-
1
-
-
0035107233
-
Amyloid precursor protein in platelets of patients with Alzheimer disease: Effect of acetylcholinesterase inhibitor treatment
-
Borroni B., Colciaghi F., Pastorino L., et al. (2001) Amyloid precursor protein in platelets of patients with Alzheimer disease: effect of acetylcholinesterase inhibitor treatment. Arch. Neurol. 58, 442-446.
-
(2001)
Arch. Neurol
, vol.58
, pp. 442-446
-
-
Borroni, B.1
Colciaghi, F.2
Pastorino, L.3
-
2
-
-
33645894183
-
Environment, physical activity, and neurogenesis: Implications for prevention and treatment of Alzhemier's disease
-
Briones T. L. (2006) Environment, physical activity, and neurogenesis: implications for prevention and treatment of Alzhemier's disease. Curr. Alzheimer Res. 3, 49-54.
-
(2006)
Curr. Alzheimer Res
, vol.3
, pp. 49-54
-
-
Briones, T.L.1
-
3
-
-
0037371279
-
Use of cholinesterase inhibitors in clinical practice: Evidence-based recommendations
-
Cummings J. L. (2003) Use of cholinesterase inhibitors in clinical practice: evidence-based recommendations. Am. J. Geriatr. Psychiatry 11, 131-145.
-
(2003)
Am. J. Geriatr. Psychiatry
, vol.11
, pp. 131-145
-
-
Cummings, J.L.1
-
4
-
-
0031715862
-
Future therapeutic approaches to Alzheimer's disease
-
Davis K. L. (1998) Future therapeutic approaches to Alzheimer's disease. J. Clin. Psychiatry 59(Suppl 11), 14-16.
-
(1998)
J. Clin. Psychiatry
, vol.59
, Issue.SUPPL. 11
, pp. 14-16
-
-
Davis, K.L.1
-
5
-
-
0038752964
-
Pathology and pathways of Alzheimer's disease with an update on new developments in treatment
-
DeKosky S. T. (2003) Pathology and pathways of Alzheimer's disease with an update on new developments in treatment. J. Am. Geriatr. Soc. 51, S314-S320.
-
(2003)
J. Am. Geriatr. Soc
, vol.51
-
-
DeKosky, S.T.1
-
6
-
-
0036451888
-
Non-cholinergic strategies for treating and preventing Alzheimer's disease
-
Doraiswamy P. M. (2002) Non-cholinergic strategies for treating and preventing Alzheimer's disease. CNS Drugs 16, 811-824.
-
(2002)
CNS Drugs
, vol.16
, pp. 811-824
-
-
Doraiswamy, P.M.1
-
7
-
-
0037375876
-
Cholinesterases: New roles in brain function and in Alzheimer's disease
-
Giacobini E. (2003) Cholinesterases: New roles in brain function and in Alzheimer's disease. Neurochem. Res. 28, 515-522.
-
(2003)
Neurochem. Res
, vol.28
, pp. 515-522
-
-
Giacobini, E.1
-
8
-
-
0028894072
-
Phenserine and ring C heteroanalogues: Drug candidates for the treatment of Alzheimer's disease
-
Greig N. H., Pei X. F., Soncrant T. T., Ingram D. K., and Brossi A. (1995) Phenserine and ring C heteroanalogues: drug candidates for the treatment of Alzheimer's disease. Med. Res. Rev. 15, 3-31.
-
(1995)
Med. Res. Rev
, vol.15
, pp. 3-31
-
-
Greig, N.H.1
Pei, X.F.2
Soncrant, T.T.3
Ingram, D.K.4
Brossi, A.5
-
9
-
-
22144494112
-
An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
-
Greig N. H., Sambamurti K., Yu Q. S., Brossi A., Bruinsma G. B., and Lahiri D. K. (2005a) An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr. Alzheimer Res. 2, 281-290.
-
(2005)
Curr. Alzheimer Res
, vol.2
, pp. 281-290
-
-
Greig, N.H.1
Sambamurti, K.2
Yu, Q.S.3
Brossi, A.4
Bruinsma, G.B.5
Lahiri, D.K.6
-
10
-
-
0034574284
-
The experimental Alzheimer drug phenserine: Preclinical pharmacokinetics and pharmacodynamics
-
Greig N. H., De Micheli E., Holloway H. W., et al. (2000) The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta Neurol. Scand. Suppl. 176, 74-84.
-
(2000)
Acta Neurol. Scand. Suppl
, vol.176
, pp. 74-84
-
-
Greig, N.H.1
De Micheli, E.2
Holloway, H.W.3
-
11
-
-
28044437122
-
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent
-
Greig N. H., Utsuki T., Ingram D. K., et al. (2005b) Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc. Natl. Acad. Sci. USA 102, 17,213-17,218.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
-
-
Greig, N.H.1
Utsuki, T.2
Ingram, D.K.3
-
12
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J. and Selkoe D. J. (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
13
-
-
0030986003
-
Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions
-
Haroutunian V., Greig N., Pei X. F., et al. (1997) Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain Res. Mol. Brain Res. 46, 161-168.
-
(1997)
Brain Res. Mol. Brain Res
, vol.46
, pp. 161-168
-
-
Haroutunian, V.1
Greig, N.2
Pei, X.F.3
-
14
-
-
25844477102
-
Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease
-
Jacobsen J. S., Reinhart P., and Pangalos M. N. (2005) Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease. NeuroRx. 2, 612-626.
-
(2005)
NeuroRx
, vol.2
, pp. 612-626
-
-
Jacobsen, J.S.1
Reinhart, P.2
Pangalos, M.N.3
-
15
-
-
0030092766
-
Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines
-
Lahiri D. K. and Farlow M. R. (1996) Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines. J. Mol. Neurosci. 7, 41-49.
-
(1996)
J. Mol. Neurosci
, vol.7
, pp. 41-49
-
-
Lahiri, D.K.1
Farlow, M.R.2
-
16
-
-
0032569990
-
The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells
-
Lahiri D. K., Farlow M. R., and Sambamurti K. (1998) The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells. Brain Res. Mol. Brain Res. 62, 131-140.
-
(1998)
Brain Res. Mol. Brain Res
, vol.62
, pp. 131-140
-
-
Lahiri, D.K.1
Farlow, M.R.2
Sambamurti, K.3
-
17
-
-
0028197477
-
Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines
-
Lahiri D. K., Lewis S., and Farlow M. R. (1994) Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines. J. Neurosci. Res. 37, 777-787.
-
(1994)
J. Neurosci. Res
, vol.37
, pp. 777-787
-
-
Lahiri, D.K.1
Lewis, S.2
Farlow, M.R.3
-
18
-
-
0036660457
-
Current drug targets for Alzheimer's disease treatment
-
Lahiri D. K., Farlow M. R., Greig N. H., and Sambamurti K. (2002) Current drug targets for Alzheimer's disease treatment. Drug Dev. Res. 56, 267-281.
-
(2002)
Drug Dev. Res
, vol.56
, pp. 267-281
-
-
Lahiri, D.K.1
Farlow, M.R.2
Greig, N.H.3
Sambamurti, K.4
-
19
-
-
1942435951
-
Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex
-
Lahiri D. K., Chen D., Ge Y. W., Bondy S. C., and Sharman E. H. (2004a) Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex. J. Pineal Res. 36, 224-231.
-
(2004)
J. Pineal Res
, vol.36
, pp. 224-231
-
-
Lahiri, D.K.1
Chen, D.2
Ge, Y.W.3
Bondy, S.C.4
Sharman, E.H.5
-
20
-
-
0034489269
-
Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease
-
Lahiri D. K., Farlow M. R., Hintz N., Utsuki T., and Greig N. H. (2000) Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease. Acta Neurol. Scand. Suppl. 176, 60-67.
-
(2000)
Acta Neurol. Scand. Suppl
, vol.176
, pp. 60-67
-
-
Lahiri, D.K.1
Farlow, M.R.2
Hintz, N.3
Utsuki, T.4
Greig, N.H.5
-
21
-
-
14944371728
-
Melatonin, metals, and gene expression: Implications in aging and neurodegenerative disorders
-
Lahiri D. K., Chen D., Lahiri P., Rogers J. T., Greig N. H., and Bondy S. (2004b) Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders. Ann. N. Y. Acad. Sci. 1035, 216-230.
-
(2004)
Ann. N. Y. Acad. Sci
, vol.1035
, pp. 216-230
-
-
Lahiri, D.K.1
Chen, D.2
Lahiri, P.3
Rogers, J.T.4
Greig, N.H.5
Bondy, S.6
-
22
-
-
0038705106
-
Role of cytokines in the gene expression of amyloid beta-protein precursor: Identification of a 5′-UTR-Binding nuclear factor and its implications in Alzheimer's disease
-
Lahiri D. K., Chen D., Vivien D., Ge Y. W., Greig N. H., and Rogers J. T. (2003a) Role of cytokines in the gene expression of amyloid beta-protein precursor: Identification of a 5′-UTR-Binding nuclear factor and its implications in Alzheimer's disease. J. Alzheimers Dis. 5, 81-90.
-
(2003)
J. Alzheimers Dis
, vol.5
, pp. 81-90
-
-
Lahiri, D.K.1
Chen, D.2
Vivien, D.3
Ge, Y.W.4
Greig, N.H.5
Rogers, J.T.6
-
23
-
-
0037315878
-
A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease
-
Lahiri D. K., Farlow M. R., Sambamurti K., Greig N. H., Giacobini E., and Schneider L. S. (2003b) A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease. Curr. Drug Targets 4, 97-112.
-
(2003)
Curr. Drug Targets
, vol.4
, pp. 97-112
-
-
Lahiri, D.K.1
Farlow, M.R.2
Sambamurti, K.3
Greig, N.H.4
Giacobini, E.5
Schneider, L.S.6
-
24
-
-
33645687131
-
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine
-
Luo W., Yu Q. S., Kulkarni S. S., et al. (2006) Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J. Med. Chem. 49, 2174-2185.
-
(2006)
J. Med. Chem
, vol.49
, pp. 2174-2185
-
-
Luo, W.1
Yu, Q.S.2
Kulkarni, S.S.3
-
25
-
-
0033607448
-
Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase
-
Munoz F. J., Aldunate R., and Inestrosa N. C. (1999) Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase. Neuroreport 10, 3621-3625.
-
(1999)
Neuroreport
, vol.10
, pp. 3621-3625
-
-
Munoz, F.J.1
Aldunate, R.2
Inestrosa, N.C.3
-
26
-
-
0042970733
-
Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein
-
Pakaski M. and Kasa P. (2003) Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein. Curr. Drug Targets CNS Neurol. Disord. 2, 163-171.
-
(2003)
Curr. Drug Targets CNS Neurol. Disord
, vol.2
, pp. 163-171
-
-
Pakaski, M.1
Kasa, P.2
-
27
-
-
0035196471
-
Reversible and irreversible acetylcholinesterase inhibitors cause changes in neuronal amyloid precursor protein processing and protein kinase C level in vitro
-
Pakaski M., Rakonczay Z., and Kasa P. (2001) Reversible and irreversible acetylcholinesterase inhibitors cause changes in neuronal amyloid precursor protein processing and protein kinase C level in vitro. Neurochem. Int. 38, 219-226.
-
(2001)
Neurochem. Int
, vol.38
, pp. 219-226
-
-
Pakaski, M.1
Rakonczay, Z.2
Kasa, P.3
-
28
-
-
0032484682
-
Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N-methyl-D-aspartate receptor
-
Patel N., Spangler E. L., Greig N. H., Yu Q. S., Ingram D. K., and Meyer R. C. (1998) Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N-methyl-D-aspartate receptor. Neuroreport 9, 171-176.
-
(1998)
Neuroreport
, vol.9
, pp. 171-176
-
-
Patel, N.1
Spangler, E.L.2
Greig, N.H.3
Yu, Q.S.4
Ingram, D.K.5
Meyer, R.C.6
-
29
-
-
0037238039
-
The pharmacology of amyloid precursor protein processing
-
Racchi M. and Govoni S. (2003) The pharmacology of amyloid precursor protein processing. Exper. Geront. 38, 145-157.
-
(2003)
Exper. Geront
, vol.38
, pp. 145-157
-
-
Racchi, M.1
Govoni, S.2
-
30
-
-
0347928847
-
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
-
Rogers J. T., Randall J. D., Cahill C. M., et al. (2002) An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript. J. Biol. Chem. 277, 45,518-45,528.
-
(2002)
J. Biol. Chem
, vol.277
-
-
Rogers, J.T.1
Randall, J.D.2
Cahill, C.M.3
-
31
-
-
0036370776
-
Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease
-
Sambamurti K., Greig N. H., and Lahiri D. K. (2002) Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromol. Med. 1, 1-31.
-
(2002)
Neuromol. Med
, vol.1
, pp. 1-31
-
-
Sambamurti, K.1
Greig, N.H.2
Lahiri, D.K.3
-
32
-
-
0035912825
-
Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development
-
Shaw K. T., Utsuki T., Rogers J., et al. (2001) Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc. Natl. Acad. Sci. USA 98, 7605-7610.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 7605-7610
-
-
Shaw, K.T.1
Utsuki, T.2
Rogers, J.3
-
33
-
-
0038647792
-
Therapeutics and mild cognitive impairment: Current status and future directions
-
Thal L. J. (2003) Therapeutics and mild cognitive impairment: current status and future directions. Alzheimer Dis. Assoc. Disord. 17(Suppl 2), 69-71.
-
(2003)
Alzheimer Dis. Assoc. Disord
, vol.17
, Issue.SUPPL. 2
, pp. 69-71
-
-
Thal, L.J.1
-
34
-
-
33745966453
-
Identification of novel small molecule inhibitors of APP protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide
-
In press
-
Utsuki T., Yu Q.-S., Davidson D., et al. (2006) Identification of novel small molecule inhibitors of APP protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide. J. Pharmacol. Exp. Ther. In press.
-
(2006)
J. Pharmacol. Exp. Ther
-
-
Utsuki, T.1
Yu, Q.-S.2
Davidson, D.3
-
35
-
-
0035935699
-
Methyl analogues of the experimental Alzheimer drug phenserine: Synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action
-
Yu Q., Holloway H. W., Flippen-Anderson J. L., Hoffman B., Brossi A., and Greig N. H. (2001) Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action. J. Med. Chem. 44, 4062-4071.
-
(2001)
J. Med. Chem
, vol.44
, pp. 4062-4071
-
-
Yu, Q.1
Holloway, H.W.2
Flippen-Anderson, J.L.3
Hoffman, B.4
Brossi, A.5
Greig, N.H.6
|