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Volumn , Issue 5, 2011, Pages 878-891

Syntheses and biological properties of brefeldin analogues

Author keywords

Brefeldin A analogues; Macrolactonization; Molecular modeling; Nozaki Hiyama Kishi reaction; Structure activity relationships; Total synthesis

Indexed keywords


EID: 79551573511     PISSN: 1434193X     EISSN: 10990690     Source Type: Journal    
DOI: 10.1002/ejoc.201001297     Document Type: Article
Times cited : (18)

References (71)
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    • [14], for brefeldin analogues derived from total synthesis, see: T. Hübscher, G. Helmchen, Synlett 2006, 1323-1326.
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    • For detailed information see. http://dtp.nci.nih.gov.
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    • The commonly used BFA numbering is used here for the brefeldin analogues (cf. Figures 1 and 2). This begins at the carbonyl group and continues anticlockwise around the molecule. All other compounds are numbered according to the IUPAC rules
    • The commonly used BFA numbering is used here for the brefeldin analogues (cf. Figures 1 and 2). This begins at the carbonyl group and continues anticlockwise around the molecule. All other compounds are numbered according to the IUPAC rules.
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    • The NCI's internal ID numbers (NSC) of the brefeldin analogues described by us: NSC 652682 (BFA lactam analogue), NSC 751150 [(6R)-hydroxy-BFA], NSC 671437 (7S)-amino-BFC. The latter compound had already been submitted to the NCI anonymously. Brefeldin analogues presented in earlier publications: NSC 746705 (4-acetoxy-4-deoxy-BFC lactam analogue), NSC 746706 (BFC lactam analogue), NSC 746707 (6,7-didehydro-BFC)
    • The NCI's internal ID numbers (NSC) of the brefeldin analogues described by us: NSC 652682 (BFA lactam analogue), NSC 751150 [(6R)-hydroxy-BFA], NSC 671437 (7S)-amino-BFC. The latter compound had already been submitted to the NCI anonymously. Brefeldin analogues presented in earlier publications: NSC 746705 (4-acetoxy-4-deoxy-BFC lactam analogue), NSC 746706 (BFC lactam analogue), NSC 746707 (6,7-didehydro-BFC).
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    • 2O was used as solvent model, and the implemented automatic setup was performed for the conformational search
    • 2O was used as solvent model, and the implemented automatic setup was performed for the conformational search.
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    • Additionally, the fungus was cultivated in a liquid medium as reported by:,. In our hands, the organism grew rapidly and in pellet form as described, but the BFA content was very low.
    • Additionally, the fungus was cultivated in a liquid medium as reported by:, T. G. McCloud, M. P. Burns, F. D. Majadly, G. M. Muschik, D. A. Miller, K. K. Poole, J. M. Roach, J. T. Ross, W. B. Lebherz, J. Ind. Microbiol. 1995, 15, 5-9. In our hands, the organism grew rapidly and in pellet form as described, but the BFA content was very low.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.