Preparation and evaluation of sulfide derivatives of the antibiotic brefeldin A as potential prodrug candidates with enhanced aqueous Solubilities

Journal of Medicinal Chemistry

Volumn 44, Issue 23, 2001, Pages 3915-3924

  Fox, B M ^a   Vroman, J A ^a   Fanwick, P E ^b   Cushman, M ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO[HYDROXYPROPYL SULFINYL]BREFELDIN A; BREFELDIN A; PRODRUG; SELENIDE; SULFIDE; SULFOXIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG METABOLISM; DRUG OXIDATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS;

ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; BREFELDIN A; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KINETICS; MACROLIDES; MAGNETIC RESONANCE SPECTROSCOPY; ORGANOSELENIUM COMPOUNDS; PRODRUGS; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; TUMOR CELLS, CULTURED;

EID: 0035829470     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010054z     Document Type: Article

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