Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects

Obesity

Volumn 19, Issue 2, 2011, Pages 305-311

  Kien, C Lawrence ^a,b   Everingham, Karen I ^a   D Stevens, Robert ^c   Fukagawa, Naomi K ^b   Muoio, Deborah M ^c,d  

^a UNIVERSITY OF VERMONT   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c DUKE UNIVERSITY   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; CARNITINE; DIACYLGLYCEROL; DRUG DERIVATIVE; FATTY ACID; OLEIC ACID; PALMITIC ACID; PALMITOYLCARNITINE; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADULT; ARTICLE; BLOOD; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; DRUG EFFECT; FAT INTAKE; FATTY ACID ANALYSIS; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; FEMALE; HISTOLOGY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LIPID COMPOSITION; MALE; METABOLISM; MUSCLE BIOPSY; MUSCLE LEVEL; NORMAL HUMAN; OXIDATION REDUCTION REACTION; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE;

ADIPOSE TISSUE; CARNITINE; DIETARY FATS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MUSCLE, SKELETAL; OLEIC ACID; OXIDATION-REDUCTION; PALMITIC ACID; TRIGLYCERIDES;

EID: 79551497655     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2010.135     Document Type: Article

References (39)

1. Kien CL. Dietary interventions for metabolic syndrome: role of modifying dietary fats. Curr Diab Rep 2009;9:43-50.
2. Chavez JA, Summers SA. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch Biochem Biophys 2003;419: 101-109.
3. Moffitt JH, Fielding BA, Evershed R et al. Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro. Diabetologia 2005;48:1819-1829.
4. Schmidt DE, Allred JB, Kien CL. Fractional oxidation of chylomicron-derived oleate is greater than that of palmitate in healthy adults fed frequent small meals. J Lipid Res 1999;40:2322-2332.
5. Kien CL, Bunn J Y, Ugrasbul F. Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure. Am J Clin Nutr 2005;82: 320-326.
6. Kien CL, Bunn JY. Gender alters the effects of palmitate and oleate on fat oxidation and energy expenditure. Obesity (Silver Spring) 2008;16:29-33.
7. Piers LS, Walker KZ, Stoney RM, Soares MJ, O'Dea K. Substitution of saturated with monounsaturated fat in a 4-week diet affects body weight and composition of overweight and obese men. Br J Nutr 2003;90: 717-727.
8. Koves TR, Li P, An J et al. Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem 2005;280:33588-33598.
9. Muoio DM, Newgard CB. Obesity-related derangements in metabolic regulation. Annu Rev Biochem 2006;75:367-401.
10. Coll T, Jové M, Rodríguez-Calvo R et al. Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation. Diabetes 2006;55:2779-2787.
11. Crunkhorn S, Dearie F, Mantzoros C et al. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem 2007;282:15439-15450.
12. Coll T, Eyre E, Rodríguez-Calvo R et al. Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells. J Biol Chem 2008;283:11107-11116.
13. Thrush AB, Heigenhauser GJ, Mullen KL, Wright DC, Dyck DJ. Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans. Am J Physiol Regul Integr Comp Physiol 2008;294: R1205-R1212.
14. Jové M, Planavila A, Sánchez RM et al. Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation. Endocrinology 2006;147:552-561.
15. Sinha S, Perdomo G, Brown NF, O'Doherty RM. Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. J Biol Chem 2004;279:41294-41301.
16. Shi H, Kokoeva M V, Inouye K et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006;116:3015-3025.
17. Lee JY, Sohn KH, Rhee SH, Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 2001;276:16683-16689.
18. Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A et al. Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab 2008;7:496-507.
19. Lee JS, Pinnamaneni SK, Eo SJ et al. Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J Appl Physiol 2006;100:1467-1474.
20. Powell DJ, Turban S, Gray A, Hajduch E, Hundal HS. Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem J 2004;382:619-629.
21. Turpin SM, Lancaster GI, Darby I, Febbraio MA, Watt MJ. Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am J Physiol Endocrinol Metab 2006;291:E1341-E1350.
22. Adams SH, Hoppel CL, Lok KH et al. Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women. J Nutr 2009;139:1073-1081.
23. Børsheim E, Kien CL, Pearl WM. Differential effects of dietary intake of palmitic acid and oleic acid on oxygen consumption during and after exercise. Metab Clin Exp 2006;55:1215-1221.
24. Mustad VA, Jonnalagadda SS, Smutko SA et al. Comparative lipid and lipoprotein responses to solid-food diets and defined liquid-formula diets. Am J Clin Nutr 1999;70:839-846.
25. Kien CL, Ugrasbul F. Prediction of daily energy expenditure during a feeding trial using measurements of resting energy expenditure, fat-free mass, or Harris-Benedict equations. Am J Clin Nutr 2004;80:876-880.
26. Stern SE, Williams K, Ferrannini E et al. Identification of individuals with insulin resistance using routine clinical measurements. Diabetes 2005;54:333-339.
27. Highstead RG, Tipton KD, Creson DL, Wolfe RR, Ferrando AA. Incidence of associated events during the performance of invasive procedures in healthy human volunteers. J Appl Physiol 2005;98:1202-1206.
28. Toth MJ, Palmer BM, LeWinter MM. Effect of heart failure on skeletal muscle myofibrillar protein content, isoform expression and calcium sensitivity. Int J Cardiol 2006;107:211-219.
29. Thyfault J P, Cree MG, Zheng D et al. Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. Am J Physiol, Cell Physiol 2007;292:C729-C739.
30. Boberg M, Croon LB, Gustafsson IB, Vessby B. Platelet fatty acid composition in relation to fatty acid composition in plasma and to serum lipoprotein lipids in healthy subjects with special reference to the linoleic acid pathway. Clin Sci 1985;68:581-587.
31. Brevik A, Veierød MB, Drevon CA, Andersen L F. Evaluation of the odd fatty acids 15:0 and 17:0 in serum and adipose tissue as markers of intake of milk and dairy fat. Eur J Clin Nutr 2005;59:1417-1422.
32. Andersson A, Nälsén C, Tengblad S, Vessby B. Fatty acid composition of skeletal muscle reflects dietary fat composition in humans. Am J Clin Nutr 2002;76:1222-1229.
33. Sowa JM, Subbaiah P V. Variable recoveries of fatty acids following the separation of lipids on commercial silica gel TLC plates Selective loss of unsaturated fatty acids on certain brands of plates. J Chromatogr B Analyt Technol Biomed Life Sci 2004;813:159-166.
34. Roe CR, Coates PM. Mitochondrial fatty acid oxidation disorders. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds). The Metabolic and Molecular Basis of Inherited Disease. McGraw-Hill: New York, 1995, pp 1501-1533.
35. Bruce CR, Thrush AB, Mertz VA et al. Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content. Am J Physiol Endocrinol Metab 2006;291:E99-E107.
36. Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 2002;51:2005-2011.
37. Kien CL, Bunn JY. Effects of palmitate and oleate on the respiratory quotient during acute feeding. Obesity (Silver Spring) 2007;15:1640-1642.
38. Grundy SM, Ahrens EH Jr. The effects of unsaturated dietary fats on absorption, excretion, synthesis, and distribution of cholesterol in man. J Clin Invest 1970;49:1135-1152.
39. Spritz N, Ahrens EH Jr, Grundy S. Sterol balance in man as plasma cholesterol concentrations are altered by exchanges of dietary fats. J Clin Invest 1965;44:1482-1493.