Synthesis of optically pure 4-fluoro-glutamines as potential metabolic imaging agents for tumors

Journal of the American Chemical Society

Volumn 133, Issue 4, 2011, Pages 1122-1133

  Qu, Wenchao ^a   Zha, Zhihao ^a   Ploessl, Karl ^a   Lieberman, Brian P ^a   Zhu, Lin ^a   Wise, David R ^a,b   Thompson, Craig B ^a,b   Kung, Hank F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

18-CROWN-6; ALTERNATIVE ENERGY SOURCE; CELL UPTAKE; FLUORINE-18; GLIOBLASTOMAS; HIGH YIELD; IN-VIVO IMAGING; METABOLIC IMAGING; OPTICAL PURITY; POTENTIAL APPLICATIONS; SYNTHETIC ROUTES; THREE COMPONENT REACTIONS; TUMOR CELLS;

AMINO ACIDS; CROWN ETHERS; FLUORINE; ORGANIC POLYMERS; SYNTHESIS (CHEMICAL); TUMORS;

POSITRON EMISSION TOMOGRAPHY;

4 FLUOROGLUTAMINE DERIVATIVE; CROWN ETHER DERIVATIVE; GLUTAMINE DERIVATIVE; POTASSIUM BICARBONATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; FLUORINATION; OPTICAL ROTATION; POSITRON EMISSION TOMOGRAPHY; TUMOR; TUMOR CELL LINE;

BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; GLUTAMINE; HALOGENATION; HUMANS; ISOTOPE LABELING; MOLECULAR IMAGING; NEOPLASMS; OPTICAL PROCESSES; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 79851483342     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja109203d     Document Type: Article

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