Association of Arachidonate 12-Lipoxygenase Genotype Variation and Glycemic Control With Albuminuria in Type 2 Diabetes

American Journal of Kidney Diseases

Volumn 52, Issue 2, 2008, Pages 242-250

  Liu, Yongmei ^a   Freedman, Barry I ^a   Burdon, Kathryn P ^a   Langefeld, Carl D ^a   Howard, Timothy ^a   Herrington, David ^a   Goff Jr , David C ^a   Bowden, Donald W ^a   Wagenknecht, Lynne E ^a   Hedrick, Catherine C ^b   Rich, Stephen S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

albuminuria; ALOX12 gene; diabetic nephropathy; genetics; Lipoxygenase; type 2 diabetes mellitus

Indexed keywords

ALBUMIN; ARACHIDONATE 12 LIPOXYGENASE; CREATININE; HEMOGLOBIN A1C;

ALBUMINURIA; ALLELE; ARACHIDONATE 12 LIPOXYGENASE 2 GENE; ARTICLE; CONFIDENCE INTERVAL; DIABETIC NEPHROPATHY; EUROPEAN AMERICAN; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLYCEMIC CONTROL; HAPLOTYPE; HEMOGLOBIN BLOOD LEVEL; HETEROZYGOTE; NON INSULIN DEPENDENT DIABETES MELLITUS; SIBLING; STATISTICAL SIGNIFICANCE;

ADULT; ALBUMINURIA; ARACHIDONATE 12-LIPOXYGENASE; BLOOD GLUCOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONTINENTAL POPULATION GROUPS; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; DNA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PREVALENCE; RETROSPECTIVE STUDIES; UNITED STATES;

EID: 47149108938     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2007.12.033     Document Type: Article

References (30)

1. Gerstein H.C., Mann J.F., Yi Q., et al. Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA 286 (2001) 421-426
2. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352 (1998) 837-853
3. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N Engl J Med 342 (2000) 381-389
4. DCCT Research Group. The absence of a glycemic threshold for the development of long-term complications: The perspective of the Diabetes Control and Complications Trial. Diabetes 45 (1996) 1289-1298
5. Stratton I.M., Adler A.I., Neil H.A., et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study. BMJ 321 (2000) 405-412
6. American Association of Clinical Endocrinologists. American College of Endocrinology Consensus Statement on Guidelines for Glycemic Control. Endocr Pract 8 suppl 1 (2002) S5-S11
7. European Diabetes Policy Group 1999. A desktop guide to type 2 diabetes mellitus. Diabet Med 16 (1999) 716-730
8. Barnett A.H. Treating to goal: Challenges of current management. Eur J Endocrinol 151 suppl 2 (2004) T3-T7
9. Ma J., Natarajan R., LaPage J., et al. 12/15-Lipoxygenase inhibitors in diabetic nephropathy in the rat. Prostaglandins Leukot Essent Fatty Acids 72 (2005) 13-20
10. Langefeld C.D., Beck S.R., Bowden D.W., et al. Heritability of GFR and albuminuria in Caucasians with type 2 diabetes mellitus. Am J Kidney Dis 43 (2004) 796-800
11. Kasinath B.S. Lipoxygenases in renal injury-Loading the matrix. Kidney Int 64 (2003) 1918-1919
12. Kim Y.S., Reddy M.A., Lanting L., et al. Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice. Kidney Int 64 (2003) 1702-1714
13. Kang S.W., Adler S.G., Nast C.C., et al. 12-Lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy. Kidney Int 59 (2001) 1354-1362
14. Kang S.W., Natarajan R., Shahed A., et al. Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes. J Am Soc Nephrol 14 (2003) 3178-3187
15. Reddy M.A., Adler S.G., Kim Y.S., et al. Interaction of MAPK and 12-lipoxygenase pathways in growth and matrix protein expression in mesangial cells. Am J Physiol Renal Physiol 283 (2002) F985-F994
16. Antonipillai I., Nadler J., Vu E.J., et al. A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease. J Clin Endocrinol Metab 81 (1996) 1940-1945
17. Fridman C., Ojopi E.P., Gregorio S.P., et al. Association of a new polymorphism in ALOX12 gene with bipolar disorder. Eur Arch Psychiatry Clin Neurosci 253 (2003) 40-43
18. Carlson C.S., Eberle M.A., Rieder M.J., et al. Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat Genet 33 (2003) 518-521
19. Devlin B., and Risch N. A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 29 (1995) 311-322
20. O'Connell J.R. Zero-recombinant haplotyping: Applications to fine mapping using SNPs. Genet Epidemiol 19 suppl 1 (2000) S64-S70
21. Analysis of Messy Data, vol I: Designed Experiments (1984), Van Nostrand Reinhold, New York, NY
22. Gabriel S.B., Schaffner S.F., Nguyen H., et al. The structure of haplotype blocks in the human genome. Science 296 (2002) 2225-2229
23. Warram J.H., Gearin G., Laffel L., et al. Effect of duration of type I diabetes on the prevalence of stages of diabetic nephropathy defined by urinary albumin/creatinine ratio. J Am Soc Nephrol 7 (1996) 930-937
24. Reilly K.B., Srinivasan S., Hatley M.E., et al. 12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo. J Biol Chem 279 (2004) 9440-9450
25. Gillmor S.A., Villasenor A., Fletterick R., et al. The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Nat Struct Biol 4 (1997) 1003-1009
26. Guo Y., Zhang X., Tan W., et al. Platelet 12-lipoxygenase Arg261Gln polymorphism: Functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. Pharmacogenet Genomics 17 (2007) 197-205
27. SeattleSNPs Programs for Genomic Applications: ALOX12:arachidonate 12-lipoxygenase. http://pga.gs.washington.edu/data/alox12/ Accessed September 20, 2007
28. Perkins B.A., Ficociello L.H., Silva K.H., et al. Regression of microalbuminuria in type 1 diabetes. N Engl J Med 348 (2003) 2285-2293
29. Davidson J.A. Treatment of the patient with diabetes: Importance of maintaining target HbA(1c) levels. Curr Med Res Opin 20 (2004) 1919-1927
30. American Diabetes Association. Clinical practice recommendations 2000. Diabetes Care 23 suppl 1 (2000) S1-S116