Discovery of the first non-peptide full agonists for the human bradykinin B2 receptor incorporating 4-(2-picolyloxy)quinoline and 1-(2-picolyl)benzimidazole frameworks

Journal of Medicinal Chemistry

Volumn 47, Issue 11, 2004, Pages 2853-2863

  Sawada, Yuki ^a   Kayakiri, Hiroshi ^a   Abe, Yoshito ^a   Mizutani, Tsuyoshi ^a   Inamura, Noriaki ^a   Asano, Masayuki ^a   Hatori, Chie ^a   Aramori, Ichiro ^a   Oku, Teruo ^a   Tanaka, Hirokazu ^a,b  

^a ASTELLAS PHARMA INC   (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 PICOLYL)BENZIMIDAZOLE; 4 (2 PICOLYLOXY)QUINOLINE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; BRADYKININ B2 RECEPTOR AGONIST; INOSITOL PHOSPHATE; LIGAND; PROSTAGLANDIN E2; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GUINEA PIG; NONHUMAN; PHARMACOPHORE; PROSTAGLANDIN SYNTHESIS; RECEPTOR OCCUPANCY; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; DINOPROSTONE; FIBROBLASTS; GLYCINE; GUINEA PIGS; HUMANS; ILEUM; INOSITOL PHOSPHATES; LIGANDS; QUINOLINES; RADIOLIGAND ASSAY; RECEPTOR, BRADYKININ B2;

EID: 2442650309     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030468n     Document Type: Article

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