Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents

Toxicological Sciences

Volumn 115, Issue 1, 2010, Pages 183-193

  Jiang, Wei ^a   Duysen, Ellen G ^a   Hansen, Heidi ^a   Shlyakhtenko, Luda ^a   Schopfer, Lawrence M ^a   Lockridge, Oksana ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Chlorpyrifos; Mass spectrometry; Nanoimaging; Neurotoxicity; Tubulin

Indexed keywords

ACETYLCHOLINESTERASE; ANAZOLENE SODIUM; BETA TUBULIN; CHLORPYRIFOS; CHLORPYRIFOS OXON; ORGANOPHOSPHORUS COMPOUND; TYROSINE; UNCLASSIFIED DRUG; CHOLINESTERASE; DRUG DERIVATIVE; INSECTICIDE; MICROTUBULE ASSOCIATED PROTEIN; O,O DIETHYL O 3,5,6 TRICHLORO 2 PYRIDYL PHOSPHATE; O,O-DIETHYL O-3,5,6-TRICHLORO-2-PYRIDYL PHOSPHATE; ORGANOPHOSPHATE; TUBULIN; TUBULIN MODULATOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOMIC FORCE MICROSCOPY; BRAIN; CONTROLLED STUDY; IN VIVO CULTURE; MASS SPECTROMETRY; MICROTUBULE; MOUSE; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; STAINING; ANIMAL; BIOTINYLATION; BODY TEMPERATURE; BODY WEIGHT; BRAIN LEVEL; CHEMISTRY; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; METABOLISM; MOUSE STRAIN; PEPTIDE MAPPING; TOXICITY AND INTOXICATION;

MUS;

ANIMALS; BIOTINYLATION; BODY TEMPERATURE; BODY WEIGHT; BRAIN; BRAIN CHEMISTRY; CHLORPYRIFOS; CHOLINESTERASES; FEMALE; INSECTICIDES; MASS SPECTROMETRY; MICE; MICE, INBRED STRAINS; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; NEUROTOXICITY SYNDROMES; PEPTIDE MAPPING; PHOSPHORIC ACID ESTERS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TUBULIN; TUBULIN MODULATORS;

EID: 79551685829     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq032     Document Type: Article

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