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Volumn 240, Issue 2, 2009, Pages 149-158

Mass spectrometry identifies multiple organophosphorylated sites on tubulin

Author keywords

Chlorpyrifos oxon; Mass spectrometry; Tubulin; Tyrosine

Indexed keywords

ALPHA TUBULIN; BETA TUBULIN; CHLORPYRIFOS; TYROSINE;

EID: 70349247687     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.07.020     Document Type: Article
Times cited : (43)

References (56)
  • 1
    • 0029029401 scopus 로고
    • Involvement of cytoskeletal proteins in the mechanisms of organophosphorus ester-induced delayed neurotoxicity
    • Abou-Donia M.B. Involvement of cytoskeletal proteins in the mechanisms of organophosphorus ester-induced delayed neurotoxicity. Clin. Exp. Pharmacol. Physiol. 22 (1995) 358-359
    • (1995) Clin. Exp. Pharmacol. Physiol. , vol.22 , pp. 358-359
    • Abou-Donia, M.B.1
  • 2
    • 3042688573 scopus 로고    scopus 로고
    • Organophosphorus ester-induced chronic neurotoxicity
    • Abou-Donia M.B. Organophosphorus ester-induced chronic neurotoxicity. Arch. Environ. Health 58 (2003) 484-497
    • (2003) Arch. Environ. Health , vol.58 , pp. 484-497
    • Abou-Donia, M.B.1
  • 3
    • 1542275600 scopus 로고    scopus 로고
    • The application of the fluoride reactivation process to the detection of sarin and soman nerve agent exposures in biological samples
    • Adams T.K., Capacio B.R., Smith J.R., Whalley C.E., and Korte W.D. The application of the fluoride reactivation process to the detection of sarin and soman nerve agent exposures in biological samples. Drug Chem. Toxicol. 27 (2004) 77-91
    • (2004) Drug Chem. Toxicol. , vol.27 , pp. 77-91
    • Adams, T.K.1    Capacio, B.R.2    Smith, J.R.3    Whalley, C.E.4    Korte, W.D.5
  • 4
    • 0242539881 scopus 로고    scopus 로고
    • Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods
    • Aldridge J.E., Seidler F.J., Meyer A., Thillai I., and Slotkin T.A. Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environ. Health Perspect. 111 (2003) 1736-1743
    • (2003) Environ. Health Perspect. , vol.111 , pp. 1736-1743
    • Aldridge, J.E.1    Seidler, F.J.2    Meyer, A.3    Thillai, I.4    Slotkin, T.A.5
  • 5
    • 0033003543 scopus 로고    scopus 로고
    • Biomarkers of exposure to organophosphorous insecticides among farmers' families in rural El Salvador: factors associated with exposure
    • Azaroff L.S. Biomarkers of exposure to organophosphorous insecticides among farmers' families in rural El Salvador: factors associated with exposure. Environ. Res. 80 (1999) 138-147
    • (1999) Environ. Res. , vol.80 , pp. 138-147
    • Azaroff, L.S.1
  • 6
    • 0035798826 scopus 로고    scopus 로고
    • Diethylphosphorylation of rat cardiac M2 muscarinic receptor by chlorpyrifos oxon in vitro
    • Bomser J.A., and Casida J.E. Diethylphosphorylation of rat cardiac M2 muscarinic receptor by chlorpyrifos oxon in vitro. Toxicol. Lett. 119 (2001) 21-26
    • (2001) Toxicol. Lett. , vol.119 , pp. 21-26
    • Bomser, J.A.1    Casida, J.E.2
  • 7
    • 0031754195 scopus 로고    scopus 로고
    • Review of health consequences from high-, intermediate- and low-level exposure to organophosphorus nerve agents
    • Brown M.A., and Brix K.A. Review of health consequences from high-, intermediate- and low-level exposure to organophosphorus nerve agents. J. Appl. Toxicol. 18 (1998) 393-408
    • (1998) J. Appl. Toxicol. , vol.18 , pp. 393-408
    • Brown, M.A.1    Brix, K.A.2
  • 8
    • 34248383598 scopus 로고    scopus 로고
    • Differential protein adduction by seven organophosphorus pesticides in both brain and thymus
    • Carter W.G., Tarhoni M., Rathbone A.J., and Ray D.E. Differential protein adduction by seven organophosphorus pesticides in both brain and thymus. Hum. Exp. Toxicol. 26 (2007) 347-353
    • (2007) Hum. Exp. Toxicol. , vol.26 , pp. 347-353
    • Carter, W.G.1    Tarhoni, M.2    Rathbone, A.J.3    Ray, D.E.4
  • 9
    • 4243148518 scopus 로고    scopus 로고
    • Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets
    • Casida J.E., and Quistad G.B. Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets. Chem. Res. Toxicol. 17 (2004) 983-998
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 983-998
    • Casida, J.E.1    Quistad, G.B.2
  • 10
    • 0035815482 scopus 로고    scopus 로고
    • Possible role of enhanced microtubule phosphorylation in dichlorvos induced delayed neurotoxicity in rat
    • Choudhary S., Joshi K., and Gill K.D. Possible role of enhanced microtubule phosphorylation in dichlorvos induced delayed neurotoxicity in rat. Brain Res. 897 (2001) 60-70
    • (2001) Brain Res. , vol.897 , pp. 60-70
    • Choudhary, S.1    Joshi, K.2    Gill, K.D.3
  • 15
    • 50649103273 scopus 로고    scopus 로고
    • Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents
    • Grigoryan H., Schopfer L.M., Thompson C.M., Terry A.V., Masson P., and Lockridge O. Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents. Chem. Biol. Interact. 175 (2008) 180-186
    • (2008) Chem. Biol. Interact. , vol.175 , pp. 180-186
    • Grigoryan, H.1    Schopfer, L.M.2    Thompson, C.M.3    Terry, A.V.4    Masson, P.5    Lockridge, O.6
  • 17
    • 0028017677 scopus 로고
    • In vivo and in vitro effects of diisopropyl phosphorofluoridate (DFP) on the rate of hen brain tubulin polymerization
    • Gupta R.P., and Abou-Donia M.B. In vivo and in vitro effects of diisopropyl phosphorofluoridate (DFP) on the rate of hen brain tubulin polymerization. Neurochem. Res. 19 (1994) 435-444
    • (1994) Neurochem. Res. , vol.19 , pp. 435-444
    • Gupta, R.P.1    Abou-Donia, M.B.2
  • 18
    • 0141542697 scopus 로고    scopus 로고
    • Direct analysis of the kinetic profiles of organophosphate-acetylcholinesterase adducts by MALDI-TOF mass spectrometry
    • Jennings L.L., Malecki M., Komives E.A., and Taylor P. Direct analysis of the kinetic profiles of organophosphate-acetylcholinesterase adducts by MALDI-TOF mass spectrometry. Biochemistry 42 (2003) 11083-11091
    • (2003) Biochemistry , vol.42 , pp. 11083-11091
    • Jennings, L.L.1    Malecki, M.2    Komives, E.A.3    Taylor, P.4
  • 20
    • 0035799319 scopus 로고    scopus 로고
    • Profiling serine hydrolase activities in complex proteomes
    • Kidd D., Liu Y., and Cravatt B.F. Profiling serine hydrolase activities in complex proteomes. Biochemistry 40 (2001) 4005-4015
    • (2001) Biochemistry , vol.40 , pp. 4005-4015
    • Kidd, D.1    Liu, Y.2    Cravatt, B.F.3
  • 21
    • 12344289246 scopus 로고    scopus 로고
    • Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition
    • Lein P.J., and Fryer A.D. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicol. Sci. 83 (2005) 166-176
    • (2005) Toxicol. Sci. , vol.83 , pp. 166-176
    • Lein, P.J.1    Fryer, A.D.2
  • 23
    • 33846389181 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411
    • Li B., Schopfer L.M., Hinrichs S.H., Masson P., and Lockridge O. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411. Anal. Biochem. 361 (2007) 263-272
    • (2007) Anal. Biochem. , vol.361 , pp. 263-272
    • Li, B.1    Schopfer, L.M.2    Hinrichs, S.H.3    Masson, P.4    Lockridge, O.5
  • 24
    • 35448956936 scopus 로고    scopus 로고
    • Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry
    • Li H., Schopfer L.M., Nachon F., Froment M.T., Masson P., and Lockridge O. Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry. Toxicol. Sci. 100 (2007) 136-145
    • (2007) Toxicol. Sci. , vol.100 , pp. 136-145
    • Li, H.1    Schopfer, L.M.2    Nachon, F.3    Froment, M.T.4    Masson, P.5    Lockridge, O.6
  • 25
    • 53049095404 scopus 로고    scopus 로고
    • Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines
    • Lockridge O., Xue W., Gaydess A., Grigoryan H., Ding S.J., Schopfer L.M., Hinrichs S.H., and Masson P. Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines. J. Biol. Chem. 283 (2008) 22582-22590
    • (2008) J. Biol. Chem. , vol.283 , pp. 22582-22590
    • Lockridge, O.1    Xue, W.2    Gaydess, A.3    Grigoryan, H.4    Ding, S.J.5    Schopfer, L.M.6    Hinrichs, S.H.7    Masson, P.8
  • 26
    • 0030726679 scopus 로고    scopus 로고
    • Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology
    • McDonough Jr. J.H., and Shih T.M. Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neurosci. Biobehav. Rev. 21 (1997) 559-579
    • (1997) Neurosci. Biobehav. Rev. , vol.21 , pp. 559-579
    • McDonough Jr., J.H.1    Shih, T.M.2
  • 27
    • 0029561808 scopus 로고
    • Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats
    • Moser V.C. Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats. Neurotoxicol. Teratol. 17 (1995) 617-625
    • (1995) Neurotoxicol. Teratol. , vol.17 , pp. 617-625
    • Moser, V.C.1
  • 31
    • 3543062947 scopus 로고    scopus 로고
    • Coumarin tags for improved analysis of peptides by MALDI-TOF MS and MS/MS. 1. Enhancement in MALDI MS signal intensities
    • Pashkova A., Moskovets E., and Karger B.L. Coumarin tags for improved analysis of peptides by MALDI-TOF MS and MS/MS. 1. Enhancement in MALDI MS signal intensities. Anal. Chem. 76 (2004) 4550-4557
    • (2004) Anal. Chem. , vol.76 , pp. 4550-4557
    • Pashkova, A.1    Moskovets, E.2    Karger, B.L.3
  • 33
    • 0033434080 scopus 로고    scopus 로고
    • Probability-based protein identification by searching sequence databases using mass spectrometry data
    • Perkins D.N., Pappin D.J., Creasy D.M., and Cottrell J.S. Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 20 (1999) 3551-3567
    • (1999) Electrophoresis , vol.20 , pp. 3551-3567
    • Perkins, D.N.1    Pappin, D.J.2    Creasy, D.M.3    Cottrell, J.S.4
  • 34
    • 0033369584 scopus 로고    scopus 로고
    • Organophosphorus pesticides: do they all have the same mechanism of toxicity?
    • Pope C.N. Organophosphorus pesticides: do they all have the same mechanism of toxicity?. J. Toxicol. Environ. Health B Crit. Rev. 2 (1999) 161-181
    • (1999) J. Toxicol. Environ. Health B Crit. Rev. , vol.2 , pp. 161-181
    • Pope, C.N.1
  • 39
    • 0348046513 scopus 로고    scopus 로고
    • Neuropsychiatric evaluation in subjects chronically exposed to organophosphate pesticides
    • Salvi R.M., Lara D.R., Ghisolfi E.S., Portela L.V., Dias R.D., and Souza D.O. Neuropsychiatric evaluation in subjects chronically exposed to organophosphate pesticides. Toxicol. Sci. 72 (2003) 267-271
    • (2003) Toxicol. Sci. , vol.72 , pp. 267-271
    • Salvi, R.M.1    Lara, D.R.2    Ghisolfi, E.S.3    Portela, L.V.4    Dias, R.D.5    Souza, D.O.6
  • 40
    • 27544434661 scopus 로고    scopus 로고
    • Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410)
    • Schopfer L.M., Champion M.M., Tamblyn N., Thompson C.M., and Lockridge O. Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410). Anal. Biochem. 345 (2005) 122-132
    • (2005) Anal. Biochem. , vol.345 , pp. 122-132
    • Schopfer, L.M.1    Champion, M.M.2    Tamblyn, N.3    Thompson, C.M.4    Lockridge, O.5
  • 41
    • 69249236018 scopus 로고    scopus 로고
    • Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates
    • Schopfer L.M., Grigoryan H., Li B., Nachon F., Masson P., and Lockridge O. Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates. J. Chromatogr. B (2009)
    • (2009) J. Chromatogr. B
    • Schopfer, L.M.1    Grigoryan, H.2    Li, B.3    Nachon, F.4    Masson, P.5    Lockridge, O.6
  • 42
    • 17644385852 scopus 로고    scopus 로고
    • Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase
    • Schopfer L.M., Voelker T., Bartels C.F., Thompson C.M., and Lockridge O. Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem. Res. Toxicol. 18 (2005) 747-754
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 747-754
    • Schopfer, L.M.1    Voelker, T.2    Bartels, C.F.3    Thompson, C.M.4    Lockridge, O.5
  • 43
    • 0036353211 scopus 로고    scopus 로고
    • Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons
    • Schuh R.A., Lein P.J., Beckles R.A., and Jett D.A. Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons. Toxicol. Appl. Pharmacol. 182 (2002) 176-185
    • (2002) Toxicol. Appl. Pharmacol. , vol.182 , pp. 176-185
    • Schuh, R.A.1    Lein, P.J.2    Beckles, R.A.3    Jett, D.A.4
  • 45
    • 0031194056 scopus 로고    scopus 로고
    • Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade
    • Song X., Seidler F.J., Saleh J.L., Zhang J., Padilla S., and Slotkin T.A. Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. Toxicol. Appl. Pharmacol. 145 (1997) 158-174
    • (1997) Toxicol. Appl. Pharmacol. , vol.145 , pp. 158-174
    • Song, X.1    Seidler, F.J.2    Saleh, J.L.3    Zhang, J.4    Padilla, S.5    Slotkin, T.A.6
  • 47
    • 33947310608 scopus 로고    scopus 로고
    • Development of a MALDI-TOF-MS method to identify and quantify butyrylcholinesterase inhibition resulting from exposure to organophosphate and carbamate pesticides
    • Sun J., and Lynn B.C. Development of a MALDI-TOF-MS method to identify and quantify butyrylcholinesterase inhibition resulting from exposure to organophosphate and carbamate pesticides. J. Am. Soc. Mass Spectrom. 18 (2007) 698-706
    • (2007) J. Am. Soc. Mass Spectrom. , vol.18 , pp. 698-706
    • Sun, J.1    Lynn, B.C.2
  • 48
    • 0022878401 scopus 로고
    • Calcium and calmodulin stimulated in vitro phosphorylation of rooster brain tubulin and MAP-2 following a single oral dose of tri-o-cresyl phosphate
    • Suwita E., Lapadula D.M., and Abou-Donia M.B. Calcium and calmodulin stimulated in vitro phosphorylation of rooster brain tubulin and MAP-2 following a single oral dose of tri-o-cresyl phosphate. Brain Res. 374 (1986) 199-203
    • (1986) Brain Res. , vol.374 , pp. 199-203
    • Suwita, E.1    Lapadula, D.M.2    Abou-Donia, M.B.3
  • 49
    • 0030292492 scopus 로고    scopus 로고
    • Detection and quantitation of beta-2-microglobulin glycosylated end products in human serum by matrix-assisted laser desorption/ionization mass spectrometry
    • Tang X., Sadeghi M., Olumee Z., Vertes A., Braatz J.A., McIlwain L.K., and Dreifuss P.A. Detection and quantitation of beta-2-microglobulin glycosylated end products in human serum by matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem. 68 (1996) 3740-3745
    • (1996) Anal. Chem. , vol.68 , pp. 3740-3745
    • Tang, X.1    Sadeghi, M.2    Olumee, Z.3    Vertes, A.4    Braatz, J.A.5    McIlwain, L.K.6    Dreifuss, P.A.7
  • 50
    • 45749121155 scopus 로고    scopus 로고
    • Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides
    • Tarhoni M.H., Lister T., Ray D.E., and Carter W.G. Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers 13 (2008) 343-363
    • (2008) Biomarkers , vol.13 , pp. 343-363
    • Tarhoni, M.H.1    Lister, T.2    Ray, D.E.3    Carter, W.G.4
  • 53
    • 0023655205 scopus 로고
    • Phosphorylation of alpha-tubulin carboxyl-terminal tyrosine prevents its incorporation into microtubules
    • Wandosell F., Serrano L., and Avila J. Phosphorylation of alpha-tubulin carboxyl-terminal tyrosine prevents its incorporation into microtubules. J. Biol. Chem. 262 (1987) 8268-8273
    • (1987) J. Biol. Chem. , vol.262 , pp. 8268-8273
    • Wandosell, F.1    Serrano, L.2    Avila, J.3
  • 54
    • 34547800796 scopus 로고    scopus 로고
    • Phosphylated tyrosine in albumin as a biomarker of exposure to organophosphorus nerve agents
    • Williams N.H., Harrison J.M., Read R.W., and Black R.M. Phosphylated tyrosine in albumin as a biomarker of exposure to organophosphorus nerve agents. Arch. Toxicol. 81 (2007) 627-639
    • (2007) Arch. Toxicol. , vol.81 , pp. 627-639
    • Williams, N.H.1    Harrison, J.M.2    Read, R.W.3    Black, R.M.4
  • 56
    • 21144445429 scopus 로고    scopus 로고
    • Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography
    • Zheng H., Hu P., Quinn D.F., and Wang Y.K. Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography. Mol. Cell Proteomics 4 (2005) 721-730
    • (2005) Mol. Cell Proteomics , vol.4 , pp. 721-730
    • Zheng, H.1    Hu, P.2    Quinn, D.F.3    Wang, Y.K.4


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