Prevalence of methylenetetrahydrofolate reductase mutations in patients with venous thrombosis

Molecular Diagnosis

Volumn 5, Issue 1, 2000, Pages 59-66

  Donnelly, James G ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Folate; Homocysteine; Methylenetetrahydrofolate reductase; Thrombosis

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE;

ADULT; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ACTIVITY; GENE MUTATION; GENETIC LINKAGE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PREVALENCE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; VEIN THROMBOSIS;

EID: 0034061368     PISSN: 10848592     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1084-8592(00)00012-6     Document Type: Article

References (5)

1. Appleby RD, Olds RJ: The inherited basis of venous thrombosis. Pathology 1997;29:341-347
2. Helmerhorst FM, Bloemenkamp KW, Rosendaal FR, Vandenbroucke JP: Oral contraceptives and thrombotic disease: Risk of venous thromboembolism. Thromb Haemost 1997;78:327-333
3. Ens GE: Disorders leading to thrombosis. In Stiene-Martin EA, Lotspeich-Steininger CA, Koepke JA: Clinical hematology: Principles, procedures, correlations. Lippincott, Philadelphia, 1998, pp. 675-681
4. Gallagher PM, Ward P, Tan S, et al.: High frequency (71%) of cystathionine β-synthase mutation G307S in Irish homocystinuria patients. Hum Mutat 1995; 6:177-180
5. Graham IM, Daly LE, Refsum HM, et al.: Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA 1997;277:1775-1781