-
1
-
-
4243413100
-
Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors
-
PCT Patent WO95/01338;
-
Amschler H. Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors. PCT Patent WO95/01338; 1995.
-
(1995)
-
-
Amschler, H.1
-
2
-
-
0035084103
-
Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro
-
Hatzelmann A., Schudt C. Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J Pharmacol Exp Ther 2001, 297:267-279.
-
(2001)
J Pharmacol Exp Ther
, vol.297
, pp. 267-279
-
-
Hatzelmann, A.1
Schudt, C.2
-
3
-
-
3342988190
-
Preferential inhibition of T helper1, but not T helper2, cytokines in vitro by L-826,141[4-[2-(3,4-Bisdiflurome thoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]3- methylpyridine-1-oxide], a potent and selective phosphodiesterase 4 inhibitor
-
Claveau D., Chen S.L., O'Keefe S., Zaller D.M., Styhler A., Liu S. Preferential inhibition of T helper1, but not T helper2, cytokines in vitro by L-826,141[4-[2-(3,4-Bisdiflurome thoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]3- methylpyridine-1-oxide], a potent and selective phosphodiesterase 4 inhibitor. J Pharmacol Exp Ther 2004, 310:752-760.
-
(2004)
J Pharmacol Exp Ther
, vol.310
, pp. 752-760
-
-
Claveau, D.1
Chen, S.L.2
O'Keefe, S.3
Zaller, D.M.4
Styhler, A.5
Liu, S.6
-
4
-
-
33845764714
-
Dose-proportional intraindividual single- and repeated-dose pharmacokinetics of roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor
-
Bethke T.D., Bohmer G.M., Hermann R., Hauns B., Fux R., Morike K., et al. Dose-proportional intraindividual single- and repeated-dose pharmacokinetics of roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor. J Clin Pharmacol 2007, 47:26-36.
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 26-36
-
-
Bethke, T.D.1
Bohmer, G.M.2
Hermann, R.3
Hauns, B.4
Fux, R.5
Morike, K.6
-
5
-
-
77953105482
-
The preclinical pharmacology of roflumilast: A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
-
Hatzelmann A., Morcillo E.J., Lungarella G., Adnot S., Sanjar S., Beume R., et al. The preclinical pharmacology of roflumilast: A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2010, 23:235-256.
-
(2010)
Pulm Pharmacol Ther
, vol.23
, pp. 235-256
-
-
Hatzelmann, A.1
Morcillo, E.J.2
Lungarella, G.3
Adnot, S.4
Sanjar, S.5
Beume, R.6
-
7
-
-
65749115739
-
The role of animal models in the pharmacological evaluation of emerging anti-inflammatory agents for the treatment of COPD
-
Fox J.C., Fitzgerald M.F. The role of animal models in the pharmacological evaluation of emerging anti-inflammatory agents for the treatment of COPD. Curr Opin Pharmacol 2009, 9:231-242.
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 231-242
-
-
Fox, J.C.1
Fitzgerald, M.F.2
-
8
-
-
51949100548
-
Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice
-
Martorana P.A., Lunghi B., Lucattelli M., De C.G., Beume R., Lungarella G. Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice. BMC Pulm Med 2008, 8:17.
-
(2008)
BMC Pulm Med
, vol.8
, pp. 17
-
-
Martorana, P.A.1
Lunghi, B.2
Lucattelli, M.3
De, C.G.4
Beume, R.5
Lungarella, G.6
-
9
-
-
84882900325
-
-
AcademicPress, Amsterdam
-
Shore S.A., Shapiro S.D. Asthma and COPD: animal models. Asthma and COPD, basic mechanisms and clinical management 2008, AcademicPress, Amsterdam, p. 99-109.
-
(2008)
Asthma and COPD: animal models. Asthma and COPD, basic mechanisms and clinical management
, pp. 99-109
-
-
Shore, S.A.1
Shapiro, S.D.2
-
11
-
-
77953090227
-
Roflumilast but not methylprednisolone inhibited cigarette smoke-induced pulmonary inflammation in Guinea pigs
-
Fitzgerald M.F., Spicer D., McAulay A.E., Wollin L., Beume R. Roflumilast but not methylprednisolone inhibited cigarette smoke-induced pulmonary inflammation in Guinea pigs. Eur Respir J Suppl 2006, (Suppl 663):P3850.
-
(2006)
Eur Respir J Suppl
, Issue.SUPPL 663
-
-
Fitzgerald, M.F.1
Spicer, D.2
McAulay, A.E.3
Wollin, L.4
Beume, R.5
-
12
-
-
25444476938
-
Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke
-
Martorana P.A., Beume R., Lucattelli M., Wollin L., Lungarella G. Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke. Am J Respir Crit Care Med 2005, 172:848-853.
-
(2005)
Am J Respir Crit Care Med
, vol.172
, pp. 848-853
-
-
Martorana, P.A.1
Beume, R.2
Lucattelli, M.3
Wollin, L.4
Lungarella, G.5
-
13
-
-
77953117539
-
Therapeutic effects of various PDE4 inhibitors on cigarette smoke-induced pulmonary neutrophilia in mice
-
Weidenbach A., Braun C., Schwoebel F., Beume R., Marx D. Therapeutic effects of various PDE4 inhibitors on cigarette smoke-induced pulmonary neutrophilia in mice. Am J Respir Crit Care Med 2008, 178:A651.
-
(2008)
Am J Respir Crit Care Med
, vol.178
-
-
Weidenbach, A.1
Braun, C.2
Schwoebel, F.3
Beume, R.4
Marx, D.5
-
14
-
-
47249112549
-
The selective MMP-12 inhibitor, AS111793 reduces airway inflammation in mice exposed to cigarette smoke
-
Le Q.C., Guenon I., Gillon J.Y., Valenca S., Cayron-Elizondo V., Lagente V., et al. The selective MMP-12 inhibitor, AS111793 reduces airway inflammation in mice exposed to cigarette smoke. Br J Pharmacol 2008, 154:1206-1215.
-
(2008)
Br J Pharmacol
, vol.154
, pp. 1206-1215
-
-
Le, Q.C.1
Guenon, I.2
Gillon, J.Y.3
Valenca, S.4
Cayron-Elizondo, V.5
Lagente, V.6
-
15
-
-
77953095767
-
Characterisation of a model that mimicks aspects of the hyper-inflammatory response observed during an acute exacerbation of COPD
-
Hardaker E.L., Freeman M.S., Dale N., Raza F., Mok J., Banner K.H., et al. Characterisation of a model that mimicks aspects of the hyper-inflammatory response observed during an acute exacerbation of COPD. Am J Respir Crit Care Med 2009, 179:A5351.
-
(2009)
Am J Respir Crit Care Med
, vol.179
-
-
Hardaker, E.L.1
Freeman, M.S.2
Dale, N.3
Raza, F.4
Mok, J.5
Banner, K.H.6
-
16
-
-
65449171997
-
Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury
-
Cortijo J., Iranzo A., Milara X., Mata M., Cerdá-Nicolás M., Ruiz-Saurí A., et al. Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury. Br J Pharmacol 2009, 156:534-544.
-
(2009)
Br J Pharmacol
, vol.156
, pp. 534-544
-
-
Cortijo, J.1
Iranzo, A.2
Milara, X.3
Mata, M.4
Cerdá-Nicolás, M.5
Ruiz-Saurí, A.6
-
17
-
-
35348853161
-
Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability
-
Sanz M.J., Cortijo J., Taha M.A., Cerdá-Nicolás M., Schatton E., Burgbacher B., et al. Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability. Br J Pharmacol 2007, 152:481-492.
-
(2007)
Br J Pharmacol
, vol.152
, pp. 481-492
-
-
Sanz, M.J.1
Cortijo, J.2
Taha, M.A.3
Cerdá-Nicolás, M.4
Schatton, E.5
Burgbacher, B.6
-
18
-
-
77953104656
-
Effects of roflumilast and other PDE4 inibitors on human CD8 p T-cell functions
-
Tenor H., Burgbacher B., Schudt C., Hatzelmann A. Effects of roflumilast and other PDE4 inibitors on human CD8 p T-cell functions. Eur Respir J Suppl 2005, 26:S717.
-
(2005)
Eur Respir J Suppl
, vol.26
-
-
Tenor, H.1
Burgbacher, B.2
Schudt, C.3
Hatzelmann, A.4
-
19
-
-
77953086126
-
The PDE4 inhibitor roflumilast N-oxide partly reversed TGFß1-induced changes in collagen I and E-cadherin expression in human airway epithelial cells
-
Milara J., Cortijo J., Mata M., Donet E., Mauricio M., Morcillo E.J. The PDE4 inhibitor roflumilast N-oxide partly reversed TGFß1-induced changes in collagen I and E-cadherin expression in human airway epithelial cells. Eur Respir J Suppl 2008, (Suppl 639):P3648.
-
(2008)
Eur Respir J Suppl
, Issue.SUPPL 639
-
-
Milara, J.1
Cortijo, J.2
Mata, M.3
Donet, E.4
Mauricio, M.5
Morcillo, E.J.6
-
20
-
-
77953088524
-
A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro
-
Sabatini F., Petecchia L., Boero S., Silvestri M., Klar J., Tenor H., et al. A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro. Pulm Pharmacol Ther 2010, 23:283-291.
-
(2010)
Pulm Pharmacol Ther
, vol.23
, pp. 283-291
-
-
Sabatini, F.1
Petecchia, L.2
Boero, S.3
Silvestri, M.4
Klar, J.5
Tenor, H.6
-
21
-
-
33748047115
-
A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro
-
Burgess J.K., Oliver B.G., Poniris M.H., Ge Q., Boustany S., Cox N., et al. A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro. J Allergy Clin Immunol 2006, 118:649-657.
-
(2006)
J Allergy Clin Immunol
, vol.118
, pp. 649-657
-
-
Burgess, J.K.1
Oliver, B.G.2
Poniris, M.H.3
Ge, Q.4
Boustany, S.5
Cox, N.6
-
22
-
-
23644436736
-
Efficacy of the PDE4 inhibitor, BAY 19-8004, in tobacco smoke models of COPD in the Guinea pig
-
Fox J.C., Spicer D., Henning R., Meshi B., Shrad M.T., Hogg J.C. Efficacy of the PDE4 inhibitor, BAY 19-8004, in tobacco smoke models of COPD in the Guinea pig. Am J Respir Crit Care Med 2003, 167:A91.
-
(2003)
Am J Respir Crit Care Med
, vol.167
-
-
Fox, J.C.1
Spicer, D.2
Henning, R.3
Meshi, B.4
Shrad, M.T.5
Hogg, J.C.6
-
23
-
-
11844249945
-
The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro
-
Jones N.A., Boswell-Smith V., Lever R., Page C.P. The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro. Pulm Pharmacol Ther 2005, 18:93-101.
-
(2005)
Pulm Pharmacol Ther
, vol.18
, pp. 93-101
-
-
Jones, N.A.1
Boswell-Smith, V.2
Lever, R.3
Page, C.P.4
-
24
-
-
77953118447
-
Roflumilast N-oxide inhibits NADPH oxidase expression and activity in human pulmonary artery smooth muscle cells
-
Muzaffar S., Shukla N., Angelini G.D., Jeremy J.Y. Roflumilast N-oxide inhibits NADPH oxidase expression and activity in human pulmonary artery smooth muscle cells. Proc Br Pharmacol Soc 2008, 6:027P.
-
(2008)
Proc Br Pharmacol Soc
, vol.6
-
-
Muzaffar, S.1
Shukla, N.2
Angelini, G.D.3
Jeremy, J.Y.4
-
25
-
-
62749171705
-
Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling
-
Namkoong S., Kim C.K., Cho Y.L., Kim J.H., Lee H., Ha K.S., et al. Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling. Cell Signal 2009, 21:906-915.
-
(2009)
Cell Signal
, vol.21
, pp. 906-915
-
-
Namkoong, S.1
Kim, C.K.2
Cho, Y.L.3
Kim, J.H.4
Lee, H.5
Ha, K.S.6
-
26
-
-
36048937539
-
Squamous metaplasia amplifies pathologic epitheliale mesenchymal interactionsin COPD patients
-
Araya J., Cambier S., Markovics J.A., Wolters P., Jablons D., Hill A. Squamous metaplasia amplifies pathologic epitheliale mesenchymal interactionsin COPD patients. J Clin Invest 2007, 117:3551-3562.
-
(2007)
J Clin Invest
, vol.117
, pp. 3551-3562
-
-
Araya, J.1
Cambier, S.2
Markovics, J.A.3
Wolters, P.4
Jablons, D.5
Hill, A.6
-
27
-
-
0034948521
-
Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis
-
Borzone G., Moreno R., Urrea R., Meneses M., Oyarzun M., Lisboa C. Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2001, 163:1648-1653.
-
(2001)
Am J Respir Crit Care Med
, vol.163
, pp. 1648-1653
-
-
Borzone, G.1
Moreno, R.2
Urrea, R.3
Meneses, M.4
Oyarzun, M.5
Lisboa, C.6
-
28
-
-
33645290774
-
Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model
-
Chaudhary N.I., Schnapp A., Park J.E. Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model. Am J Respir Crit Care Med 2006, 173:769-776.
-
(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 769-776
-
-
Chaudhary, N.I.1
Schnapp, A.2
Park, J.E.3
-
29
-
-
0036014828
-
PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels
-
Kohyama T., Liu X., Wen F.Q., Zhu Y.K., Wang H., Kim H.J. PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels. Am J Respir Cell Mol Biol 2002, 26:694-701.
-
(2002)
Am J Respir Cell Mol Biol
, vol.26
, pp. 694-701
-
-
Kohyama, T.1
Liu, X.2
Wen, F.Q.3
Zhu, Y.K.4
Wang, H.5
Kim, H.J.6
-
30
-
-
2942562534
-
Cytokines modulate cilomilast response in lung fibroblasts
-
Kohyama T., Liu X., Wen F.Q., Kobayashi T., Fang Q., Abe S. Cytokines modulate cilomilast response in lung fibroblasts. Clin Immunol 2004, 111:297-302.
-
(2004)
Clin Immunol
, vol.111
, pp. 297-302
-
-
Kohyama, T.1
Liu, X.2
Wen, F.Q.3
Kobayashi, T.4
Fang, Q.5
Abe, S.6
-
32
-
-
67649873075
-
Effects of roflumilast, a phosphodiesterase-4 inhibitor, on hypoxia- and monocrotaline-induced pulmonary hypertension in rats
-
Izikki M., Raffestin B., Klar J., Hatzelmann A., Marx D., Tenor H., et al. Effects of roflumilast, a phosphodiesterase-4 inhibitor, on hypoxia- and monocrotaline-induced pulmonary hypertension in rats. J Pharmacol Exp Ther 2009, 330:54-62.
-
(2009)
J Pharmacol Exp Ther
, vol.330
, pp. 54-62
-
-
Izikki, M.1
Raffestin, B.2
Klar, J.3
Hatzelmann, A.4
Marx, D.5
Tenor, H.6
-
33
-
-
0026354677
-
Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai
-
Schudt C., Winder S., Forderkunz S., Hatzelmann A., Ullrich V. Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai. Naunyn Schmiedebergs Arch Pharmacol 1991, 344:682-690.
-
(1991)
Naunyn Schmiedebergs Arch Pharmacol
, vol.344
, pp. 682-690
-
-
Schudt, C.1
Winder, S.2
Forderkunz, S.3
Hatzelmann, A.4
Ullrich, V.5
-
34
-
-
2942720573
-
The nature of small-airway obstruction in chronic obstructive pulmonary disease
-
Hogg J.C., Chu F., Utokaparch S., Woods R., Elliott W.M., Buzatu L., et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004, 350:2645-2653.
-
(2004)
N Engl J Med
, vol.350
, pp. 2645-2653
-
-
Hogg, J.C.1
Chu, F.2
Utokaparch, S.3
Woods, R.4
Elliott, W.M.5
Buzatu, L.6
-
35
-
-
18244367647
-
COPD, a multicomponent disease: Implications for management
-
Agusti A.G. COPD, a multicomponent disease: Implications for management. Respir Med 2005, 99:670-682.
-
(2005)
Respir Med
, vol.99
, pp. 670-682
-
-
Agusti, A.G.1
-
37
-
-
77953113594
-
Effect of roflumilast, a PDE4 inhibitor on ciliary beat frequency in human nasal epithelial cells
-
Milara J., Cortijo J., Armengot M., Banuls P., Gabarda E., Morcillo E. Effect of roflumilast, a PDE4 inhibitor on ciliary beat frequency in human nasal epithelial cells. Eur Respir J Suppl 2008, (Suppl 639):P3651.
-
(2008)
Eur Respir J Suppl
, Issue.SUPPL 639
-
-
Milara, J.1
Cortijo, J.2
Armengot, M.3
Banuls, P.4
Gabarda, E.5
Morcillo, E.6
-
38
-
-
77953107370
-
Stimulation of CFTR-dependent chloride secretion by roflumilast
-
Pedemonte N., Galietta L. Stimulation of CFTR-dependent chloride secretion by roflumilast. Eur Respir J Suppl 2008, (Suppl 644):P3672.
-
(2008)
Eur Respir J Suppl
, Issue.SUPPL 644
-
-
Pedemonte, N.1
Galietta, L.2
-
39
-
-
13544273183
-
Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells
-
Mata M., Sarria B., Buenestado A., Cortijo J., Cerdá M., Morcillo E.J. Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells. Thorax 2005, 60:144-152.
-
(2005)
Thorax
, vol.60
, pp. 144-152
-
-
Mata, M.1
Sarria, B.2
Buenestado, A.3
Cortijo, J.4
Cerdá, M.5
Morcillo, E.J.6
-
40
-
-
79851471608
-
Steroid insensitivity in a shortterm model of cigarette smoke induced pulmonary inflammation in mice
-
Weidenbach A., Braun C., Schwoebel F., Beume R., Marx D. Steroid insensitivity in a shortterm model of cigarette smoke induced pulmonary inflammation in mice. Am J Respir Crit Care Med 2008, 177:A651.
-
(2008)
Am J Respir Crit Care Med
, vol.177
-
-
Weidenbach, A.1
Braun, C.2
Schwoebel, F.3
Beume, R.4
Marx, D.5
-
41
-
-
69249123772
-
Current status of research on osteoporosis in COPD: A systematic review
-
Graat-Verboom L., Wouters E.F., Smeenk F.W., Van den Borne B.E., Lunde R., Spruit M.A. Current status of research on osteoporosis in COPD: A systematic review. Eur Respir J 2009, 34:209-218.
-
(2009)
Eur Respir J
, vol.34
, pp. 209-218
-
-
Graat-Verboom, L.1
Wouters, E.F.2
Smeenk, F.W.3
Van den Borne, B.E.4
Lunde, R.5
Spruit, M.A.6
-
42
-
-
34547868158
-
Rolipram, a phosphodiesterase 4 inhibitor, prevented cancellous and cortical bone loss by inhibiting endosteal bone resorption and maintaining the elevated periosteal bone formation in adult ovariectomized rats
-
Yao W., Tian X.Y., Chen J., Setterberg R.B., Lundy M.W., Chmielzwski P., et al. Rolipram, a phosphodiesterase 4 inhibitor, prevented cancellous and cortical bone loss by inhibiting endosteal bone resorption and maintaining the elevated periosteal bone formation in adult ovariectomized rats. J Musculoskelet Neuronal Interact 2007, 7:119-130.
-
(2007)
J Musculoskelet Neuronal Interact
, vol.7
, pp. 119-130
-
-
Yao, W.1
Tian, X.Y.2
Chen, J.3
Setterberg, R.B.4
Lundy, M.W.5
Chmielzwski, P.6
-
43
-
-
67349238305
-
Inhibition of osteoblastic bone formation by nuclear factor-kappaB
-
Chang J., Wang Z., Tang E., Fan Z., McCauley L., Franceschi R., et al. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med 2009, 15:682-689.
-
(2009)
Nat Med
, vol.15
, pp. 682-689
-
-
Chang, J.1
Wang, Z.2
Tang, E.3
Fan, Z.4
McCauley, L.5
Franceschi, R.6
-
44
-
-
28544448461
-
Phosphodiesterase 4 inhibition reduces skeletal muscle atrophy
-
Hinkle R.T., Dolan E., Cody D.B., Bauer M.B., Isfort R.J. Phosphodiesterase 4 inhibition reduces skeletal muscle atrophy. Muscle Nerve 2005, 32:775-781.
-
(2005)
Muscle Nerve
, vol.32
, pp. 775-781
-
-
Hinkle, R.T.1
Dolan, E.2
Cody, D.B.3
Bauer, M.B.4
Isfort, R.J.5
-
45
-
-
1342264246
-
Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)
-
O'Donnell J.M., Zhang H.T. Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4). Trends Pharmacol Sci 2004, 25:158-163.
-
(2004)
Trends Pharmacol Sci
, vol.25
, pp. 158-163
-
-
O'Donnell, J.M.1
Zhang, H.T.2
-
46
-
-
34547418119
-
Insulin resistance and inflammation: A further systemic complication of COPD
-
Bolton C.E., Evans M., Ionescu A.A., Edwards S.M., Morris R.H., Dunseath G., et al. Insulin resistance and inflammation: A further systemic complication of COPD. COPD 2007, 4:121-126.
-
(2007)
COPD
, vol.4
, pp. 121-126
-
-
Bolton, C.E.1
Evans, M.2
Ionescu, A.A.3
Edwards, S.M.4
Morris, R.H.5
Dunseath, G.6
-
47
-
-
55949119217
-
The metabolic syndrome, diabetes and lung dysfunction
-
Tiengo A., Fadini G.P., Avogaro A. The metabolic syndrome, diabetes and lung dysfunction. Diabetes Metab 2008, 34:447-454.
-
(2008)
Diabetes Metab
, vol.34
, pp. 447-454
-
-
Tiengo, A.1
Fadini, G.P.2
Avogaro, A.3
-
48
-
-
51249111507
-
Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets
-
Waddleton D., Wu W., Feng Y., Thompson C., Wu M., Zhou Y.P., et al. Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Biochem Pharmacol 2008, 76:884-893.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 884-893
-
-
Waddleton, D.1
Wu, W.2
Feng, Y.3
Thompson, C.4
Wu, M.5
Zhou, Y.P.6
-
49
-
-
70349898505
-
The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon- like peptide- 1 release
-
Ong W.K., Gribble F.M., Reimann F., Lynch M.J., Houslay M.D., Baillie G.S., et al. The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon- like peptide- 1 release. Br J Pharmacol 2009, 157:633-644.
-
(2009)
Br J Pharmacol
, vol.157
, pp. 633-644
-
-
Ong, W.K.1
Gribble, F.M.2
Reimann, F.3
Lynch, M.J.4
Houslay, M.D.5
Baillie, G.S.6
-
50
-
-
67649667009
-
Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B
-
Zhang R., Maratos-Flier E., Flier J.S. Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B. Endocrinology 2009, 150:3076-3082.
-
(2009)
Endocrinology
, vol.150
, pp. 3076-3082
-
-
Zhang, R.1
Maratos-Flier, E.2
Flier, J.S.3
-
51
-
-
77953099921
-
The use of PDE4D in the screening for medicaments against atherosclerosis
-
PCT Patent WO2004/ 090157;.
-
Evers S, Fingerle J, Himber J, Gretarsdottir S, Gulcher J. The use of PDE4D in the screening for medicaments against atherosclerosis. PCT Patent WO2004/ 090157; 2004.
-
(2004)
-
-
Evers, S.1
Fingerle, J.2
Himber, J.3
Gretarsdottir, S.4
Gulcher, J.5
-
52
-
-
0031045482
-
Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD
-
Keatings V.M., Jatakanon A., Worsdell Y.M., Barnes P.J. Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med 1997, 155:542-548.
-
(1997)
Am J Respir Crit Care Med
, vol.155
, pp. 542-548
-
-
Keatings, V.M.1
Jatakanon, A.2
Worsdell, Y.M.3
Barnes, P.J.4
-
53
-
-
9744220302
-
Cigarette smoke alters chromatine modelin gand induces proinflammatory genes inratlungs
-
Marwick J.A., Kirkham P.A., Stevenson C.S., Danahay H., Giddings J., Butler K. Cigarette smoke alters chromatine modelin gand induces proinflammatory genes inratlungs. Am J Respir Cell Mol Biol 2004, 31:633-642.
-
(2004)
Am J Respir Cell Mol Biol
, vol.31
, pp. 633-642
-
-
Marwick, J.A.1
Kirkham, P.A.2
Stevenson, C.S.3
Danahay, H.4
Giddings, J.5
Butler, K.6
-
54
-
-
65249151877
-
Inhibition of PI3Kdelta restores glucocorticoid functionin smoking- induced airway inflammation in mice
-
Marwick J.A., Caramori G., Stevenson C.S., Casolari P., Jazrawi E., Barnes P.J. Inhibition of PI3Kdelta restores glucocorticoid functionin smoking- induced airway inflammation in mice. Am J Respir Crit Care Med 2009, 179:542-548.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 542-548
-
-
Marwick, J.A.1
Caramori, G.2
Stevenson, C.S.3
Casolari, P.4
Jazrawi, E.5
Barnes, P.J.6
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