Cathelicidins: A family of endogenous antimicrobial peptides

Current Opinion in Hematology

Volumn 9, Issue 1, 2002, Pages 18-22

  Lehrer, R I ^a   Ganz, T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; GENE PRODUCT; MYELOBLASTIN; PR 39; PROTEGRIN; PROTEIN HCAP 18; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIMICROBIAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CELL GRANULE; CHEMOTAXIS; CLINICAL TRIAL; DEGRANULATION; DRUG EFFICACY; DRUG ISOLATION; EPIDIDYMIS; HEART MUSCLE INJURY; HUMAN; MUCOSA INFLAMMATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROCESSING; REVIEW; SPERMATID;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD PROTEINS; CHEMOTAXIS, LEUKOCYTE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NEUTROPHILS; PEPTIDES; PROTEINS;

EID: 0036135697     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200201000-00004     Document Type: Review

References (31)

1. Cathelicidins: A novel protein family with a common proregion and a variable C-terminal antimicrobial domain
2. Primary structure of a new cysteine proteinase inhibitor from pig leukocytes
3. Structural features and biologic activities of the cathelicidin-derived antimicrobial peptides
4. Structure and biology of cathelicidins
5. Human antimicrobial peptides: Analysis and application
6. Molecular cloning of a novel myeloid granule protein
7. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3
8. Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds
9. Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus
10. The human cationic antimicrobial protein (hCAP-18) is expressed in the epithelium of human epididymis, is present in seminal plasma at high concentrations, and is attached to spermatozoa
11. Cloning and sequencing of SOB3, a human gene coding for a sperm protein homologous to an antimicrobial protein and potentially involved in zona pellucida binding
12. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, uses formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells
13. The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations
14. Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator
15. Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells
16. The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection
17. Bacterial phosphorylcholine decreases susceptibility to the antimicrobial peptide LL-37/hCAP18 expressed in the upper respiratory tract
18. Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with I-lysine
19. The D-alanine residues of Staphylococcus aureus teichoic acids alter the susceptibility to vancomycin and the activity of autolytic enzymes
20. Identification of proteus mirabilis mutants with increased sensitivity to antimicrobial peptides
21. Anti-microbial activity and cell binding are controlled by sequence determinants in the anti-microbial peptide PR-39
22. PR-39, a proline/arginine-rich antimicrobial peptide, exerts cardioprotective effects in myocardial ischemia-reperfusion
23. PR-39, a potent neutrophil inhibitor attenuates myocardial ischemia-reperfusion injury in mice
24. In vitro activity of PR-39, a proline-arginine-rich peptide, against susceptible and multi-drug-resistant Mycobacterium tuberculosis
25. Regulation of cathelicidin gene expression: Induction by lipopolysaccharide, interleukin-6, retinoic acid, and Salmonella enterica serovar typhimurium infection
26. Neutrophil-specific granule deficiency: Homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein-epsilon
27. Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide
28. Protegrins: New antibiotics of mammalian origin
29. Development of protegrins for the treatment and prevention of oral mucositis: Structure-activity relationships of synthetic protegrin analogues
30. Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family
31. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins