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Volumn 25, Issue 2, 2011, Pages 236-245

Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress

Author keywords

acute leukemia; mass spectrometry; nucleus; PKR; post translational modification

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE R;

EID: 79751528879     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.264     Document Type: Article
Times cited : (40)

References (38)
  • 1
    • 0017180822 scopus 로고
    • Interferon-induced inhibition of protein synthesis in L-cell extracts: An ATP-dependent step in the activation of an inhibitor by double-stranded RNA
    • Roberts WK, Clemens MJ, Kerr IM. Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA. Proc Natl Acad Sci USA 1976; 73: 3136-3140.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 3136-3140
    • Roberts, W.K.1    Clemens, M.J.2    Kerr, I.M.3
  • 2
    • 0033230617 scopus 로고    scopus 로고
    • PKR; A sentinel kinase for cellular stress
    • Williams BR. PKR; a sentinel kinase for cellular stress. Oncogene 1999; 18: 6112-6120.
    • (1999) Oncogene , vol.18 , pp. 6112-6120
    • Williams, B.R.1
  • 5
    • 77951880589 scopus 로고    scopus 로고
    • New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses
    • Yoon CH, Miah MA, Kim KP, Bae YS. New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses. EMBO Rep 2010; 11: 393-399.
    • (2010) EMBO Rep , vol.11 , pp. 393-399
    • Yoon, C.H.1    Miah, M.A.2    Kim, K.P.3    Bae, Y.S.4
  • 6
    • 75749108288 scopus 로고    scopus 로고
    • Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
    • Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N et al. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010; 140: 338-348.
    • (2010) Cell , vol.140 , pp. 338-348
    • Nakamura, T.1    Furuhashi, M.2    Li, P.3    Cao, H.4    Tuncman, G.5    Sonenberg, N.6
  • 8
    • 69249223438 scopus 로고    scopus 로고
    • PKR activity is required for acute leukemic cell maintenance and growth: A role for PKR-mediated phosphatase activity to regulate GSK-3 phosphorylation
    • Blalock WL, Grimaldi C, Fala F, Follo M, Horn S, Basecke J et al. PKR activity is required for acute leukemic cell maintenance and growth: a role for PKR-mediated phosphatase activity to regulate GSK-3 phosphorylation. J Cell Physiol 2009; 221: 232-241.
    • (2009) J Cell Physiol , vol.221 , pp. 232-241
    • Blalock, W.L.1    Grimaldi, C.2    Fala, F.3    Follo, M.4    Horn, S.5    Basecke, J.6
  • 9
    • 57849100514 scopus 로고    scopus 로고
    • PKR is activated in MDS patients and its subcellular localization depends on disease severity
    • Follo MY, Finelli C, Mongiorgi S, Clissa C, Bosi C, Martinelli G et al. PKR is activated in MDS patients and its subcellular localization depends on disease severity. Leukemia 2008; 22: 2267-2269.
    • (2008) Leukemia , vol.22 , pp. 2267-2269
    • Follo, M.Y.1    Finelli, C.2    Mongiorgi, S.3    Clissa, C.4    Bosi, C.5    Martinelli, G.6
  • 10
    • 0037069935 scopus 로고    scopus 로고
    • Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR
    • DOI 10.1038/sj.onc.1205987
    • Kim SH, Gunnery S, Choe JK, Mathews MB. Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR. Oncogene 2002; 21: 8741-8748. (Pubitemid 36132395)
    • (2002) Oncogene , vol.21 , Issue.57 , pp. 8741-8748
    • Kim, S.H.1    Gunnery, S.2    Choe, J.K.3    Mathews, M.B.4
  • 11
    • 0034702174 scopus 로고    scopus 로고
    • Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR
    • Kim SH, Forman AP, Mathews MB, Gunnery S. Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR. Oncogene 2000; 19: 3086-3094. (Pubitemid 30438465)
    • (2000) Oncogene , vol.19 , Issue.27 , pp. 3086-3094
    • Kim, S.H.1    Forman, A.P.2    Mathews, M.B.3    Gunnery, S.4
  • 13
    • 77955067224 scopus 로고    scopus 로고
    • Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity
    • Pataer A, Swisher SG, Roth JA, Logothetis CJ, Corn P. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biol Ther 2009; 8: 245-252.
    • (2009) Cancer Biol Ther , vol.8 , pp. 245-252
    • Pataer, A.1    Swisher, S.G.2    Roth, J.A.3    Logothetis, C.J.4    Corn, P.5
  • 14
    • 58849114125 scopus 로고    scopus 로고
    • Inhibition of activation of dsRNA-dependent protein kinase and tumour growth inhibition
    • Eley HL, McDonald PS, Russell ST, Tisdale MJ. Inhibition of activation of dsRNA-dependent protein kinase and tumour growth inhibition. Cancer Chemother Pharmacol 2009; 63: 651-659.
    • (2009) Cancer Chemother Pharmacol , vol.63 , pp. 651-659
    • Eley, H.L.1    McDonald, P.S.2    Russell, S.T.3    Tisdale, M.J.4
  • 15
    • 0029043142 scopus 로고
    • Nuclear localization of the interferoninducible protein kinase PKR in human cells and transfected mouse cells
    • Jeffrey IW, Kadereit S, Meurs EF, Metzger T, Bachmann M, Schwemmle M et al. Nuclear localization of the interferoninducible protein kinase PKR in human cells and transfected mouse cells. Exp Cell Res 1995; 218: 17-27.
    • (1995) Exp Cell Res , vol.218 , pp. 17-27
    • Jeffrey, I.W.1    Kadereit, S.2    Meurs, E.F.3    Metzger, T.4    Bachmann, M.5    Schwemmle, M.6
  • 17
    • 34249308840 scopus 로고    scopus 로고
    • The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation
    • DOI 10.1158/0008-5472.CAN-06-4409
    • Follo MY, Mongiorgi S, Bosi C, Cappellini A, Finelli C, Chiarini F et al. The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation. Cancer Res 2007; 67: 4287-4294. (Pubitemid 46815076)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4287-4294
    • Follo, M.Y.1    Mongiorgi, S.2    Bosi, C.3    Cappellini, A.4    Finelli, C.5    Chiarini, F.6    Papa, V.7    Libra, M.8    Martinelli, G.9    Cocco, L.10    Martelli, A.M.11
  • 18
    • 31444440033 scopus 로고    scopus 로고
    • Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients
    • DOI 10.1038/sj.leu.2404057, PII 2404057
    • Nyakern M, Tazzari PL, Finelli C, Bosi C, Follo MY, Grafone T et al. Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients. Leukemia 2006; 20: 230-238. (Pubitemid 43148660)
    • (2006) Leukemia , vol.20 , Issue.2 , pp. 230-238
    • Nyakern, M.1    Tazzari, P.L.2    Finelli, C.3    Bosi, C.4    Follo, M.Y.5    Grafone, T.6    Piccaluga, P.P.7    Martinelli, G.8    Cocco, L.9    Martelli, A.M.10
  • 19
    • 0035816675 scopus 로고    scopus 로고
    • Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop
    • Zhang F, Romano PR, Nagamura-Inoue T, Tian B, Dever TE, Mathews MB et al. Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop. J Biol Chem 2001; 276: 24946-24958.
    • (2001) J Biol Chem , vol.276 , pp. 24946-24958
    • Zhang, F.1    Romano, P.R.2    Nagamura-Inoue, T.3    Tian, B.4    Dever, T.E.5    Mathews, M.B.6
  • 22
    • 25144477805 scopus 로고    scopus 로고
    • Mechanistic link between PKR dimerization, autophosphorylation, and eIF2α substrate recognition
    • DOI 10.1016/j.cell.2005.06.041, PII S0092867405006938
    • Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F et al. Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell 2005; 122: 901-913. (Pubitemid 41345207)
    • (2005) Cell , vol.122 , Issue.6 , pp. 901-913
    • Dey, M.1    Cao, C.2    Dar, A.C.3    Tamura, T.4    Ozato, K.5    Sicheri, F.6    Dever, T.E.7
  • 24
    • 0035148472 scopus 로고    scopus 로고
    • Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain
    • DOI 10.1128/JVI.75.3.1265-1273.2001
    • Taylor DR, Tian B, Romano PR, Hinnebusch AG, Lai MM, Mathews MB. Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain. J Virol 2001; 75: 1265-1273. (Pubitemid 32094685)
    • (2001) Journal of Virology , vol.75 , Issue.3 , pp. 1265-1273
    • Taylor, D.R.1    Tian, B.2    Romano, P.R.3    Hinnebusch, A.G.4    Lai, M.M.C.5    Mathews, M.B.6
  • 25
    • 33746596969 scopus 로고    scopus 로고
    • RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection
    • DOI 10.1182/blood-2005-11-006817
    • Bennett RL, Blalock WL, Abtahi DM, Pan Y, Moyer SA, May WS. RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection. Blood 2006; 108: 821-829. (Pubitemid 44154613)
    • (2006) Blood , vol.108 , Issue.3 , pp. 821-829
    • Bennett, R.L.1    Blalock, W.L.2    Abtahi, D.M.3    Pan, Y.4    Moyer, S.A.5    May, W.S.6
  • 26
    • 0031761118 scopus 로고    scopus 로고
    • Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells
    • McCubrey JA, Steelman LS, Hoyle PE, Blalock WL, Weinstein-Oppenheimer C, Franklin RA et al. Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells. Leukemia 1998; 12: 1903-1929. (Pubitemid 28554464)
    • (1998) Leukemia , vol.12 , Issue.12 , pp. 1903-1929
    • McCubrey, J.A.1    Steelman, L.S.2    Hoyle, P.E.3    Blalock, W.L.4    Weinstein-Oppenheimer, C.5    Franklin, R.A.6    Cherwinski, H.7    Bosch, E.8    McMahon, M.9
  • 29
  • 30
    • 0035957939 scopus 로고    scopus 로고
    • Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR
    • Li S, Koromilas AE. Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR. J Biol Chem 2001; 276: 13881-13890.
    • (2001) J Biol Chem , vol.276 , pp. 13881-13890
    • Li, S.1    Koromilas, A.E.2
  • 32
    • 1842562209 scopus 로고    scopus 로고
    • An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease
    • DOI 10.1038/sj.emboj.7600049
    • Onuki R, Bando Y, Suyama E, Katayama T, Kawasaki H, Baba T et al. An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer0s disease. Embo J 2004; 23: 959-968. (Pubitemid 38418762)
    • (2004) EMBO Journal , vol.23 , Issue.4 , pp. 959-968
    • Onuki, R.1    Bando, Y.2    Suyama, E.3    Katayama, T.4    Kawasaki, H.5    Baba, T.6    Tohyama, M.7    Taira, K.8
  • 33
    • 6344244517 scopus 로고    scopus 로고
    • The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR)
    • DOI 10.1074/jbc.M403884200
    • Zhang X, Li J, Sejas DP, Rathbun KR, Bagby GC, Pang Q. The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR). J Biol Chem 2004; 279: 43910-43919. (Pubitemid 39390699)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.42 , pp. 43910-43919
    • Zhang, X.1    Li, J.2    Sejas, D.P.3    Rathbun, K.R.4    Bagby, G.C.5    Pang, Q.6
  • 36
    • 70749128265 scopus 로고    scopus 로고
    • PTEN inhibits BMI1 function independently of its phosphatase activity
    • Fan C, He L, Kapoor A, Rybak AP, De Melo J, Cutz JC et al. PTEN inhibits BMI1 function independently of its phosphatase activity. Mol Cancer 2009; 8: 98.
    • (2009) Mol Cancer , vol.8 , pp. 98
    • Fan, C.1    He, L.2    Kapoor, A.3    Rybak, A.P.4    De Melo, J.5    Cutz, J.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.