(-)-epigallocatechin-3-gallate induces apoptosis of human hepatoma cells by mitochondrial pathways related to reactive oxygen species

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 15, 2009, Pages 6685-6691

  Li, Wenjuan ^a   Nie, Shaopiing ^a   Yu, Qiang ^a   Xie, Ming Yong ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

( ) epigallocatechin 3 gallate; Apoptosis; Green tea; Hepatocarcinoma; Reactive oxygen species

Indexed keywords

CATECHIN; CYTOCHROME C; DRUG DERIVATIVE; EPIGALLOCATECHIN GALLATE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CHEMISTRY; DRUG EFFECT; HUMAN; LIVER TUMOR; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PATHOPHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; CATECHIN; CELL LINE, TUMOR; CYTOCHROMES C; HUMANS; LIVER NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; REACTIVE OXYGEN SPECIES;

EID: 68249095178     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf901396f     Document Type: Article

References (33)

1. Xiao, J. B.; Chen, X. Q.; Zhang. L.; Talbot. S. G.; Li, G. C.; Xu. M. Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method. J. Agric. Food Chem. 2008, 56, 910-915.
2. Hu, J. H.; Zhou, D. R.; Chen, Y. Q. Preparation and antioxidant activity of green tea extract enriched in epigallocatechin (EGC) and epigallocatechin gallate (EGCG). J. Agric. Food Chem. 2009, 57, 1349-1353.
3. Mojzisová, G.; Sarisský, M.; Mirossay, L.; Martinka, P.; Mojzis, J. Effect of flavonoids on daunorubicin-induced toxicity in H9c2 cardiomyoblasts. Phytother Res. 2009, 23, 136-139.
4. Omata, M.; Tateishi, R.; Yoshida, H.; Shiina. S. Treatment of hepatocellular carcinoma by percutaneous tumor ablation methods: ethanol injection therapy and radiofrequency ablation. Gastroenterology 2004, 127, S159-S166.
5. Wang, R.; Zhou, W. B.; Jiang. X. H. Reaction kinetics of degradation and epimerization of epigallocatechin gallate (EGCG) in aqueous system over a wide temperature range. J. Agric. Food Chem. 2008, 56, 2694-2701.
6. Sehm, J.; Polster, J.; Pfaffl, M. W. Effects of varied EGCG and (+)-catechin concentrations on proinflammatory cytokines mRNA expression inConA-stimulated primary white blood cell cultures. J. Agric. Food Chem. 2005, 53, 6907-6911.
7. Dreosti, I. E.; Wargovich, M. J.; Yang, C. S. Inhibition of carcinogenesis by tea: the evidence from experimental studies. Crit. Rev. Food Sci. Nutr. 1997, 37, 761-770.
8. Fujiki, H.; Suganuma, M.; Okabe, S.; Sueoka, N.; Komori, A.; Sueoka, E.; Kozu, T.; Tada, Y.; Suga, K.; Imai, K.; Nakachi, K. Cancer inhibition by green tea. Mutat. Res. 1998, 402, 307-310.
9. Li, Y. M.; Chan, H. Y.; Huang, Y.; Chen, Z. Y. Green tea catechins upregulate superoxide dismutase and catalase in fruit flies. Mol. Nutr. Food Res. 2007, 51, 546-554.
10. Zhang, G.; Miura, Y.; Yagasaki, K. Suppression of adhesion and invasion of hepatoma cells in culture by tea compounds through antioxidative activity. Cancer Lett. 2000, 159, 169-173.
11. Kresty, L. A.; Howell, A. B.; Baird, M. Cranberry proanthocyanidins induce apoptosis and inhibit acid-induced proliferation of human esophageal adenocarcinoma cells. J. Agric. Food Chem. 2008, 56, 676-680.
12. Saelens, X.; Festjens, N.; Walle, L. V.; Van Gurp, M.; van Loo, G.; Vandenabeele, P. Toxic proteins released from mitochondria in cell death. Oncogene 2004, 23, 2861-2874.
13. Tan, S.; Sagara, Y.; Liu, Y.; Maher, P.; Schubert, D. The regulation of reactive oxygen species production during programmed cell death. J. Cell Biol. 1998, 141, 1423-1432.
14. Yao. K.; Ye, P.; Zhang, L.; Tan, J.; Tang, X.; Zhang, Y. Epigallocatechin gallate protects against oxidative stress-induced mitochondria-dependent apoptosis in human lens epithelial cells. Mol. Vis. 2008, 14, 217-223.
15. Gupta. S.; Ahmad. N.; Nieminen, A. L.; Mukhtar. H. Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (-)-epigallocatechin-3-gallate in androgensensitive and androgen-insensitive human prostate carcinoma cells. Toxicol. Appl. Pharmacol. 2000, 164. 82-90.
16. Lambert, J. D.; Yang, C. S. Mechanisms of cancer prevention by tea constituents. J. Nutr. 2003, 133, 3262S-3267S.
17. Kluck, R. M.; Bossy-Wetzel, E.; Green, D. R.; Newmeyer. D. D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997, 275. 1132-1136.
18. Nakazalo, T.; Ito, K.; Miyakawa, Y.; Kinjo, K.; Yamada, T.; Hozumi, N.; Ikeda, Y.; Kizaki, M. Catechin, a green tea component, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo. Haematologica 2005, 90, 317-325.
19. Horie, N.; Hirabayashi, N.; Takahashi, Y.; Miyauchi, Y.; Taguchi, H.; Takeishi, K. Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells. Biol. Pharm. Bull. 2005, 28, 574-579.
20. Zhang, Q.; Tang, X.; Lu, Q.; Zhang, Z.; Rao, J.; Le, A. D. Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1alpha protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells. Mol. Cancer Ther. 2006, 5, 1227-1238.
21. Takada. M.; Nakamura, Y.; Koizumi, T.; Toyama, H.; Kamigaki, T.; Suzuki, Y.; Takeyama, Y.; Kuroda, Y. Suppression of human pancreatic carcinoma cell growth and invasion by epigallocatechin3-gallate. Pancreas 2002, 25, 45-48.
22. Guicciardi, M.. E.; Gores, G. J. Apoptosis: a mechanism of acute and chronic liver injury. Gut 2005, 54, 1024-1033.
23. Wang, X. The expanding role of mitochondria in apoptosis. Genes Dev. 2001, 15, 2922-2933.
24. An, J.; Chen, Y.; Huang, Z. Critical upstream signals of cytochrome c release induced by a novel Bcl-2 inhibitor. J. Biol. Chem. 2004, 279, 19133-19140.
25. Yeh, C. T.; Yen, G. C. Induction of apoptosis by the anthocyanidins through regulation of Bcl-2 gene and activation of c-Jun N-terminal kinase cascade in hepatoma cells. J. Agric. Food Chem. 2005, 53 (5), 1740-1749.
26. Antonsson, B.; Montessuit, S.; Sanchez, B.; Martinou, J. C. Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J. Biol. Chem. 2001, 276. 11615-11623.
27. Simon, H. U.; Haj-Yehia, A.; Levi-Schaffer, F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000, 5, 415-418.
28. Zhou, Y. J.; Zhang, S. P.; Liu, C. W.; Cai. Y. Q. The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK(1) cells. Toxicol In Vitro 2009, 23, 288-294.
29. Ogura, A.; Oowada, S.; Kon, Y.; Hirayama, A.; Yasui, H.; Meike, S.; Kobayashi, S.; Kuwabara, M.; Inanami, O. Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells. Cancer Lett. 2009, 277, 64-71.
30. Yang. C. S.; Maliakal, P.; Meng, X. Inhibition of carcinogenesis by tea. Annu. Rev. Pharmacol. Toxicol. 2002, 42, 25-54.
31. Sakagami, H.; Arakawa, H.; Maeda, M.; Satoh, K.; Kadofuku, T.; Fukuchi, K.; Gomi, K. Production of hydrogen peroxide and methionine sulfoxide by epigallocatechin gallate and antioxidants. Anticancer Res. 2001, 21, 2633-2641.
32. Chen, Y. C; Lin-Shiau, S. Y.; Lin, J. K. Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis. J. Cell Physiol. 1998, 177, 324-433.
33. Grad, J. M.; Bahlis, N. J.; Reis, L; Oshiro, M. M.; Dalton, W. S.; Boise, L. H. Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells. Blood 2001, 98, 805-813.