-
1
-
-
0017180822
-
Interferon-induced inhibition of protein synthesis in L-cell extracts: An ATP-dependent step in the activation of an inhibitor by double-stranded RNA
-
Roberts WK, Clemens MJ, Kerr IM. Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA. Proc Natl Acad Sci USA 1976; 73: 3136-3140.
-
(1976)
Proc Natl Acad Sci USA
, vol.73
, pp. 3136-3140
-
-
Roberts, W.K.1
Clemens, M.J.2
Kerr, I.M.3
-
2
-
-
0033230617
-
PKR; A sentinel kinase for cellular stress
-
Williams BR. PKR; a sentinel kinase for cellular stress. Oncogene 1999; 18: 6112-6120.
-
(1999)
Oncogene
, vol.18
, pp. 6112-6120
-
-
Williams, B.R.1
-
3
-
-
61449174865
-
An antiviral response directed by PKR phosphorylation of the RNA helicase A
-
Sadler AJ, Latchoumanin O, Hawkes D, Mak J, Williams BR. An antiviral response directed by PKR phosphorylation of the RNA helicase A. PLoS Pathog 2009; 5: e1000311.
-
(2009)
PLoS Pathog
, vol.5
-
-
Sadler, A.J.1
Latchoumanin, O.2
Hawkes, D.3
Mak, J.4
Williams, B.R.5
-
4
-
-
77951231756
-
A role for PKR in hematologic malignancies
-
Blalock WL, Bavelloni A, Piazzi M, Faenza I, Cocco L. A role for PKR in hematologic malignancies. J Cell Physiol 2010; 223: 572-591.
-
(2010)
J Cell Physiol
, vol.223
, pp. 572-591
-
-
Blalock, W.L.1
Bavelloni, A.2
Piazzi, M.3
Faenza, I.4
Cocco, L.5
-
5
-
-
77951880589
-
New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses
-
Yoon CH, Miah MA, Kim KP, Bae YS. New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses. EMBO Rep 2010; 11: 393-399.
-
(2010)
EMBO Rep
, vol.11
, pp. 393-399
-
-
Yoon, C.H.1
Miah, M.A.2
Kim, K.P.3
Bae, Y.S.4
-
6
-
-
75749108288
-
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
-
Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N et al. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010; 140: 338-348.
-
(2010)
Cell
, vol.140
, pp. 338-348
-
-
Nakamura, T.1
Furuhashi, M.2
Li, P.3
Cao, H.4
Tuncman, G.5
Sonenberg, N.6
-
7
-
-
77952492303
-
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway
-
Mounir Z, Krishnamoorthy JL, Robertson GP, Scheuner D, Kaufman RJ, Georgescu MM et al. Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. Sci Signal 2009; 2: ra85.
-
(2009)
Sci Signal
, vol.2
-
-
Mounir, Z.1
Krishnamoorthy, J.L.2
Robertson, G.P.3
Scheuner, D.4
Kaufman, R.J.5
Georgescu, M.M.6
-
8
-
-
69249223438
-
PKR activity is required for acute leukemic cell maintenance and growth: A role for PKR-mediated phosphatase activity to regulate GSK-3 phosphorylation
-
Blalock WL, Grimaldi C, Fala F, Follo M, Horn S, Basecke J et al. PKR activity is required for acute leukemic cell maintenance and growth: a role for PKR-mediated phosphatase activity to regulate GSK-3 phosphorylation. J Cell Physiol 2009; 221: 232-241.
-
(2009)
J Cell Physiol
, vol.221
, pp. 232-241
-
-
Blalock, W.L.1
Grimaldi, C.2
Fala, F.3
Follo, M.4
Horn, S.5
Basecke, J.6
-
9
-
-
57849100514
-
PKR is activated in MDS patients and its subcellular localization depends on disease severity
-
Follo MY, Finelli C, Mongiorgi S, Clissa C, Bosi C, Martinelli G et al. PKR is activated in MDS patients and its subcellular localization depends on disease severity. Leukemia 2008; 22: 2267-2269.
-
(2008)
Leukemia
, vol.22
, pp. 2267-2269
-
-
Follo, M.Y.1
Finelli, C.2
Mongiorgi, S.3
Clissa, C.4
Bosi, C.5
Martinelli, G.6
-
10
-
-
0037069935
-
Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR
-
DOI 10.1038/sj.onc.1205987
-
Kim SH, Gunnery S, Choe JK, Mathews MB. Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR. Oncogene 2002; 21: 8741-8748. (Pubitemid 36132395)
-
(2002)
Oncogene
, vol.21
, Issue.57
, pp. 8741-8748
-
-
Kim, S.H.1
Gunnery, S.2
Choe, J.K.3
Mathews, M.B.4
-
11
-
-
0034702174
-
Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR
-
Kim SH, Forman AP, Mathews MB, Gunnery S. Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR. Oncogene 2000; 19: 3086-3094. (Pubitemid 30438465)
-
(2000)
Oncogene
, vol.19
, Issue.27
, pp. 3086-3094
-
-
Kim, S.H.1
Forman, A.P.2
Mathews, M.B.3
Gunnery, S.4
-
12
-
-
0031037172
-
Role of double-stranded RNA-activated protein kinase in human hematological malignancies
-
Basu S, Panayiotidis P, Hart SM, He LZ, Man A, Hoffbrand AV et al. Role of double-stranded RNA-activated protein kinase in human hematological malignancies. Cancer Res 1997; 57: 943-947. (Pubitemid 27098022)
-
(1997)
Cancer Research
, vol.57
, Issue.5
, pp. 943-947
-
-
Basu, S.1
Panayiotidis, P.2
Hart, S.M.3
He, L.-Z.4
Man, A.5
Hoffbrand, A.V.6
Ganeshaguru, K.7
-
13
-
-
77955067224
-
Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity
-
Pataer A, Swisher SG, Roth JA, Logothetis CJ, Corn P. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biol Ther 2009; 8: 245-252.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 245-252
-
-
Pataer, A.1
Swisher, S.G.2
Roth, J.A.3
Logothetis, C.J.4
Corn, P.5
-
15
-
-
0029043142
-
Nuclear localization of the interferoninducible protein kinase PKR in human cells and transfected mouse cells
-
Jeffrey IW, Kadereit S, Meurs EF, Metzger T, Bachmann M, Schwemmle M et al. Nuclear localization of the interferoninducible protein kinase PKR in human cells and transfected mouse cells. Exp Cell Res 1995; 218: 17-27.
-
(1995)
Exp Cell Res
, vol.218
, pp. 17-27
-
-
Jeffrey, I.W.1
Kadereit, S.2
Meurs, E.F.3
Metzger, T.4
Bachmann, M.5
Schwemmle, M.6
-
16
-
-
64049093243
-
Neuronal Phosphorylated RNA-Dependent Protein Kinase in Creutzfeldt-Jakob Disease
-
Paquet C, Bose A, Polivka M, Peoc0h K, Brouland JP, Keohane C et al. Neuronal Phosphorylated RNA-Dependent Protein Kinase in Creutzfeldt-Jakob Disease. J Neuropathol Exp Neurol 2009; 68: 190-198.
-
(2009)
J Neuropathol Exp Neurol
, vol.68
, pp. 190-198
-
-
Paquet, C.1
Bose, A.2
Polivka, M.3
Peocoh, K.4
Brouland, J.P.5
Keohane, C.6
-
17
-
-
34249308840
-
The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation
-
DOI 10.1158/0008-5472.CAN-06-4409
-
Follo MY, Mongiorgi S, Bosi C, Cappellini A, Finelli C, Chiarini F et al. The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation. Cancer Res 2007; 67: 4287-4294. (Pubitemid 46815076)
-
(2007)
Cancer Research
, vol.67
, Issue.9
, pp. 4287-4294
-
-
Follo, M.Y.1
Mongiorgi, S.2
Bosi, C.3
Cappellini, A.4
Finelli, C.5
Chiarini, F.6
Papa, V.7
Libra, M.8
Martinelli, G.9
Cocco, L.10
Martelli, A.M.11
-
18
-
-
31444440033
-
Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients
-
DOI 10.1038/sj.leu.2404057, PII 2404057
-
Nyakern M, Tazzari PL, Finelli C, Bosi C, Follo MY, Grafone T et al. Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients. Leukemia 2006; 20: 230-238. (Pubitemid 43148660)
-
(2006)
Leukemia
, vol.20
, Issue.2
, pp. 230-238
-
-
Nyakern, M.1
Tazzari, P.L.2
Finelli, C.3
Bosi, C.4
Follo, M.Y.5
Grafone, T.6
Piccaluga, P.P.7
Martinelli, G.8
Cocco, L.9
Martelli, A.M.10
-
19
-
-
0035816675
-
Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop
-
Zhang F, Romano PR, Nagamura-Inoue T, Tian B, Dever TE, Mathews MB et al. Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop. J Biol Chem 2001; 276: 24946-24958.
-
(2001)
J Biol Chem
, vol.276
, pp. 24946-24958
-
-
Zhang, F.1
Romano, P.R.2
Nagamura-Inoue, T.3
Tian, B.4
Dever, T.E.5
Mathews, M.B.6
-
20
-
-
0031899816
-
Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2α kinases PKR and GCN2
-
Romano PR, Garcia-Barrio MT, Zhang X, Wang Q, Taylor DR, Zhang F et al. Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2. Mol Cell Biol 1998; 18: 2282-2297. (Pubitemid 28152676)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.4
, pp. 2282-2297
-
-
Romano, P.R.1
Garcia-Barrio, M.T.2
Zhang, X.3
Wang, Q.4
Taylor, D.R.5
Zhang, F.6
Herring, C.7
Mathews, M.B.8
Qin, J.9
Hinnebusch, A.G.10
-
21
-
-
30444452652
-
Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2α RNA-dependent protein kinase
-
DOI 10.1073/pnas.0508207103
-
Su Q, Wang S, Baltzis D, Qu LK, Wong AH, Koromilas AE. Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. Proc Natl Acad Sci USA 2006; 103: 63-68. (Pubitemid 43076105)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.1
, pp. 63-68
-
-
Su, Q.1
Wang, S.2
Baltzis, D.3
Qu, L.-K.4
Wong, A.H.-T.5
Koromilas, A.E.6
-
22
-
-
25144477805
-
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2α substrate recognition
-
DOI 10.1016/j.cell.2005.06.041, PII S0092867405006938
-
Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F et al. Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell 2005; 122: 901-913. (Pubitemid 41345207)
-
(2005)
Cell
, vol.122
, Issue.6
, pp. 901-913
-
-
Dey, M.1
Cao, C.2
Dar, A.C.3
Tamura, T.4
Ozato, K.5
Sicheri, F.6
Dever, T.E.7
-
23
-
-
49449085504
-
A quantitative atlas of mitotic phosphorylation
-
Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ et al. A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci USA 2008; 105: 10762-10767.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 10762-10767
-
-
Dephoure, N.1
Zhou, C.2
Villen, J.3
Beausoleil, S.A.4
Bakalarski, C.E.5
Elledge, S.J.6
-
24
-
-
0035148472
-
Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain
-
DOI 10.1128/JVI.75.3.1265-1273.2001
-
Taylor DR, Tian B, Romano PR, Hinnebusch AG, Lai MM, Mathews MB. Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain. J Virol 2001; 75: 1265-1273. (Pubitemid 32094685)
-
(2001)
Journal of Virology
, vol.75
, Issue.3
, pp. 1265-1273
-
-
Taylor, D.R.1
Tian, B.2
Romano, P.R.3
Hinnebusch, A.G.4
Lai, M.M.C.5
Mathews, M.B.6
-
25
-
-
33746596969
-
RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection
-
DOI 10.1182/blood-2005-11-006817
-
Bennett RL, Blalock WL, Abtahi DM, Pan Y, Moyer SA, May WS. RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection. Blood 2006; 108: 821-829. (Pubitemid 44154613)
-
(2006)
Blood
, vol.108
, Issue.3
, pp. 821-829
-
-
Bennett, R.L.1
Blalock, W.L.2
Abtahi, D.M.3
Pan, Y.4
Moyer, S.A.5
May, W.S.6
-
26
-
-
0031761118
-
Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells
-
McCubrey JA, Steelman LS, Hoyle PE, Blalock WL, Weinstein-Oppenheimer C, Franklin RA et al. Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells. Leukemia 1998; 12: 1903-1929. (Pubitemid 28554464)
-
(1998)
Leukemia
, vol.12
, Issue.12
, pp. 1903-1929
-
-
McCubrey, J.A.1
Steelman, L.S.2
Hoyle, P.E.3
Blalock, W.L.4
Weinstein-Oppenheimer, C.5
Franklin, R.A.6
Cherwinski, H.7
Bosch, E.8
McMahon, M.9
-
27
-
-
0034101950
-
Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia
-
Liu TC, Lin PM, Chang JG, Lee JP, Chen TP, Lin SF. Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia. Am J Hematol 2000; 63: 170-175.
-
(2000)
Am J Hematol
, vol.63
, pp. 170-175
-
-
Liu, T.C.1
Lin, P.M.2
Chang, J.G.3
Lee, J.P.4
Chen, T.P.5
Lin, S.F.6
-
28
-
-
0032898096
-
PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies
-
DOI 10.1093/hmg/8.2.185
-
Dahia PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H et al. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Hum Mol Genet 1999; 8: 185-193. (Pubitemid 29054260)
-
(1999)
Human Molecular Genetics
, vol.8
, Issue.2
, pp. 185-193
-
-
Dahia, P.L.M.1
Aguiar, R.C.T.2
Alberta, J.3
Kum, J.B.4
Caron, S.5
Sill, H.6
Marsh, D.J.7
Ritz, J.8
Freedman, A.9
Stiles, C.10
Eng, C.11
-
29
-
-
0032212223
-
PTEN gene alterations in lymphoid neoplasms
-
Sakai A, Thieblemont C, Wellmann A, Jaffe ES, Raffeld M. PTEN gene alterations in lymphoid neoplasms. Blood 1998; 92: 3410-3415. (Pubitemid 28492352)
-
(1998)
Blood
, vol.92
, Issue.9
, pp. 3410-3415
-
-
Sakai, A.1
Thieblemont, C.2
Wellmann, A.3
Jaffe, E.S.4
Raffeld, M.5
-
30
-
-
0035957939
-
Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR
-
Li S, Koromilas AE. Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR. J Biol Chem 2001; 276: 13881-13890.
-
(2001)
J Biol Chem
, vol.276
, pp. 13881-13890
-
-
Li, S.1
Koromilas, A.E.2
-
32
-
-
1842562209
-
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease
-
DOI 10.1038/sj.emboj.7600049
-
Onuki R, Bando Y, Suyama E, Katayama T, Kawasaki H, Baba T et al. An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer0s disease. Embo J 2004; 23: 959-968. (Pubitemid 38418762)
-
(2004)
EMBO Journal
, vol.23
, Issue.4
, pp. 959-968
-
-
Onuki, R.1
Bando, Y.2
Suyama, E.3
Katayama, T.4
Kawasaki, H.5
Baba, T.6
Tohyama, M.7
Taira, K.8
-
33
-
-
6344244517
-
The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR)
-
DOI 10.1074/jbc.M403884200
-
Zhang X, Li J, Sejas DP, Rathbun KR, Bagby GC, Pang Q. The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR). J Biol Chem 2004; 279: 43910-43919. (Pubitemid 39390699)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.42
, pp. 43910-43919
-
-
Zhang, X.1
Li, J.2
Sejas, D.P.3
Rathbun, K.R.4
Bagby, G.C.5
Pang, Q.6
-
34
-
-
35948993428
-
The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor κB and Akt activation
-
DOI 10.1158/1078-0432.CCR-06-2932
-
Von Holzen U, Pataer A, Raju U, Bocangel D, Vorburger SA, Liu Y et al. The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation. Clin Cancer Res 2007; 13: 6032-6039. (Pubitemid 350075059)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.20
, pp. 6032-6039
-
-
Von Holzen, U.1
Pataer, A.2
Raju, U.3
Bocangel, D.4
Vorburger, S.A.5
Liu, Y.6
Lu, X.7
Roth, J.A.8
Aggarwal, B.B.9
Barber, G.N.10
Keyomarsi, K.11
Hunt, K.K.12
Swisher, S.G.13
-
36
-
-
70749128265
-
PTEN inhibits BMI1 function independently of its phosphatase activity
-
Fan C, He L, Kapoor A, Rybak AP, De Melo J, Cutz JC et al. PTEN inhibits BMI1 function independently of its phosphatase activity. Mol Cancer 2009; 8: 98.
-
(2009)
Mol Cancer
, vol.8
, pp. 98
-
-
Fan, C.1
He, L.2
Kapoor, A.3
Rybak, A.P.4
De Melo, J.5
Cutz, J.C.6
-
37
-
-
33748937018
-
Antiviral action of the tumor suppressor ARF
-
DOI 10.1038/sj.emboj.7601302, PII 7601302
-
Garcia MA, Collado M, Munoz-Fontela C, Matheu A, Marcos-Villar L, Arroyo J et al. Antiviral action of the tumor suppressor ARF. Embo J 2006; 25: 4284-4292. (Pubitemid 44435226)
-
(2006)
EMBO Journal
, vol.25
, Issue.18
, pp. 4284-4292
-
-
Garcia, M.A.1
Collado, M.2
Muoz-Fontela, C.3
Matheu, A.4
Marcos-Villar, L.5
Arroyo, J.6
Esteban, M.7
Serrano, M.8
Rivas, C.9
-
38
-
-
22544487172
-
Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways
-
DOI 10.1073/pnas.0504754102
-
Zhao C, Denison C, Huibregtse JM, Gygi S, Krug RM. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Proc Natl Acad Sci USA 2005; 102: 10200-10205. (Pubitemid 41023349)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.29
, pp. 10200-10205
-
-
Zhao, C.1
Denison, C.2
Huibregtse, J.M.3
Gygi, S.4
Krug, R.M.5
|