J. Exp. Biol. 207 3221 3231 1:CAS:528:DC%2BD2cXovF2ku70%3D 10.1242/jeb.01022 15299043 (Pubitemid 39275296)
56. RA Winters J Zukowski N Ercal RH Matthews DR Spitz 1995 Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by N-(1-pyrenyl)maleimide Anal. Biochem. 277 14 21 10.1006/abio.1995.1246
57. K Yoshino T Matsuura M Sano SCh Saito I Tomita 1986 Fluorometric liquid chromatographic of aliphatic aldehydes arising from lipid peroxides Chem. Pharm. Bull. 34 1694 1700 1:CAS:528:DyaL28XkvFert7k%3D 3719870