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Volumn 2, Issue 2, 2011, Pages 317-323

Association of a functional polymorphism (Gln261Arg) in 12-lipoxygenase with breast cancer

Author keywords

12 lipoxygenase; 2 hydroxyeicosatetraenoic acid; Arachidonyl lipoxygenase 12; Breast cancer; Lipoxygenase; Polymorphism and gene variants; Single nucleotide polymorphism

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; ARGININE; GLUTAMINE;

EID: 79551652304     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2011.209     Document Type: Article
Times cited : (18)

References (63)
  • 2
    • 0029895338 scopus 로고    scopus 로고
    • Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis
    • Tang DG, Chen YQ and Honn KV: Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Proc Natl Acad Sci USA 93: 5241-5246, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5241-5246
    • Tang, D.G.1    Chen, Y.Q.2    Honn, K.V.3
  • 3
    • 0032561157 scopus 로고    scopus 로고
    • Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice
    • Connolly JM and Rose DP: Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice. Cancer Lett 132: 107-112, 1998.
    • (1998) Cancer Lett , vol.132 , pp. 107-112
    • Connolly, J.M.1    Rose, D.P.2
  • 4
    • 0034464098 scopus 로고    scopus 로고
    • The possible involvement of 15-lipoxygenase/ leukocyte type 12-lipoxygenase in colorectal carcinogenesis
    • Kamitani H, Ikwa H, Hsi LC, Wantanabe T, Dubois RN and Eling TE: The possible involvement of 15-lipoxygenase/ leukocyte type 12-lipoxygenase in colorectal carcinogenesis. Adv Exp Med Biol 469: 593-598, 1999.
    • (1999) Adv Exp Med Biol , vol.469 , pp. 593-598
    • Kamitani, H.1    Ikwa, H.2    Hsi, L.C.3    Wantanabe, T.4    Dubois, R.N.5    Eling, T.E.6
  • 6
    • 33746865318 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia
    • Jatana M, Giri CC, Ansari MA, Elango C, Singh AK, Singh I and Khan I: Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. J Neuroinflammation 11: 3-12, 2006.
    • (2006) J Neuroinflammation , vol.11 , pp. 3-12
    • Jatana, M.1    Giri, C.C.2    Ansari, M.A.3    Elango, C.4    Singh, A.K.5    Singh, I.6    Khan, I.7
  • 7
    • 33749612562 scopus 로고    scopus 로고
    • What are cycloxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?
    • Furstenberger G, Krieg P, Muller-Decker K and Habenicht AJ: What are cycloxygenases and lipoxygenases doing in the driver's seat of carcinogenesis? int J Cancer 119: 2247-2254, 2006.
    • (2006) Int J Cancer , vol.119 , pp. 2247-2254
    • Furstenberger, G.1    Krieg, P.2    Muller-Decker, K.3    Habenicht, A.J.4
  • 8
    • 40549108939 scopus 로고    scopus 로고
    • A dual COX/5-LOX inhibitor induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade
    • Tavolari S, Bonafe M, Marina MM, et al: A dual COX/5-LOX inhibitor induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis 29: 371-380, 2008.
    • (2008) Carcinogenesis , vol.29 , pp. 371-380
    • Tavolari, S.1    Bonafe, M.2    Marina, M.M.3
  • 9
    • 77955454197 scopus 로고    scopus 로고
    • Potential role of the lipoxygenase-derived lipid mediators in atherosclerosis; leukotrienes, lipoxins and resolvins
    • Hersberger M: Potential role of the lipoxygenase-derived lipid mediators in atherosclerosis; leukotrienes, lipoxins and resolvins. Clin Chem Lab Med 48: 1063-1073, 2010.
    • (2010) Clin Chem Lab Med , vol.48 , pp. 1063-1073
    • Hersberger, M.1
  • 10
    • 0035976575 scopus 로고    scopus 로고
    • Prostaglandins and leukotrienes: Advances in eicosanoid biology
    • Funk CD: Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294: 1871-1875, 2001.
    • (2001) Science , vol.294 , pp. 1871-1875
    • Funk, C.D.1
  • 11
    • 0036283215 scopus 로고    scopus 로고
    • Cyclooxygenase, lipoxygenase and tumor angiogenesis
    • Nie D and Honn KV: Cyclooxygenase, lipoxygenase and tumor angiogenesis. Cell Mol Life Sci 59: 799-807, 2002.
    • (2002) Cell Mol Life Sci , vol.59 , pp. 799-807
    • Nie, D.1    Honn, K.V.2
  • 12
    • 4544236324 scopus 로고    scopus 로고
    • Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: Effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase
    • Hong J, Bose M, Ju J, Ryu JH, Chen X, Sang S, Lee MJ and Yang CS: Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis 25: 1671-1679, 2004.
    • (2004) Carcinogenesis , vol.25 , pp. 1671-1679
    • Hong, J.1    Bose, M.2    Ju, J.3    Ryu, J.H.4    Chen, X.5    Sang, S.6    Lee, M.J.7    Yang, C.S.8
  • 13
    • 79551647739 scopus 로고    scopus 로고
    • The target of arachidonic acid pathway is a new anticancer strategy for human prostate cancer
    • Matsuyama M and Yoshimura R: The target of arachidonic acid pathway is a new anticancer strategy for human prostate cancer. Biologics: Targets and Therapy 2: 725-732.
    • Biologics: Targets and Therapy , vol.2 , pp. 725-732
    • Matsuyama, M.1    Yoshimura, R.2
  • 14
    • 0033588022 scopus 로고    scopus 로고
    • Lipoxygenases: Occurrence, functions, catalysis, and acquisitions of substrate
    • Brash AR: Lipoxygenases: occurrence, functions, catalysis, and acquisitions of substrate. J Biol Chem 274: 23769-23682, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 23769-23682
    • Brash, A.R.1
  • 16
    • 0035417925 scopus 로고    scopus 로고
    • Lipoxygenase modulation to reverse carcinogenesis
    • Shureiqi I and Lippman SM: Lipoxygenase modulation to reverse carcinogenesis. Cancer Res 61: 6307-6312, 2001.
    • (2001) Cancer Res , vol.61 , pp. 6307-6312
    • Shureiqi, I.1    Lippman, S.M.2
  • 17
    • 33747885659 scopus 로고    scopus 로고
    • Cyclooxygenases, lipoxygenases and epoxygenases in CNS: Their role and involvement in neurological disorders
    • Phillis JW, Horrocks LA and Farooqui AA: Cyclooxygenases, lipoxygenases and epoxygenases in CNS: their role and involvement in neurological disorders. Brain Res Rev 52: 201-243, 2006.
    • (2006) Brain Res Rev , vol.52 , pp. 201-243
    • Phillis, J.W.1    Horrocks, L.A.2    Farooqui, A.A.3
  • 18
    • 56349109857 scopus 로고    scopus 로고
    • Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes
    • Prasad VVTS, Nithipatikom K and Harder DR: Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes. Neurochem Int 53: 220-229, 2008.
    • (2008) Neurochem Int , vol.53 , pp. 220-229
    • Prasad, V.V.T.S.1    Nithipatikom, K.2    Harder, D.R.3
  • 20
    • 0034523901 scopus 로고    scopus 로고
    • The role of cyclooxygenase and lipoxygenase in cancer chemoprevention
    • Cuendet M and Pezzuto JM: The role of cyclooxygenase and lipoxygenase in cancer chemoprevention. Drug Metabol Drug Interact 17: 109-157, 2000.
    • (2000) Drug Metabol Drug Interact , vol.17 , pp. 109-157
    • Cuendet, M.1    Pezzuto, J.M.2
  • 22
    • 0346368096 scopus 로고    scopus 로고
    • Targeting cyclooxygenase 2 in human neoplasia: Rationale and promise
    • Dannenberg AJ and Subbaramaiah K: Targeting cyclooxygenase 2 in human neoplasia: rationale and promise. Cancer Cell 4: 431-436, 2003.
    • (2003) Cancer Cell , vol.4 , pp. 431-436
    • Dannenberg, A.J.1    Subbaramaiah, K.2
  • 24
    • 25444475777 scopus 로고    scopus 로고
    • Elevation of 12/15-lipoxygenase products in AD and mild cognitive impairment
    • Yao Y, Clark CM, Trojanowski JQ, Lee VMY and Pratico D: Elevation of 12/15-lipoxygenase products in AD and mild cognitive impairment. Ann Neurol 58: 623-626, 2005.
    • (2005) Ann Neurol , vol.58 , pp. 623-626
    • Yao, Y.1    Clark, C.M.2    Trojanowski, J.Q.3    Lee, V.M.Y.4    Pratico, D.5
  • 25
    • 0033812812 scopus 로고    scopus 로고
    • Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor - deficient mice
    • Harats D, Shaish A, George J, Mulkins M, Kurihara H, Levkovitz H and Sigal E: Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor - deficient mice. Arterioscl Thromb Vasc Biol 20: 2100-2105, 2000.
    • (2000) Arterioscl Thromb Vasc Biol , vol.20 , pp. 2100-2105
    • Harats, D.1    Shaish, A.2    George, J.3    Mulkins, M.4    Kurihara, H.5    Levkovitz, H.6    Sigal, E.7
  • 26
    • 14044268133 scopus 로고    scopus 로고
    • Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis
    • Takahashi Y, Zhu H and Yoshimoto T: Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis. Antioxid Redox Signal 7: 425-431, 2005.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 425-431
    • Takahashi, Y.1    Zhu, H.2    Yoshimoto, T.3
  • 27
    • 31544454435 scopus 로고    scopus 로고
    • A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE in hypertension
    • Quintana LF, Guzman B, Collado S, Claria J and Poch E: A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE in hypertension. Kidney Int 69: 526-530, 2006.
    • (2006) Kidney Int , vol.69 , pp. 526-530
    • Quintana, L.F.1    Guzman, B.2    Collado, S.3    Claria, J.4    Poch, E.5
  • 28
    • 33646549564 scopus 로고    scopus 로고
    • Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration
    • Musiek ES, Breeding RS, Milne GL, Zanoni G, Marrow JD and McLaughlin B: Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration. J Neurochem 97: 1301-113, 2006.
    • (2006) J Neurochem , vol.97 , pp. 1301-1113
    • Musiek, E.S.1    Breeding, R.S.2    Milne, G.L.3    Zanoni, G.4    Marrow, J.D.5    McLaughlin, B.6
  • 29
    • 34249287061 scopus 로고    scopus 로고
    • Physiologic and pathophysiologic roles of lipid mediators in the kidney
    • Hao CM and Breyer MD: Physiologic and pathophysiologic roles of lipid mediators in the kidney. Kidney Int 71: 1105-1115, 2007.
    • (2007) Kidney Int , vol.71 , pp. 1105-1115
    • Hao, C.M.1    Breyer, M.D.2
  • 30
    • 0036312330 scopus 로고    scopus 로고
    • A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer
    • Howe LR and Dannenberg AJ: A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer. Semin Oncol 29 (Suppl 11): 111-119, 2002.
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL 11 , pp. 111-119
    • Howe, L.R.1    Dannenberg, A.J.2
  • 32
    • 37249062653 scopus 로고    scopus 로고
    • 12-Lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway
    • Chen FL, Wang XZ, Li JY, Yu P, Huang Y and Chen ZX: 12-Lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway. Dig Dis Sci 53: 181-187, 2008.
    • (2008) Dig Dis Sci , vol.53 , pp. 181-187
    • Chen, F.L.1    Wang, X.Z.2    Li, J.Y.3    Yu, P.4    Huang, Y.5    Chen, Z.X.6
  • 34
    • 63849232779 scopus 로고    scopus 로고
    • A positive feedback between activated extracellularly regulated kinase and cyclooxygenase/lipoxygenase maintains proliferation and migration of breast cancer cells
    • You J, Mi D, Zhou X, Qiao L, Zhang H, Zhang X and Ye L: A positive feedback between activated extracellularly regulated kinase and cyclooxygenase/lipoxygenase maintains proliferation and migration of breast cancer cells. Endocrinology 150: 1607-1617, 2009.
    • (2009) Endocrinology , vol.150 , pp. 1607-1617
    • You, J.1    Mi, D.2    Zhou, X.3    Qiao, L.4    Zhang, H.5    Zhang, X.6    Ye, L.7
  • 37
    • 33846225642 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: Impact on prognosis and therapy
    • Mohammad AM, Abdel HA, Abdel W, Ahmed AM, Weel T and Eimen G: Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: impact on prognosis and therapy. Indian J Cancer 43: 163-168, 2009.
    • (2009) Indian J Cancer , vol.43 , pp. 163-168
    • Mohammad, A.M.1    Abdel, H.A.2    Abdel, W.3    Ahmed, A.M.4    Weel, T.5    Eimen, G.6
  • 38
    • 0035849787 scopus 로고    scopus 로고
    • Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion
    • Krueger JS, Keshamouni VG, Atanaskova N and Reddy KB: Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion. Oncogene 20: 4209-4218, 2001.
    • (2001) Oncogene , vol.20 , pp. 4209-4218
    • Krueger, J.S.1    Keshamouni, V.G.2    Atanaskova, N.3    Reddy, K.B.4
  • 39
    • 52149114882 scopus 로고    scopus 로고
    • Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through crosstalk with activated ERK 1/2
    • Zhou X, Lin Y, You J, Zhang X and Ye L: Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through crosstalk with activated ERK 1/2. Cancer Lett 270: 312-327, 2008.
    • (2008) Cancer Lett , vol.270 , pp. 312-327
    • Zhou, X.1    Lin, Y.2    You, J.3    Zhang, X.4    Ye, L.5
  • 40
    • 34447558399 scopus 로고    scopus 로고
    • Association of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer
    • Tan W, Wu J, Zhang X, Guo Y, Liu J, Sun T, Zhang B, Zhao D, Yang M, Yu D and Lin D: Association of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. Carcinogenesis 28: 1197-1201, 2007.
    • (2007) Carcinogenesis , vol.28 , pp. 1197-1201
    • Tan, W.1    Wu, J.2    Zhang, X.3    Guo, Y.4    Liu, J.5    Sun, T.6    Zhang, B.7    Zhao, D.8    Yang, M.9    Yu, D.10    Lin, D.11
  • 41
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • Miller S, Dykes D and Polesky H: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16: 1215, 1988.
    • (1988) Nucleic Acids Res , vol.16 , pp. 1215
    • Miller, S.1    Dykes, D.2    Polesky, H.3
  • 42
    • 10344220480 scopus 로고    scopus 로고
    • Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk
    • Goodman JE, Bowman ED, Chanock SJ, Alberg AJ and Harris CC: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. Carcinogenesis 25: 2467-2472, 2004.
    • (2004) Carcinogenesis , vol.25 , pp. 2467-2472
    • Goodman, J.E.1    Bowman, E.D.2    Chanock, S.J.3    Alberg, A.J.4    Harris, C.C.5
  • 43
    • 33847405410 scopus 로고    scopus 로고
    • Common polymorphisms in 5-lipoxy-genase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma
    • Gong Z, Hebert JR, Bostick RM, Deng Z, Hurley TG, Dixon DA, Nitcheva D and Xie D: Common polymorphisms in 5-lipoxy-genase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma. Cancer 109: 849-857, 2007.
    • (2007) Cancer , vol.109 , pp. 849-857
    • Gong, Z.1    Hebert, J.R.2    Bostick, R.M.3    Deng, Z.4    Hurley, T.G.5    Dixon, D.A.6    Nitcheva, D.7    Xie, D.8
  • 44
    • 77954529978 scopus 로고    scopus 로고
    • Association between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population
    • Kim T, Kim HJ, Park JK, Kim JW and Chung JH: Association between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population. Behav Brain Functions 6: 44, 2010.
    • (2010) Behav Brain Functions , vol.6 , pp. 44
    • Kim, T.1    Kim, H.J.2    Park, J.K.3    Kim, J.W.4    Chung, J.H.5
  • 46
    • 27844472511 scopus 로고    scopus 로고
    • Causes of cancer in the world: Comparative risk assessment of nine behavioral and environmental risk factors
    • Danaei G, Hoorn SV, Lopez AD, Murray CJ and Ezzati M: Causes of cancer in the world: comparative risk assessment of nine behavioral and environmental risk factors. Lancet 366: 1784-1793, 2005.
    • (2005) Lancet , vol.366 , pp. 1784-1793
    • Danaei, G.1    Hoorn, S.V.2    Lopez, A.D.3    Murray, C.J.4    Ezzati, M.5
  • 47
    • 45349096041 scopus 로고    scopus 로고
    • American Cancer Society, American Cancer Society, Atlanta
    • American Cancer Society: Cancer Facts and Figures 2008. American Cancer Society, Atlanta, 2008.
    • (2008) Cancer Facts and Figures 2008
  • 48
    • 73349100507 scopus 로고    scopus 로고
    • Global trends in breast cancer incidence and mortality
    • Porter PL: Global trends in breast cancer incidence and mortality. Salud Public Mex (Suppl 2): 141-146, 2009.
    • (2009) Salud Public Mex , Issue.SUPPL 2 , pp. 141-146
    • Porter, P.L.1
  • 49
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A and McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177-182, 1987.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 50
    • 79551634523 scopus 로고    scopus 로고
    • Advances in systemic therapy for HER2-positive metastatic breast cancer
    • Morrow KPH, Zambrana F and Esteva FJ: Advances in systemic therapy for HER2-positive metastatic breast cancer. Breast cancer Res 11: 209, 2009.
    • (2009) Breast cancer Res , vol.11 , pp. 209
    • Morrow, K.P.H.1    Zambrana, F.2    Esteva, F.J.3
  • 51
    • 37849039228 scopus 로고    scopus 로고
    • Hereditary breast cancer: Part I. Diagnosing hereditary breast cancer syndromes
    • Lynch HT, Silva E, Snyder C and Lynch JF: Hereditary breast cancer: Part I. Diagnosing hereditary breast cancer syndromes. Breast J 14: 3-13, 2008.
    • (2008) Breast J , vol.14 , pp. 3-13
    • Lynch, H.T.1    Silva, E.2    Snyder, C.3    Lynch, J.F.4
  • 52
    • 79551647739 scopus 로고    scopus 로고
    • The target of arachidonic acid pathway is a new anticancer strategy for human prostate cancer
    • Matsuyama M and Yoshimura R: The target of arachidonic acid pathway is a new anticancer strategy for human prostate cancer. Biologics 294: 725-732, 2008.
    • (2008) Biologics , vol.294 , pp. 725-732
    • Matsuyama, M.1    Yoshimura, R.2
  • 54
    • 74549129423 scopus 로고    scopus 로고
    • ALOX12 gene is associated with the onset of natural menopause in white women
    • Liu LP, Recker RR, Deng HW and Dvornyk V: ALOX12 gene is associated with the onset of natural menopause in white women. Menopause 17: 152-156, 2010.
    • (2010) Menopause , vol.17 , pp. 152-156
    • Liu, L.P.1    Recker, R.R.2    Deng, H.W.3    Dvornyk, V.4
  • 55
    • 34247597263 scopus 로고    scopus 로고
    • Platelet 12-lipoxygenase Arg261Gln Polymorphism: Functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms
    • Guo Y, Zhang X, Ta W, Miao X, Sun T, Zhao D and Lin D: Platelet 12-lipoxygenase Arg261Gln Polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. Pharmacogenet Genomics 17: 197-205, 2007.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 197-205
    • Guo, Y.1    Zhang, X.2    Ta, W.3    Miao, X.4    Sun, T.5    Zhao, D.6    Lin, D.7
  • 56
    • 38049120330 scopus 로고    scopus 로고
    • Human platelet 12-lipoxy-genase, new findings about its activity, membrane binding and resolution structure
    • Aleem AM, Jankun J, Dignam JD, Walther M, Kohn H, Svergun D and Skrzypczak-Jankun E: Human platelet 12-lipoxy-genase, new findings about its activity, membrane binding and resolution structure. J Mol Biol 376: 193-209, 2007.
    • (2007) J Mol Biol , vol.376 , pp. 193-209
    • Aleem, A.M.1    Jankun, J.2    Dignam, J.D.3    Walther, M.4    Kohn, H.5    Svergun, D.6    Skrzypczak-Jankun, E.7
  • 57
    • 70350772548 scopus 로고    scopus 로고
    • Human platelet 12-lipoxygenase: Naturally occurring Q261/R261 variants and N544L mutant show altered activity but unaffected substrate binding and membrane association behavior
    • Aleem AM, Wells L, Jankun J, Walther M, Kohn H, Reinartz J and Skrzypczak-Jankun E: Human platelet 12-lipoxygenase: naturally occurring Q261/R261 variants and N544L mutant show altered activity but unaffected substrate binding and membrane association behavior. Int J Mol Med 24: 759-764, 2009.
    • (2009) Int J Mol Med , vol.24 , pp. 759-764
    • Aleem, A.M.1    Wells, L.2    Jankun, J.3    Walther, M.4    Kohn, H.5    Reinartz, J.6    Skrzypczak-Jankun, E.7
  • 58
    • 0036570319 scopus 로고    scopus 로고
    • Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells
    • Pidgeon GP, Kandouz M, Meram A and Honn KV: Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Cancer Res 62: 2721-2727, 2002.
    • (2002) Cancer Res , vol.62 , pp. 2721-2727
    • Pidgeon, G.P.1    Kandouz, M.2    Meram, A.3    Honn, K.V.4
  • 59
    • 33846965296 scopus 로고    scopus 로고
    • Lipoxygenase inhibitor in breast cancer brain metastases
    • Flavin DFA: Lipoxygenase inhibitor in breast cancer brain metastases. J Neurooncol 82: 91-93, 2007.
    • (2007) J Neurooncol , vol.82 , pp. 91-93
    • Flavin, D.F.A.1


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