Chlorpyrifos, chlorpyrifos-oxon, and diisopropylfluorophosphate inhibit kinesin-dependent microtubule motility

Toxicology and Applied Pharmacology

Volumn 218, Issue 1, 2007, Pages 20-29

  Gearhart, Debra A ^a   Sickles, Dale W ^a   Buccafusco, Jerry J ^a,b   Prendergast, Mark A ^c   Terry Jr , Alvin V ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Axonal transport; Chlorpyrifos; Chlorpyrifos oxon; Cholinesterase; DFP; Diisopropylfluorophosphate; Kinesin; Kinesin superfamily (KIF); Microtubule motility; Microtubules; Organophosphates; Organophosphorus; Pesticides; Tubulin

Indexed keywords

CHEMICAL WARFARE AGENT; CHLORPYRIFOS; CHLORPYRIFOS OXON; CHOLINESTERASE; DYFLOS; KINESIN; ORGANOPHOSPHATE; TUBULIN; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL ORGANELLE; CELL TRANSPORT; CELL VACUOLE; CENTRAL NERVOUS SYSTEM; CONCENTRATION (PARAMETERS); COW; ENZYME INHIBITION; EUKARYOTIC CELL; IN VITRO STUDY; MICROTUBULE ASSEMBLY; NERVE CELL; NERVE ENDING; NERVE FIBER TRANSPORT; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRESYNAPTIC NERVE; PROTEIN SYNTHESIS;

ANIMALS; AXONAL TRANSPORT; BRAIN; BRAIN CHEMISTRY; CATTLE; CHEMICAL WARFARE AGENTS; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; KINESIN; MICROTUBULES; MOLECULAR STRUCTURE; PESTICIDES; PHOSPHORIC TRIESTER HYDROLASES; TUBULIN;

BOVINAE; EUKARYOTA; RATTUS;

EID: 33846025142     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.10.008     Document Type: Article

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