The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses

Infection and Immunity

Volumn 70, Issue 10, 2002, Pages 5346-5354

  Peiser, Leanne ^a   De Winther, Menno P J ^a   Makepeace, Katherine ^a   Hollinshead, Michael ^a   Coull, Philip ^a   Plested, Joyce ^a   Kodama, Tatsuhiko ^a   Moxon, E Richard ^a   Gordon, Siamon ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; INTERLEUKIN 10; INTERLEUKIN 12; LIPID A; OPSONIN; SCAVENGER RECEPTOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ESCHERICHIA COLI; KNOCKOUT MOUSE; MACROPHAGE; MACROPHAGE ACTIVATION; MENINGOCOCCOSIS; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; CYTOKINES; DROSOPHILA PROTEINS; LIPID A; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MENINGOCOCCAL INFECTIONS; MICE; MICE, INBRED C3H; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; NEISSERIA MENINGITIDIS; PHAGOCYTOSIS; PHAGOSOMES; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS A; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 0036786519     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.10.5346-5354.2002     Document Type: Article

References (47)

1. Pathogenesis of meningococcal infections
2. Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: Identification of interleukin-10 as a major functional deactivator of human monocytes
3. Introduction and historical aspects
4. Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages
5. The role of the interleukin-1/Toll-like receptor family in inflammation and host defence
6. Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor
7. Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: Lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein
8. Macrophages and the immune response
9. Antigen markers of macrophage differentiation in murine tissues
10. Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions
11. Recognition and plasma clearance of endotoxin by scavenger receptors
12. The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock
13. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
14. Neutrophil response to Neisseria meningitidis: Inhibition of adhesion molecule expression and phagocytosis by recombinant bactericidal/permeability-increasing protein (rBPI21)
15. Serotypes of Neisseria meningitidis isolated from patients in Norway during the first six months of 1978
16. Murine macrophage scavenger receptor: In vivo expression and function as receptor for macrophage adhesion in lymphoid and non-lymphoid organs
17. Membrane-associated proteins of a lipopolysaccharide-deficient mutant of Neisseria meningitidis activate the inflammatory response through toll-like receptor 2
18. Zur aetiologie der meningitis cerebrospinalis epidemica
19. Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria
20. CD14, new aspects of ligand and signal diversity
21. Polymorphonuclear granulocytes enhance lipopolysaccharide-induced soluble p75 tumor necrosis factor receptor release from mononuclear cells
22. Interactions of intraleukocytic bacteria with antibiotics
23. Toll-like receptors
24. The function of scavenger receptors expressed by macrophages and their role in the regulation of inflammation
25. Macrophage class A scavenger receptor-mediated phagocytosis of Escherichia coli: Role of cell heterogeneity, microbial strain, and culture conditions in vitro
26. Development of natural immunity to Neisseria meningitidis
27. Surface structures and secreted products of meningococci
28. A lipopolysaccharide-deficient mutant of Neisseria meningitidis elicits attenuated cytokine release by human macrophages and signals via Toll-like receptor (TLR) 2 but not via TLR4/MD2
29. Biochemistry of endotoxins
30. Experimental infection of human nasal mucosal explants with Neisseria meningitidis
31. The (α2→8)-linked polysialic acid capsule of group B Neisseria meningitidis modifies multiple steps during interaction with human macrophages
32. Killing of Neisseria meningitidis by human neutrophils: Implications for normal and complement-deficient individuals
33. Meningitis bacterium is viable without endotoxin
34. The multiple roles of macrophage scavenger receptors (MSR) in vivo: Resistance to atherosclerosis and susceptibility to infection in MSR knockout mice
35. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
36. Elimination of extracellular bacteria by antibiotics in quantitative assays of bacterial ingestion and killing by phagocytes
37. Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis
38. Identification of a locus involved in meningococcal lipopolysaccharide biosynthesis by deletion mutagenesis
39. Update on meningococcal disease with emphasis on pathogenesis and clinical management
40. The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cells
41. Interactions of Haemophilus influenzae with cultured human endothelial cells
42. Meningococcal Opa and Opc proteins: Their role in colonization and invasion of human epithelial and endothelial cells
43. Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic Neisseriae
44. Opc- and pilus-dependent interactions of meningococci with human endothelial cells: Molecular mechanisms and modulation by surface polysaccharides
45. Mechanisms of neisserial serum resistance
46. Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease
47. CD14: Cell surface receptor and differentiation marker