Design and synthesis of brefeldin A sulfide derivatives as prodrug candidates with enhanced aqueous solubilities

Journal of Medicinal Chemistry

Volumn 41, Issue 18, 1998, Pages 3337-3346

  Argade, Ankush B ^a   Devraj, Rajesh ^a   Vroman, Jeffrey A ^a   Haugwitz, Rudiger D ^b   Hollingshead, Melinda ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREFELDIN A; CYTOTOXIC AGENT; PRODRUG; SULFIDE; SULFOXIDE;

ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CHEMICAL REACTION KINETICS; CYTOTOXICITY; DRUG DESIGN; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TRANSFORMATION; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; BREFELDIN A; CELL DIVISION; CYCLOPENTANES; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MACROLIDES; MICE; NEOPLASM TRANSPLANTATION; PRODRUGS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; SULFONES; SULFOXIDES; TUMOR CELLS, CULTURED;

EID: 0032572823     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970746g     Document Type: Article

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