Cytosolic phospholipase A2 inhibition is involved in the protective effect of nortriptyline in primary astrocyte cultures exposed to combined oxygen-glucose deprivation

Pharmacological Reports

Volumn 62, Issue 5, 2010, Pages 814-826

  Gabryel, Bozena ^a   Bielecka, Anna ^a   Stolecka, Anna ^b   Bernacki, Jacek ^a   Langfort, Józef ^b  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b INSTITUTE OF SPORT SCIENCES   (Poland)

Author keywords

Astrocytes; Ischemia; Nortriptyline

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ARACHIDONIC ACID; CYTOSOLIC PHOSPHOLIPASE A2; GLUCOSE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NORTRIPTYLINE; OXYGEN; PROTEIN KINASE C; NEUROPROTECTIVE AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CELL MEMBRANE DEPOLARIZATION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; IN VITRO STUDY; MITOCHONDRIAL PERMEABILITY; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL HYPOXIA; CYTOLOGY; DRUG ANTAGONISM; METABOLISM; NECROSIS; WISTAR RAT;

ANIMALS; APOPTOSIS; ARACHIDONIC ACID; ASTROCYTES; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; GLUCOSE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NECROSIS; NEUROPROTECTIVE AGENTS; NORTRIPTYLINE; PHOSPHOLIPASES A2, CYTOSOLIC; PROTEIN KINASE C; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 79551479167     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(10)70342-X     Document Type: Article

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