A lipoxygenase inhibitor in breast cancer brain metastases

Journal of Neuro-Oncology

Volumn 82, Issue 1, 2007, Pages 91-93

  Flavin, D F ^a  

^a Foundation for Collaborative Medicine and Research   (United States)

Author keywords

Arachidonate: Oxygen oxidoreductase; Boswellia serrata; Brain Cancer; Breast Cancer; Breast Cancer Remission; Cancer; Herceptin; Lipoxygenase; Lipoxygenase inhibitor; LOX inhibitors; Metastases; Oxidoreductase inhibitor

Indexed keywords

ARACHIDONATE LIPOXYGENASE; BOSWELLIA SERRATA EXTRACT; CA 15-3 ANTIGEN; CAPECITABINE; CARCINOEMBRYONIC ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; LIPOXYGENASE INHIBITOR; TRASTUZUMAB;

ABSENCE OF SIDE EFFECTS; ADJUVANT THERAPY; ADULT; APOPTOSIS; ARTICLE; BONE METASTASIS; BRAIN METASTASIS; BREAST CANCER; BREAST SURGERY; CANCER PATIENT; CANCER RADIOTHERAPY; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DOWN REGULATION; FEMALE; GROWTH INHIBITION; HEADACHE; HUMAN; IN VITRO STUDY; INHIBITION KINETICS; MONOTHERAPY; NAUSEA; TREATMENT OUTCOME; TUMOR GROWTH;

ADULT; ARACHIDONATE LIPOXYGENASES; BOSWELLIA; BRAIN NEOPLASMS; BREAST NEOPLASMS; FEMALE; HUMANS; LIPOXYGENASE INHIBITORS; PHYTOTHERAPY; REMISSION INDUCTION; TREATMENT OUTCOME;

EID: 33846965296     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-006-9248-4     Document Type: Article

References (14)

1. Kirsch D, Ledezma C, Mathews C et al (2005) Survival after brain metastases from brest cancer in the Trastuzumab era. J Clin Oncol 23(9):2114-2116
2. Langer C, Mehta M (2005) Current management of brain metastases, with a focus on systemic options. J Clin Oncol 23(25):6207-6219
3. Loeffler JS, Kooy HM, Wen PY et al (1990) The treatment of recurrent brain metastases with stereotactic radiosurgery. J Clin Oncol 8:576-582
4. Giller CA, Berger BD (2005) New frontiers in radiosurgery for the brain and body. BUMC Proc 18:311-319
5. Hazuka MB, Burleson WD, Stroud DN et al (1993) Multiple brian metastases are associated with poor survival in patients treated with surgery and radiotherapy. J Clin Oncol 11:369-373
6. Lin NU, Bellon JR, Winer EP (2004) CNS metastases in breast cancer. J Clin Oncol 22(17):3608-3617
7. Tang DG, Chen YQ, Honn KV (1996) Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Proc Natl Acad Sci USA 93:5241-5246
8. Chen JK, Capdevila J, Harris RC (2001) Cytochrome P450 epoxygenase metabolism of arachidonic acid inhibits apoptosis. Mol Cell Biol 21(18):6322-6331
9. Kelavkar UP, Badr KF (1999) Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: Evidence that 15-lipoxygenase is a mutator gene. Proc Natl Acad Sci USA 96:4378-4383
10. Reo GN, Alexander RW, Runge MS (1995) Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. J Clin Invest 96:842-847
11. Boado RJ, Pardridge WM, Vinters HV, Black KL (1992) Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: Evidence for the expression of a multitranscript family. Proc Natl Acad Sci USA 89:9044-9048
12. Ghosh J, Myers CE (1998) Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells. Proc Natl Acad Sci USA 95:13182-13187
13. Ding XZ, Hennig R, Adrian TE (2003) Lipoxygenase and cyclooxygenase metabolism: New insights in treatement in chemoprevention of pancreatic cancer. Mol Cancer 2:10
14. Noguchi M, Rose DP, Erashi M et al (1995) The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. Oncology 52:265-271